Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.2103 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.004 | 0.0292 | 0.139 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0053 | 0.2103 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2103 | 0.1865 |
Mycobacterium ulcerans | hypothetical protein | 0.0053 | 0.2103 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2103 | 0.1865 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.2103 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0053 | 0.2103 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.2103 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.004 | 0.0292 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.2103 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.2103 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0053 | 0.2103 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0053 | 0.2103 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.004 | 0.0292 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.5235 | 0.5092 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.2103 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.5809 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.004 | 0.0292 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2103 | 0.1865 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5809 | 1 |
Brugia malayi | hypothetical protein | 0.0081 | 0.5809 | 0.4693 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0081 | 0.5809 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5809 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5809 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0053 | 0.2103 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0053 | 0.2103 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0081 | 0.5809 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.5235 | 0.3967 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0053 | 0.2103 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5809 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.2103 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0081 | 0.5809 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.2103 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 58 % | Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 12.5 uM measured on day 3 by Alamar Blue assay relative to 100 pM GLP2 | ChEMBL. | 22944117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.