Detailed information for compound 171819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.29 | Formula: C18H11F6N3O
  • H donors: 2 H acceptors: 2 LogP: 4.43 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc2c1ccnc2)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
  • InChi: 1S/C18H11F6N3O/c19-17(20,21)11-6-12(18(22,23)24)8-13(7-11)26-16(28)27-15-3-1-2-10-9-25-5-4-14(10)15/h1-9H,(H2,26,27,28)
  • InChiKey: CKLFTQRSYHFUFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Leishmania major oxidoreductase, putative 0.0058 0.0241 0.1397
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0332 0.1201
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0314 0.1138
Echinococcus granulosus tumor protein p63 0.0312 0.1677 0.607
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0058 0.0241 0.0303
Echinococcus multilocularis dro:myosuppressin receptor 0.0071 0.0314 0.0757
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0314 0.0757
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.061 0.3363 0.6033
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0067 0.0288 0.0363
Brugia malayi metabotropic glutamate receptor type 2 0.0028 0.007 0.0061
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0036 0.0115 0.0902
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0016 0.0059
Schistosoma mansoni bromodomain containing protein 0.0045 0.0163 0.0589
Echinococcus granulosus serotonin transporter 0.0504 0.2762 1
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0059 0.0246 0.0261
Brugia malayi Adrenodoxin-like protein, mitochondrial precursor, putative 0.0055 0.0219 0.021
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0058 0.0241 0.0264
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Entamoeba histolytica pyruvate kinase, putative 0.0021 0.0027 0.0203
Mycobacterium ulcerans electron transfer protein FdxB 0.0067 0.0288 0.0363
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0085 0.0394 0.1427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0101 0.0484 0.0612
Loa Loa (eye worm) hypothetical protein 0.0504 0.2762 0.3117
Echinococcus multilocularis 0.0043 0.0152 0.0366
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0085 0.0394 0.1427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0425 0.0477
Plasmodium vivax flavodoxin domain containing protein 0.0095 0.045 0.3596
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.0078 0.0046
Mycobacterium ulcerans quinone reductase Qor 0.0058 0.0241 0.0303
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0036 0.0115 0.0854
Echinococcus multilocularis pyruvate kinase 0.0023 0.0043 0.0102
Brugia malayi RE15519p 0.0071 0.0314 0.0305
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0071 0.0314 0.1138
Trypanosoma brucei lanosterol synthase 0.0026 0.0059 0.0407
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0034 0.028
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Toxoplasma gondii adrenodoxin-type ferredoxin, putative 0.0055 0.0219 0.0378
Schistosoma mansoni tyrosine kinase 0.0074 0.033 0.1193
Echinococcus multilocularis serotonin receptor 0.0177 0.091 0.2194
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0407
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis voltage gated potassium channel 0.0019 0.0016 0.0039
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0769 0.4263 0.5418
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0133 0.0661 0.1592
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Loa Loa (eye worm) hypothetical protein 0.0144 0.0727 0.0817
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0095 0.0448 0.0566
Brugia malayi putative neuropeptide receptor NPR1 0.0071 0.0314 0.0305
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0621 0.343 0.4336
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0108 0.0519 0.125
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Plasmodium vivax amine transporter, putative 0.0085 0.0394 0.3149
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0144 0.0727 0.0921
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0034 0.004
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.094 0.5233 0.5229
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus granulosus allatostatin A receptor 0.0071 0.0314 0.1138
Brugia malayi neuropeptide F receptor 0.0071 0.0314 0.0305
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0058 0.0241 0.0243
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi follicle stimulating hormone receptor 0.0071 0.0314 0.0305
Onchocerca volvulus 0.0085 0.0394 0.038
Echinococcus granulosus sodium and chloride dependent glycine 0.0085 0.0394 0.1427
Trichomonas vaginalis Ferredoxin 4 0.0055 0.0219 0.0221
Brugia malayi Dopamine receptor 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) fatty acid synthase 0.0927 0.5162 0.5827
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0135 0.0673 0.5391
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0058 0.0241 0.1871
Brugia malayi Metabotropic glutamate receptor precursor. 0.0058 0.0238 0.0229
Giardia lamblia Rab geranylgeranyltransferase 0.0139 0.07 0.4405
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0058 0.0241 0.0303
Schistosoma mansoni neuropeptide f receptor 76f 0.0071 0.0314 0.1138
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0314 0.1138
Toxoplasma gondii acyl carrier protein ACP 0.0095 0.0448 0.0789
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0236 0.1246 0.1238
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0998 0.5564 0.7061
Mycobacterium tuberculosis Probable thioesterase TesA 0.0783 0.4346 0.5523
Echinococcus multilocularis epidermal growth factor receptor 0.0138 0.0691 0.1665
Trypanosoma brucei acyl transferase-like protein 0.0059 0.0246 0.1914
Mycobacterium ulcerans polyketide synthase Pks13 0.1405 0.7866 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0171 0.019
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0998 0.5564 0.7072
Schistosoma mansoni [ACP] S-malonyltransferase 0.0059 0.0246 0.089
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0115 0.0854
Echinococcus granulosus neuropeptide receptor 0.0071 0.0314 0.1138
Plasmodium vivax geranylgeranyltransferase, putative 0.0026 0.0059 0.0457
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0749 0.415 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0048 0.0181 0.0181
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0019 0.0016 0.0039
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0036 0.0115 0.0277
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0295 0.1582 0.2009
Trypanosoma cruzi adrenodoxin precursor, putative 0.0055 0.0219 0.1698
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0108 0.0519 0.3278
Mycobacterium ulcerans thioesterase TesA 0.0783 0.4346 0.5523
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0035
Schistosoma mansoni hypothetical protein 0.0095 0.0448 0.1621
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005
Echinococcus granulosus neuropeptide s receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0034 0.004
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0756 0.4193 0.531
Brugia malayi FAD binding domain containing protein 0.0108 0.0519 0.051
