Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | isoleucyl-tRNA synthetase | 0.0061 | 0.0829 | 1 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0054 | 0.0703 | 0.8481 |
Schistosoma mansoni | valine-tRNA ligase | 0.0022 | 0.0149 | 0.18 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0061 | 0.0829 | 1 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0047 | 0.0593 | 0.653 |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0054 | 0.0703 | 0.8481 |
Onchocerca volvulus | 0.0022 | 0.0149 | 0.2466 | |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0054 | 0.0703 | 0.8481 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.059 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0047 | 0.0593 | 0.3648 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0061 | 0.0829 | 1 |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0043 | 0.0515 | 0.6205 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0054 | 0.0703 | 0.8147 |
Echinococcus granulosus | valyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Onchocerca volvulus | 0.0048 | 0.0605 | 1 | |
Chlamydia trachomatis | valine--tRNA ligase | 0.0022 | 0.0149 | 0.18 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, mitochondrial | 0.0048 | 0.0605 | 0.7296 |
Chlamydia trachomatis | isoleucine--tRNA ligase | 0.0061 | 0.0829 | 1 |
Mycobacterium ulcerans | valyl-tRNA synthetase | 0.0022 | 0.0149 | 0.0149 |
Mycobacterium tuberculosis | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) | 0.0092 | 0.1367 | 0.1236 |
Echinococcus granulosus | isoleucyl trna synthetase mitochondrial | 0.0048 | 0.0605 | 0.7296 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0113 | 0.174 | 1 |
Chlamydia trachomatis | threonine--tRNA ligase | 0.0054 | 0.0703 | 0.8481 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0092 | 0.1367 | 0.1367 |
Wolbachia endosymbiont of Brugia malayi | isoleucyl-tRNA synthetase | 0.0061 | 0.0829 | 0.5587 |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0047 | 0.0593 | 0.0451 |
Trypanosoma cruzi | valyl-tRNA synthetase, putative | 0.0022 | 0.0149 | 0.18 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Echinococcus granulosus | valyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0092 | 0.1367 | 0.1367 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0061 | 0.0829 | 1 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0054 | 0.0703 | 0.8147 |
Brugia malayi | threonyl-tRNA synthetase, cytoplasmic | 0.0054 | 0.0703 | 0.8147 |
Mycobacterium ulcerans | isoleucyl-tRNA synthetase | 0.0061 | 0.0829 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0605 | 0.7296 |
Trypanosoma cruzi | isoleucyl-tRNA synthetase, putative | 0.0061 | 0.0829 | 1 |
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.0061 | 0.0829 | 1 |
Trypanosoma cruzi | leucyl-tRNA synthetase, putative | 0.0022 | 0.0149 | 0.18 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0047 | 0.0593 | 0.653 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0061 | 0.0829 | 1 |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0047 | 0.0593 | 0.0593 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0061 | 0.0829 | 1 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0054 | 0.0703 | 0.8481 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0061 | 0.0829 | 1 |
Toxoplasma gondii | isoleucyl-tRNA synthetase family protein | 0.0061 | 0.0829 | 0.069 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0054 | 0.0703 | 0.8481 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0022 | 0.0149 | 0.18 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0047 | 0.0593 | 0.7155 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0022 | 0.0149 | 0.18 |
Treponema pallidum | valyl-tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0149 | 0.18 |
Mycobacterium tuberculosis | Possible DNA glycosylase | 0.0092 | 0.1367 | 0.1236 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.059 | 1 | 1 |
Mycobacterium leprae | isoleucyl-tRNA synthetase IleS | 0.0061 | 0.0829 | 0.069 |
Trypanosoma brucei | isoleucyl-tRNA synthetase, putative | 0.0061 | 0.0829 | 1 |
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0047 | 0.0593 | 0.0451 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0061 | 0.0829 | 1 |
Wolbachia endosymbiont of Brugia malayi | formamidopyrimidine-DNA glycosylase | 0.0092 | 0.1367 | 1 |
Echinococcus granulosus | leucyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0061 | 0.0829 | 0.4275 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0829 | 1 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.0061 | 0.0829 | 1 |
Mycobacterium tuberculosis | Isoleucyl-tRNA synthetase IleS | 0.0039 | 0.0456 | 0.0311 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.059 | 1 | 1 |
Echinococcus granulosus | leucyl tRNA synthetase | 0.0022 | 0.0149 | 0.18 |
Mycobacterium leprae | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) | 0.0092 | 0.1367 | 0.1236 |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0047 | 0.0593 | 0.0451 |
Plasmodium falciparum | threonine--tRNA ligase | 0.0047 | 0.0593 | 0.2792 |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0047 | 0.0593 | 0.653 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0047 | 0.0593 | 0.7155 |
Schistosoma mansoni | valine-tRNA ligase | 0.0022 | 0.0149 | 0.18 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.0061 | 0.0829 | 1 |
Plasmodium vivax | isoleucine--tRNA ligase, putative | 0.0061 | 0.0829 | 1 |
Leishmania major | isoleucyl-tRNA synthetase, putative | 0.0061 | 0.0829 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.