Detailed information for compound 171819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.29 | Formula: C18H11F6N3O
  • H donors: 2 H acceptors: 2 LogP: 4.43 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc2c1ccnc2)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
  • InChi: 1S/C18H11F6N3O/c19-17(20,21)11-6-12(18(22,23)24)8-13(7-11)26-16(28)27-15-3-1-2-10-9-25-5-4-14(10)15/h1-9H,(H2,26,27,28)
  • InChiKey: CKLFTQRSYHFUFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0034 0.01 0.007
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0085 0.0394 0.1427
Plasmodium falciparum amino acid transporter, putative 0.0085 0.0394 0.3149
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0546
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0457
Brugia malayi Metabotropic glutamate receptor precursor. 0.0058 0.0238 0.0229
Mycobacterium ulcerans thioesterase TesA 0.0783 0.4346 0.5523
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Giardia lamblia Hypothetical protein 0.0095 0.045 0.2684
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0783 0.4346 0.5505
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0071 0.0314 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.1514 0.1581
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0503 0.2761 0.3507
Mycobacterium tuberculosis Conserved hypothetical protein 0.0095 0.0448 0.0566
Trypanosoma cruzi pyruvate kinase 2, putative 0.003 0.0078 0.0556
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0095 0.045 0.0463
Mycobacterium ulcerans pyruvate kinase 0.003 0.0078 0.0096
Loa Loa (eye worm) hypothetical protein 0.0048 0.0184 0.0205
Leishmania major p450 reductase, putative 0.0108 0.0519 0.3278
Schistosoma mansoni tyrosine kinase 0.0074 0.033 0.1193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0025 0.0053 0.0129
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0144 0.0727 0.0921
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0041 0.0143 0.1081
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0139 0.07 0.0726
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0139 0.07 0.2534
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0314 0.1138
Trypanosoma brucei oxidoreductase, putative 0.0058 0.0241 0.1871
Mycobacterium tuberculosis Hypothetical protein 0.0283 0.1514 0.1922
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1405 0.7866 1
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus multilocularis epidermal growth factor receptor 0.0074 0.033 0.0794
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0044 0.016 0.0384
Brugia malayi neuropeptide F receptor 0.0071 0.0314 0.0305
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Echinococcus granulosus Niemann Pick C1 protein 0.0091 0.0425 0.1538
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0026 0.0059 0.0143
Loa Loa (eye worm) FAD binding domain-containing protein 0.0066 0.0286 0.032
Loa Loa (eye worm) TYRA-2 protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0097
Echinococcus multilocularis pyruvate kinase 0.003 0.0078 0.0188
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis 0.0043 0.0152 0.0366
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0026 0.0059 0.0064
Echinococcus granulosus neuropeptide s receptor 0.0071 0.0314 0.1138
Treponema pallidum quinoline 2-oxidoreductase 0.027 0.1437 0.494
Toxoplasma gondii type I fatty acid synthase 0.0144 0.0727 0.129
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0058 0.0241 0.0303
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0039 0.0131 0.0145
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis orexin receptor type 2 0.0071 0.0314 0.0757
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0314 0.1138
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.061 0.3363 0.6033
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0034 0.004
Onchocerca volvulus 0.0071 0.0314 0.0296
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0026 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0314 0.1138
Toxoplasma gondii pyruvate kinase PyK1 0.003 0.0078 0.0124
Brugia malayi Alcohol dehydrogenase class III 0.0058 0.0241 0.0232
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0854
Mycobacterium ulcerans acyl carrier protein 0.0095 0.0448 0.0566
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0573 0.3157 0.4011
Schistosoma mansoni biogenic amine receptor 0.0071 0.0314 0.1138
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0038 0.0127 0.0459
Chlamydia trachomatis pyruvate kinase 0.003 0.0078 0.0606
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi Melatonin receptor type 1A 0.0071 0.0314 0.0305
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0026 0.0059 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.01 0.0364
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0049 0.0185 0.0445
Echinococcus granulosus metabotropic glutamate receptor 2 0.0049 0.0185 0.0669
Schistosoma mansoni hypothetical protein 0.0095 0.0448 0.1621
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0085 0.0394 0.095
Schistosoma mansoni cytochrome P450 reductase 0.0108 0.0519 0.1879
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0144 0.0727 0.0921
Mycobacterium ulcerans acyl-CoA synthetase 0.0101 0.0484 0.0612
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0026 0.0059 0.0568
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0009 0.0033
Schistosoma mansoni hypothetical protein 0.0033 0.0098 0.0355
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0026 0.0059 0.0053
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0036 0.0115 0.0902
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0442
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0139 0.07 0.2534
Echinococcus granulosus sodium and chloride dependent glycine 0.0085 0.0394 0.1427
Echinococcus granulosus dro:myosuppressin receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0036 0.0115 0.0127
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0096 0.0453 0.0572
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.094 0.5233 0.6652
Brugia malayi Serotonin receptor 0.0071 0.0314 0.0305
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0095 0.0448 0.0503
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0058 0.0241 0.058
Echinococcus granulosus serotonin receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0884 0.492 0.6253
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0058 0.0241 0.0303
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Mycobacterium ulcerans oxygenase 0.0067 0.0288 0.0363
Brugia malayi Bromodomain containing protein 0.0053 0.0209 0.02
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0692
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0236 0.1246 0.4511
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0314 0.1138
Brugia malayi Dopamine receptor 0.0071 0.0314 0.0305
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0059 0.0246 0.0261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0998 0.5564 0.7061
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0174 0.0894 0.093
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0016 0.0059
Echinococcus multilocularis SAM and MBT domain containing protein 0.0034 0.01 0.0242
