Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0246 | 0.0246 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0091 | 0.4935 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0082 | 0.0082 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0107 | 0.6011 | 0.6011 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0082 | 0.0082 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.3661 | 0.3661 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2857 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1142 | 0.1497 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.309 | 0.309 |
Treponema pallidum | hypothetical protein | 0.0019 | 0.0202 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0104 | 0.5776 | 0.5776 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0.0202 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5831 | 0.7643 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0091 | 0.4935 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0315 | 0.0412 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.5831 | 0.7643 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1355 | 0.1776 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.3628 | 0.3628 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2857 | 0.2857 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1469 | 0.1925 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0082 | 0.0082 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0019 | 0.0202 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.763 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3574 | 0.4685 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1464 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.4935 | 0.6469 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1623 | 0.2127 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3393 | 0.4447 |
Mycobacterium ulcerans | integral membrane protein | 0.0019 | 0.0202 | 0.5 |
Brugia malayi | Transient-receptor-potential like protein | 0.004 | 0.159 | 0.2084 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3661 | 0.4798 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.5831 | 0.7643 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.3853 | 0.505 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.1142 | 0.1497 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.5831 | 0.7643 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0091 | 0.4935 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.3628 | 0.3628 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1142 | 0.1142 |
Plasmodium falciparum | protease, putative | 0.0019 | 0.0202 | 1 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0091 | 0.4935 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.3628 | 0.3628 |
Chlamydia trachomatis | hypothetical protein | 0.0019 | 0.0202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.159 | 0.2084 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.1142 | 0.1497 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0091 | 0.4935 | 0.4935 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0202 | 1 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0091 | 0.4935 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0082 | 0.0107 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0593 | 0.0777 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.004 | 0.159 | 0.159 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0082 | 0.0082 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0246 | 0.0246 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0019 | 0.0202 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0439 | 0.0439 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0082 | 0.0082 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1142 | 0.1142 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.131 | 0.131 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.6011 | 0.7878 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.004 | 0.159 | 0.159 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.3661 | 0.4798 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0.0202 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0.0202 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0246 | 0.0246 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0107 | 0.6011 | 0.6011 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.763 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0107 | 0.6011 | 0.6011 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.763 | 1 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0107 | 0.6011 | 0.6011 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.131 | 0.131 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0122 | 0.0159 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.3628 | 0.3628 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0091 | 0.4935 | 0.4935 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0082 | 0.0082 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0019 | 0.0202 | 1 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0082 | 0.0082 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0082 | 0.0082 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0.0202 | 0.5 |
Plasmodium vivax | protease, putative | 0.0019 | 0.0202 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1142 | 0.1142 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0091 | 0.4935 | 0.4935 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0091 | 0.4935 | 0.6469 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0019 | 0.0202 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0439 | 0.0439 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.3628 | 0.3628 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1747 | 0.229 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.3628 | 0.3628 |
Giardia lamblia | Hypothetical protein | 0.0091 | 0.4935 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0091 | 0.4935 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0091 | 0.4935 | 0.4935 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1142 | 0.1142 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.1142 | 0.1497 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0104 | 0.5776 | 0.5776 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.1142 | 0.1142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 26.6 uM | Antileishmanial activity against promastigote form of Leishmania major MHOM/IL/81/BNI after 96 hrs by resazurin-based spectrofluorimetric method | ChEMBL. | 23164660 |
IC50 (ADMET) | = 48 uM | Cytotoxicity against human HeLa cells after 96 hrs by resazurin-based spectrofluorimetric method | ChEMBL. | 23164660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.