Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase | 614 aa | 507 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0223 | 0.4011 | 0.4011 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0223 | 0.4011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | nuclear hormone receptor | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0223 | 0.4011 | 0.7283 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0223 | 0.4011 | 0.4011 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0223 | 0.4011 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0223 | 0.4011 | 0.7283 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0223 | 0.4011 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0223 | 0.4011 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0223 | 0.4011 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0223 | 0.4011 | 0.7283 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0223 | 0.4011 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | nuclear receptor NHR-88 | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | steroid hormone receptor | 0.038 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0223 | 0.4011 | 0.4011 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0223 | 0.4011 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0223 | 0.4011 | 1 |
Onchocerca volvulus | 0.0223 | 0.4011 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0223 | 0.4011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0223 | 0.4011 | 0.4011 |
Schistosoma mansoni | thyroid hormone receptor | 0.0223 | 0.4011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0223 | 0.4011 | 0.4011 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0223 | 0.4011 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0223 | 0.4011 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0223 | 0.4011 | 0.4011 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0223 | 0.4011 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0223 | 0.4011 | 0.7283 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0223 | 0.4011 | 0.4011 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0223 | 0.4011 | 0.7283 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0223 | 0.4011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0223 | 0.4011 | 0.4011 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0223 | 0.4011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0223 | 0.4011 | 0.4011 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0263 | 0.5508 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0223 | 0.4011 | 0.4011 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0223 | 0.4011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0223 | 0.4011 | 0.4011 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0223 | 0.4011 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0223 | 0.4011 | 0.7283 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0223 | 0.4011 | 0.4011 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0223 | 0.4011 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0223 | 0.4011 | 0.4011 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0223 | 0.4011 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0223 | 0.4011 | 0.4011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0223 | 0.4011 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0223 | 0.4011 | 0.7283 |
Schistosoma mansoni | thyroid hormone receptor | 0.0223 | 0.4011 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0223 | 0.4011 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0223 | 0.4011 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | ecdysteroid receptor | 0.0223 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.4011 | 0.4011 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0223 | 0.4011 | 0.4011 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0223 | 0.4011 | 0.7283 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0223 | 0.4011 | 0.7283 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0223 | 0.4011 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0223 | 0.4011 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14.08 uM | Inhibition of Swiss albino mouse RBC AChE after 30 mins by Ellman method | ChEMBL. | 23026084 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.