Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transmembrane protease, serine 6 | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Onchocerca volvulus | 0.0062 | 0.0726 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0726 | 0.0726 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0.0726 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0726 | 0.0904 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0726 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0726 | 0.0726 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0.0726 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0726 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0726 | 0.0904 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0.0726 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0366 | 0.8028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Onchocerca volvulus | 0.0062 | 0.0726 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0062 | 0.0726 | 0.0726 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0366 | 0.8028 | 0.8028 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0062 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0726 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0062 | 0.0726 | 0.5 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0726 | 0.0726 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0726 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.8028 | 1 |
Onchocerca volvulus | 0.0062 | 0.0726 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0366 | 0.8028 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0366 | 0.8028 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0366 | 0.8028 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0726 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.8028 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0366 | 0.8028 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0366 | 0.8028 | 1 |
Onchocerca volvulus | 0.0062 | 0.0726 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0726 | 0.0904 |
Brugia malayi | Carboxylesterase family protein | 0.0366 | 0.8028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Schistosoma mansoni | gliotactin | 0.0062 | 0.0726 | 0.0726 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0062 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Brugia malayi | Carboxylesterase family protein | 0.0366 | 0.8028 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0726 | 0.0904 |
Echinococcus granulosus | acetylcholinesterase | 0.0366 | 0.8028 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0726 | 0.0904 |
Echinococcus granulosus | acetylcholinesterase | 0.0366 | 0.8028 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 8.2 uM | Inhibition of human thrombin using fluorogenic Cbz-Gly-Gly-Arg-NH-Mec as substrate measured over 400 secs by spectrophotometry | ChEMBL. | 23026080 |
Ki (binding) | = 8.9 uM | Inhibition of human matriptase-2 expressed in HEK-MT2 cells using fluorogenic Boc- Gln-Ala-Arg-NH-Mec as substrate measured over 400 secs by spectrophotometry | ChEMBL. | 23026080 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.