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0098 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0332 0.1201
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0085 0.0394 0.095
Plasmodium falciparum ferredoxin, putative 0.0055 0.0219 0.1741
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0058 0.0241 0.0303
Treponema pallidum hypothetical protein 0.0276 0.1473 0.5079
Loa Loa (eye worm) mbt repeat family protein 0.0034 0.01 0.0111
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0095 0.0448 0.3545
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0059 0.0246 0.1957
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0144 0.0727 0.0921
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0174 0.0894 0.1007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0071 0.0314 0.0305
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0026 0.0059 0.0407
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) acyl carrier protein 0.0095 0.0448 0.0503
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0036 0.0115 0.0854
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0148 0.0537
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0067 0.0288 0.0363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0332 0.1201
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0016 0.0059
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0058 0.0241 0.0871
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0088 0.0079
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0085 0.0394 0.1427
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0036 0.0115 0.0854
Loa Loa (eye worm) hypothetical protein 0.0059 0.0246 0.0275
Echinococcus granulosus epidermal growth factor receptor 0.0138 0.0691 0.2501
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0058 0.0241 0.0232
Plasmodium falciparum adrenodoxin-type ferredoxin, putative 0.0055 0.0219 0.1741
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0332 0.08
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0055 0.0219 0.1252
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0067 0.0288 0.0363
Mycobacterium tuberculosis Probable oxidoreductase 0.0067 0.0288 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0131 0.0128
Echinococcus granulosus biogenic amine 5HT receptor 0.0177 0.091 0.3296
Schistosoma mansoni tyrosine kinase 0.0044 0.016 0.0578
Echinococcus multilocularis insulin receptor 0.0044 0.016 0.0384
Brugia malayi Phosphopantetheine attachment site family protein 0.0095 0.0448 0.0439
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0036 0.0115 0.0277
Trypanosoma cruzi acyl transferase-like protein, putative 0.0059 0.0246 0.1914
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0756 0.4193 0.5329
Chlamydia trachomatis acyl carrier protein 0.0095 0.0448 0.3579
Mycobacterium ulcerans polyketide synthase MbtC 0.0236 0.1246 0.1581
Schistosoma mansoni metabotropic glutamate receptor 0.0028 0.007 0.0253
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0071 0.0314 0.0352
Onchocerca volvulus 0.0058 0.0241 0.0218
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0139 0.07 0.0726
Plasmodium vivax acyl carrier protein, putative 0.0095 0.0448 0.3579
Echinococcus multilocularis somatostatin receptor 0.0071 0.0314 0.0757
Trypanosoma brucei pyruvate kinase 1 0.003 0.0078 0.0556
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0621 0.343 0.4359
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0058 0.0241 0.0303
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0101 0.0484 0.0612
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.094 0.5233 0.5229
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0071 0.0314 0.0757
Echinococcus granulosus polycomb protein SCMH1 0.0034 0.01 0.0364
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0236 0.1246 0.3002
Echinococcus multilocularis histone acetyltransferase MYST2 0.0038 0.0127 0.0306
Loa Loa (eye worm) flavodoxin family protein 0.0041 0.0143 0.0158
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0407
Loa Loa (eye worm) FAD binding domain-containing protein 0.0108 0.0519 0.0583
Leishmania major nuclear receptor binding factor-like protein 0.0058 0.0241 0.1397
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.014
Mycobacterium ulcerans Type I modular polyketide synthase 0.094 0.5233 0.6652
Trypanosoma cruzi acyl transferase-like protein 0.0059 0.0246 0.1914
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0036 0.0115 0.0902
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis sodium and chloride dependent glycine 0.0085 0.0394 0.095
Brugia malayi neuropeptide F receptor 0.0071 0.0314 0.0305
Echinococcus multilocularis Niemann Pick C1 protein 0.013 0.0646 0.1556
Giardia lamblia Pyruvate kinase 0.003 0.0078 0.0127
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0055 0.0222 0.0536
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0034 0.004
Echinococcus granulosus expressed conserved protein 0.0085 0.0394 0.1425
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0573 0.3157 0.4011
Trichomonas vaginalis pyruvate kinase, putative 0.003 0.0078 0.0072
Brugia malayi flavodoxin family protein 0.0041 0.0143 0.0134
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0174 0.0894 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0071 0.0314 0.0305
Mycobacterium ulcerans oxidoreductase 0.0067 0.0288 0.0363
Schistosoma mansoni adenoreceptor 0.0071 0.0314 0.1138
Onchocerca volvulus 0.1642 0.9212 0.9689
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.08 0.4444 0.5648
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Echinococcus multilocularis epidermal growth factor receptor 0.0138 0.0691 0.1665
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0101 0.0484 0.0612
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0351
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0034 0.01 0.0364
Plasmodium vivax flavodoxin domain containing protein 0.0095 0.045 0.3596
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Schistosoma mansoni myosin xvIII 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans polyketide synthase Pks9 0.0621 0.343 0.4359
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0058 0.0241 0.2615
Echinococcus granulosus Adrenodoxin mitochondrial 0.0055 0.0219 0.0793
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0058 0.0241 0.0269
Trichomonas vaginalis Ferredoxin 1 0.0055 0.0219 0.0221
Plasmodium vivax amine transporter, putative 0.0085 0.0394 0.3149
Trypanosoma cruzi oxidoreductase, putative 0.0058 0.0241 0.1871
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0071 0.0314 0.0757
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Toxoplasma gondii acyl transferase domain-containing protein 0.0059 0.0246 0.0426
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0085 0.0394 0.1427
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0071 0.0314 0.0757
Schistosoma mansoni sodium-dependent amino acid transporter 0.0085 0.0394 0.1427
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0059 0.0246 0.1957
Mycobacterium ulcerans oxidoreductase 0.0055 0.0219 0.0275
Onchocerca volvulus Neuropeptide F receptor homolog 0.0071 0.0314 0.0296
