Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0035 | 0.794 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0035 | 0.794 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.794 | 0.7285 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.794 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.794 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.794 | 0.7285 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.794 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0035 | 0.794 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.794 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.794 | 1 |
Leishmania major | pyruvate kinase | 0.0035 | 0.794 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.794 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.794 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.0035 | 0.794 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.794 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0035 | 0.794 | 0.5 |
Leishmania major | pyruvate kinase | 0.0035 | 0.794 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.0035 | 0.794 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0035 | 0.794 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.794 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.794 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.794 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.794 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.794 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.794 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 124 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cell membrane | ChEMBL. | 23098605 |
Ki (binding) | = 136 nM | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cell membrane | ChEMBL. | 23098605 |
Ki (binding) | = 525 nM | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cell membrane | ChEMBL. | 23098605 |
Ki (functional) | > 10000 nM | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity | ChEMBL. | 23098605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.