Toxoplasma gondii hypothetical protein 0.0085 0.0394 0.0692
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0101 0.0484 0.0612
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0026 0.0059 0.0457
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0071 0.0314 0.0757
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0692
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis allatostatin A receptor 0.0071 0.0314 0.0757
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0058 0.0241 0.0303
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.038 0.2063 0.262
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0236 0.1246 0.1581
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0108 0.0519 0.4152
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0019 0.0016 0.0059
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0016 0.0059
Echinococcus multilocularis pyruvate kinase 0.003 0.0078 0.0188
Echinococcus granulosus serotonin receptor 0.0071 0.0314 0.1138
Toxoplasma gondii type I fatty acid synthase, putative 0.0999 0.5569 1
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0219 0.1698
Trypanosoma brucei pyruvate kinase 1 0.003 0.0078 0.0556
Onchocerca volvulus 0.0071 0.0314 0.0296
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0144 0.0727 0.0921
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Onchocerca volvulus 0.0085 0.0394 0.038
Brugia malayi FAD binding domain containing protein 0.0066 0.0286 0.0277
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0034 0.004
Mycobacterium ulcerans polyketide synthase Pks9 0.0621 0.343 0.4359
Mycobacterium leprae Probable pyruvate kinase PykA 0.003 0.0078 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0314 0.1138
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0058 0.0241 0.0232
Brugia malayi neuropeptide F receptor 0.0071 0.0314 0.0305
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0066 0.0286 0.1035
Echinococcus granulosus g protein coupled receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable oxidoreductase 0.0058 0.0241 0.0303
Mycobacterium tuberculosis Conserved hypothetical protein 0.0095 0.0448 0.0566
Brugia malayi AKH receptor 0.0071 0.0314 0.0305
Echinococcus granulosus hypothetical protein 0.0071 0.0314 0.1138
Schistosoma mansoni NADPH flavin oxidoreductase 0.0054 0.0217 0.0785
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0144 0.0727 0.0921
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0058 0.0241 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Schistosoma mansoni tyrosine kinase 0.0073 0.0325 0.1177
Schistosoma mansoni myelin transcription factor 1 myt1 0.0038 0.0127 0.0459
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans pyruvate kinase 0.003 0.0078 0.0096
Trypanosoma cruzi oxidoreductase, putative 0.0058 0.0241 0.1871
Trypanosoma cruzi pyruvate kinase 2, putative 0.003 0.0078 0.0556
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0041 0.0143 0.1081
Toxoplasma gondii type I fatty acid synthase, putative 0.0669 0.3699 0.6637
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0139 0.07 0.2534
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0139 0.07 0.5609
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0131 0.0128
Brugia malayi Bromodomain containing protein 0.0027 0.0063 0.0054
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0095 0.0448 0.0566
Schistosoma mansoni biogenic amine (5HT) receptor 0.0177 0.091 0.3296
Loa Loa (eye worm) hypothetical protein 0.003 0.008 0.0088
Leishmania major hypothetical protein, conserved 0.0055 0.0219 0.1252
Schistosoma mansoni biogenic amine receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0101 0.0484 0.0612
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0058 0.0241 0.1397
Onchocerca volvulus Putative alcohol dehydrogenase 0.0058 0.0241 0.0218
Schistosoma mansoni growth hormone secretagogue receptor 0.0071 0.0314 0.1138
Schistosoma mansoni pyruvate kinase 0.003 0.0078 0.0282
Echinococcus granulosus somatostatin receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans oxidoreductase 0.0067 0.0288 0.0363
Loa Loa (eye worm) TK/EGFR protein kinase 0.0138 0.0691 0.0777
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0058 0.0241 0.0243
Giardia lamblia Nitric oxide synthase, inducible 0.0095 0.045 0.2684
Schistosoma mansoni sodium/chloride dependent transporter 0.0085 0.0394 0.1427
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0314 0.1138
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0055 0.0219 0.1252
Leishmania major hypothetical protein, conserved 0.0283 0.1514 1
Brugia malayi G-protein coupled receptor 0.0071 0.0314 0.0305
Schistosoma mansoni pyruvate kinase 0.003 0.0078 0.0282
Echinococcus granulosus AMP dependent ligase 0.0096 0.0453 0.1639
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0034 0.01 0.007
Echinococcus multilocularis serotonin receptor 0.0177 0.091 0.2194
Brugia malayi Melatonin receptor type 1A 0.0071 0.0314 0.0305
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0058 0.0241 0.0303
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0071 0.0314 0.0756
Trypanosoma brucei NADH-ubiquinone oxidoreductase complex I subunit, putative 0.0055 0.0219 0.1698
Echinococcus granulosus G protein coupled receptor 139 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0323 0.174 0.2209
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0034 0.0025
Trypanosoma cruzi protein farnesyltransferase, putative 0.0026 0.0059 0.0407
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.0078 0.0046
Leishmania major zinc binding dehydrogenase-like protein 0.0058 0.0241 0.1397
Echinococcus granulosus epidermal growth factor receptor 0.0074 0.033 0.1193
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0058 0.0241 0.0303
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.1514 0.1581
Trichomonas vaginalis Ferredoxin 7 0.0055 0.0219 0.0221
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0058 0.0241 0.0303
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0314 0.1138
Echinococcus multilocularis neuropeptide receptor A26 0.0071 0.0314 0.0757
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0036 0.0115 0.0854
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0332 0.1201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0332 0.08
Loa Loa (eye worm) hypothetical protein 0.0177 0.091 0.1025
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0085 0.0394 0.095
Toxoplasma gondii hypothetical protein 0.0103 0.0495 0.0874
Leishmania major d-xylulose reductase, putative 0.0058 0.0241 0.1397
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Toxoplasma gondii flavodoxin domain-containing protein 0.0053 0.0212 0.0365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0442
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.009
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0573 0.3157 0.4011
Plasmodium falciparum acyl carrier protein 0.0095 0.0448 0.3579
Brugia malayi Pyruvate kinase, muscle isozyme 0.003 0.0078 0.0069
Echinococcus multilocularis insulin receptor 0.0044 0.016 0.0384
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0026 0.0059 0.0215
