Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta mV (functional) | = 10 | Compound measured for hyperpolarization of smooth muscle cells of the rabbit main pulmonary artery at concentration 100 uM. | ChEMBL. | 1920358 |
IC50 (functional) | > 100 uM | Relaxing effect determined by measuring inhibition of acetylcholine-induced contractions in pig coronary arteries. | ChEMBL. | 1920358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.