TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.514 | Formula: C20H28N2O2S
H donors: 1 H acceptors: 3 LogP: 3.2 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCSc1ncccc1C(=O)N([C@@H]1[C@@H]2CC3C[C@H]1C[C@](C2)(C3)O)C
InChi: 1S/C20H28N2O2S/c1-3-7-25-18-16(5-4-6-21-18)19(23)22(2)17-14-8-13-9-15(17)12-20(24,10-13)11-14/h4-6,13-15,17,24H,3,7-12H2,1-2H3/t13?,14-,15+,17-,20-
InChiKey: MYUWJGFKFGXFOP-ACCPSQPCSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxysteroid (11-beta) dehydrogenase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_132866	All targets in OG5_132866
Mycobacterium ulcerans	short chain dehydrogenase	Get druggable targets OG5_132866	All targets in OG5_132866

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid (11-beta) dehydrogenase 1	292 aa	250 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	microtubule associated protein 2	0.0675	0.8547	1
Loa Loa (eye worm)	acetyltransferase	0.0142	0.1731	0.3463
Loa Loa (eye worm)	nuclear hormone receptor	0.0042	0.046	0.092
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0278	0.049
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0098	0.1166	0.2061
Brugia malayi	ecdysteroid receptor	0.0397	0.4997	0.8835
Loa Loa (eye worm)	glutamate receptor	0.0016	0.0117	0.0233
Leishmania major	short chain dehydrogenase/reductase, putative	0.0009	0.0038	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Schistosoma mansoni	thyroid hormone receptor	0.0098	0.1166	0.1166
Onchocerca volvulus		0.0009	0.0038	0.0075
Brugia malayi	Nuclear hormone receptor E75	0.0042	0.046	0.0812
Schistosoma mansoni	nuclear receptor	0.0042	0.046	0.0459
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0098	0.1166	0.2333
Onchocerca volvulus		0.0009	0.0038	0.0075
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2529	0.506
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0042	0.046	0.092
Onchocerca volvulus		0.0009	0.0038	0.0075
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0055	0.0625	0.0731
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Echinococcus multilocularis	ecdysone induced protein 78C	0.0098	0.1166	0.1364
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Echinococcus granulosus	nuclear receptor nhr 48	0.0042	0.046	0.0538
Leishmania major	hypothetical protein, conserved	0.0009	0.0038	0.5
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0098	0.1166	0.2333
Schistosoma mansoni	cpg binding protein	0.003	0.0298	0.0298
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0098	0.1166	0.2061
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0055	0.0625	0.125
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0042	0.046	0.0812
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0009	0.0038	0.0044
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0009	0.0038	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0009	0.0038	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0098	0.1166	0.1166
Loa Loa (eye worm)	dehydrogenase	0.0009	0.0038	0.0075
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0098	0.1166	0.1166
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0042	0.046	0.0538
Trypanosoma brucei	oxidoreductase-like protein	0.0009	0.0038	0.5
Onchocerca volvulus		0.0009	0.0038	0.0075
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.03	0.035
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.03	0.4229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0098	0.1166	0.2333
Echinococcus multilocularis	retinol dehydrogenase 13	0.0009	0.0038	0.0044
Echinococcus granulosus	WW domain containing oxidoreductase	0.0009	0.0038	0.0044
Brugia malayi	nuclear hormone receptor family member odr-7	0.0042	0.046	0.0812
Brugia malayi	nuclear hormone receptor	0.0098	0.1166	0.2061
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0033	0.034	0.0398
Mycobacterium leprae	Probable oxidoreductase	0.0009	0.0038	0.5
Onchocerca volvulus		0.0009	0.0038	0.0075
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0098	0.1166	0.2061
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0009	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0042	0.046	0.092
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Leishmania major	3-keto-dihydrosphingosine reductase	0.0009	0.0038	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0009	0.0038	0.5
Schistosoma mansoni	carbonyl reductase	0.0009	0.0038	0.0037
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0098	0.1166	0.2061
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Leishmania major	short chain dehydrogenase, putative	0.0009	0.0038	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0098	0.1166	0.1166
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0098	0.1166	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0625	0.125
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Leishmania major	short chain dehydrogenase-like protein	0.0009	0.0038	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0038	0.0044
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0009	0.0038	0.0037
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0009	0.0038	0.0044
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0009	0.0038	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.03	0.0299
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0452	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0042	0.046	0.0538
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0042	0.046	0.0459
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.046	0.0459
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0009	0.0038	0.0075
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0009	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0095
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0098	0.1166	0.1364
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0038	0.0044
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0098	0.1166	0.2061
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Onchocerca volvulus		0.0009	0.0038	0.0075
Brugia malayi	nuclear receptor NHR-67	0.0042	0.046	0.0812
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0009	0.0038	0.0131
