TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 406.482 | Formula: C25H22N6
H donors: 2 H acceptors: 3 LogP: 3.47 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ncccc1c1nc2c(n1c1ccc(cc1)CNCc1ccccc1)nccc2
InChi: 1S/C25H22N6/c26-23-21(8-4-14-28-23)24-30-22-9-5-15-29-25(22)31(24)20-12-10-19(11-13-20)17-27-16-18-6-2-1-3-7-18/h1-15,27H,16-17H2,(H2,26,28)
InChiKey: LQSXSFCEWIASQF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0003	0.004	0.0074
Brugia malayi	protein kinase C II.	0.0013	0.03	0.0793
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Brugia malayi	hypothetical protein	0.0002	0.0033	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Brugia malayi	probable spectrin beta chain	0.0002	0.0033	0.0087
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0025	0.061	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0003	0.004	0.0111
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0013	0.03	0.03
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0002	0.0033	0.0033
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0002	0.0033	0.0033
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.0673	1
Onchocerca volvulus	Putative zinc finger protein	0.0002	0.0033	0.5
Echinococcus granulosus	Pleckstrin y	0.0002	0.0033	0.0033
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0002	0.0033	0.0087
Echinococcus multilocularis	serine threonine protein kinase	0.0013	0.03	0.03
Loa Loa (eye worm)	PH domain-containing protein	0.0002	0.0033	0.0328
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0002	0.0033	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0003	0.004	0.0079
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0013	0.03	0.03
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Brugia malayi	p70 ribosomal S6 kinase beta	0.0038	0.0933	0.2469
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Giardia lamblia	Kinase, AGC PKA	0.0025	0.061	0.5
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0391	0.9972	1
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0002	0.0033	0.0033
Schistosoma mansoni	hypothetical protein	0.0001	0.0000037154	0.0000037154
Brugia malayi	Hr1 repeat family protein	0.0013	0.03	0.0793
Schistosoma mansoni	oxysterol-binding protein 1	0.0002	0.0033	0.0033
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0013	0.03	0.03
Brugia malayi	MAX-1A	0.0002	0.0033	0.0087
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Schistosoma mansoni	serine/threonine kinase	0.0013	0.03	0.03
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0013	0.03	0.03
Entamoeba histolytica	protein kinase 2, putative	0.0025	0.061	0.1541
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0013	0.03	0.3006
Echinococcus multilocularis	beta 1 syntrophin	0.0002	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Entamoeba histolytica	hypothetical protein	0.0149	0.378	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0013	0.03	0.03
Echinococcus multilocularis	protein kinase c iota type	0.0013	0.03	0.03
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0003	0.004	0.0074
Echinococcus granulosus	serine threonine protein kinase nrc	0.0025	0.061	0.0612
Echinococcus multilocularis	oxysterol binding protein 9	0.0002	0.0033	0.0033
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0025	0.061	1
Entamoeba histolytica	p21-activated kinase	0.0003	0.004	0.0019
Brugia malayi	Syntrophin-1	0.0002	0.0033	0.0087
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0002	0.0033	0.0033
Onchocerca volvulus		0.0002	0.0033	0.5
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0997	1
Echinococcus multilocularis	actin binding protein anillin	0.0002	0.0033	0.0033
Echinococcus multilocularis	pdz domain containing protein	0.0002	0.0033	0.0033
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0002	0.0033	0.0033
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0013	0.03	0.03
Entamoeba histolytica	protein kinase, putative	0.0003	0.004	0.0019
Schistosoma mansoni	dynamin	0.0002	0.0033	0.0033
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0002	0.0033	0.0328
Brugia malayi	hypothetical protein	0.0149	0.378	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0013	0.03	0.03
Trypanosoma cruzi	NIMA-related kinase, putative	0.0003	0.004	0.0111
Echinococcus multilocularis	Pleckstrin y	0.0002	0.0033	0.0033
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0003	0.004	1
Echinococcus granulosus	Glutaredoxin protein 5	0.0025	0.0603	0.0605
Loa Loa (eye worm)	syntrophin-1	0.0002	0.0033	0.0328
Onchocerca volvulus		0.0002	0.0033	0.5
Echinococcus granulosus	GRB2 associated binding protein 3	0.0002	0.0033	0.0033
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0025	0.0603	0.0605
Entamoeba histolytica	hypothetical protein	0.0149	0.378	1
Entamoeba histolytica	protein kinase, putative	0.004	0.0997	0.2572
Echinococcus multilocularis	oxysterol binding protein 3	0.0002	0.0033	0.0033
