Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3781 | 0.5 |
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3781 | 0.5 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0 | 0.0003 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus multilocularis | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.3781 | 0.3792 |
Echinococcus multilocularis | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.3781 | 0.3781 |
Echinococcus granulosus | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.3781 | 0.3781 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0094 | 0.9972 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0094 | 0.9972 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0036 | 0.3781 | 1 |
Brugia malayi | Kelch-like protein X | 0 | 0.0003 | 0.0007 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0094 | 0.9972 | 0.9972 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | Klhl5 protein | 0 | 0.0003 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3781 | 0.3781 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0094 | 0.9972 | 0.9972 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3781 | 0.5 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0094 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus granulosus | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | ring canal kelch protein | 0 | 0.0003 | 1 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Brugia malayi | BTB/POZ domain containing protein | 0 | 0.0003 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Induction of Nrf2-mediated GPx protein expression in H2O2-stimulated human U373MG cells preincubated at 5 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated CAT protein expression in H2O2-stimulated human U373MG cells preincubated at 10 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated HO-1 protein expression in H2O2-stimulated human U373MG cells preincubated at 5 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated SOD protein expression in H2O2-stimulated human U373MG cells preincubated at 10 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated glutathione reductase protein expression in H2O2-stimulated human U373MG cells preincubated at 10 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated GPx protein expression in H2O2-stimulated human U373MG cells preincubated at 10 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated HO-1 protein expression in H2O2-stimulated human U373MG cells preincubated at 10 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated CAT protein expression in H2O2-stimulated human U373MG cells preincubated at 5 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated glutathione reductase protein expression in H2O2-stimulated human U373MG cells preincubated at 5 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 | |
Activity (binding) | Induction of Nrf2-mediated SOD protein expression in H2O2-stimulated human U373MG cells preincubated at 5 uM for 24 hrs before H2O2 challenge by Western blot method | ChEMBL. | 23046382 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.