Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein phosphatase 2B, putative | 0.0041 | 0.0461 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.0766 | 0.369 |
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0041 | 0.0461 | 0.3424 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.0039 | 0.0426 | 0.0426 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0583 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0583 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.1347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0426 | 0.1331 |
Chlamydia trachomatis | oxoacy-ACP reductase | 0.0039 | 0.0426 | 0.0426 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0039 | 0.0426 | 0.1331 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.1347 | 1 |
Toxoplasma gondii | protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein | 0.0041 | 0.0461 | 0.0036 |
Brugia malayi | hypothetical protein | 0.0197 | 0.3204 | 1 |
Schistosoma mansoni | protein phosphatase-2b | 0.0041 | 0.0461 | 0.0379 |
Trypanosoma cruzi | serine/threonine protein phosphatase 2B catalytic subunit A2, putative | 0.0041 | 0.0461 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0039 | 0.0426 | 0.9243 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0039 | 0.0426 | 0.3165 |
Leishmania major | oxidoreductase-like protein | 0.0039 | 0.0426 | 0.9243 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0041 | 0.0461 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.2935 | 0.9031 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0039 | 0.0426 | 0.9243 |
Leishmania major | serine/threonine protein phosphatase 2B catalytic subunit A2, putative | 0.0041 | 0.0461 | 1 |
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0041 | 0.0461 | 0.3424 |
Plasmodium vivax | serine/threonine protein phosphatase 2B catalytic subunit A, putative | 0.0041 | 0.0461 | 0.0036 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0039 | 0.0426 | 0.9243 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0041 | 0.0461 | 0.3424 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.1347 | 1 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.0766 | 0.1223 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0039 | 0.0426 | 0.3165 |
Mycobacterium ulcerans | putative regulatory protein | 0.0043 | 0.0497 | 0.0074 |
Brugia malayi | Serine/threonine protein phosphatase 2B catalytic subunit 2 | 0.0041 | 0.0461 | 0.0126 |
Schistosoma mansoni | protein phosphatase-2b | 0.0041 | 0.0461 | 0.0379 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0583 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1347 | 1 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0041 | 0.0461 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0039 | 0.0426 | 0.9243 |
Entamoeba histolytica | Ser/Thr protein phosphatase, putative | 0.0041 | 0.0461 | 1 |
Trypanosoma cruzi | serine/threonine protein phosphatase, putative | 0.0041 | 0.0461 | 1 |
Onchocerca volvulus | 0.0039 | 0.0426 | 0.8577 | |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0583 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0583 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0583 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.1347 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0039 | 0.0426 | 0.1331 |
Plasmodium falciparum | serine/threonine protein phosphatase 2B catalytic subunit A | 0.0041 | 0.0461 | 0.0036 |
Leishmania major | serine/threonine protein phosphatase, putative | 0.0041 | 0.0461 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0039 | 0.0426 | 0.9243 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3204 | 1 |
Trypanosoma cruzi | serine/threonine protein phosphatase, putative | 0.0041 | 0.0461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0461 | 0.144 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1347 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.0497 | 0.0255 |
Echinococcus granulosus | single minded 2 | 0.0043 | 0.0497 | 0.369 |
Entamoeba histolytica | Ser/Thr protein phosphatase, putative | 0.0041 | 0.0461 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.2935 | 0.916 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0041 | 0.0461 | 1 |
Leishmania major | pteridine reductase 1 | 0.0039 | 0.0426 | 0.9243 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.1347 | 0.4205 |
Onchocerca volvulus | 0.0039 | 0.0426 | 0.8577 | |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0039 | 0.0426 | 0.9243 |
Onchocerca volvulus | 0.0043 | 0.0497 | 1 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.1347 | 0.3315 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0583 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0451 | 0.1408 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0041 | 0.0461 | 0.3424 |
Schistosoma mansoni | single-minded | 0.0059 | 0.0766 | 0.369 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0041 | 0.0461 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0043 | 0.0497 | 0.369 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0583 | 1 | 1 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.0039 | 0.0426 | 0.0426 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0039 | 0.0426 | 0.1331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 20 uM | Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by SRB assay | ChEMBL. | 23153200 |
IC50 (binding) | = 2.17 uM | Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assay | ChEMBL. | 23153200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.