Entamoeba histolytica	protein kinase, putative	0.0003	0.004	0.0019
Schistosoma mansoni	hypothetical protein	0.0392	1	1
Brugia malayi	Uncoordinated protein 104	0.0002	0.0033	0.0087
Schistosoma mansoni	hypothetical protein	0.0002	0.0033	0.0033
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.0997	1
Schistosoma mansoni	zinc finger protein	0.0002	0.0033	0.0033
Echinococcus granulosus	kelch protein 18	0.0001	0.0000037154	0.0000037258
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0002	0.0033	0.0033
Echinococcus multilocularis	kelch protein 3	0.0001	0.0000037154	0.0000037154
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Entamoeba histolytica	protein kinase, putative	0.0003	0.004	0.0019
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Trypanosoma cruzi	NIMA-related kinase, putative	0.0003	0.004	0.0111
Brugia malayi	Variant SH3 domain containing protein	0.0002	0.0033	0.0087
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0002	0.0033	0.0033
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0002	0.0033	0.0033
Schistosoma mansoni	hypothetical protein	0.0002	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Entamoeba histolytica	hypothetical protein	0.0003	0.004	0.0019
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0038	0.0933	0.9364
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Schistosoma mansoni	zinc finger protein	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0997	1
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0003	0.004	0.0111
Echinococcus granulosus	protein kinase c epsilon type	0.0013	0.03	0.03
Echinococcus granulosus	cytohesin 1	0.0002	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0013	0.03	0.3006
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0002	0.0033	0.0033
Loa Loa (eye worm)	rho-GTPase-activating	0.0002	0.0033	0.0328
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Onchocerca volvulus		0.0002	0.0033	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0673	0.171
Echinococcus granulosus	kelch protein 12	0.0001	0.0000037154	0.0000037258
Brugia malayi	Plekhf2 protein	0.0002	0.0033	0.0087
Echinococcus multilocularis	dynamin 1	0.0002	0.0033	0.0033
Onchocerca volvulus	outspread protein homolog	0.0002	0.0033	0.5
Entamoeba histolytica	protein kinase, putative	0.004	0.0997	0.2572
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0002	0.0033	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0013	0.03	0.3006
Onchocerca volvulus		0.0002	0.0033	0.5
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0013	0.03	0.03
Onchocerca volvulus		0.0002	0.0033	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Echinococcus multilocularis	kelch ECH associated protein 1	0.0391	0.9972	0.9972
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Onchocerca volvulus		0.0002	0.0033	0.5
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0002	0.0033	0.0033
Echinococcus granulosus	myotubularin protein 13	0.0002	0.0033	0.0033
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0002	0.0033	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Echinococcus granulosus	oxysterol binding protein 1	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.03	0.2769
Echinococcus granulosus	protein kinase C gamma type	0.0013	0.03	0.03
Echinococcus granulosus	Rho GTPase activating protein 24	0.0002	0.0033	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0013	0.03	0.0793
Echinococcus granulosus	Pleckstrin y	0.0002	0.0033	0.0033
Entamoeba histolytica	protein kinase, putative	0.0038	0.0933	0.2403
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0003	0.004	0.0019
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0003	0.004	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0673	0.171
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0673	0.0673
Schistosoma mansoni	dynamin	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0002	0.0033	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.03	0.03
Echinococcus granulosus	beta 1 syntrophin	0.0002	0.0033	0.0033
Brugia malayi	Dynamin	0.0002	0.0033	0.0087
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0003	0.004	1
Echinococcus multilocularis	Pleckstrin y	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0013	0.03	0.3006
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.03	0.2769
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Echinococcus granulosus	kelch protein 3	0.0001	0.0000037154	0.0000037258
Entamoeba histolytica	hypothetical protein	0.0149	0.378	1
Schistosoma mansoni	hypothetical protein	0.0001	0.0000037154	0.0000037154
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Trypanosoma brucei	protein kinase, putative	0.0003	0.004	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0391	0.9972	1
Schistosoma mansoni	syntrophin	0.0002	0.0033	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.03	0.03
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0025	0.061	0.901