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.08 0.4444 0.5648
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0036 0.0115 0.0416
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0058 0.0241 0.0303
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans Type I modular polyketide synthase 0.094 0.5233 0.6652
Leishmania major hypothetical protein, conserved 0.0059 0.0246 0.1433
Onchocerca volvulus 0.0046 0.0169 0.0142
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0096 0.0453 0.0572
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0236 0.1246 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0108 0.0519 0.1879
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Mycobacterium ulcerans quinone oxidoreductase 0.0058 0.0241 0.0303
Mycobacterium ulcerans polyketide synthase MbtD 0.0289 0.1547 0.1964
Onchocerca volvulus 0.0058 0.0241 0.0218
Trichomonas vaginalis Ferredoxin 1 0.0055 0.0219 0.0221
Toxoplasma gondii hypothetical protein 0.0085 0.0394 0.0692
Schistosoma mansoni patched 1 0.0039 0.0131 0.0474
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0026 0.0059 0.0215
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0036 0.0115 0.0854
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0071 0.0314 0.1138
Echinococcus granulosus metabotropic glutamate receptor 5 0.0071 0.0314 0.1136
Giardia lamblia Pyruvate kinase 0.003 0.0078 0.0127
Schistosoma mansoni alcohol dehydrogenase 0.0058 0.0241 0.0871
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0324 0.1746 0.2217
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0071 0.0314 0.1138
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0058 0.0241 0.0303
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.08 0.4444 0.5648
Trypanosoma brucei electron transfer protein, putative 0.0055 0.0219 0.1698
Mycobacterium ulcerans oxidoreductase FadB5 0.0058 0.0241 0.0303
Toxoplasma gondii pyruvate kinase PyK1 0.003 0.0078 0.0124
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Echinococcus multilocularis sodium and chloride dependent glycine 0.0085 0.0394 0.095
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0095 0.0448 0.0437
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus multilocularis pyruvate kinase 0.003 0.0078 0.0188
Echinococcus multilocularis Adrenodoxin, mitochondrial 0.0055 0.0219 0.0528
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0058 0.0241 0.0264
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0009 0.0022
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0236 0.1246 0.8192
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.094 0.5233 0.6639
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0692
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0059 0.0246 0.089
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus multilocularis protein patched 0.0039 0.0131 0.0315
Brugia malayi flavodoxin family protein 0.0041 0.0143 0.0134
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0058 0.0241 0.0303
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.2154
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0442
Echinococcus multilocularis serotonin transporter 0.0504 0.2762 0.6656
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.0078 0.0046
Toxoplasma gondii flavodoxin domain-containing protein 0.0053 0.0212 0.0365
Toxoplasma gondii ferodoxin FD 0.0055 0.0219 0.0378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0095 0.045 0.0463
Echinococcus granulosus g protein coupled receptor 0.0071 0.0314 0.1138
Schistosoma mansoni cytochrome P450 reductase 0.0108 0.0519 0.1879
Loa Loa (eye worm) pyruvate kinase 0.003 0.0078 0.0085
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0058 0.0241 0.058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0041 0.0143 0.1128
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Echinococcus granulosus g-protein coupled receptor 0.0071 0.0314 0.1138
Treponema pallidum hypothetical protein 0.0227 0.1197 0.4025
Loa Loa (eye worm) flavodoxin family protein 0.0041 0.0143 0.0158
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0034 0.0025
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0085 0.0394 0.0385
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0169 0.061
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0101 0.0484 0.0612
Chlamydia trachomatis pyruvate kinase 0.003 0.0078 0.0606
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0026 0.0059 0.0215
Mycobacterium tuberculosis Possible dehydrogenase 0.0058 0.0241 0.0303
Echinococcus granulosus histone acetyltransferase MYST2 0.0038 0.0127 0.0459
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.003 0.0078 0.0096
Mycobacterium tuberculosis Hypothetical protein 0.0283 0.1514 0.1922
Schistosoma mansoni [ACP] S-malonyltransferase 0.0059 0.0246 0.089
Echinococcus granulosus methionine synthase reductase 0.0066 0.0286 0.1035
Trichomonas vaginalis Ferredoxin 2 0.0055 0.0219 0.0221
Loa Loa (eye worm) TYRA-2 protein 0.0071 0.0314 0.0352
Schistosoma mansoni diflavin oxidoreductase 0.0053 0.0212 0.0768
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0053
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.01 0.0364
Loa Loa (eye worm) pyruvate kinase 0.003 0.0078 0.0085
Loa Loa (eye worm) norepinephrine transporter 0.0504 0.2762 0.3117
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0071 0.0314 0.0305
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0071 0.0314 0.0757
Schistosoma mansoni sodium-dependent amino acid transporter 0.0085 0.0394 0.1427
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0101 0.0484 0.0475
Trypanosoma brucei oxidoreductase, putative 0.0058 0.0241 0.1871
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0314 0.0757
Trichomonas vaginalis pyruvate kinase, putative 0.003 0.0078 0.0072
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium ulcerans short-chain dehydrogenase 0.0058 0.0241 0.0303
Mycobacterium ulcerans oxidoreductase 0.0055 0.0219 0.0275
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0998 0.5564 0.7072
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0096 0.0453 0.0572
Trypanosoma cruzi lanosterol synthase, putative 0.0026 0.0059 0.0407
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0025 0.0053 0.0129
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0115 0.0416
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0058 0.0241 0.0416
Brugia malayi larval opioid receptor 0.0071 0.0314 0.0305
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0058 0.0241 0.0303
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0139 0.07 0.0788
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0534 0.2936 0.3731
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0049 0.0185 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Conserved protein 0.0283 0.1514 0.1922
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0074 0.0332 0.0372
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0071 0.0314 0.0352
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0026 0.0059 0.0053
Echinococcus granulosus sterol regulatory element binding protein 0.0039 0.0131 0.0474
Toxoplasma gondii quinone oxidoreductase, putative 0.0058 0.0241 0.0416
