Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0179 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.3781 | 0.3781 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0003 | 0.0007 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0179 | 0.3781 | 0.3781 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | ring canal kelch protein | 0.0001 | 0.0003 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0001 | 0.0003 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0179 | 0.3781 | 0.5 |
Echinococcus granulosus | kelch protein 3 | 0.0001 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0179 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0472 | 1 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0471 | 0.9972 | 1 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0471 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0471 | 0.9972 | 0.9972 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 18 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0179 | 0.3781 | 0.3792 |
Brugia malayi | Kelch-like protein X | 0.0001 | 0.0003 | 0.0007 |
Echinococcus multilocularis | kelch protein 18 | 0.0001 | 0.0003 | 0.0003 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0003 | 0.0007 |
Echinococcus multilocularis | kelch protein 12 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0471 | 0.9972 | 0.9972 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0179 | 0.3781 | 0.3781 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 3 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 10 | 0.0001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | Klhl5 protein | 0.0001 | 0.0003 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0471 | 0.9972 | 1 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Echinococcus multilocularis | kelch protein 10 | 0.0001 | 0.0003 | 0.0003 |
Brugia malayi | BTB/POZ domain containing protein | 0.0001 | 0.0003 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0179 | 0.3781 | 0.5 |
Echinococcus granulosus | kelch protein 12 | 0.0001 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0179 | 0.3781 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 300 uM | Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay | ChEMBL. | 22533986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.