Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.0986 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.1871 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0227 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.1871 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.1871 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.1871 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.0986 | 0.0986 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.1871 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1871 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.0986 | 0.0986 |
Onchocerca volvulus | 0.0389 | 0.0986 | 0.5 | |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1871 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.0986 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.1871 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0389 | 0.0986 | 0.0986 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.0986 | 0.0986 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.0986 | 0.0986 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1871 | 1 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0227 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.0986 | 0.0986 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.0986 | 0.0986 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1871 | 1 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0227 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 97 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
Control (functional) | = 97 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
IC50 (binding) | = 5.29 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (functional) | = 0.14 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (functional) | = 0.14 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (binding) | = 5.16 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (binding) | = 5.16 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2231608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.