TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 551.458 | Formula: C24H27FN3O9P
H donors: 3 H acceptors: 5 LogP: 1.88 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)[C@@H](NP(=O)(Oc1cccc2c1cccc2)OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O)C
InChi: 1S/C24H27FN3O9P/c1-3-34-23(31)14(2)27-38(33,37-19-10-6-8-15-7-4-5-9-16(15)19)35-13-20-18(29)11-21(36-20)28-12-17(25)22(30)26-24(28)32/h4-10,12,14,18,20-21,29H,3,11,13H2,1-2H3,(H,27,33)(H,26,30,32)/t14-,18-,20+,21+,38?/m0/s1
InChiKey: MQBGVILUUXJFCV-BNTXDFHDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.001	0.0102	0.087
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.1422	0.1515
Brugia malayi	Steroid receptor seven-up type 2	0.0036	0.1175	0.1175
Brugia malayi	nuclear hormone receptor	0.0036	0.1175	0.1175
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0036	0.1175	0.1175
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0102	0.0109
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.1658	0.1767
Brugia malayi	G-protein alpha subunit	0.001	0.0102	0.0102
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0388	0.0414
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.1658	0.1658
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0102	0.0102
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0388	0.0414
Brugia malayi	tailless protein	0.0017	0.0388	0.0388
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0036	0.1175	0.1252
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0472	0.0472
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0102	0.0109
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0472	0.0472
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.001	0.0102	0.087
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.1172	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0036	0.1175	0.1252
Schistosoma mansoni	retinoic acid receptor RXR	0.0036	0.1175	0.1252
Loa Loa (eye worm)	hypothetical protein	0.001	0.0102	0.0102
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0036	0.1175	0.1085
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.1658	0.1658
Onchocerca volvulus		0.0017	0.0388	0.0289
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0152	0.5922	0.5922
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0036	0.1175	0.1175
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0036	0.1175	0.1175
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0102	0.0109
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0388	0.0414
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0036	0.1175	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Schistosoma mansoni	nuclear receptor nhr-48	0.0017	0.0388	0.0414
Echinococcus multilocularis	GPCR, family 2	0.0048	0.1658	0.1767
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0237	0.9386	1
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.5167	0.5504
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0237	0.9386	1
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0146	0.0156
Entamoeba histolytica	G protein alpha subunit, putative	0.001	0.0102	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0036	0.1175	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0472	0.0472
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.001	0.0102	0.0102
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0388	0.0289
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0102	0.0109
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0017	0.0388	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Schistosoma mansoni	hypothetical protein	0.0104	0.3948	0.4207
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0017	0.0388	0.0414
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.5167	0.5504
Echinococcus multilocularis	FTZ F1 alpha	0.0036	0.1175	0.1252
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0102	0.0109
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0017	0.0388	0.0388
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0102	0.087
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0036	0.1175	0.1252
Schistosoma mansoni	coup transcription factor	0.0036	0.1175	0.1252
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0102	0.087
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0036	0.1175	0.1175
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0036	0.1175	0.1252
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.1276	0.136
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0017	0.0388	0.0388
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.1175	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.1175	0.1175
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0102	0.087
Brugia malayi	hypothetical protein	0.0019	0.0472	0.0472
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0102	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.1175	0.1175
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0036	0.1175	0.1252
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.001	0.0102	0.0102
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.1175	0.1175
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0237	0.9386	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.1175	0.1252
Schistosoma mansoni	nuclear receptor	0.0017	0.0388	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0017	0.0388	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0036	0.1175	0.1175
Onchocerca volvulus	Protein ultraspiracle homolog	0.0036	0.1175	0.1085
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0036	0.1175	0.1252
Echinococcus granulosus	expressed protein	0.001	0.0102	0.0109
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.1658	0.1767
Loa Loa (eye worm)	hypothetical protein	0.001	0.0102	0.0102
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.001	0.0102	0.0102
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.1658	0.1658
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0237	0.9386	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0036	0.1175	0.1175
Loa Loa (eye worm)	TAR-binding protein	0.0134	0.5167	0.5167
Brugia malayi	photoreceptor-specific nuclear receptor	0.0036	0.1175	0.1175
Brugia malayi	hypothetical protein	0.0019	0.0472	0.0472
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0237	0.9386	0.9386
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0146	0.0156
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.1658	0.1767
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0036	0.1175	0.1252
Loa Loa (eye worm)	hypothetical protein	0.001	0.0102	0.0102
Echinococcus granulosus	tar DNA binding protein	0.0134	0.5167	0.5504
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0102	0.0109
Loa Loa (eye worm)	hypothetical protein	0.001	0.0102	0.0102
Brugia malayi	nuclear receptor RXR	0.0017	0.0388	0.0388
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0102	0.0109
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0036	0.1175	0.1252
Schistosoma mansoni	hypothetical protein	0.0048	0.1658	0.1767
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0146	0.0156
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0472	0.0503
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0017	0.0388	0.0388
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0102	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0152	0.5922	0.5922
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0036	0.1175	0.1252
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0036	0.1175	0.1252
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0102	0.0109
Loa Loa (eye worm)	pax transcription factor protein 2	0.0252	1	1
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0146	0.0156
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.1175	0.1175
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0388	0.0414
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0036	0.1175	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0472	0.0472
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0472	0.0503
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.001	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0146	0.0146
Onchocerca volvulus		0.0252	1	1
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.001	0.0102	0.0102
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0102	0.0109
Echinococcus multilocularis	tar DNA binding protein	0.0134	0.5167	0.5504
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0102	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0036	0.1175	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0472	0.0472
