TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 455.555 | Formula: C26H29N7O
H donors: 2 H acceptors: 3 LogP: 4.72 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O1CCN(CC1)c1ccc(cc1)Nc1ncc2c(n1)n(C1CCCC1)c(n2)Nc1ccccc1
InChi: 1S/C26H29N7O/c1-2-6-19(7-3-1)29-26-30-23-18-27-25(31-24(23)33(26)22-8-4-5-9-22)28-20-10-12-21(13-11-20)32-14-16-34-17-15-32/h1-3,6-7,10-13,18,22H,4-5,8-9,14-17H2,(H,29,30)(H,27,28,31)
InChiKey: RRAOKNRZBNRGBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Plasmodium falciparum	ataxin-2 like protein, putative	0.018	0.0959	1
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0065	0.0188	0.0188
Onchocerca volvulus		0.005	0.0086	0.0886
Trichomonas vaginalis	ubiquitin specific protease, putative	0.005	0.0086	0.0879
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0199	0.1084	0.1084
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.005	0.0086	0.0086
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 36	0.005	0.0086	0.0086
Giardia lamblia	Kinase, PLK	0.0093	0.0376	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.005	0.0086	0.0086
Schistosoma mansoni	Smad4	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0065	0.0188	0.0188
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	Ubiquitin carboxyl terminal hydrolase 48	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	tar DNA-binding protein	0.074	0.4725	0.4725
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0065	0.0188	0.0188
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0065	0.0188	0.0188
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0065	0.0188	0.0188
Brugia malayi	N-terminal motif family protein	0.0182	0.0973	0.0973
Brugia malayi	RNA recognition motif domain containing protein	0.074	0.4725	0.4725
Schistosoma mansoni	ubiquitin-specific peptidase 22 (C19 family)	0.005	0.0086	0.0086
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase	0.005	0.0086	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1524	1	1
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Entamoeba histolytica	G protein alpha subunit, putative	0.0065	0.0188	0.3506
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Onchocerca volvulus		0.0065	0.0188	0.1929
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 24	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0065	0.0188	0.4077
Brugia malayi	ubiquitin carboxyl-terminal hydrolase 46	0.005	0.0086	0.0086
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase	0.005	0.0086	0.0086
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0065	0.0188	0.0188
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0065	0.0188	0.0188
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.005	0.0086	0.0879
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 24	0.005	0.0086	0.0086
Brugia malayi	Smad1	0.0084	0.0313	0.0313
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1524	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.0376	0.0376
Brugia malayi	ubiquitin specific protease 14	0.005	0.0086	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.074	0.4725	0.4725
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Echinococcus multilocularis	smad	0.0084	0.0313	0.0313
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.005	0.0086	0.0879
Brugia malayi	MH2 domain containing protein	0.1234	0.8047	0.8047
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0199	0.1084	0.1084
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0064	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Loa Loa (eye worm)	RNA binding protein	0.074	0.4725	0.4725
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.005	0.0086	0.0086
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0065	0.0188	0.0188
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0065	0.0188	0.4077
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0065	0.0188	0.4077
Schistosoma mansoni	ubiquitin-specific peptidase 42 (C19 family)	0.005	0.0086	0.0086
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0973	0.0973
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0065	0.0188	0.0188
Brugia malayi	G-protein alpha subunit	0.0065	0.0188	0.0188
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.005	0.0086	0.0086
Echinococcus multilocularis	expressed protein	0.0065	0.0188	0.0188
Brugia malayi	MH2 domain containing protein	0.0084	0.0313	0.0313
Schistosoma mansoni	smad1 5 8 and	0.0084	0.0313	0.0313
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 47	0.005	0.0086	0.0086
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0376	1
Brugia malayi	hypothetical protein	0.005	0.0086	0.0086
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	family C19 unassigned peptidase (C19 family)	0.005	0.0086	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0065	0.0188	0.0188
Plasmodium vivax	ataxin-2 like protein, putative	0.018	0.0959	1
Loa Loa (eye worm)	hypothetical protein	0.018	0.0959	0.0959
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	hypothetical protein	0.0047	0.0064	0.0064
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0065	0.0188	0.4077
Echinococcus multilocularis	expressed protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0084	0.0313	0.0313
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0065	0.0188	0.0188
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1524	1	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	ubiquitin-specific peptidase 24 (C19 family)	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0065	0.0188	0.0188
Echinococcus granulosus	ubiquitin specific peptidase c family	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1524	1	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 47	0.005	0.0086	0.0086
Schistosoma mansoni	hypothetical protein	0.0081	0.0291	0.0291
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.005	0.0086	0.0086
Schistosoma mansoni	hypothetical protein	0.0047	0.0064	0.0064
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0064	0.0064
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 5	0.005	0.0086	0.0086
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0065	0.0188	0.0188
