Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0114 | 0.0347 |
Echinococcus granulosus | protein kinase C gamma type | 0.0054 | 0.2835 | 0.8601 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0061 | 0.3297 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0012 | 0.0281 | 0.0852 |
Onchocerca volvulus | 0.0012 | 0.0281 | 0.0301 | |
Echinococcus multilocularis | neuroglian | 0.0013 | 0.0293 | 0.0889 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0012 | 0.0252 | 0.0763 |
Brugia malayi | protein-tyrosine kinase | 0.0012 | 0.0281 | 0.0179 |
Leishmania major | protein kinase, putative | 0.0061 | 0.3297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0012 | 0.0252 | 0.0763 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0012 | 0.0281 | 0.0852 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.001 | 0.0134 | 0.003 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0281 | 0.0179 |
Trichomonas vaginalis | AGC family protein kinase | 0.0061 | 0.3297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0114 | 0.0114 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0061 | 0.3297 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.001 | 0.0114 | 0.0347 |
Echinococcus granulosus | neuroglian | 0.0013 | 0.0293 | 0.0889 |
Brugia malayi | hypothetical protein | 0.001 | 0.0134 | 0.003 |
Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.001 | 0.0104 | 0.0316 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Loa Loa (eye worm) | AUR protein kinase | 0.0061 | 0.3297 | 0.3297 |
Entamoeba histolytica | protein kinase , putative | 0.0061 | 0.3297 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0061 | 0.3297 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0061 | 0.3297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | aurora kinase A | 0.0061 | 0.3297 | 1 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0012 | 0.0252 | 0.0763 |
Schistosoma mansoni | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.001 | 0.0114 | 0.0114 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0012 | 0.0252 | 0.0252 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0012 | 0.0281 | 0.0852 |
Onchocerca volvulus | 0.0012 | 0.0281 | 0.0301 | |
Echinococcus granulosus | c src tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.001 | 0.0114 | 0.0114 |
Echinococcus granulosus | twitchin | 0.0013 | 0.0336 | 0.102 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.3297 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.001 | 0.0114 | 0.0347 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Onchocerca volvulus | 0.0012 | 0.0281 | 0.0301 | |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0134 | 0.0407 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.001 | 0.0134 | 0.0407 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0012 | 0.0281 | 0.0852 |
Brugia malayi | Protein kinase c protein 2 | 0.0051 | 0.268 | 0.2603 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0061 | 0.3297 | 0.3226 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.001 | 0.0114 | 0.0347 |
Brugia malayi | Protein kinase domain containing protein | 0.0012 | 0.0281 | 0.0179 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0013 | 0.0337 | 0.1022 |
Echinococcus granulosus | Immunoglobulin | 0.001 | 0.0134 | 0.0407 |
Schistosoma mansoni | cell adhesion molecule | 0.0013 | 0.0337 | 0.1022 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.001 | 0.0114 | 0.0347 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0018 | 0.0603 | 0.1828 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.001 | 0.0114 | 0.0114 |
Schistosoma mansoni | atypical protein kinase C | 0.0016 | 0.0519 | 0.1573 |
Echinococcus granulosus | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Loa Loa (eye worm) | TK protein kinase | 0.0012 | 0.0281 | 0.0281 |
Brugia malayi | serine/threonine kinase 12 | 0.0061 | 0.3297 | 0.3226 |
Entamoeba histolytica | protein kinase, putative | 0.0061 | 0.3297 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0018 | 0.0603 | 0.1828 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Schistosoma mansoni | serine/threonine kinase | 0.001 | 0.0114 | 0.0347 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0061 | 0.3297 | 0.5 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.001 | 0.0114 | 0.0114 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.001 | 0.0114 | 0.0347 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.001 | 0.0114 | 0.0114 |
Onchocerca volvulus | 0.0012 | 0.0281 | 0.0301 | |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0114 | 0.001 |
Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.001 | 0.0104 | 0.0316 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0045 | 0.2276 | 0.2276 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0012 | 0.0252 | 0.0763 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0134 | 0.0407 |
Echinococcus granulosus | protein kinase c iota type | 0.0016 | 0.0519 | 0.1573 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0496 | 0.0496 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0054 | 0.2835 | 0.8601 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2553 | 0.2553 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0496 | 0.1504 |
Brugia malayi | SH2 domain containing protein | 0.0012 | 0.0281 | 0.0179 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0061 | 0.3297 | 0.3226 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0014 | 0.0349 | 0.106 |
Entamoeba histolytica | protein kinase, putative | 0.0061 | 0.3297 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Giardia lamblia | Aurora kinase | 0.0061 | 0.3297 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0012 | 0.0281 | 0.0852 |
Onchocerca volvulus | 0.0149 | 0.8741 | 0.9365 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0012 | 0.0281 | 0.0523 |
Trichomonas vaginalis | AGC family protein kinase | 0.0061 | 0.3297 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0012 | 0.0281 | 0.0852 |
Brugia malayi | Variant SH3 domain containing protein | 0.0012 | 0.0252 | 0.0149 |
Schistosoma mansoni | protein kinase | 0.0061 | 0.3297 | 1 |
Toxoplasma gondii | aurora kinase | 0.0061 | 0.3297 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0061 | 0.3297 | 0.3297 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.0307 | 0.0931 |
