Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0038 | 0.1579 | 0.1602 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0103 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0076 | 0.6516 | 0.6613 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0052 | 0.3435 | 0.3435 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0103 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0049 | 0.3007 | 0.3052 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.003 | 0.0534 | 0.1775 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0082 | 0.738 | 0.749 |
Trypanosoma brucei | unspecified product | 0.0052 | 0.3435 | 0.3435 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0101 | 0.9854 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0076 | 0.6516 | 0.6516 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0076 | 0.6516 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.9854 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0103 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0096 | 0.9136 | 0.9136 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0101 | 0.9854 | 0.9854 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0103 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.4299 | 0.4299 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1579 | 0.2423 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0049 | 0.3007 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0076 | 0.6516 | 0.6516 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1579 | 0.2423 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0049 | 0.3007 | 0.3007 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0076 | 0.6516 | 0.5967 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.4299 | 0.4299 |
Giardia lamblia | DINP protein human, muc B family | 0.0082 | 0.738 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1579 | 0.2423 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.4299 | 0.4299 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0103 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0101 | 0.9854 | 0.9854 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0101 | 0.9854 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0103 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0076 | 0.6516 | 0.6613 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0101 | 0.9854 | 0.9854 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1579 | 0.2423 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3153 | 0.32 |
Schistosoma mansoni | DNA polymerase eta | 0.0101 | 0.9854 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0096 | 0.9136 | 0.9136 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1579 | 0.1579 |
Brugia malayi | polk-prov protein | 0.005 | 0.3153 | 0.32 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1579 | 0.1579 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0082 | 0.738 | 0.738 |
Echinococcus granulosus | dna polymerase eta | 0.0101 | 0.9854 | 0.9854 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.005 | 0.3153 | 0.3153 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0082 | 0.738 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0082 | 0.738 | 0.749 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0103 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0076 | 0.6516 | 0.5967 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.005 | 0.3153 | 0.3153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.