Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0072 | 0.0072 |
Schistosoma mansoni | intermediate filament proteins | 0.0111 | 0.0732 | 0.0926 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0276 | 0.0349 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | tumor protein p63 | 0.1067 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0276 | 0.0349 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0072 | 0.0092 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.0154 | 0.0194 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | lamin dm0 | 0.0111 | 0.0732 | 0.0732 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0001 | 0.0001 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0103 | 0.066 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0276 | 0.0349 |
Trypanosoma brucei | RNA helicase, putative | 0.0136 | 0.0981 | 0.124 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.071 | 0.6546 | 0.6546 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.3217 | 0.4069 |
Schistosoma mansoni | lamin | 0.0111 | 0.0732 | 0.0926 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0851 | 0.7906 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.0154 | 0.0194 |
Echinococcus multilocularis | lamin | 0.0111 | 0.0732 | 0.0732 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0059 | 0.0234 | 0.0296 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0851 | 0.7906 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0001 | 0.0001 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0154 | 0.0194 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0795 | 0.7362 | 0.7362 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0851 | 0.7906 | 1 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0103 | 0.066 | 0.0835 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0154 | 0.0194 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0276 | 0.0276 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0103 | 0.066 | 1 |
Onchocerca volvulus | 0.0047 | 0.0117 | 0.0992 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0157 | 0.0199 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0103 | 0.066 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0103 | 0.066 | 0.066 |
Onchocerca volvulus | 0.0111 | 0.0732 | 0.6241 | |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0851 | 0.7906 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0851 | 0.7906 | 1 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0103 | 0.066 | 0.0835 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0001 | 0.0001 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0103 | 0.066 | 0.0835 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0737 | 0.0933 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0154 | 0.0195 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0103 | 0.066 | 0.0835 |
Brugia malayi | hypothetical protein | 0.0232 | 0.1905 | 0.241 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0072 | 0.0092 |
Echinococcus granulosus | lamin dm0 | 0.0111 | 0.0732 | 0.0732 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0117 | 0.0148 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0851 | 0.7906 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0396 | 0.0501 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0111 | 0.0732 | 0.0926 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0117 | 0.0148 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0851 | 0.7906 | 0.7906 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1905 | 0.241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0001 | 0.0001 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0103 | 0.066 | 0.0835 |
Onchocerca volvulus | 0.0156 | 0.1172 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0712 | 0.0901 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0276 | 0.0349 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0276 | 0.0349 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.0981 | 0.124 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0072 | 0.0072 |
Echinococcus granulosus | lamin | 0.0111 | 0.0732 | 0.0732 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.0154 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0157 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0732 | 0.0926 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0276 | 0.0349 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.1844 | 0.2332 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0072 | 0.0092 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0851 | 0.7906 | 1 |
Brugia malayi | intermediate filament protein | 0.0111 | 0.0732 | 0.0926 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0103 | 0.066 | 0.066 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0396 | 0.0501 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0053 | 0.0177 | 0.0177 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0103 | 0.066 | 0.066 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.0154 | 0.0194 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.3217 | 0.4069 |
Schistosoma mansoni | lamin | 0.0111 | 0.0732 | 0.0926 |
Echinococcus granulosus | intermediate filament protein | 0.0111 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0276 | 0.0349 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0001 | 0.0001 |
Brugia malayi | isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0103 | 0.066 | 0.0835 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0001 |
Echinococcus granulosus | geminin | 0.0367 | 0.3217 | 0.3217 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.1905 | 0.1905 |
Echinococcus granulosus | microtubule associated protein 2 | 0.071 | 0.6546 | 0.6546 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0103 | 0.066 | 0.0834 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.1905 | 0.1905 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0103 | 0.066 | 0.0835 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1172 | 0.1483 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0103 | 0.066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.066 | 0.0835 |
Brugia malayi | Isocitrate dehydrogenase | 0.0851 | 0.7906 | 1 |
Onchocerca volvulus | 0.0111 | 0.0732 | 0.6241 | |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0103 | 0.066 | 0.0835 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.0737 | 0.0933 |
Echinococcus multilocularis | musashi | 0.0111 | 0.0732 | 0.0732 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0103 | 0.066 | 0.066 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0156 | 0.1172 | 0.1483 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0851 | 0.7906 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0001 | 0.0001 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0053 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.0103 | 0.066 | 0.0834 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.0737 | 0.0933 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0059 | 0.0234 | 0.0296 |
Schistosoma mansoni | microtubule-associated protein tau | 0.071 | 0.6546 | 0.8279 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0177 | 0.0224 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0154 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | geminin | 0.0367 | 0.3217 | 0.3217 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0103 | 0.066 | 0.0835 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0103 | 0.066 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0001 | 0.0001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.0396 | 0.0501 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | intermediate filament protein | 0.0111 | 0.0732 | 0.0926 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0111 | 0.0732 | 0.0926 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0851 | 0.7906 | 0.7906 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0117 | 0.0148 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.0737 | 0.0933 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log RA (functional) | = 1.1 | Antimalarial activity of the compound was determined against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W-2 clone | ChEMBL. | 11784134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.