Brugia malayi	hypothetical protein	0.0009	0.0038	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0043	0.005
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0038	0.0044
Brugia malayi	steroid hormone receptor	0.0098	0.1166	0.2061
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Leishmania major	hypothetical protein, conserved	0.0009	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0625	0.125
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0278	0.0555
Onchocerca volvulus		0.0232	0.2888	0.578
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.046	0.0459
Brugia malayi	nuclear receptor NHR-88	0.0098	0.1166	0.2061
Onchocerca volvulus	Protein ultraspiracle homolog	0.0098	0.1166	0.2333
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Echinococcus granulosus	oxidoreductase	0.0009	0.0038	0.0044
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0038	0.5
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0009	0.0038	0.0044
Schistosoma mansoni	carbonyl reductase	0.0009	0.0038	0.0037
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0022	0.0025
Echinococcus multilocularis	steroid dehydrogenase	0.0009	0.0038	0.0044
Mycobacterium ulcerans	short chain dehydrogenase	0.0676	0.8556	1
Schistosoma mansoni	nuclear hormone receptor	0.0098	0.1166	0.1166
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.001	0.0048	0.0095
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0694	0.0694
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0098	0.1166	0.2333
Echinococcus granulosus	hypothetical protein	0.0009	0.0038	0.0044
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.1166	0.1364
Echinococcus multilocularis	cpg binding protein	0.003	0.0298	0.0348
Brugia malayi	metabotropic glutamate receptor type 2	0.0019	0.0164	0.0289
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0042	0.046	0.0812
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0009	0.0038	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.1731	0.306
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Leishmania major	pteridine reductase 1	0.0009	0.0038	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0098	0.1166	0.1364
Schistosoma mansoni	zinc finger protein	0.0042	0.046	0.0459
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0043	0.0086
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.0625	0.1104
Loa Loa (eye worm)	dehydrogenase	0.0009	0.0038	0.0075
Loa Loa (eye worm)	DR-78	0.0042	0.046	0.092
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0009	0.0038	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0625	0.125
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0009	0.0038	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0022	0.0025
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0022	0.0025
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0009	0.0038	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0098	0.1166	0.2333
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0042	0.046	0.092
Brugia malayi	Retinol dehydrogenase 12	0.0009	0.0038	0.0066
Echinococcus granulosus	FTZ F1 alpha	0.0098	0.1166	0.1364
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0038	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0098	0.1166	0.2061
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0098	0.1166	0.1166
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0039	0.0422	0.0746
Brugia malayi	dehydrogenases, short chain protein 9	0.0009	0.0038	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0625	0.125
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0098	0.1166	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0098	0.1166	0.2061
Schistosoma mansoni	RAR-like nuclear receptor	0.0098	0.1166	0.1166
Schistosoma mansoni	carbonyl reductase	0.0009	0.0038	0.0037
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0009	0.0038	0.5
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0009	0.0038	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0009	0.0038	0.0066
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0009	0.0038	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.0009	0.0038	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0397	0.4997	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0098	0.1166	0.2061
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0055	0.0625	0.0625
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0009	0.0038	0.0037
Schistosoma mansoni	hypothetical protein	0.04	0.5033	0.5033
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0452	0.1564
Brugia malayi	conserved hypotetical protein	0.0042	0.046	0.0812
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0038	0.0044
Schistosoma mansoni	metabotropic glutamate receptor	0.0019	0.0164	0.0164
Echinococcus multilocularis	conserved hypothetical protein	0.0009	0.0038	0.0044
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0009	0.0038	0.0044
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.03	0.0299
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	nuclear receptor NHR-88	0.0042	0.046	0.0812
Loa Loa (eye worm)	hypothetical protein	0.003	0.03	0.0599
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0009	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1166	0.2333
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0098	0.1166	0.2061
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0042	0.046	0.092
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0038	0.5
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0049	0.0538	0.063
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0009	0.0038	0.0131
Echinococcus granulosus	steroid dehydrogenase	0.0009	0.0038	0.0044
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0098	0.1166	0.1364
Onchocerca volvulus		0.0009	0.0038	0.0075
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Schistosoma mansoni	nuclear receptor nhr-48	0.0042	0.046	0.0459
Onchocerca volvulus		0.0009	0.0038	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1166	0.2333
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0009	0.0038	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0098	0.1166	0.1166