Leishmania major p450 reductase, putative 0.0108 0.0519 0.3278
Giardia lamblia Rab geranylgeranyltransferase 0.0036 0.0115 0.038
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0572 0.6355
Brugia malayi mbt repeat family protein 0.0034 0.01 0.0091
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0026 0.0059 0.005
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0058 0.0241 0.0303
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.094 0.5233 0.6652
Leishmania major oxidoreductase-like protein 0.0058 0.0241 0.1397
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0058 0.0241 0.0303
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0884 0.492 0.5553
Echinococcus granulosus Niemann Pick C1 protein 0.013 0.0646 0.2338
Schistosoma mansoni adrenodoxin 0.0055 0.0219 0.0793
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0139 0.07 0.0788
Mycobacterium ulcerans oxygenase 0.0067 0.0288 0.0363
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni tyrosine kinase 0.0044 0.016 0.0578
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Chlamydia trachomatis acyl carrier protein 0.0095 0.0448 0.3579
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0236 0.1246 1
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0911 0.507 0.6444
Trichomonas vaginalis Ferredoxin 3 0.0055 0.0219 0.0221
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0055 0.0222 0.0805
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0058 0.0241 0.2615
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0055 0.0222 0.0536
Schistosoma mansoni zinc binding dehydrogenase 0.0058 0.0241 0.0871
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.08 0.4444 0.5648
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) FAD binding domain-containing protein 0.0108 0.0519 0.0583
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.0757
Loa Loa (eye worm) FAD binding domain-containing protein 0.0066 0.0286 0.032
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Echinococcus granulosus tachykinin peptides receptor 99D 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0101 0.0484 0.0612
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0174 0.0894 1
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0036 0.0115 0.0106
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0103 0.0495 0.0511
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0095 0.0448 0.3545
Leishmania major hypothetical protein, conserved 0.0041 0.0143 0.0736
Trypanosoma cruzi oxidoreductase, putative 0.0058 0.0241 0.1871
Echinococcus multilocularis sex peptide receptor 0.0071 0.0314 0.0757
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.094 0.5233 0.6652
Leishmania major ferredoxin 2fe-2s-like protein 0.0055 0.0219 0.1252
Brugia malayi sulfakinin receptor protein 0.0071 0.0314 0.0305
Mycobacterium ulcerans oxidoreductase 0.0058 0.0241 0.0303
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus granulosus peptide allatostatin:somatostatin 0.0071 0.0314 0.1138
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0095 0.0448 0.2225
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0111
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0067 0.0288 0.0363
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0071 0.0314 0.0757
Brugia malayi ORL1-like opioid receptor 0.0071 0.0314 0.0305
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0026 0.0059 0.0072
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0071 0.0314 0.1138
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0133 0.0661 0.2391
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0854
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0457
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0314 0.1138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis polycomb protein SCMH1 0.0034 0.01 0.0242
Echinococcus multilocularis sodium and chloride dependent glycine 0.0085 0.0394 0.095
Mycobacterium ulcerans hypothetical protein 0.0276 0.1473 0.187
Schistosoma mansoni metabotropic glutamate receptor 0.0049 0.0185 0.0669
Mycobacterium tuberculosis Possible oxygenase 0.0067 0.0288 0.0363
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0675 0.3734 0.4745
Treponema pallidum acyl carrier protein 0.0095 0.0448 0.1163
Onchocerca volvulus Neuropeptide F receptor homolog 0.0071 0.0314 0.0296
Loa Loa (eye worm) hypothetical protein 0.158 0.8858 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0101 0.0484 0.0575
Mycobacterium leprae Probable oxidireductase 0.0058 0.0241 0.0264
Plasmodium falciparum geranylgeranyltransferase, putative 0.0026 0.0059 0.0457
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni histamine h1 receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) glutamate receptor 0.0058 0.0238 0.0266
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Loa Loa (eye worm) hypothetical protein 0.0039 0.0131 0.0145
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0314 0.1138
Brugia malayi Protein kinase domain containing protein 0.0044 0.016 0.0151
Loa Loa (eye worm) hypothetical protein 0.0108 0.0519 0.0583
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0453 0.0572
Echinococcus multilocularis neuropeptide s receptor 0.0071 0.0314 0.0757
Toxoplasma gondii hypothetical protein 0.0036 0.0115 0.019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0034 0.004
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0085 0.0394 0.1427
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0041 0.0143 0.1081
Echinococcus multilocularis g-protein coupled receptor 0.0071 0.0314 0.0757
Mycobacterium ulcerans hypothetical protein 0.0022 0.0034 0.004
Onchocerca volvulus 0.1642 0.9212 0.9689
Onchocerca volvulus 0.0085 0.0394 0.038
Echinococcus multilocularis sterol regulatory element binding protein 0.0039 0.0131 0.0315
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0236 0.1246 1
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus granulosus insulin receptor 0.0044 0.016 0.0578
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0059 0.0246 0.1957
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.0757
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0092 0.0433 0.1567
Brugia malayi Pyruvate kinase, M2 isozyme 0.003 0.0078 0.0069
Echinococcus granulosus orexin receptor type 2 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0101 0.0484 0.0612
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0085 0.0394 0.3149
Onchocerca volvulus 0.0071 0.0314 0.0296
Onchocerca volvulus 0.0101 0.0484 0.0475
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0108 0.0519 0.125
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0385
Mycobacterium ulcerans Type I modular polyketide synthase 0.094 0.5233 0.6652
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0236 0.1246 1
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0026 0.0059 0.009
Schistosoma mansoni tyrosine kinase 0.0073 0.0325 0.1177
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0039 0.0131 0.0145
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0573 0.3157 0.4011
Brugia malayi GnHR receptor homolog 0.0071 0.0314 0.0305
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0453 0.5012
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0053
