Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.5 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.