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0098	0.1166	0.2333
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0098	0.1166	0.2061
Echinococcus multilocularis	retinol dehydrogenase 11	0.0009	0.0038	0.0044
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0042	0.046	0.0538
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0452	0.6681
Onchocerca volvulus		0.003	0.03	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0038	0.5
Schistosoma mansoni	metabotropic glutamate receptor	0.0033	0.034	0.034
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0036	0.0375	0.0662
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0009	0.0038	0.0131
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.0625	0.1104
Onchocerca volvulus		0.0098	0.1166	0.2333
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0407	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Schistosoma mansoni	retinal dehydrogenase	0.0009	0.0038	0.0037
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0038	0.0044
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0042	0.046	0.0538
Loa Loa (eye worm)	glutamate receptor	0.0039	0.0422	0.0844
Echinococcus granulosus	microtubule associated protein 2	0.0675	0.8547	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0042	0.046	0.0812
Leishmania major	hypothetical protein, conserved	0.0009	0.0038	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0098	0.1166	0.2061
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.03	0.0299
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0098	0.1166	0.1364
Echinococcus granulosus	ecdysone induced protein 78C	0.0098	0.1166	0.1364
Onchocerca volvulus	Bile acid receptor homolog	0.0397	0.4997	1
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.2888	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Plasmodium vivax	SET domain protein, putative	0.003	0.03	0.633
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0009	0.0038	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0009	0.0038	0.0044
Brugia malayi	Serotonin receptor	0.0449	0.5656	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.0009	0.0038	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0098	0.1166	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.03	0.035
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.1166	0.1364
Schistosoma mansoni	cpg binding protein	0.0028	0.0278	0.0277
Brugia malayi	hypothetical protein	0.0055	0.0625	0.1104
Brugia malayi	nuclear receptor RXR	0.0055	0.0625	0.1104
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.046	0.0538
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0009	0.0038	0.5
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0022	0.0025
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0038	0.5
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0452	0.6681
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0538	0.1077
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0042	0.046	0.0538
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0098	0.1166	0.2061
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0009	0.0038	0.0044
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0009	0.0038	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0038	0.5
Schistosoma mansoni	cpg binding protein	0.003	0.0298	0.0298
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.1731	0.1731
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0038	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0038	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0009	0.0038	0.0066
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0009	0.0038	0.0044
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0049	0.0538	0.063
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.03	0.0299
Schistosoma mansoni	nuclear receptor	0.0042	0.046	0.0459
Echinococcus multilocularis	oxidoreductase	0.0009	0.0038	0.0044
Onchocerca volvulus		0.0042	0.046	0.092
Echinococcus multilocularis	transient receptor potential cation channel	0.0009	0.0038	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0009	0.0038	0.0044
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Mycobacterium tuberculosis	Probable oxidoreductase	0.0676	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0278	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Brugia malayi	hypothetical protein	0.0009	0.0038	0.0066
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0009	0.0038	0.5
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.1731	0.2025
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0009	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0038	0.0044
Echinococcus multilocularis	retinol dehydrogenase 11	0.0009	0.0038	0.0044
Onchocerca volvulus		0.0009	0.0038	0.0075
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0033	0.034	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Brugia malayi	Steroid receptor seven-up type 2	0.0098	0.1166	0.2061
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.5
Echinococcus granulosus	cpg binding protein	0.003	0.0298	0.0348
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0452	0.0528
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0098	0.1166	0.2333
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0407	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0045	0.0491	0.0491
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0009	0.0038	0.5
Brugia malayi	hypothetical protein	0.0042	0.046	0.0812
Leishmania major	hypothetical protein, conserved	0.0009	0.0038	0.5
Echinococcus multilocularis	nuclear receptor nhr 48	0.0042	0.046	0.0538
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0009	0.0038	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0009	0.0038	0.0037
Echinococcus multilocularis	FTZ F1 alpha	0.0098	0.1166	0.1364
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0009	0.0038	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0098	0.1166	0.1364
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0009	0.0038	0.5
Brugia malayi	ecdysone receptor	0.0042	0.046	0.0812
Loa Loa (eye worm)	steroid hormone receptor	0.0098	0.1166	0.2333
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0009	0.0038	0.0075