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Onchocerca volvulus Fatty acid synthase homolog 0.1694 0.9506 1
Brugia malayi FAD binding domain containing protein 0.0066 0.0286 0.0277
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis voltage gated potassium channel 0.0019 0.0016 0.0039
Leishmania major oxidoreductase, putative 0.0058 0.0241 0.1397
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0058 0.0241 0.0264
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0028
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.0078 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0314 0.0757
Trypanosoma cruzi adrenodoxin precursor, putative 0.0055 0.0219 0.1698
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0314 0.1138
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.094 0.5233 0.6639
Onchocerca volvulus 0.0071 0.0314 0.0296
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0058 0.0241 0.1871
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0026 0.0059 0.0215
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0756 0.4193 0.5329
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0385
Schistosoma mansoni adrenodoxin 0.0055 0.0219 0.0793
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0036 0.0115 0.0854
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0442
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0058 0.0241 0.0303
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0135 0.0673 0.5391
Brugia malayi Dopamine receptor protein 1 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans dehydrogenase 0.0058 0.0241 0.0303
Echinococcus granulosus ferredoxin 0.0055 0.0219 0.0793
Echinococcus multilocularis neuropeptide s receptor 0.0071 0.0314 0.0757
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Trypanosoma cruzi p450 reductase, putative 0.0108 0.0519 0.4121
Toxoplasma gondii ferredoxin, putative 0.0055 0.0219 0.0378
Echinococcus multilocularis pyruvate kinase 0.003 0.0078 0.0188
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0314 0.0757
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0058 0.0241 0.1871
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0139 0.07 0.5609
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0058 0.0241 0.0416
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0236 0.1246 0.1581
Brugia malayi putative neuropeptide receptor NPR1 0.0071 0.0314 0.0305
Leishmania major farnesyltransferase beta subunit 0.0026 0.0059 0.0173
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0071 0.0314 0.0757
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0111
Echinococcus multilocularis G-protein coupled receptor, putative 0.0071 0.0314 0.0757
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0091 0.0425 0.4696
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0048 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0144 0.0727 0.0884
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.08 0.4444 0.5648
Loa Loa (eye worm) hypothetical protein 0.0091 0.0425 0.0477
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0911 0.507 0.6444
Echinococcus granulosus sex peptide receptor 0.0071 0.0314 0.1138
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0026 0.0059 0.0457
Echinococcus multilocularis g-protein coupled receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis G protein coupled receptor 139 0.0071 0.0314 0.0757
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0621 0.343 0.4336
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0071 0.0314 0.1138
Brugia malayi G protein-coupled receptor 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0025 0.0053 0.0194
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0998 0.5564 0.7072
Brugia malayi Tachykinin-like peptides receptor 99D 0.0071 0.0314 0.0305
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0098 0.0355
Brugia malayi metabotropic glutamate receptor type 2 0.0028 0.007 0.0061
Echinococcus granulosus neuropeptide receptor A26 0.0071 0.0314 0.1138
Echinococcus granulosus Niemann Pick C1 protein 0.013 0.0646 0.2338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0026 0.0059 0.0143
Schistosoma mansoni histamine h1 receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0038 0.0127 0.0306
Leishmania major acyl carrier protein, putative 0.0095 0.0448 0.2796
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Trypanosoma brucei pyruvate kinase 1, putative 0.003 0.0078 0.0556
Schistosoma mansoni hypothetical protein 0.0031 0.0088 0.0319
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0139 0.07 0.0788
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0143 0.1128
Mycobacterium ulcerans short-chain dehydrogenase 0.0058 0.0241 0.0303
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0059 0.0246 0.089
Toxoplasma gondii flavodoxin domain-containing protein 0.0053 0.0212 0.0365
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0108 0.0519 0.4152
Schistosoma mansoni [ACP] S-malonyltransferase 0.0059 0.0246 0.089
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0066 0.0283 0.1024
Trypanosoma brucei electron transfer protein, putative 0.0055 0.0219 0.1698
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0675 0.3734 0.4745
Onchocerca volvulus Adrenodoxin, mitochondrial homolog 0.0055 0.0219 0.0196
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Brugia malayi Pyruvate kinase, muscle isozyme 0.003 0.0078 0.0069
Brugia malayi hypothetical protein 0.0033 0.0098 0.0089
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Echinococcus multilocularis dro:myosuppressin receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0133 0.0661 0.1592
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0058 0.0241 0.0243
Trypanosoma cruzi protein farnesyltransferase, putative 0.0026 0.0059 0.0407
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Echinococcus granulosus orexin receptor type 2 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0573 0.3157 0.4011
Mycobacterium ulcerans polyketide synthase Pks13 0.1405 0.7866 1
Echinococcus granulosus pyruvate kinase 0.003 0.0078 0.0282
Mycobacterium ulcerans quinone oxidoreductase 0.0058 0.0241 0.0303
Trypanosoma cruzi adrenodoxin precursor, putative 0.0055 0.0219 0.1698
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0092 0.0433 0.1567
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0058 0.0241 0.2615
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0171 0.0162
Onchocerca volvulus 0.0071 0.0314 0.0296
Schistosoma mansoni tyrosine kinase 0.0074 0.033 0.1193
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0026 0.0059 0.0215
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0108 0.0519 0.1879
Onchocerca volvulus 0.0071 0.0314 0.0296
Brugia malayi mbt repeat family protein 0.0034 0.01 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable oxidoreductase 0.0058 0.0241 0.0303
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.005 0.0192 0.0214
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0009 0.0033
Mycobacterium ulcerans quinone oxidoreductase 0.0058 0.0241 0.0303
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0385
Loa Loa (eye worm) norepinephrine transporter 0.0504 0.2762 0.3117
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0854
Onchocerca volvulus 0.0085 0.0394 0.038