Leishmania major	serine/threonine-protein kinase a, putative	0.0003	0.004	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0997	1
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0002	0.0033	0.0328
Echinococcus granulosus	Protein kinase C brain isozyme	0.0013	0.03	0.03
Onchocerca volvulus		0.0002	0.0033	0.5
Entamoeba histolytica	hypothetical protein	0.0149	0.378	1
Toxoplasma gondii	AGC kinase	0.0038	0.0933	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0025	0.061	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0013	0.03	0.03
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0003	0.004	0.0019
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0013	0.03	0.03
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0002	0.0033	0.0033
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0013	0.03	0.3006
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0003	0.004	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0002	0.0033	0.0033
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0003	0.004	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0002	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Echinococcus multilocularis	kelch protein 18	0.0001	0.0000037154	0.0000037154
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0002	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Loa Loa (eye worm)	cytohesin 3	0.0002	0.0033	0.0328
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0003	0.004	0.0111
Schistosoma mansoni	hypothetical protein	0.0149	0.378	0.378
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.03	0.03
Toxoplasma gondii	protein kinase domain-containing protein	0.0003	0.004	0.0079
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0003	0.004	0.0074
Echinococcus multilocularis	cytohesin 1	0.0002	0.0033	0.0033
Schistosoma mansoni	hypothetical protein	0.0001	0.0000037154	0.0000037154
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Echinococcus granulosus	DCC interacting protein 13 beta	0.0002	0.0033	0.0033
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0025	0.0603	0.0603
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0149	0.378	0.379
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.03	0.03
Schistosoma mansoni	atypical protein kinase C	0.0013	0.03	0.03
Echinococcus granulosus	nervana 2	0.0025	0.0603	0.0605
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0002	0.0033	0.0033
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0013	0.03	0.3006
Brugia malayi	Variant SH3 domain containing protein	0.0002	0.0033	0.0087
Schistosoma mansoni	goodpasture antigen-binding protein	0.0002	0.0033	0.0033
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.0673	0.0675
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.03	0.03
Schistosoma mansoni	hypothetical protein	0.0002	0.0033	0.0033
Echinococcus granulosus	oxysterol binding protein 3	0.0002	0.0033	0.0033
Echinococcus granulosus	pleckstrin y domain containing family A	0.0002	0.0033	0.0033
Entamoeba histolytica	protein kinase, putative	0.0003	0.004	0.0019
Trypanosoma brucei	rac serine-threonine kinase, putative	0.004	0.0997	1
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0003	0.004	0.0111
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0149	0.378	0.378
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Schistosoma mansoni	rho gtpase activating protein	0.0002	0.0033	0.0033
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0003	0.004	0.0111
Brugia malayi	TBC domain containing protein	0.0002	0.0033	0.0087
Echinococcus granulosus	pdz domain containing protein	0.0002	0.0033	0.0033
Echinococcus multilocularis	Oxysterol binding protein 11	0.0002	0.0033	0.0033
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0002	0.0033	0.0033
Brugia malayi	Pleckstrin Homology Domain	0.0002	0.0033	0.0087
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0997	1
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0997	1
Echinococcus granulosus	dynamin 1	0.0002	0.0033	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.03	0.03
Echinococcus granulosus	protein kinase c iota type	0.0013	0.03	0.03
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0025	0.061	0.061
Echinococcus multilocularis	Pleckstrin y	0.0002	0.0033	0.0033
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0003	0.004	0.0111
Echinococcus multilocularis	myotubularin protein 13	0.0002	0.0033	0.0033
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0013	0.03	0.3006
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0002	0.0033	0.0033
Echinococcus granulosus	kelch ECH associated protein 1	0.0391	0.9972	1
Brugia malayi	Protein kinase domain containing protein	0.0013	0.03	0.0793
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0002	0.0033	0.0033
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0003	0.004	0.0019
Echinococcus granulosus	calcium dependent secretion activator 1	0.0002	0.0033	0.0033