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0098	0.1166	0.2061
Leishmania major	hypothetical protein, conserved	0.0009	0.0038	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0009	0.0038	0.0037
Onchocerca volvulus		0.0009	0.0038	0.0075
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Brugia malayi	nuclear hormone receptor	0.0042	0.046	0.0812
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0098	0.1166	0.1364
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.001	0.0048	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1166	0.2333
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0009	0.0038	0.0044
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0452	0.1564
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.1166	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0009	0.0038	0.0066
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0043	0.005
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.03	0.035
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1166	0.2333
Echinococcus granulosus	dnaJ subfamily B	0.04	0.5033	0.5888
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0009	0.0038	0.0075
Schistosoma mansoni	retinoic acid receptor RXR	0.0098	0.1166	0.1166
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.168	0.1965
Echinococcus multilocularis	dnaJ subfamily B	0.04	0.5033	0.5888
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0009	0.0038	0.5
Echinococcus granulosus	hypothetical protein	0.0009	0.0038	0.0044
Brugia malayi	Receptor family ligand binding region containing protein	0.001	0.0048	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1166	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Brugia malayi	hypothetical protein	0.0042	0.046	0.0812
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0038	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0042	0.046	0.0538
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0009	0.0038	0.5
Brugia malayi	Pre-SET motif family protein	0.0204	0.2529	0.447
Brugia malayi	Pre-SET motif family protein	0.003	0.03	0.0529
Brugia malayi	hypothetical protein	0.0055	0.0625	0.1104
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0042	0.046	0.0538
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0009	0.0038	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0042	0.046	0.0812
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0042	0.0074
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0038	0.0044
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0657	1
Onchocerca volvulus		0.0009	0.0038	0.0075
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0407	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0042	0.046	0.0538
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.1166	0.1364
Brugia malayi	tailless protein	0.0042	0.046	0.0812
Onchocerca volvulus		0.0009	0.0038	0.0075
Brugia malayi	dehydrogenases, short chain protein 2	0.0009	0.0038	0.0066
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0009	0.0038	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0098	0.1166	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.092
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.046	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Brugia malayi	photoreceptor-specific nuclear receptor	0.0098	0.1166	0.2061
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0055	0.0625	0.0731
Leishmania major	short chain dehydrogenase, putative	0.0009	0.0038	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0098	0.1166	0.1364
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0038	0.0066
Leishmania major	dehydrogenase-like protein	0.0009	0.0038	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Brugia malayi	nuclear receptor RXR	0.0042	0.046	0.0812
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0009	0.0038	0.0066
Schistosoma mansoni	coup transcription factor	0.0098	0.1166	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0625	0.125
Onchocerca volvulus		0.0028	0.0278	0.0555
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0022	0.0021
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0009	0.0038	0.5
Onchocerca volvulus		0.0009	0.0038	0.0075
Schistosoma mansoni	thyroid hormone receptor	0.0098	0.1166	0.1166
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0055	0.0625	0.0625
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0009	0.0038	0.0075
Brugia malayi	oxidoreductase	0.0009	0.0038	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1166	0.2333
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0098	0.1166	0.1364
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0009	0.0038	0.0131
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0038	0.0131
Leishmania major	oxidoreductase-like protein	0.0009	0.0038	0.5
Schistosoma mansoni	microtubule-associated protein tau	0.0675	0.8547	0.8547
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0038	0.0075
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0038	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1166	0.2333
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0009	0.0038	0.0066
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0038	0.0037
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0038	0.0037
Onchocerca volvulus		0.0042	0.046	0.092
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0038	0.0075
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0098	0.1166	0.2333
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0038	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0009	0.0038	0.0044
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0009	0.0038	0.0044
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0098	0.1166	0.2061
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0009	0.0038	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.012 uM	Inhibition of N-terminal His6-tagged full length human 11betaHSD1 expressed in baculovirus infected cells using cortisone as substrate after 25 mins by HTRF assay	ChEMBL.	22691057

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2153179

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1719125