Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.3239 | 0.2823 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0044 | 0.058 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0186 | 0.3585 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0044 | 0.058 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.058 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.3818 | 0.3448 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.3239 | 0.2823 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0044 | 0.058 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.058 | 0.1617 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0488 | 0.9971 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.058 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.058 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0044 | 0.058 | 0.1518 |
Trypanosoma brucei | glucosidase, putative | 0.0044 | 0.058 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.3585 | 0.3191 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.058 | 0.1617 |
Entamoeba histolytica | hypothetical protein | 0.0186 | 0.3585 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0186 | 0.3585 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0044 | 0.058 | 0.1518 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0488 | 0.9971 | 0.9969 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.058 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0186 | 0.3585 | 0.3191 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0186 | 0.3585 | 0.3191 |
Entamoeba histolytica | hypothetical protein | 0.0186 | 0.3585 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.058 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.3818 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.3818 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.058 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0044 | 0.058 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0186 | 0.3585 | 0.3201 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.058 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.3818 | 0.3438 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0488 | 0.9971 | 1 |
Onchocerca volvulus | 0.0114 | 0.2063 | 1 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.058 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.058 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0489 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.3818 | 0.3438 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0488 | 0.9971 | 0.9969 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0488 | 0.9971 | 1 |
Brugia malayi | hypothetical protein | 0.0186 | 0.3585 | 0.939 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25.9 uM | Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assay | ChEMBL. | 22834902 |
IC50 (binding) | = 36.61 uM | Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assay | ChEMBL. | 22834902 |
Potency (functional) | = 1.157 um | PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate Using an Alternate Red Fluorescent Substrate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 20.575 uM | PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1466, AID1473, AID2293] | ChEMBL. | No reference |
Potency (functional) | = 25.9024 um | PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] | ChEMBL. | No reference |
Potency (functional) | = 32.6092 um | PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase Using an Alternate Red Fluorescent Substrate. (Class of assay: confirmatory) [Related pubchem assays: 1466, 1473 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.