Detailed information for compound 171936

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 537.091 | Formula: C26H35ClN3O5S-
  • H donors: 5 H acceptors: 5 LogP: 2.69 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CSCC[C@H](C(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NCc1ccccc1O.[Cl-]
  • InChi: 1S/C26H35N3O5S.ClH/c1-17(2)23(27-16-19-11-7-8-12-22(19)30)25(32)29-21(15-18-9-5-4-6-10-18)24(31)28-20(26(33)34)13-14-35-3;/h4-12,17,20-21,23,27,30H,13-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34);1H/p-1/t20-,21-,23-;/m0./s1
  • InChiKey: KPTDLOVTDRIJPH-XCZLHMEYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0018 0.0203 0.0191
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0324 0.2838
Schistosoma mansoni ran 0.0022 0.0281 0.037
Echinococcus granulosus cpg binding protein 0.0067 0.1129 0.1076
Schistosoma mansoni hypothetical protein 0.0172 0.3102 0.4091
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0025 0.0331 0.0273
Schistosoma mansoni hypothetical protein 0.0074 0.1258 0.1659
Loa Loa (eye worm) hypothetical protein 0.003 0.0433 0.0496
Schistosoma mansoni isocitrate dehydrogenase 0.005 0.0797 0.105
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0025 0.0331 0.2928
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.006 0.0078
Schistosoma mansoni hypothetical protein 0.0034 0.0506 0.0667
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0976 0.1047
Giardia lamblia Rab geranylgeranyltransferase 0.0025 0.0331 0.1377
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0067 0.113 0.1077
Trichomonas vaginalis helicase, putative 0.0014 0.0131 0.1121
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0324 0.0163
Loa Loa (eye worm) hypothetical protein 0.0018 0.0203 0.0191
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0324 0.2838
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0408 0.7584 0.7569
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.005 0.0797 0.0741
Echinococcus multilocularis neuropeptide s receptor 0.0536 1 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.006 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0018 0.0203 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0669 0.5905
Giardia lamblia Prenyltransferase 0.0067 0.113 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0018 0.0203 0.0191
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0506 0.0449
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0025 0.0331 0.0173
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0018 0.0203 0.0268
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0976 0.1047
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0025 0.0331 0.0173
Brugia malayi RNA, U transporter 1 0.0086 0.1491 0.1903
Toxoplasma gondii isocitrate dehydrogenase 0.0408 0.7584 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0281 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0331 0.0173
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0669 0.0631
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0157 0.0098
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0506 0.0594
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0131 0.1121
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0018 0.0203 0.0145
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0018 0.0203 0.0268
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0049 0.0785 0.0789
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0669 0.0631
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0018 0.0203 0.0145
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0067 0.113 0.1491
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0408 0.7584 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0976 0.8627
Loa Loa (eye worm) hypothetical protein 0.0025 0.0331 0.0361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0506 0.0449
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0067 0.113 0.1256
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1906 0.2454
Plasmodium falciparum geranylgeranyltransferase, putative 0.0018 0.0203 0.0268
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0025 0.0331 0.0173
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0025 0.0331 0.0273
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0669 0.0613
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0408 0.7584 0.7569
Entamoeba histolytica hypothetical protein 0.0025 0.0324 0.2866
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0976 0.8627
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0976 0.8627
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0976 0.8627
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.006 0.0078
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.113 1
Echinococcus multilocularis cpg binding protein 0.0067 0.1129 0.1076
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.113 0.1256
Leishmania major lanosterol synthase, putative 0.0056 0.0909 0.0956
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.2135 0.2618
Schistosoma mansoni coup transcription factor 0.0011 0.006 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0131 0.1121
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Schistosoma mansoni thyroid hormone receptor 0.0011 0.006 0.0078
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0025 0.0331 0.2901
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0067 0.113 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0976 0.1047
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0025 0.0331 0.0361
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0018 0.0203 0.1767
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1906 0.2454
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0408 0.7584 1
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0018 0.0203 0.0191
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0408 0.7584 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0976 0.1047
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0281 0.0105
Echinococcus multilocularis geminin 0.0172 0.3102 0.3061
Schistosoma mansoni unc-13 (munc13) 0.005 0.0797 0.105
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0067 0.113 0.1256