Brugia malayi	latrophilin 2 splice variant baaae	0.0104	0.3948	0.3948
Schistosoma mansoni	nuclear receptor	0.0017	0.0388	0.0414
Brugia malayi	TAR-binding protein	0.0134	0.5167	0.5167
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0102	0.0109
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0102	0.0109
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0036	0.1175	0.1252
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.001	0.0102	0.0102
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0388	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0472	0.0472
Schistosoma mansoni	RAR-like nuclear receptor	0.0036	0.1175	0.1252
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0036	0.1175	0.1175
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.001	0.0102	0.0109
Brugia malayi	nuclear hormone receptor	0.0017	0.0388	0.0388
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0388	0.0414
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.5167	0.5504
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.001	0.0102	0.0102
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.1175	0.1252
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0388	0.0388
Echinococcus granulosus	GPCR family 2	0.0048	0.1658	0.1767
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0388	0.0414
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0388	0.0414
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0388	0.0414
Onchocerca volvulus		0.0017	0.0388	0.0289
Echinococcus multilocularis	ecdysone induced protein 78C	0.0036	0.1175	0.1252
Brugia malayi	nuclear hormone receptor family member odr-7	0.0017	0.0388	0.0388
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.1172	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0017	0.0388	0.0414
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0017	0.0388	0.0388
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0244	0.9676	0.9676
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0472	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0104	0.3948	0.3948
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0036	0.1175	0.1175
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.1658	0.1767
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0102	0.0109
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.001	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.1175	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1066	0.1066
Loa Loa (eye worm)	steroid hormone receptor	0.0036	0.1175	0.1175
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0036	0.1175	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0134	0.5167	0.5167
Brugia malayi	steroid hormone receptor	0.0036	0.1175	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0472	0.0472
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0036	0.1175	0.1252
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.1175	0.1252
Brugia malayi	nuclear receptor NHR-88	0.0036	0.1175	0.1175
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.001	0.0102	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Brugia malayi	hypothetical protein	0.0017	0.0388	0.0388
Brugia malayi	RNA recognition motif domain containing protein	0.0134	0.5167	0.5167
Loa Loa (eye worm)	nuclear hormone receptor	0.0017	0.0388	0.0388
Echinococcus multilocularis	expressed protein	0.001	0.0102	0.0109
Schistosoma mansoni	zinc finger protein	0.0017	0.0388	0.0414
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0036	0.1175	0.1252
Brugia malayi	orphan nuclear receptor NR2E1	0.0017	0.0388	0.0388
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0237	0.9386	0.9386
Loa Loa (eye worm)	RNA binding protein	0.0134	0.5167	0.5167
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0152	0.5922	0.5922
Echinococcus granulosus	thyroid hormone receptor alpha	0.0017	0.0388	0.0414
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0472	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Brugia malayi	hypothetical protein	0.001	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0237	0.9386	1
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0146	0.0156
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.1276	0.136
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.001	0.0102	0.087
Schistosoma mansoni	hypothetical protein	0.0048	0.1658	0.1767
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0472	0.0503
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.1175	0.1175
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.001	0.0102	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1658	0.1658
Brugia malayi	hypothetical protein	0.0017	0.0388	0.0388
Onchocerca volvulus	Bile acid receptor homolog	0.0036	0.1175	0.1085
Onchocerca volvulus		0.0036	0.1175	0.1085
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0102	0.0109
Echinococcus granulosus	nuclear receptor nhr 48	0.0017	0.0388	0.0414
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0017	0.0388	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Brugia malayi	ecdysone receptor	0.0017	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.001	0.0102	0.0102
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.1175	0.1252
Brugia malayi	conserved hypotetical protein	0.0017	0.0388	0.0388
Brugia malayi	RNA binding protein	0.0134	0.5167	0.5167
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.1175	0.1175
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.1276	0.1276
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0102	0.0109
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.1175	0.1175
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0102	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0036	0.1175	0.1175
Echinococcus granulosus	ecdysone induced protein 78C	0.0036	0.1175	0.1252
Schistosoma mansoni	hypothetical protein	0.0048	0.1658	0.1767
Brugia malayi	follicle stimulating hormone receptor	0.0244	0.9676	0.9676
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0102	0.0102
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.1175	0.1252
Loa Loa (eye worm)	G protein alpha subunit 3	0.001	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1175	0.1175
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.001	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0036	0.1175	0.1252
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0102	0.0109
Brugia malayi	nuclear receptor NHR-67	0.0017	0.0388	0.0388
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0237	0.9386	1
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.1175	0.1252
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0388	0.0388
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.5167	0.5504
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.1276	0.1276
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.001	0.0102	0.0102
Schistosoma mansoni	hypothetical protein	0.0048	0.1658	0.1767
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0036	0.1175	0.1175
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0102	0.0102
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.001	0.0102	0.087
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.001	0.0102	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0036	0.1175	0.1175
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0152	0.5922	0.5922
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0388	0.0388
Brugia malayi	nuclear receptor RXR	0.0019	0.0472	0.0472
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.001	0.0102	0.087
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0017	0.0388	0.0414
Brugia malayi	ecdysteroid receptor	0.0036	0.1175	0.1175
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0036	0.1175	0.1175
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0237	0.9386	1
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.5167	0.5504
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0146	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0388
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.1422	0.1515
Loa Loa (eye worm)	DR-78	0.0017	0.0388	0.0388

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.095 uM	Cytostatic activity against Mycoplasma hyorhinis-infected mouse L1210 cells after 48 hrs by cell counting	ChEMBL.	21892829
IC50 (functional)	= 2.8 uM	Cytostatic activity against thymidine-kinase deficient human HeLa cells after 72 hrs by cell counting	ChEMBL.	21892829

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	21892829
Homo sapiens	ChEMBL23	21892829

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2181566

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1720061