Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0219 | 0.4316 | 0.4316 |
Echinococcus multilocularis | Protein lozenge | 0.0058 | 0.0622 | 0.2042 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.3049 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3049 | 0.3049 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3049 | 0.3049 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.3049 | 0.3049 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3049 | 1 |
Loa Loa (eye worm) | runx1 | 0.0058 | 0.0622 | 0.0622 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3049 | 0.3049 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3049 | 1 |
Onchocerca volvulus | 0.0465 | 1 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3049 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0219 | 0.4316 | 0.4316 |
Trichomonas vaginalis | set domain proteins, putative | 0.0249 | 0.5012 | 0.5 |
Onchocerca volvulus | 0.0249 | 0.5012 | 0.5012 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.3049 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.3049 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | lozenge | 0.0058 | 0.0622 | 0.2042 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.3049 | 0.3049 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3049 | 0.3049 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3049 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.8 | Inhibition of electric eel AChE using acetylthiocholine chloride substrate incubated for 5 mins before substrate addition measured at 3 min interval by Ellman method | ChEMBL. | 23000296 |
IC50 (binding) | = 7.83 | Inhibition of equine serum BuChE using butyrylthiocholine chloride substrate incubated for 5 mins before substrate addition measured at 3 min interval by Ellman method | ChEMBL. | 23000296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.