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0034 0.004
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0055 0.0219 0.1252
Schistosoma mansoni opsin-like receptor 0.0071 0.0314 0.1138
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Schistosoma mansoni sodium/chloride dependent transporter 0.0085 0.0394 0.1427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Plasmodium falciparum acyl carrier protein 0.0095 0.0448 0.3579
Trypanosoma brucei NADH-ubiquinone oxidoreductase complex I subunit, putative 0.0055 0.0219 0.1698
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0385
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.3237
Schistosoma mansoni alpha-1 adrenergic receptor 0.0071 0.0314 0.1138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Leishmania major ferredoxin, 2fe-2s-like protein 0.0055 0.0219 0.1252
Mycobacterium ulcerans electron transfer protein 0.0055 0.0219 0.0275
Brugia malayi sulfakinin receptor protein 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Mycobacterium ulcerans oxidoreductase FadB5 0.0058 0.0241 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0034 0.0025
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0103 0.0495 0.0511
Mycobacterium ulcerans polyketide synthase 0.0998 0.5564 0.7072
Onchocerca volvulus 0.0071 0.0314 0.0296
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0071 0.0314 0.1138
Echinococcus granulosus methionine synthase reductase 0.0066 0.0286 0.1035
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni neuropeptide f receptor 76f 0.0071 0.0314 0.1138
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Loa Loa (eye worm) hypothetical protein 0.0046 0.0171 0.019
Echinococcus multilocularis Niemann Pick C1 protein 0.0091 0.0425 0.1024
Schistosoma mansoni alcohol dehydrogenase 0.0058 0.0241 0.0871
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0058 0.0241 0.0303
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0009 0.0022
Mycobacterium leprae Probable polyketide synthase Pks1 0.0998 0.5564 0.7061
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.3237
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0071 0.0314 0.0757
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0236 0.1246 1
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0036 0.0115 0.0277
Schistosoma mansoni growth hormone secretagogue receptor 0.0071 0.0314 0.1138
Brugia malayi putative neuropeptide receptor 0.0071 0.0314 0.0305
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0036 0.0115 0.0416
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0332 0.1201
Echinococcus granulosus hypothetical protein 0.0071 0.0314 0.1138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0332 0.1201
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0067 0.0288 0.0363
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0034 0.004
Schistosoma mansoni diflavin oxidoreductase 0.0053 0.0212 0.0768
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0101 0.0484 0.0612
Loa Loa (eye worm) MBCTL1 0.0038 0.0127 0.014
Toxoplasma gondii acyl carrier protein ACP 0.0095 0.0448 0.0789
Loa Loa (eye worm) hypothetical protein 0.0144 0.0727 0.0817
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0071 0.0314 0.1138
Trichomonas vaginalis Ferredoxin 6 0.0055 0.0219 0.0221
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0095 0.0448 0.0566
Plasmodium falciparum geranylgeranyltransferase, putative 0.0026 0.0059 0.0457
Leishmania major geranylgeranyltransferase, putative 0.0026 0.0059 0.0173
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0169 0.061
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans Type I modular polyketide synthase 0.094 0.5233 0.6652
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0066 0.0286 0.1035
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0058 0.0241 0.0303
Onchocerca volvulus 0.0101 0.0484 0.0475
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0055 0.0222 0.0213
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0139 0.07 0.0726
Echinococcus multilocularis expressed conserved protein 0.0085 0.0394 0.0948
Leishmania major pyruvate kinase 0.003 0.0078 0.0297
Schistosoma mansoni pyruvate kinase 0.003 0.0078 0.0282
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Loa Loa (eye worm) hypothetical protein 0.0048 0.0181 0.0201
Schistosoma mansoni tyrosine kinase 0.0073 0.0325 0.1177
Brugia malayi Methyltransferase-like protein 4 0.0283 0.1514 0.1506
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0236 0.1246 0.2225
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Trypanosoma brucei acyl transferase-like protein 0.0059 0.0246 0.1914
Trypanosoma cruzi protein farnesyltransferase, putative 0.0026 0.0059 0.0407
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.2154
Schistosoma mansoni hypothetical protein 0.0204 0.1068 0.3866
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0058 0.0241 0.1397
Brugia malayi RE15519p 0.0071 0.0314 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0407
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0052 0.0207 0.0198
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.094 0.5233 0.6652
Toxoplasma gondii hypothetical protein 0.0085 0.0394 0.0692
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0236 0.1246 1
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0095 0.0448 0.2225
Onchocerca volvulus 0.0884 0.492 0.5158
Schistosoma mansoni biogenic amine (5HT) receptor 0.0177 0.091 0.3296
Loa Loa (eye worm) fatty acid synthase 0.0927 0.5162 0.5827
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0314 0.0757
Echinococcus granulosus neuropeptide receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0324 0.1746 0.2217
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0064
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0034 0.004
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0174 0.0894 0.0886
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0504 0.2762 1
Giardia lamblia [2Fe-2S] ferredoxin 0.0055 0.0219 0.1098
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0108 0.0519 0.125
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0071 0.0314 0.0352
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0053
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0108 0.0519 0.4121
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0108 0.0519 0.4121
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0133 0.0661 0.2391
Echinococcus multilocularis protein dispatched 1 0.0045 0.0162 0.0391
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0314 0.0352
Schistosoma mansoni biogenic amine receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1405 0.7866 1
Entamoeba histolytica pyruvate kinase, putative 0.0021 0.0027 0.0203
Loa Loa (eye worm) hypothetical protein 0.0504 0.2762 0.3117
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0035
Onchocerca volvulus 0.0036 0.0115 0.0085
Loa Loa (eye worm) pyruvate kinase 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) hypothetical protein 0.0046 0.0169 0.0187
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0041 0.0143 0.1128
Brugia malayi hypothetical protein 0.0085 0.0394 0.0385
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.0078 0.0046