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0131 0.1121
Echinococcus multilocularis GPCR, family 2 0.0034 0.0506 0.0449
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0131 0.1121
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0281 0.0223
Brugia malayi Isocitrate dehydrogenase 0.0408 0.7584 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0433 0.0311
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0157 0.0098
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.006 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.1254 0.1424
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0506 0.0449
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0976 0.1047
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0281 0.0837
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0669 0.0631
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.1254 0.1424
Echinococcus multilocularis importin subunit beta 1 0.003 0.0433 0.0375
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0067 0.113 0.1491
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0976 0.8332
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Schistosoma mansoni hypothetical protein 0.0172 0.3102 0.4091
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0976 0.0922
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0669 0.0882
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0225 0.022
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0067 0.113 1
Entamoeba histolytica tartrate dehydrogenase, putative 0.005 0.0797 0.7047
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.2901
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.006 0.0078
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0331 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Echinococcus granulosus isocitrate dehydrogenase NAD 0.005 0.0797 0.0741
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0281 0.0223
Schistosoma mansoni nuclear hormone receptor 0.0011 0.006 0.0078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0506 0.0594
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.113 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0131 0.1121
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.005 0.0797 0.5
Brugia malayi isocitrate dehydrogenase 0.0408 0.7584 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0433 0.0311
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0408 0.7584 0.7569
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0025 0.0331 0.0436
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0976 0.0922
Echinococcus multilocularis isocitrate dehydrogenase 0.0408 0.7584 0.7569
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.2408 0.3175
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0324 0.2838
Schistosoma mansoni cpg binding protein 0.0064 0.106 0.1398
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0025 0.0331 0.0436
Brugia malayi CXXC zinc finger family protein 0.0064 0.106 0.133
Leishmania major farnesyltransferase beta subunit 0.0067 0.113 0.1256
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0018 0.0203 0.1767
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.2901
Leishmania major isocitrate dehydrogenase, putative 0.005 0.0797 0.0804
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0157 0.0098
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0074 0.1254 0.0674
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0281 0.0105
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0281 0.0294
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0281 0.0294
Schistosoma mansoni hypothetical protein 0.0034 0.0506 0.0667
Echinococcus granulosus snurportin 1 0.0324 0.599 0.5966
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.2928
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0408 0.7584 1
Toxoplasma gondii hypothetical protein 0.0025 0.0331 0.0173
Toxoplasma gondii isocitrate dehydrogenase 0.0408 0.7584 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.006 0.0078
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0976 0.1047
Loa Loa (eye worm) hypothetical protein 0.005 0.0797 0.098
Echinococcus multilocularis neuropeptide receptor A26 0.0536 1 1
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.005 0.0797 0.0741
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0669 0.5026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0281 0.0105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0506 0.0594
Leishmania major GTP-binding protein, putative 0.0022 0.0281 0.0105
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0018 0.0203 0.1767
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0025 0.0331 0.0361
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.005 0.0797 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0536 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0669 0.081
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0976 0.0922
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.0173
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0669 0.0882
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0669 0.081
Schistosoma mansoni cpg binding protein 0.0067 0.1129 0.1488
Trypanosoma brucei protein kinase, putative 0.0059 0.0976 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0408 0.7584 0.7569
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0408 0.7584 1
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.005 0.0797 0.098
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0067 0.113 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0281 0.037
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0025 0.0331 0.0361
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.005 0.0797 0.5
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0025 0.0331 0.0173
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0408 0.7584 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.006 0.0078
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0067 0.113 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0976 0.1047
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0018 0.0203 0.1799
Loa Loa (eye worm) hypothetical protein 0.0018 0.0203 0.0191