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0324 0.1746 0.2217
Mycobacterium ulcerans thioesterase 0.0783 0.4346 0.5523
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0314 0.0352
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0139 0.07 0.7806
Echinococcus granulosus pyruvate kinase 0.003 0.0078 0.0282
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0015
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0314 0.0757
Mycobacterium ulcerans acyl carrier protein 0.0095 0.0448 0.0566
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1405 0.7866 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0085 0.0394 0.095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0314 0.0757
Brugia malayi CHE-14 protein 0.0039 0.0131 0.0122
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0236 0.1246 0.3002
Brugia malayi Dopamine receptor protein 1 0.0071 0.0314 0.0305
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0998 0.5564 0.7072
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0071 0.0314 0.0757
Leishmania major pyruvate kinase 0.003 0.0078 0.0297
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Leishmania major quinone oxidoreductase, putative 0.0058 0.0241 0.1397
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0236 0.1246 0.1581
Schistosoma mansoni adrenodoxin 0.0055 0.0219 0.0793
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0059 0.0246 0.0309
Plasmodium vivax acyl carrier protein, putative 0.0095 0.0448 0.3579
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0476 0.2605 0.467
Echinococcus granulosus 7tm_1 domain containing protein 0.0071 0.0314 0.1138
Echinococcus granulosus dro:myosuppressin receptor 0.0071 0.0314 0.1138
Onchocerca volvulus 0.0036 0.0115 0.0085
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0036 0.0115 0.0127
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0059 0.0246 0.1957
Schistosoma mansoni biogenic amine receptor 0.0071 0.0314 0.1138
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Trypanosoma cruzi acyl transferase-like protein, putative 0.0059 0.0246 0.1914
Echinococcus granulosus voltage gated potassium channel 0.0019 0.0016 0.0059
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0071 0.0314 0.0305
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0854
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0058 0.0241 0.0303
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0085 0.0394 0.1427
Brugia malayi Serotonin receptor 0.0071 0.0314 0.0305
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0067 0.0288 0.0363
Plasmodium vivax pyruvate kinase, putative 0.003 0.0078 0.0606
Mycobacterium ulcerans oxidoreductase 0.0058 0.0241 0.0303
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0074 0.0332 0.0323
Echinococcus granulosus fmrfamide receptor 0.0071 0.0314 0.1138
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0085 0.0394 0.1427
Leishmania major geranylgeranyltransferase, putative 0.0026 0.0059 0.0173
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi Tachykinin-like peptides receptor 99D 0.0071 0.0314 0.0305
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0108 0.0519 0.4121
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Brugia malayi Methyltransferase-like protein 4 0.0283 0.1514 0.1506
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0058 0.0241 0.0232
Mycobacterium ulcerans fatty acid synthase Fas 0.0295 0.1582 0.2009
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0314 0.0757
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0038 0.0127 0.0118
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0139 0.07 0.0726
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0314 0.0352
Echinococcus multilocularis methionine synthase reductase 0.0066 0.0286 0.0689
Loa Loa (eye worm) hypothetical protein 0.0177 0.091 0.1025
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0085 0.0394 0.095
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0314 0.0757
Onchocerca volvulus 0.0058 0.0241 0.0218
Mycobacterium tuberculosis Possible dehydrogenase 0.0058 0.0241 0.0303
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0314 0.0757
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Plasmodium falciparum nitric oxide synthase, putative 0.0108 0.0519 0.4152
Loa Loa (eye worm) solute carrier family 6 member 4 0.0504 0.2762 0.3117
Loa Loa (eye worm) melatonin receptor type 1A 0.0071 0.0314 0.0352
Leishmania major cytochrome P450 reductase, putative 0.0095 0.045 0.281
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0055 0.0219 0.1252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0144 0.0727 0.0884
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0036 0.0115 0.0902
Toxoplasma gondii type I fatty acid synthase 0.0144 0.0727 0.129
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0236 0.1246 0.4511
Echinococcus multilocularis Niemann Pick C1 protein 0.013 0.0646 0.1556
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0091 0.0425 0.4696
Echinococcus granulosus pyruvate kinase 0.003 0.0078 0.0282
Mycobacterium ulcerans Type I modular polyketide synthase 0.094 0.5233 0.6652
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Onchocerca volvulus 0.0071 0.0314 0.0296
Loa Loa (eye worm) hypothetical protein 0.0048 0.0184 0.0205
Trypanosoma cruzi protein farnesyltransferase, putative 0.0026 0.0059 0.0407
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0058 0.0241 0.0303
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0108 0.0519 0.1879
Onchocerca volvulus 0.0071 0.0314 0.0296
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0071 0.0314 0.0296
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0314 0.1138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0108 0.0519 0.0657
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0034 0.028
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Brugia malayi AMP-binding enzyme family protein 0.029 0.1552 0.1544
Echinococcus granulosus neuropeptide receptor 0.0071 0.0314 0.1138
Trichomonas vaginalis xanthine dehydrogenase, putative 0.1698 0.9527 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0171 0.0162
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0998 0.5564 0.7072
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0351
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0074 0.033 0.1193
Treponema pallidum hypothetical protein 0.0276 0.1473 0.5079
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0143 0.1128
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0059 0.0407
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0171 0.019
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0026 0.0059 0.0457
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0026 0.0059 0.0568
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0058 0.0241 0.2615
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0058 0.0241 0.0303
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0009 0.0033
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.01 0.0364
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0036 0.0115 0.1194
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0058 0.0241 0.0232