Toxoplasma gondii adrenodoxin-type ferredoxin, putative 0.0055 0.0219 0.0378
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0058 0.0241 0.0232
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Chlamydia trachomatis ferredoxin 0.0055 0.0219 0.1741
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0108 0.0519 0.125
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0085 0.0394 0.095
Brugia malayi mbt repeat family protein 0.0034 0.01 0.0091
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0058 0.0241 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0101 0.0484 0.0612
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0236 0.1246 1
Plasmodium falciparum pyruvate kinase 0.003 0.0078 0.0606
Mycobacterium ulcerans oxidoreductase 0.0058 0.0241 0.0303
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0295 0.1582 0.1977
Trypanosoma cruzi adrenodoxin precursor, putative 0.0055 0.0219 0.1698
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0058 0.0241 0.0243
Onchocerca volvulus 0.0085 0.0394 0.038
Brugia malayi G-protein coupled receptor 0.0071 0.0314 0.0305
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0453 0.0535
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0236 0.1246 0.8192
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0177 0.091 0.1025
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0059 0.0246 0.0309
Trypanosoma cruzi lanosterol synthase, putative 0.0026 0.0059 0.0407
Loa Loa (eye worm) pyruvate kinase 0.003 0.0078 0.0085
Schistosoma mansoni acyl carrier protein 0.0095 0.0448 0.1621
Mycobacterium ulcerans electron transfer protein FdxB 0.0067 0.0288 0.0363
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0019 0.0016 0.0059
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0108 0.0519 0.4121
Mycobacterium ulcerans oxidoreductase 0.0058 0.0241 0.0303
Toxoplasma gondii type I fatty acid synthase, putative 0.0669 0.3699 0.6637
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0314 0.1138
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0085 0.0394 0.3149
Loa Loa (eye worm) acyl carrier protein 0.0432 0.2358 0.266
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0177 0.091 0.1025
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0034 0.004
Trichomonas vaginalis aldehyde oxidase, putative 0.1698 0.9527 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0101 0.0484 0.0612
Mycobacterium ulcerans polyketide synthase MbtD 0.0289 0.1547 0.1964
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0053
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0314 0.0757
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0314 0.1138
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0249 0.0902
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.0757
Schistosoma mansoni opsin-like receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0071 0.0314 0.0757
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0071 0.0314 0.1138
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0055 0.0222 0.0805
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0071 0.0314 0.0305
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0998 0.5564 0.7072
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0115 0.0854
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.009
Echinococcus granulosus fmrfamide receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) glutamate receptor 0.0058 0.0238 0.0266
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.038 0.2063 0.262
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0854
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0038 0.0127 0.0118
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0769 0.4263 0.5418
Loa Loa (eye worm) hypothetical protein 0.0504 0.2762 0.3117
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium tuberculosis Possible dehydrogenase 0.0058 0.0241 0.0303
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0314 0.1138
Onchocerca volvulus 0.0055 0.0219 0.0196
Echinococcus granulosus somatostatin receptor 0.0071 0.0314 0.1138
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0058 0.0241 0.0243
Echinococcus granulosus G protein coupled receptor 139 0.0071 0.0314 0.1138
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0041 0.0143 0.1081
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0095 0.0448 0.0566
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0332 0.1201
Brugia malayi CHE-14 protein 0.0039 0.0131 0.0122
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0115 0.0416
Echinococcus multilocularis methionine synthase reductase 0.0066 0.0286 0.0689
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0071 0.0314 0.1138
Schistosoma mansoni metabotropic glutamate receptor 0.0049 0.0185 0.0669
Brugia malayi 2Fe-2S iron-sulfur cluster binding domain containing protein 0.0055 0.0219 0.021
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0071 0.0314 0.1138
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0036 0.0115 0.0416
Trichomonas vaginalis Ferredoxin 4 0.0055 0.0219 0.0221
Echinococcus granulosus g protein coupled receptor 0.0071 0.0314 0.1138
Treponema pallidum sodium- and chloride- dependent transporter 0.0504 0.2762 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Toxoplasma gondii hypothetical protein 0.0085 0.0394 0.0692
Echinococcus granulosus g-protein coupled receptor 0.0071 0.0314 0.1138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0034 0.028
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0058 0.0241 0.0303
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.094 0.5233 0.6652
Trypanosoma cruzi oxidoreductase, putative 0.0058 0.0241 0.1871
Treponema pallidum hypothetical protein 0.0227 0.1197 0.4025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0101 0.0484 0.0475
Entamoeba histolytica type A flavoprotein, putative 0.0041 0.0143 0.1511
Echinococcus granulosus Protein patched homolog 1 0.0039 0.0131 0.0474
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0058 0.0241 0.0303
Brugia malayi larval opioid receptor 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.005
Onchocerca volvulus 0.0071 0.0314 0.0296
Schistosoma mansoni sodium/chloride dependent transporter 0.0504 0.2762 1
Mycobacterium ulcerans fatty acid synthase Fas 0.0295 0.1582 0.2009
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0314 0.0757
Schistosoma mansoni bromodomain containing protein 0.0045 0.0163 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus multilocularis NADH dehydrogenase 0.0095 0.0448 0.1079
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0534 0.2936 0.3731
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0026 0.0059 0.0457
Onchocerca volvulus Pyruvate kinase homolog 0.003 0.0078 0.0046
Echinococcus granulosus AMP dependent ligase 0.0096 0.0453 0.1639
Onchocerca volvulus 0.0071 0.0314 0.0296
Toxoplasma gondii hypothetical protein 0.0036 0.0115 0.019
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0058 0.0241 0.0303
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0314 0.0757
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0236 0.1246 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.07 0.0788
Brugia malayi Adrenodoxin-like protein, mitochondrial precursor, putative 0.0055 0.0219 0.021