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0018 0.0203 0.0268
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.006 0.0078
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0025 0.0331 0.0273
Brugia malayi Importin beta-1 subunit 0.003 0.0433 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.0173
Schistosoma mansoni importin beta-1 0.003 0.0433 0.057
Echinococcus granulosus geminin 0.0172 0.3102 0.3061
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.005 0.0797 0.7035
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0018 0.0203 0.0268
Plasmodium falciparum importin beta, putative 0.003 0.0433 0.057
Leishmania major importin beta-1 subunit, putative 0.0025 0.0324 0.0163
Schistosoma mansoni cpg binding protein 0.0067 0.1129 0.1488
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.005 0.0797 0.098
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.005 0.0797 0.105
Plasmodium vivax importin-beta 2, putative 0.003 0.0433 0.0311
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0669 0.0613
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0025 0.0331 0.0273
Brugia malayi Probable isocitrate dehydrogenase 0.005 0.0797 0.098
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0408 0.7584 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0281 0.0105
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0025 0.0331 0.0436
Onchocerca volvulus 0.0064 0.106 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.023 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Schistosoma mansoni ran 0.0022 0.0281 0.037
Loa Loa (eye worm) isocitrate dehydrogenase 0.0408 0.7584 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0976 0.1287
Echinococcus granulosus GPCR family 2 0.0034 0.0506 0.0449
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.005 0.0797 0.0741
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0408 0.7584 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0131 0.1121
Schistosoma mansoni hypothetical protein 0.0034 0.0506 0.0667
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0025 0.0331 0.0361
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0669 0.0613
Onchocerca volvulus 0.0025 0.0331 0.2713
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.1258 0.1593
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0669 0.0631
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0067 0.113 0.1423
Schistosoma mansoni hypothetical protein 0.0324 0.599 0.7898
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0669 0.5905
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.106 0.133
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0025 0.0331 0.0173
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.599 0.7882
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0131 0.1121
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0131 0.1121
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.023 0.0172
Loa Loa (eye worm) histone methyltransferase 0.002 0.023 0.0227
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0976 0.1047
Brugia malayi Probable isocitrate dehydrogenase 0.005 0.0797 0.098
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0669 0.0613
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.005 0.0797 0.098
Trichomonas vaginalis ran, putative 0.0022 0.0281 0.2456
Entamoeba histolytica Ran family GTPase 0.0022 0.0281 0.2485
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0976 0.1218
Loa Loa (eye worm) hypothetical protein 0.0074 0.1258 0.1593
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0331 0.0173
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0157 0.0098
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.0173
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.005 0.0797 0.098
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0669 0.592
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0669 0.0613
Brugia malayi MAP kinase sur-1 0.0059 0.0976 0.1218
Trypanosoma brucei lanosterol synthase 0.0074 0.1254 0.1424
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0067 0.113 0.1256
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.113 1
Echinococcus multilocularis snurportin 1 0.0324 0.599 0.5966
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0506 0.0449
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0025 0.0331 0.0436
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0031 0.004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.006 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0157 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0131 0.1121
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0018 0.0203 0.1799
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0433 0.0311
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0025 0.0331 0.0273
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0025 0.0331 0.0273
Echinococcus granulosus importin subunit beta 1 0.003 0.0433 0.0375
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0976 0.0922
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0408 0.7584 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0669 0.5905
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1906 0.2454
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0067 0.113 0.1077
Schistosoma mansoni hypothetical protein 0.0034 0.0506 0.0667
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.0173
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0506 0.0594
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0408 0.7584 0.7569
Loa Loa (eye worm) hypothetical protein 0.0108 0.1906 0.2454
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0669 0.0613
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.006 0.0078
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.113 0.1256
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0025 0.0331 0.2901
Giardia lamblia Rab geranylgeranyltransferase 0.0025 0.0331 0.1377
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0067 0.113 0.1423

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.4 uM Inhibition of farnesyl transferase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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