Schistosoma mansoni | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.006 | 0.324 | 0.9827 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2149 | 0.2149 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0012 | 0.0281 | 0.0852 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.017 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Echinococcus granulosus | N chimaerin | 0.0012 | 0.0252 | 0.0763 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0012 | 0.0281 | 0.0852 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0061 | 0.3297 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.001 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0337 | 0.0337 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0114 | 0.001 |
Echinococcus granulosus | aurora kinase A | 0.0061 | 0.3297 | 1 |
Schistosoma mansoni | nephrin | 0.0013 | 0.0293 | 0.0889 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0012 | 0.0281 | 0.0852 |
Onchocerca volvulus | 0.0012 | 0.0281 | 0.0301 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0012 | 0.0281 | 0.0852 |
Onchocerca volvulus | 0.0012 | 0.0281 | 0.0301 | |
Brugia malayi | Protein kinase domain containing protein | 0.0012 | 0.0281 | 0.0179 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0114 | 0.0347 |
Loa Loa (eye worm) | SRC-1 | 0.0012 | 0.0281 | 0.0281 |
Brugia malayi | Protein kinase domain containing protein | 0.0012 | 0.0281 | 0.0179 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Echinococcus multilocularis | protein kinase c iota type | 0.0016 | 0.0519 | 0.1573 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0114 | 0.001 |
Brugia malayi | Hr1 repeat family protein | 0.001 | 0.0114 | 0.001 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0061 | 0.3297 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0012 | 0.0281 | 0.0852 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0012 | 0.0281 | 0.0179 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0012 | 0.0281 | 0.0852 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.001 | 0.0114 | 0.001 |
Schistosoma mansoni | serine/threonine protein kinase | 0.006 | 0.324 | 0.9827 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.001 | 0.0114 | 0.0347 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Loa Loa (eye worm) | TK protein kinase | 0.001 | 0.0104 | 0.0104 |
Brugia malayi | Protein kinase domain containing protein | 0.0012 | 0.0281 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0018 | 0.0603 | 0.0603 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0134 | 0.0407 |
Echinococcus granulosus | defective proboscis extension response | 0.001 | 0.0134 | 0.0407 |
Brugia malayi | SH2 domain containing protein | 0.0012 | 0.0281 | 0.0179 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0012 | 0.0281 | 0.0852 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0012 | 0.0281 | 0.0852 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0061 | 0.3297 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0012 | 0.0281 | 0.0852 |
Brugia malayi | Fibronectin type III domain containing protein | 0.001 | 0.0134 | 0.003 |
Brugia malayi | RhoGAP domain containing protein | 0.0012 | 0.0252 | 0.0149 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0014 | 0.0349 | 0.106 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0012 | 0.0281 | 0.0852 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0012 | 0.0281 | 0.0852 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0012 | 0.0281 | 0.0852 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0134 | 0.0407 |
Echinococcus granulosus | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0012 | 0.0281 | 0.0852 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.001 | 0.0114 | 0.0347 |
Loa Loa (eye worm) | AUR protein kinase | 0.0061 | 0.3297 | 0.3297 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Brugia malayi | SRC-1 | 0.0012 | 0.0281 | 0.0179 |
Trypanosoma brucei | aurora B kinase | 0.0061 | 0.3297 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0114 | 0.0347 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.006 | 0.324 | 0.9827 |
Brugia malayi | protein kinase C II. | 0.0018 | 0.0603 | 0.0504 |
Echinococcus multilocularis | roundabout 2 | 0.0016 | 0.0496 | 0.1504 |
Trichomonas vaginalis | AGC family protein kinase | 0.0061 | 0.3297 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0134 | 0.0407 |
Brugia malayi | Protein kinase domain containing protein | 0.0012 | 0.0281 | 0.0179 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0114 | 0.0134 |
Schistosoma mansoni | serine/threonine protein kinase | 0.006 | 0.324 | 0.9827 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0061 | 0.3297 | 1 |
Schistosoma mansoni | vav2 | 0.0012 | 0.0252 | 0.0763 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0603 | 0.1828 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.001 | 0.0114 | 0.0347 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Schistosoma mansoni | tyrosine kinase | 0.0012 | 0.0281 | 0.0852 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0043 | 0.2149 | 0.6518 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.001 | 0.0104 | 0.0104 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.0349 | 0.106 |
Echinococcus granulosus | NDR protein kinase | 0.001 | 0.0114 | 0.0347 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0159 | 0.9334 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0012 | 0.0281 | 0.0852 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.001 | 0.0114 | 0.0347 |
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0114 | 0.0347 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0012 | 0.0281 | 0.0852 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.001 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | N chimaerin | 0.0012 | 0.0252 | 0.0763 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0013 | 0.0324 | 0.0983 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0043 | 0.2149 | 0.6518 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0043 | 0.2149 | 0.6518 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0012 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0012 | 0.0281 | 0.0281 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0012 | 0.0281 | 0.0852 |
Trichomonas vaginalis | AGC family protein kinase | 0.0061 | 0.3297 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.001 | 0.0114 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0281 | 0.0281 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 26032 after 24 hrs by two fold serial dilution method | ChEMBL. | 23031593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.