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0376	0.3315
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0149	0.0748	0.0748
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	Smad1	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.005	0.0086	0.0086
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.0376	0.0376
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	calpain-7 (C02 family)	0.005	0.0086	0.0086
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0182	0.0973	1
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0376	1
Schistosoma mansoni	hypothetical protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Onchocerca volvulus		0.0065	0.0188	0.1929
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	MH1 domain containing protein	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.005	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0046	0.006	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0064	0.0064
Echinococcus granulosus	expressed protein	0.0065	0.0188	0.0188
Echinococcus granulosus	mothers against decapentaplegic 5	0.0084	0.0313	0.0313
Schistosoma mansoni	ubiquitin-specific peptidase 46 (C19 family)	0.005	0.0086	0.0086
Schistosoma mansoni	ubiquitin-specific peptidase 14 (C19 family)	0.005	0.0086	0.0086
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase 46	0.005	0.0086	0.0086
Trypanosoma cruzi	PAB1-binding protein , putative	0.018	0.0959	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0065	0.0188	0.0188
Plasmodium falciparum	ataxin-2 like protein, putative	0.018	0.0959	1
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0065	0.0188	0.0188
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.0376	0.0376
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 23	0.005	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Schistosoma mansoni	ubiquitin-specific peptidase 10 (C19 family)	0.005	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1524	1	1
Echinococcus granulosus	tar DNA binding protein	0.074	0.4725	0.4725
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.005	0.0086	0.0086
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0376	1
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.005	0.0086	0.0086
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0081	0.0291	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Echinococcus multilocularis	Ubiquitin carboxyl terminal hydrolase 48	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	tar DNA-binding protein	0.074	0.4725	0.4725
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0065	0.0188	0.0188
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0065	0.0188	0.0188
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.0431	0.0431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 12	0.005	0.0086	0.0086
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.005	0.0086	0.0086
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.0376	0.0376
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.03	0.1768	0.1768
Schistosoma mansoni	ubiquitin-specific peptidase 16 (C19 family)	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	MH2 domain-containing protein	0.1234	0.8047	0.8047
Schistosoma mansoni	smad1 5 8 and	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0376	1
Echinococcus multilocularis	ubiquitin specific peptidase 42 (C19 family)	0.005	0.0086	0.0086
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0084	0.0313	0.0313
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0065	0.0188	0.4077
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 20	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	smad	0.0084	0.0313	0.0313
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Echinococcus multilocularis	Smad4	0.0084	0.0313	0.0313
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 20	0.005	0.0086	0.0086
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.0376	0.386
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0065	0.0188	0.0188
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0065	0.0188	0.0188
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0065	0.0188	0.4077
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 16	0.005	0.0086	0.0086
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Schistosoma mansoni	ubiquitin-specific peptidase 4 (C19 family)	0.005	0.0086	0.0086
Echinococcus multilocularis	ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase	0.005	0.0086	0.0086
Trypanosoma cruzi	PAB1-binding protein , putative	0.018	0.0959	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.005	0.0086	0.0879
Leishmania major	hypothetical protein, conserved	0.018	0.0959	1
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0065	0.0188	0.0188
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0064	0.0064
Schistosoma mansoni	ubiquitin-specific peptidase 7 (C19 family)	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	G protein alpha subunit 3	0.0065	0.0188	0.0188
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 4	0.005	0.0086	0.0086
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.0376	1
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	smad	0.0084	0.0313	0.0313
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0376	0.3315
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Schistosoma mansoni	peptidase	0.0051	0.0088	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Schistosoma mansoni	ubiquitin-specific peptidase 48 (C19 family)	0.005	0.0086	0.0086
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0065	0.0188	0.0188
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 16	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	hypothetical protein	0.03	0.1768	0.1768
Toxoplasma gondii	LsmAD domain-containing protein	0.018	0.0959	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 14	0.005	0.0086	0.0086
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 36	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 7	0.005	0.0086	0.0086
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0065	0.0188	0.0188
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0065	0.0188	0.0188