Schistosoma mansoni opsin-like receptor 0.0071 0.0314 0.1138
Echinococcus granulosus Protein patched homolog 1 0.0039 0.0131 0.0474
Schistosoma mansoni tyrosine kinase 0.0074 0.033 0.1193
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0034 0.004
Echinococcus granulosus SAM and MBT domain containing protein 0.0034 0.01 0.0364
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.005
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0034 0.01 0.0364
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0026 0.0059 0.0064
Echinococcus granulosus expressed conserved protein 0.0085 0.0394 0.1425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0332 0.1201
Leishmania major zinc-binding dehydrogenase-like protein 0.0058 0.0241 0.1397
Brugia malayi Bromodomain containing protein 0.0053 0.0209 0.02
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0028
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0053
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0071 0.0314 0.1138
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0066 0.0283 0.1024
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0394 0.3149
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0071 0.0314 0.0305
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0568
Onchocerca volvulus 0.0504 0.2762 0.2881
Onchocerca volvulus Fatty acid synthase homolog 0.1694 0.9506 1
Trypanosoma brucei oxidoreductase, putative 0.0058 0.0241 0.1871
Loa Loa (eye worm) mbt repeat family protein 0.0034 0.01 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0035
Trypanosoma cruzi lanosterol synthase, putative 0.0026 0.0059 0.0407
Brugia malayi putative neuropeptide receptor 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0071 0.0314 0.0305
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0692
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0059 0.0246 0.0237
Schistosoma mansoni myosin xvIII 0.0071 0.0314 0.1138
Mycobacterium ulcerans dehydrogenase 0.0058 0.0241 0.0303
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0249 0.0902
Mycobacterium ulcerans polyketide synthase MbtC 0.0236 0.1246 0.1581
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0044 0.016 0.0384
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0058 0.0241 0.0303
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0041 0.0143 0.1081
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0034 0.004
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0756 0.4193 0.5329
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0071 0.0314 0.0352
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0098 0.0355
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0058 0.0241 0.1871
Brugia malayi 2Fe-2S iron-sulfur cluster binding domain containing protein 0.0055 0.0219 0.021
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0036 0.0115 0.0277
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni adenoreceptor 0.0071 0.0314 0.1138
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0019 0.0016 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0067 0.0288 0.0363
Schistosoma mansoni hypothetical protein 0.0204 0.1068 0.3866
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0095 0.0448 0.1079
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Giardia lamblia Methyltransferase like 2 0.0283 0.1514 1
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0546
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0095 0.0448 0.3545
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0504 0.2762 1
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0053
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0139 0.07 0.0691
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0071 0.0314 0.0352
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0314 0.1138
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0385
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0026 0.0059 0.0457
Loa Loa (eye worm) pyruvate kinase 0.003 0.0078 0.0085
Trypanosoma cruzi oxidoreductase, putative 0.0058 0.0241 0.1871
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0058 0.0241 0.0303
Echinococcus granulosus sex peptide receptor 0.0071 0.0314 0.1138
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0026 0.0059 0.0407
Leishmania major ferredoxin, 2fe-2s-like protein 0.0055 0.0219 0.1252
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0998 0.5564 0.7061
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0314 0.0352
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0071 0.0314 0.1138
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0236 0.1246 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0098 0.0355
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.094 0.5233 0.6639
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Onchocerca volvulus 0.0071 0.0314 0.0296
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0236 0.1246 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0314 0.0757
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0071 0.0314 0.1138
Schistosoma mansoni sodium/chloride dependent transporter 0.0504 0.2762 1
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005
Brugia malayi G protein-coupled receptor 0.0071 0.0314 0.0305
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0139 0.07 0.0726
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Loa Loa (eye worm) TK/INSR protein kinase 0.0044 0.016 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0079
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0101 0.0484 0.0612
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0148 0.0537
Onchocerca volvulus 0.0884 0.492 0.5158
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0059 0.0246 0.0593
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0058 0.0241 0.0303
Plasmodium falciparum adrenodoxin-type ferredoxin, putative 0.0055 0.0219 0.1741
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi hypothetical protein 0.0085 0.0394 0.0385
Mycobacterium leprae Probable polyketide synthase Pks1 0.0998 0.5564 0.7061
Trichomonas vaginalis sulfite reductase, putative 0.0108 0.0519 0.0536
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0095 0.0448 0.0439
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0036 0.0115 0.0416
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0026 0.0059 0.0053
Echinococcus granulosus g protein coupled receptor 0.0071 0.0314 0.1138
Echinococcus granulosus sodium and chloride dependent glycine 0.0085 0.0394 0.1427
Plasmodium vivax ferredoxin, putative 0.0055 0.0219 0.1741
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.1125 0.628 0.7983
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis protein dispatched 1 0.0045 0.0162 0.0391
Plasmodium falciparum transporter, putative 0.0085 0.0394 0.3149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0068
Schistosoma mansoni opsin-like receptor 0.0071 0.0314 0.1138
Plasmodium falciparum pyruvate kinase 0.003 0.0078 0.0606
Echinococcus granulosus alpha 1A adrenergic receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1405 0.7866 1
Echinococcus multilocularis ferredoxin adrenodoxin 0.0055 0.0219 0.0528
Trypanosoma cruzi acyl transferase-like protein 0.0059 0.0246 0.1914