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0101 0.0484 0.0612
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0074 0.0332 0.0372
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0041 0.0143 0.1081
Brugia malayi GnHR receptor homolog 0.0071 0.0314 0.0305
Leishmania major hypothetical protein, conserved 0.0059 0.0246 0.1433
Echinococcus multilocularis neuropeptide FF receptor 2 0.0071 0.0314 0.0757
Echinococcus granulosus insulin receptor 0.0044 0.016 0.0578
Loa Loa (eye worm) hypothetical protein 0.003 0.008 0.0088
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0108 0.0519 0.4121
Brugia malayi AMP-binding enzyme family protein 0.0884 0.492 0.4915
Mycobacterium leprae conserved hypothetical protein 0.0095 0.0448 0.0528
Trichomonas vaginalis pyruvate kinase, putative 0.003 0.0078 0.0072
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0067 0.0288 0.0363
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0332 0.08
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0884 0.492 0.5553
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Echinococcus granulosus tachykinin peptides receptor 99D 0.0071 0.0314 0.1138
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0236 0.1246 0.1581
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0098 0.0355
Echinococcus multilocularis ferredoxin adrenodoxin 0.0055 0.0219 0.0528
Onchocerca volvulus 0.0071 0.0314 0.0296
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0171 0.019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0035
Echinococcus granulosus metabotropic glutamate receptor 5 0.0071 0.0314 0.1136
Echinococcus granulosus epidermal growth factor receptor 0.0074 0.033 0.1193
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0219 0.1698
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0314 0.0757
Trypanosoma cruzi oxidoreductase, putative 0.0058 0.0241 0.1871
Leishmania major ferredoxin 2fe-2s-like protein 0.0055 0.0219 0.1252
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0295 0.1582 0.2009
Trypanosoma brucei oxidoreductase, putative 0.0058 0.0241 0.1871
Brugia malayi Niemann-Pick C1 protein precursor 0.0091 0.0425 0.0416
Giardia lamblia Rab geranylgeranyltransferase 0.0036 0.0115 0.038
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0058 0.0241 0.0303
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.01 0.0364
Echinococcus granulosus histone acetyltransferase MYST2 0.0038 0.0127 0.0459
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0058 0.0241 0.0303
Mycobacterium ulcerans hypothetical protein 0.0095 0.0448 0.0566
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Echinococcus multilocularis allatostatin A receptor 0.0071 0.0314 0.0757
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0071 0.0314 0.1138
Loa Loa (eye worm) melatonin receptor type 1A 0.0071 0.0314 0.0352
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0058 0.0241 0.0209
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0026 0.0059 0.0053
Schistosoma mansoni hypothetical protein 0.0071 0.0314 0.1138
Trypanosoma brucei lanosterol synthase 0.0026 0.0059 0.0407
Trichomonas vaginalis Ferredoxin 7 0.0055 0.0219 0.0221
Schistosoma mansoni zinc binding dehydrogenase 0.0058 0.0241 0.0871
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0139 0.07 0.7806
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0071 0.0314 0.1138
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0034 0.0025
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0101 0.0484 0.0612
Onchocerca volvulus 0.0071 0.0314 0.0296
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0998 0.5564 0.7061
Toxoplasma gondii type I fatty acid synthase, putative 0.0999 0.5569 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0111
Brugia malayi G-protein coupled receptor 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0236 0.1246 0.1404
Schistosoma mansoni pyruvate kinase 0.003 0.0078 0.0282
Schistosoma mansoni [ACP] S-malonyltransferase 0.0059 0.0246 0.089
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Schistosoma mansoni myelin transcription factor 1 myt1 0.0038 0.0127 0.0459
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.1138
Mycobacterium leprae Probable oxidireductase 0.0058 0.0241 0.0264
Loa Loa (eye worm) serotonin transporter b 0.0504 0.2762 0.3117
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0139 0.07 0.1687
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0026 0.0059 0.0053
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0059 0.0246 0.1957
Brugia malayi Bromodomain containing protein 0.0027 0.0063 0.0054
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0095 0.0448 0.3545
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.08 0.4444 0.5648
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0079
Echinococcus granulosus neuropeptide FF receptor 2 0.0071 0.0314 0.1138
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0998 0.5564 0.7072
Toxoplasma gondii ferodoxin FD 0.0055 0.0219 0.0378
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0572 0.6355
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0058 0.0241 0.0303
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0026 0.0059 0.009
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0059 0.0246 0.0237
Leishmania major cytochrome P450 reductase, putative 0.0095 0.045 0.281
Brugia malayi AMP-binding enzyme family protein 0.029 0.1552 0.1544
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0074 0.033 0.1193
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0095 0.0448 0.0566
Schistosoma mansoni tyrosine kinase 0.0044 0.016 0.0578
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0026 0.0059 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0059 0.0407
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0058 0.0241 0.1871
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0036 0.0115 0.1194
Plasmodium falciparum transporter, putative 0.0085 0.0394 0.3149
Toxoplasma gondii flavodoxin domain-containing protein 0.0053 0.0212 0.0365
Echinococcus granulosus tumor protein p63 0.0312 0.1677 0.607
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0071 0.0314 0.0352
Mycobacterium tuberculosis Probable thioesterase TesA 0.0783 0.4346 0.5523
Loa Loa (eye worm) hypothetical protein 0.0504 0.2762 0.3117
Loa Loa (eye worm) pyruvate kinase 0.003 0.0078 0.0085
Schistosoma mansoni methyltransferase-related 0.0283 0.1514 0.5479
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0394 0.3149
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0071 0.0314 0.0305
Mycobacterium tuberculosis Possible oxygenase 0.0067 0.0288 0.0363
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Onchocerca volvulus 0.0071 0.0314 0.0296
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0041 0.0143 0.1128
Leishmania major d-xylulose reductase, putative 0.0058 0.0241 0.1397
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0059 0.0246 0.0593
Echinococcus multilocularis serotonin receptor 0.0177 0.091 0.2194
Echinococcus granulosus neuropeptide receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0314 0.0352
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0019 0.0016 0.0007
Schistosoma mansoni tyrosine kinase 0.0073 0.0325 0.1177