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 7	0.005	0.0086	0.0086
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0376	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 14	0.005	0.0086	0.0086
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0149	0.0748	0.0748
Onchocerca volvulus		0.005	0.0086	0.0886
Brugia malayi	TAR-binding protein	0.074	0.4725	0.4725
Loa Loa (eye worm)	TAR-binding protein	0.074	0.4725	0.4725
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1524	1	1
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.005	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	MH1 domain containing protein	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0376	1
Schistosoma mansoni	kinase	0.0047	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	RNA binding protein	0.074	0.4725	0.4725
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	hypothetical protein	0.018	0.0959	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0431	0.0431
Loa Loa (eye worm)	transcription factor SMAD2	0.1234	0.8047	0.8047
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 4	0.005	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold	0.005	0.0086	0.0086
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.005	0.0086	0.0086
Echinococcus granulosus	Smad4	0.0084	0.0313	0.0313
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0065	0.0188	0.4077
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	hypothetical protein	0.0116	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0065	0.0188	0.0188
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0064	0.0064
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Onchocerca volvulus		0.005	0.0086	0.0886
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.005	0.0086	0.0086
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1524	1	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0188	0.0188
Schistosoma mansoni	ubiquitin-specific peptidase 30 (C19 family)	0.005	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	MH1 domain containing protein	0.0046	0.006	0.006
Echinococcus granulosus	5'partial\|Ubiquitin carboxyl terminal hydrolase 48	0.005	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Loa Loa (eye worm)	MH2 domain-containing protein	0.0084	0.0313	0.0313
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0065	0.0188	0.4077
Brugia malayi	MH1 domain containing protein	0.0046	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Onchocerca volvulus		0.0065	0.0188	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0188	0.0188
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.005	0.0086	0.0086
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.005	0.0086	0.0086
Brugia malayi	hypothetical protein	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0065	0.0188	0.0188
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.005	0.0086	0.0086
Trypanosoma brucei	polo-like protein kinase	0.0093	0.0376	0.3315
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	hypothetical protein	0.0047	0.0064	0.0064
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.0376	0.0376
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0064	0.0064
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0065	0.0188	0.0188
Echinococcus granulosus	ubiquitin specific protease 41	0.005	0.0086	0.0086
Brugia malayi	MH2 domain containing protein	0.0084	0.0313	0.0313
Echinococcus multilocularis	ubiquitin specific protease 41	0.005	0.0086	0.0086
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0081	0.0291	0.0291
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.0376	0.3315
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.1524	1	1
Loa Loa (eye worm)	nuclear factor I	0.0046	0.006	0.006
Echinococcus granulosus	GPCR family 2	0.0047	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Loa Loa (eye worm)	MH1 domain-containing protein	0.0084	0.0313	0.0313
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Schistosoma mansoni	tar DNA-binding protein	0.074	0.4725	0.4725
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0376	1
Schistosoma mansoni	hypothetical protein	0.0102	0.0431	0.0431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0086
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.005	0.0086	0.0086
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.005	0.0086	0.0086
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 12	0.005	0.0086	0.0086
Schistosoma mansoni	ubiquitin-specific peptidase 45 (C19 family)	0.005	0.0086	0.0086
Trichomonas vaginalis	ubiquitin specific protease, putative	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Echinococcus multilocularis	tar DNA binding protein	0.074	0.4725	0.4725
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.005	0.0086	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0086	0.0879
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.005	0.0086	0.0086
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.005	0.0086	0.0086
Trypanosoma brucei	PAB1-binding protein , putative	0.018	0.0959	1
Schistosoma mansoni	calpain-7 (C02 family)	0.005	0.0086	0.0086
Schistosoma mansoni	smad1 5 8 and	0.0084	0.0313	0.0313
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0065	0.0188	0.0188
Schistosoma mansoni	hypothetical protein	0.0047	0.0064	0.0064
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.074	0.4725	0.4725
Trichomonas vaginalis	ubiquitin specific protease, putative	0.005	0.0086	0.0879
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0065	0.0188	0.0188
Echinococcus granulosus	ubiquitin specific peptidase 30 (C19 family)	0.005	0.0086	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.074	0.4725	0.4725
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0065	0.0188	0.0188

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 5 uM	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	ChEMBL.	23116168

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23116168

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2178356

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1720737