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0071 0.0314 0.0757
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0041 0.0143 0.1081
Echinococcus multilocularis G-protein coupled receptor, putative 0.0071 0.0314 0.0757
Echinococcus multilocularis neuropeptide FF receptor 2 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0314 0.0757
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0139 0.07 0.0726
Echinococcus granulosus ferredoxin 0.0055 0.0219 0.0793
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0071 0.0314 0.0757
Leishmania major nuclear receptor binding factor-like protein 0.0058 0.0241 0.1397
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0621 0.343 0.4359
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) hypothetical protein 0.0059 0.0246 0.0275
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0174 0.0894 0.0886
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.3237
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0108 0.0519 0.4121
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Loa Loa (eye worm) glutamate receptor 0.0023 0.0039 0.0041
Brugia malayi Furin-like cysteine rich region family protein 0.0138 0.0691 0.0682
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0144 0.0727 0.0921
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0044 0.016 0.0578
Schistosoma mansoni sodium/chloride dependent transporter 0.0085 0.0394 0.1427
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0026 0.0059 0.0053
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0998 0.5564 0.7072
Schistosoma mansoni tyrosine kinase 0.0138 0.0691 0.2501
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0236 0.1246 0.2225
Brugia malayi mbt repeat family protein 0.0034 0.01 0.0091
Echinococcus multilocularis histone acetyltransferase MYST2 0.0038 0.0127 0.0306
Loa Loa (eye worm) 2Fe-2S iron-sulfur cluster binding domain-containing protein 0.0055 0.0219 0.0245
Schistosoma mansoni [ACP] S-malonyltransferase 0.0059 0.0246 0.089
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0108 0.0519 0.4121
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Echinococcus granulosus epidermal growth factor receptor 0.0138 0.0691 0.2501
Echinococcus granulosus Niemann Pick C1 protein 0.0091 0.0425 0.1538
Brugia malayi AMP-binding enzyme family protein 0.0884 0.492 0.4915
Echinococcus multilocularis orexin receptor type 2 0.0071 0.0314 0.0757
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0295 0.1582 0.1977
Schistosoma mansoni alpha-1 adrenergic receptor 0.0071 0.0314 0.1138
Onchocerca volvulus Adrenodoxin, mitochondrial homolog 0.0055 0.0219 0.0196
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Giardia lamblia Hypothetical protein 0.0095 0.045 0.2684
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Mycobacterium ulcerans acyl carrier protein 0.0095 0.0448 0.0566
Loa Loa (eye worm) hypothetical protein 0.0504 0.2762 0.3117
Chlamydia trachomatis sulfite reductase 0.0066 0.0286 0.2279
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Trichomonas vaginalis Ferredoxin 6 0.0055 0.0219 0.0221
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0071 0.0314 0.0305
Echinococcus granulosus biogenic amine 5HT receptor 0.0177 0.091 0.3296
Echinococcus multilocularis Niemann Pick C1 protein 0.0091 0.0425 0.1024
Echinococcus multilocularis tumor protein p63 0.0312 0.1677 0.404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Schistosoma mansoni tyrosine kinase 0.0073 0.0325 0.1177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0332 0.08
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0171 0.0162
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0783 0.4346 0.5505
Echinococcus granulosus metabotropic glutamate receptor 2 0.0049 0.0185 0.0669
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0453 0.0535
Echinococcus multilocularis somatostatin receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0071 0.0314 0.0757
Echinococcus granulosus Adrenodoxin mitochondrial 0.0055 0.0219 0.0793
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0088 0.0079
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.094 0.5233 0.6652
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0101 0.0484 0.0612
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Echinococcus granulosus 7TM GPCR rhodopsin 0.0071 0.0314 0.1138
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0071 0.0314 0.1138
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0854
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0059 0.0246 0.1957
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0034 0.0025
Echinococcus granulosus polycomb protein SCMH1 0.0034 0.01 0.0364
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0026 0.0059 0.009
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0095 0.0448 0.0566
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0144 0.0727 0.0817
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0026 0.0059 0.0143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0034 0.004
Loa Loa (eye worm) acyl carrier protein 0.0095 0.0448 0.0503
Schistosoma mansoni hypothetical protein 0.0033 0.0098 0.0355
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0314 0.0757
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Brugia malayi G protein-coupled receptor F59B2.13 0.0071 0.0314 0.0305
Onchocerca volvulus 0.0034 0.01 0.007
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0048 0.0181 0.0181
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0058 0.0241 0.1871
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0053
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0324 0.1746 0.2217
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0289 0.1547 0.1964
Echinococcus multilocularis epidermal growth factor receptor 0.0074 0.033 0.0794
Onchocerca volvulus 0.0071 0.0314 0.0296
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Echinococcus granulosus NADH dehydrogenase 0.0095 0.0448 0.1621
Giardia lamblia [2Fe-2S] ferredoxin 0.0055 0.0219 0.1098
Loa Loa (eye worm) hypothetical protein 0.0048 0.0181 0.0201
Trypanosoma cruzi adrenodoxin precursor, putative 0.0055 0.0219 0.1698
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0139 0.07 0.1687
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0095 0.0448 0.0503
Schistosoma mansoni opsin-like receptor 0.0071 0.0314 0.1138
Echinococcus granulosus acyl carrier protein mitochondrial 0.0095 0.0448 0.1621
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.3237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0332 0.1201
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0058 0.0241 0.0243
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0148 0.0358
Plasmodium falciparum ferredoxin, putative 0.0055 0.0219 0.1741
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.094 0.5233 0.6652
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) hypothetical protein 0.0046 0.0169 0.0187
Echinococcus multilocularis SAM and MBT domain containing protein 0.0034 0.01 0.0242
Schistosoma mansoni metabotropic glutamate receptor 0.0028 0.007 0.0253
Brugia malayi hypothetical protein 0.0033 0.0098 0.0089
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0058 0.0241 0.0871