Echinococcus granulosus alpha 1A adrenergic receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Plasmodium vivax geranylgeranyltransferase, putative 0.0026 0.0059 0.0457
Brugia malayi Pyruvate kinase, M2 isozyme 0.003 0.0078 0.0069
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0071 0.0314 0.0757
Echinococcus granulosus 7TM GPCR rhodopsin 0.0071 0.0314 0.1138
Echinococcus multilocularis serotonin transporter 0.0504 0.2762 0.6656
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0476 0.2605 0.467
Leishmania major pyruvate kinase 0.003 0.0078 0.0297
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0058 0.0241 0.0264
Echinococcus multilocularis tumor protein p63 0.0312 0.1677 0.404
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0139 0.07 0.5609
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0101 0.0484 0.0575
Mycobacterium leprae Probable pyruvate kinase PykA 0.003 0.0078 0.0056
Leishmania major quinone oxidoreductase, putative 0.0058 0.0241 0.1397
Mycobacterium ulcerans hypothetical protein 0.0022 0.0034 0.004
Schistosoma mansoni opsin-like receptor 0.0071 0.0314 0.1138
Schistosoma mansoni NADPH flavin oxidoreductase 0.0054 0.0217 0.0785
Giardia lamblia Nitric oxide synthase, inducible 0.0095 0.045 0.2684
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium tuberculosis Conserved protein 0.0283 0.1514 0.1922
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0071 0.0314 0.0305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0453 0.0572
Mycobacterium tuberculosis Possible dehydrogenase 0.0058 0.0241 0.0303
Plasmodium vivax hypothetical protein, conserved 0.0135 0.0673 0.5391
Loa Loa (eye worm) hypothetical protein 0.0085 0.0394 0.0442
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0756 0.4193 0.531
Giardia lamblia Rab geranylgeranyltransferase 0.0139 0.07 0.4405
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0058 0.0241 0.0303
Leishmania major hypothetical protein, conserved 0.0041 0.0143 0.0736
Leishmania major zinc-binding dehydrogenase-like protein 0.0058 0.0241 0.1397
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0085 0.0394 0.1427
Mycobacterium leprae Polyketide synthase Pks13 0.1405 0.7866 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0314 0.0757
Echinococcus multilocularis AMP dependent ligase 0.0096 0.0453 0.1091
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0034 0.0025
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0036 0.0115 0.0106
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0053
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0289 0.1547 0.1964
Loa Loa (eye worm) pyruvate kinase-PB 0.0021 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0085 0.0394 0.1427
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0071 0.0314 0.0352
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0058 0.0241 0.0303
Onchocerca volvulus Putative alcohol dehydrogenase 0.0058 0.0241 0.0218
Loa Loa (eye worm) hypothetical protein 0.0144 0.0727 0.0817
Mycobacterium ulcerans hypothetical protein 0.0276 0.1473 0.187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0314 0.1138
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0998 0.5564 0.7072
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0034 0.028
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0071 0.0314 0.0756
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0059 0.0407
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0095 0.0448 0.0437
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0096 0.0453 0.0572
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0085 0.0394 0.0385
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0026 0.0059 0.009
Mycobacterium ulcerans thioesterase 0.0783 0.4346 0.5523
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0236 0.1246 0.1238
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0041 0.0143 0.0141
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0034 0.004
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0058 0.0241 0.2615
Echinococcus granulosus peptide allatostatin:somatostatin 0.0071 0.0314 0.1138
Schistosoma mansoni patched 1 0.0039 0.0131 0.0474
Plasmodium vivax pyruvate kinase, putative 0.003 0.0078 0.0606
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0058 0.0241 0.0264
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0058 0.0241 0.1871
Mycobacterium ulcerans polyketide synthase 0.094 0.5233 0.6652
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0453 0.5012
Echinococcus granulosus sterol regulatory element binding protein 0.0039 0.0131 0.0474
Chlamydia trachomatis sulfite reductase 0.0066 0.0286 0.2279
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Onchocerca volvulus 0.0504 0.2762 0.2881
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.0757
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0314 0.1138
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0108 0.0519 0.0657
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0314 0.1138
Onchocerca volvulus 0.0034 0.01 0.007
Leishmania major oxidoreductase-like protein 0.0058 0.0241 0.1397
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0323 0.174 0.2209
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0071 0.0314 0.0296
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0139 0.07 0.0691
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.003 0.0078 0.0096
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0034 0.004
Loa Loa (eye worm) 2Fe-2S iron-sulfur cluster binding domain-containing protein 0.0055 0.0219 0.0245
Mycobacterium ulcerans quinone reductase Qor 0.0058 0.0241 0.0303
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0236 0.1246 1
Schistosoma mansoni biogenic amine receptor 0.0071 0.0314 0.1138
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0911 0.507 0.6444
Brugia malayi AKH receptor 0.0071 0.0314 0.0305
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0108 0.0519 0.3278
Echinococcus granulosus pyruvate kinase 0.003 0.0078 0.0282
Treponema pallidum acyl carrier protein 0.0095 0.0448 0.1163
Schistosoma mansoni sodium/chloride dependent transporter 0.0085 0.0394 0.1427
Brugia malayi Dopamine receptor protein 2 0.0071 0.0314 0.0305
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Echinococcus multilocularis sodium and chloride dependent glycine 0.0085 0.0394 0.095
Loa Loa (eye worm) hypothetical protein 0.0071 0.0314 0.0352
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.094 0.5233 0.6639
Plasmodium falciparum nitric oxide synthase, putative 0.0108 0.0519 0.4152
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0058 0.0241 0.0303
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0174 0.0894 0.3237
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0314 0.1138
Loa Loa (eye worm) solute carrier family 6 member 4 0.0504 0.2762 0.3117
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0314 0.0352
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0067 0.0288 0.2298
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0236 0.1246 0.4511
Echinococcus granulosus voltage gated potassium channel 0.0019 0.0016 0.0059
Schistosoma mansoni amine GPCR 0.0071 0.0314 0.1138
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0026 0.0059 0.0215
