Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexokinase, putative | 0.0707 | 0.9317 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0707 | 0.9317 | 0.5 |
Leishmania major | hexokinase, putative | 0.0707 | 0.9317 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.5028 | 0.5205 |
Echinococcus granulosus | hexokinase | 0.0707 | 0.9317 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0707 | 0.9317 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0443 | 0.429 | 0.4441 |
Trypanosoma brucei | hexokinase | 0.0707 | 0.9317 | 0.5 |
Brugia malayi | hexokinase type II | 0.0225 | 0.0115 | 0.0119 |
Brugia malayi | hexokinase | 0.0707 | 0.9317 | 0.9645 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0725 | 0.966 | 1 |
Echinococcus multilocularis | hexokinase | 0.0707 | 0.9317 | 0.5 |
Onchocerca volvulus | 0.0707 | 0.9317 | 0.8804 | |
Leishmania major | hexokinase, putative | 0.0707 | 0.9317 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0707 | 0.9317 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0707 | 0.9317 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0443 | 0.429 | 0.4441 |
Echinococcus granulosus | hexokinase | 0.0707 | 0.9317 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0707 | 0.9317 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0707 | 0.9317 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0707 | 0.9317 | 0.9645 |
Onchocerca volvulus | 0.0707 | 0.9317 | 0.8804 | |
Loa Loa (eye worm) | hypothetical protein | 0.0709 | 0.9356 | 0.9686 |
Loa Loa (eye worm) | hexokinase type II | 0.0707 | 0.9317 | 0.9645 |
Echinococcus multilocularis | hexokinase | 0.0707 | 0.9317 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0707 | 0.9317 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0707 | 0.9317 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0707 | 0.9317 | 0.5 |
Onchocerca volvulus | 0.0707 | 0.9317 | 0.8804 | |
Brugia malayi | nuclear hormone receptor | 0.0725 | 0.966 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0707 | 0.9317 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0707 | 0.9317 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0707 | 0.9317 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0707 | 0.9317 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0707 | 0.9317 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.0115 | 0.0119 |
Brugia malayi | Hexokinase family protein | 0.0707 | 0.9317 | 0.9645 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.0115 | 0.0119 |
Loa Loa (eye worm) | hexokinase | 0.0707 | 0.9317 | 0.9645 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 5 % | Antagonist activity at human A2B adenosine receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation at 10 uM after 20 mins | ChEMBL. | 23342198 |
Ki (binding) | = 0.2 uM | Displacement of [3H]DPCPX from human A3 adenosine receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 23342198 |
Ki (binding) | = 0.8 uM | Inhibition of human A1 adenosine receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 23342198 |
Ki (binding) | = 1.1 uM | Displacement of [3H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting | ChEMBL. | 23342198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.