Mycobacterium leprae conserved hypothetical protein 0.0095 0.0448 0.0528
Plasmodium falciparum amino acid transporter, putative 0.0085 0.0394 0.3149
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0314 0.0757
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0756 0.4193 0.5329
Echinococcus multilocularis G protein coupled receptor 139 0.0071 0.0314 0.0757
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0139 0.07 0.2534
Loa Loa (eye worm) hypothetical protein 0.0527 0.2893 0.3263
Loa Loa (eye worm) MBCTL1 0.0038 0.0127 0.014
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0236 0.1246 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0052 0.0207 0.0198
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0041 0.0143 0.1128
Mycobacterium ulcerans acyl-CoA synthetase 0.0101 0.0484 0.0612
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0249 0.0902
Brugia malayi G-protein coupled receptor 0.0071 0.0314 0.0305
Trypanosoma cruzi pyruvate kinase 2, putative 0.003 0.0078 0.0556
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0055 0.0222 0.0213
Loa Loa (eye worm) serotonin transporter b 0.0504 0.2762 0.3117
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0135 0.0673 0.5391
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0911 0.507 0.6444
Brugia malayi flavodoxin family protein 0.0108 0.0519 0.051
Brugia malayi Niemann-Pick C1 protein precursor 0.0091 0.0425 0.0416
Echinococcus multilocularis AMP dependent ligase 0.0096 0.0453 0.1091
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0067 0.0288 0.2298
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0071 0.0314 0.0352
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0038 0.0127 0.0306
Trypanosoma cruzi adrenodoxin precursor, putative 0.0055 0.0219 0.1698
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Echinococcus multilocularis NADH dehydrogenase 0.0095 0.0448 0.1079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi Phosphopantetheine attachment site family protein 0.0095 0.0448 0.0439
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0058 0.0241 0.2615
Onchocerca volvulus 0.0071 0.0314 0.0296
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0236 0.1246 0.4511
Leishmania major acyl carrier protein, putative 0.0095 0.0448 0.2796
Echinococcus granulosus neuropeptide FF receptor 2 0.0071 0.0314 0.1138
Schistosoma mansoni methyltransferase-related 0.0283 0.1514 0.5479
Trichomonas vaginalis xanthine dehydrogenase, putative 0.1698 0.9527 1
Echinococcus multilocularis expressed conserved protein 0.0085 0.0394 0.0948
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0098 0.0236
Toxoplasma gondii acyl transferase domain-containing protein 0.0059 0.0246 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0059 0.0407
Treponema pallidum quinoline 2-oxidoreductase 0.027 0.1437 0.494
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0071 0.0314 0.0352
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0038 0.0127 0.0459
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0034 0.004
Trichomonas vaginalis pyruvate kinase, putative 0.003 0.0078 0.0072
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0854
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0174 0.0894 0.093
Trichomonas vaginalis aldehyde oxidase, putative 0.1698 0.9527 1
Brugia malayi Serotonin receptor 0.0071 0.0314 0.0305
Schistosoma mansoni tyrosine kinase 0.0044 0.016 0.0578
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0139 0.07 0.5609
Mycobacterium ulcerans hypothetical protein 0.0095 0.0448 0.0566
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0854
Schistosoma mansoni acyl carrier protein 0.0095 0.0448 0.1621
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0174 0.0894 0.1007
Onchocerca volvulus 0.0055 0.0219 0.0196
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Treponema pallidum sodium- and chloride- dependent transporter 0.0504 0.2762 1
Loa Loa (eye worm) hypothetical protein 0.0504 0.2762 0.3117
Onchocerca volvulus 0.0071 0.0314 0.0296
Loa Loa (eye worm) hypothetical protein 0.005 0.0192 0.0214
Trypanosoma brucei pyruvate kinase 1, putative 0.003 0.0078 0.0556
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.1138
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0058 0.0241 0.0269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) acyl carrier protein 0.0432 0.2358 0.266
Brugia malayi Alcohol dehydrogenase class III 0.0058 0.0241 0.0232
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Leishmania major farnesyltransferase beta subunit 0.0026 0.0059 0.0173
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0385
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0025 0.0053 0.0194
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.023 0.1211 0.1536
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0503 0.2761 0.3507
Chlamydia trachomatis ferredoxin 0.0055 0.0219 0.1741
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0064
Toxoplasma gondii ferredoxin, putative 0.0055 0.0219 0.0378
Loa Loa (eye worm) pyruvate kinase-PB 0.0021 0.0027 0.0028
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0314 0.0352
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.3237
Leishmania major pyruvate kinase 0.003 0.0078 0.0297
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0884 0.492 0.6253
Mycobacterium leprae Polyketide synthase Pks13 0.1405 0.7866 1
Mycobacterium ulcerans polyketide synthase 0.094 0.5233 0.6652
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0332 0.1201
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0058 0.0241 0.0303
Schistosoma mansoni biogenic amine receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans electron transfer protein 0.0055 0.0219 0.0275
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0026 0.0059 0.0143
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0314 0.1138
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0058 0.0241 0.0209
Trypanosoma cruzi p450 reductase, putative 0.0108 0.0519 0.4121
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0236 0.1246 0.1404
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0407
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.014
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0573 0.3157 0.4011
Mycobacterium ulcerans polyketide synthase 0.0998 0.5564 0.7072
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0055 0.0222 0.0248
Mycobacterium ulcerans quinone oxidoreductase 0.0058 0.0241 0.0303
Echinococcus granulosus neuropeptide receptor A26 0.0071 0.0314 0.1138
Brugia malayi Dopamine receptor protein 2 0.0071 0.0314 0.0305
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable oxidoreductase 0.0067 0.0288 0.0363
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0504 0.2762 0.2756
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 32 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
IC50 (functional) = 32 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
Ki (binding) = 1.4 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643
Ki (binding) = 1.4 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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