Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 119 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | G protein-coupled receptor 119 | 335 aa | 274 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.6517 | 0.6517 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.6517 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.1124 | 0.1124 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.6517 | 0.6517 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.6517 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1678 | 0.2574 |
Echinococcus multilocularis | musashi | 0.0028 | 0.6517 | 0.6517 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.6517 | 0.6517 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0933 | 0.1432 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.6517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0933 | 0.1432 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.6517 | 0.6517 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.6517 | 0.6517 |
Echinococcus granulosus | lamin | 0.0028 | 0.6517 | 0.6517 |
Onchocerca volvulus | 0.0028 | 0.6517 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.6327 | 0.9707 |
Echinococcus multilocularis | lamin | 0.0028 | 0.6517 | 0.6517 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.6517 | 0.6517 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1124 | 0.1725 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.1124 | 0.1124 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.6517 | 0.6517 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.6517 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.6517 | 0.6517 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 5 | Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay | ChEMBL. | 23214471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.