Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0044 | 0.0136 | 0.0136 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0275 | 0.1575 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1629 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0275 | 0.1575 | 0.1524 |
Loa Loa (eye worm) | hypothetical protein | 0.1629 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0275 | 0.1575 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0044 | 0.0136 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0275 | 0.1575 | 0.1524 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0275 | 0.1575 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0044 | 0.0136 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0275 | 0.1575 | 0.1512 |
Echinococcus multilocularis | aminopeptidase N | 0.0034 | 0.0075 | 0.0014 |
Echinococcus granulosus | neuroligin | 0.0275 | 0.1575 | 0.1512 |
Loa Loa (eye worm) | carboxylesterase | 0.1629 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1629 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0044 | 0.0136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.1629 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1629 | 1 | 1 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0044 | 0.0136 | 0.0075 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Schistosoma mansoni | gliotactin | 0.0275 | 0.1575 | 0.1575 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0275 | 0.1575 | 0.1524 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0275 | 0.1575 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.1575 | 0.1512 |
Echinococcus multilocularis | acetylcholinesterase | 0.1629 | 1 | 1 |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1629 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0275 | 0.1575 | 0.1575 |
Schistosoma mansoni | acetylcholinesterase | 0.0275 | 0.1575 | 0.1575 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | aminopeptidase N | 0.0044 | 0.0136 | 0.0136 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Echinococcus granulosus | acetylcholinesterase | 0.1629 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0034 | 0.0075 | 0.0075 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Entamoeba histolytica | aminopeptidase, putative | 0.0044 | 0.0136 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0275 | 0.1575 | 0.1524 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0034 | 0.0075 | 0.5508 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Brugia malayi | Peptidase family M1 containing protein | 0.0044 | 0.0136 | 0.0061 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0275 | 0.1575 | 0.1512 |
Loa Loa (eye worm) | hypothetical protein | 0.1629 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Brugia malayi | Carboxylesterase family protein | 0.1629 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0275 | 0.1575 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0275 | 0.1575 | 0.1512 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0044 | 0.0136 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1629 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0275 | 0.1575 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 6.73 % | Antiproliferative activity against human Jurkat cells assessed as 3rd generation cell population at 10 uM after 24 hrs using CFSE staining by flow cytometry relative to control | ChEMBL. | 23063518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.