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0095 0.0448 0.0439
Trypanosoma cruzi pyruvate kinase 2, putative 0.003 0.0078 0.0556
Loa Loa (eye worm) hypothetical protein 0.0039 0.0131 0.0145
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0269
Echinococcus granulosus g protein coupled receptor 0.0071 0.0314 0.1138
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0854
Mycobacterium ulcerans Type I modular polyketide synthase 0.094 0.5233 0.6652
Brugia malayi ORL1-like opioid receptor 0.0071 0.0314 0.0305
Echinococcus multilocularis sex peptide receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis sterol regulatory element binding protein 0.0039 0.0131 0.0315
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.023 0.1211 0.1536
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0044 0.016 0.0578
Leishmania major zinc binding dehydrogenase-like protein 0.0058 0.0241 0.1397
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0236 0.1246 1
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0058 0.0241 0.0303
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0692
Echinococcus granulosus allatostatin A receptor 0.0071 0.0314 0.1138
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0071 0.0314 0.1138
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0314 0.0757
Echinococcus granulosus NADH dehydrogenase 0.0095 0.0448 0.1621
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0236 0.1246 1
Trichomonas vaginalis xanthine dehydrogenase, putative 0.1698 0.9527 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0101 0.0484 0.0612
Schistosoma mansoni tyrosine kinase 0.0073 0.0325 0.1177
Mycobacterium ulcerans acyl carrier protein 0.0095 0.0448 0.0566
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0048 0.0181 0.0181
Loa Loa (eye worm) glutamate receptor 0.0023 0.0039 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0085 0.0394 0.0692
Schistosoma mansoni adrenodoxin 0.0055 0.0219 0.0793
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0074 0.0332 0.0323
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0055 0.0222 0.0248
Loa Loa (eye worm) hypothetical protein 0.0108 0.0519 0.0583
Onchocerca volvulus 0.0085 0.0394 0.038
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0095 0.0448 0.1079
Plasmodium vivax ferredoxin, putative 0.0055 0.0219 0.1741
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0144 0.0727 0.0921
Brugia malayi FAD binding domain containing protein 0.0108 0.0519 0.051
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0998 0.5564 0.7072
Trichomonas vaginalis Ferredoxin 2 0.0055 0.0219 0.0221
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0749 0.415 1
Echinococcus granulosus serotonin transporter 0.0504 0.2762 1
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0041 0.0143 0.1081
Loa Loa (eye worm) hypothetical protein 0.158 0.8858 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0171 0.0162
Toxoplasma gondii hypothetical protein 0.0103 0.0495 0.0874
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0148 0.0358
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.094 0.5233 0.6652
Brugia malayi Serotonin receptor 0.0071 0.0314 0.0305
Schistosoma mansoni tyrosine kinase 0.0138 0.0691 0.2501
Schistosoma mansoni hypothetical protein 0.0038 0.0123 0.0445
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.1125 0.628 0.7983
Toxoplasma gondii quinone oxidoreductase, putative 0.0058 0.0241 0.0416
Echinococcus multilocularis protein patched 0.0039 0.0131 0.0315
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0053
Trichomonas vaginalis Ferredoxin 3 0.0055 0.0219 0.0221
Brugia malayi Furin-like cysteine rich region family protein 0.0138 0.0691 0.0682
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0504 0.2762 0.2756
Onchocerca volvulus 0.0058 0.0241 0.0218
Schistosoma mansoni neuropeptide receptor 0.0071 0.0314 0.1138
Loa Loa (eye worm) TK/EGFR protein kinase 0.0138 0.0691 0.0777
Leishmania major hypothetical protein, conserved 0.0055 0.0219 0.1252
Loa Loa (eye worm) TK/INSR protein kinase 0.0044 0.016 0.0177
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0058 0.0241 0.0303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0064
Onchocerca volvulus 0.0046 0.0169 0.0142
Leishmania major hypothetical protein, conserved 0.0283 0.1514 1
Echinococcus multilocularis Adrenodoxin, mitochondrial 0.0055 0.0219 0.0528
Brugia malayi hypothetical protein 0.0071 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.0527 0.2893 0.3263
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0085 0.0394 0.1427
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0324 0.1746 0.2217
Trypanosoma cruzi lanosterol synthase, putative 0.0026 0.0059 0.0407
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0324 0.1746 0.2217
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0026 0.0059 0.0568
Echinococcus granulosus SAM and MBT domain containing protein 0.0034 0.01 0.0364
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0058 0.0241 0.0232
Echinococcus multilocularis serotonin receptor 0.0177 0.091 0.2194
Echinococcus multilocularis polycomb protein SCMH1 0.0034 0.01 0.0242
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0036 0.0115 0.0854
Echinococcus granulosus acyl carrier protein mitochondrial 0.0095 0.0448 0.1621
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0314 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0314 0.0757
Schistosoma mansoni voltage-gated potassium channel 0.006 0.0249 0.0902
Entamoeba histolytica hypothetical protein 0.0033 0.0098 0.1005
Giardia lamblia Methyltransferase like 2 0.0283 0.1514 1
Schistosoma mansoni [ACP] S-malonyltransferase 0.0059 0.0246 0.089
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0314 0.1138
Echinococcus granulosus 7tm_1 domain containing protein 0.0071 0.0314 0.1138
Brugia malayi follicle stimulating hormone receptor 0.0071 0.0314 0.0305
Brugia malayi flavodoxin family protein 0.0108 0.0519 0.051
Trichomonas vaginalis xanthine dehydrogenase, putative 0.1698 0.9527 1
Brugia malayi Protein kinase domain containing protein 0.0044 0.016 0.0151
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0314 0.0757
Echinococcus multilocularis pyruvate kinase 0.0023 0.0043 0.0102
Echinococcus multilocularis neuropeptide receptor A26 0.0071 0.0314 0.0757
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0108 0.0519 0.1879
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0026 0.0059 0.0457
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0019 0.0016 0.0039
Echinococcus granulosus g protein coupled receptor 0.0071 0.0314 0.1138
Echinococcus granulosus sodium and chloride dependent glycine 0.0085 0.0394 0.1427
Trichomonas vaginalis sulfite reductase, putative 0.0108 0.0519 0.0536
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0314 0.0757

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 32 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
IC50 (functional) = 32 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
Ki (binding) = 1.4 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643
Ki (binding) = 1.4 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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