Brugia malayi	Oxysterol-binding protein	0.0002	0.0033	0.0087
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.0673	0.0673
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Echinococcus multilocularis	nervana 2	0.0025	0.0603	0.0603
Entamoeba histolytica	protein kinase, putative	0.0003	0.004	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Schistosoma mansoni	hypothetical protein	0.0001	0.0000037154	0.0000037154
Loa Loa (eye worm)	oxysterol binding protein	0.0002	0.0033	0.0328
Echinococcus multilocularis	kelch protein 12	0.0001	0.0000037154	0.0000037154
Schistosoma mansoni	myotubularin-related protein	0.0002	0.0033	0.0033
Trypanosoma cruzi	Protein kinase B	0.0028	0.0673	1
Loa Loa (eye worm)	Plekhf2 protein	0.0002	0.0033	0.0328
Leishmania major	protein kinase, putative	0.0003	0.004	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0002	0.0033	0.0033
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0003	0.004	0.0074
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0003	0.004	0.0074
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0002	0.0033	0.0033
Echinococcus granulosus	NDR protein kinase	0.0013	0.03	0.03
Echinococcus multilocularis	ectoderm neural cortex protein 1	0.0001	0.0000037154	0.0000037154
Brugia malayi	PH domain containing protein	0.0002	0.0033	0.0087
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0002	0.0033	0.0328
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0003	0.004	0.0111
Entamoeba histolytica	hypothetical protein	0.0003	0.004	0.0019
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0002	0.0033	0.0033
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0013	0.0293	0.2695
Echinococcus granulosus	ectoderm neural cortex protein 1	0.0001	0.0000037154	0.0000037258
Echinococcus granulosus	serine:threonine protein kinase N2	0.0013	0.03	0.03
Schistosoma mansoni	hypothetical protein	0.0002	0.0033	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.03	0.03
Echinococcus granulosus	oxysterol binding protein 9	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0363	0.3427
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Schistosoma mansoni	centaurin alpha	0.0002	0.0033	0.0033
Schistosoma mansoni	goodpasture antigen-binding protein	0.0002	0.0033	0.0033
Leishmania major	protein kinase, putative	0.0003	0.004	1
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.03	0.2769
Echinococcus multilocularis	Glutaredoxin protein 5	0.0025	0.0603	0.0603
Echinococcus granulosus	Pleckstrin y	0.0002	0.0033	0.0033
Echinococcus multilocularis	oxysterol binding protein 1	0.0002	0.0033	0.0033
Echinococcus granulosus	Oxysterol binding protein 11	0.0002	0.0033	0.0033
Brugia malayi	Protein kinase domain containing protein	0.004	0.0997	0.2637
Entamoeba histolytica	protein kinase, putative	0.0013	0.03	0.0712
Brugia malayi	Cytohesin 3	0.0002	0.0033	0.0087
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0003	0.004	0.0123
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0002	0.0033	0.0328
Echinococcus multilocularis	nervana 2	0.0025	0.0603	0.0603
Leishmania major	folate/biopterin transporter, putative	0.0003	0.004	1
Schistosoma mansoni	transcription factor LCR-F1	0.0149	0.378	0.378
Echinococcus multilocularis	kelch ECH associated protein 1	0.0391	0.9972	0.9972
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0997	1
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0002	0.0033	0.0033
Schistosoma mansoni	hypothetical protein	0.0002	0.0033	0.0033
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0002	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0673	0.0673
Brugia malayi	Cadps2 protein	0.0002	0.0033	0.0087
Onchocerca volvulus	Protein melted homolog	0.0002	0.0033	0.5
Brugia malayi	Oxysterol binding protein	0.0002	0.0033	0.0087
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0002	0.0033	0.0087
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0003	0.004	0.0123
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0002	0.0033	0.0033
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0013	0.03	0.03
Brugia malayi	Dynamin	0.0002	0.0033	0.0087
Echinococcus granulosus	nervana 2	0.0025	0.0603	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0033	0.0328
Loa Loa (eye worm)	uncoordinated protein 104	0.0002	0.0033	0.0328
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0997	1
Schistosoma mansoni	vav2	0.0002	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0003	0.004	0.0074

Activities

Activity type	Activity value	Assay description	Source	Reference
Delta Tm (binding)	= 4.9 degrees C	Binding affinity to Akt1 (1 to 480) expressed in Sf9 cells assessed as change in melting temperature at 30 uM	ChEMBL.	22533986
IC50 (binding)	= 0.26 uM	Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay	ChEMBL.	22533986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2177824

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1718737