Detailed information for compound 1719523

Basic information

Technical information
  • TDR Targets ID: 1719523
  • Name: SR-01000632869-1
  • MW: 417.242 | Formula: C20H14Cl2N2O4
  • H donors: 2 H acceptors: 4 LogP: 4.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1C(=O)O)Nc1ncccc1OCc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C20H14Cl2N2O4/c21-15-8-7-12(10-16(15)22)11-28-17-6-3-9-23-18(17)24-19(25)13-4-1-2-5-14(13)20(26)27/h1-10H,11H2,(H,26,27)(H,23,24,25)
  • InChiKey: GGTWJBXFOJAHBS-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • Maybridge3_002129
  • HTS 04549
  • Oprea1_336612
  • IDI1_013516

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Giardia lamblia DINP protein human, muc B family 0.0082 0.738 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.1579 0.1579
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0103 1 1
Echinococcus multilocularis dna polymerase eta 0.0101 0.9854 0.9854
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.0534 0.1775
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.738 0.738
Mycobacterium ulcerans DNA polymerase IV 0.0103 1 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Leishmania major DNA polymerase eta, putative 0.0101 0.9854 1
Leishmania major DNA polymerase kappa, putative 0.0082 0.738 0.749
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0076 0.6516 0.6516
Trypanosoma brucei unspecified product 0.0052 0.3435 0.3435
Trypanosoma brucei DNA polymerase IV, putative 0.0103 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Entamoeba histolytica hypothetical protein 0.0038 0.1579 0.2423
Entamoeba histolytica hypothetical protein 0.0038 0.1579 0.2423
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0076 0.6516 0.6516
Echinococcus multilocularis dna polymerase kappa 0.0103 1 1
Plasmodium falciparum flap endonuclease 1 0.0026 0 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.3007 0.3007
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.6516 0.6613
Trypanosoma brucei DNA polymerase IV, putative 0.0103 1 1
Echinococcus granulosus dna polymerase eta 0.0101 0.9854 0.9854
Trypanosoma brucei unspecified product 0.0096 0.9136 0.9136
Brugia malayi ImpB/MucB/SamB family protein 0.0101 0.9854 1
Entamoeba histolytica hypothetical protein 0.0038 0.1579 0.2423
Entamoeba histolytica hypothetical protein 0.0038 0.1579 0.2423
Brugia malayi hypothetical protein 0.0038 0.1579 0.1602
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.4299 0.4299
Schistosoma mansoni DNA polymerase eta 0.0101 0.9854 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0103 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Brugia malayi polk-prov protein 0.005 0.3153 0.32
Loa Loa (eye worm) hypothetical protein 0.005 0.3153 0.32
Trypanosoma brucei unspecified product 0.0052 0.3435 0.3435
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.3153 0.3153
Entamoeba histolytica deoxycytidyl transferase, putative 0.0076 0.6516 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 1 1
Plasmodium vivax flap endonuclease 1, putative 0.0026 0 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.4299 0.4299
Mycobacterium ulcerans DNA polymerase IV 0.0103 1 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.738 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0076 0.6516 0.6613
Loa Loa (eye worm) hypothetical protein 0.0101 0.9854 1
Trypanosoma brucei DNA polymerase eta, putative 0.0101 0.9854 0.9854
Schistosoma mansoni terminal deoxycytidyl transferase 0.0076 0.6516 0.5967
Trypanosoma brucei DNA polymerase kappa, putative 0.0103 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.3007 1
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.9136 0.9136
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.4299 0.4299
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.738 0.749
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.6516 0.5967
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.1579 0.1579
Trypanosoma cruzi DNA polymerase eta, putative 0.0101 0.9854 0.9854
Trypanosoma cruzi DNA polymerase kappa, putative 0.0103 1 1
Leishmania major DNA polymerase eta, putative 0.0049 0.3007 0.3052
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.3153 0.3153

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.