Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.6256 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6256 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.036 | 0.6793 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.6793 | 0.6793 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 1 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.036 | 0.6793 | 0.6793 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6256 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6256 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6256 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 11 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 11 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 11 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 11 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 11 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 4 % | Percent inhibition against rat liver Dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 4 % | Percent inhibition against rat liver Dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 6 % | Percent inhibition against Toxoplasma gondii Dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 6 % | Percent inhibition against Toxoplasma gondii Dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 11 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Inhibition (binding) | = 11 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.