TDR Targets

Basic information

Technical information

TDR Targets ID: 1721595
Name: (8R)-spiro[1-azabicyclo[2.2.2]octane-8,2'-3H- furo[5,4-b]pyridine]
MW: 216.279 | Formula: C13H16N2O
H donors: 0 H acceptors: 1 LogP: 1.63 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: c1cnc2c(c1)C[C@]1(O2)CN2CCC1CC2
InChi: 1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1
InChiKey: OCKIPDMKGPYYJS-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R)-spiro[3H-furo[5,4-b]pyridine-2,3'-quinuclidine]
AR-R23465XX

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, nicotinic, alpha 4 (neuronal)	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, nicotinic, beta 2 (neuronal)		References
Homo sapiens	cholinergic receptor, nicotinic, alpha 7 (neuronal)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Onchocerca volvulus	Putative nachr subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128160	All targets in OG5_128160
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	Get druggable targets OG5_130932	All targets in OG5_130932
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Brugia malayi	Cation transporter family protein	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Schistosoma japonicum	IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing	Get druggable targets OG5_130932	All targets in OG5_130932
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cation transporter family protein	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	484 aa	469 aa	28.6 %
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	cholinergic receptor, nicotinic, alpha 7 (neuronal)	502 aa	513 aa	33.9 %
Brugia malayi	Cation transporter family protein	cholinergic receptor, nicotinic, beta 2 (neuronal)	502 aa	482 aa	32.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0032	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0283	0.1118	0.1118
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.006	0.0184	0.0184
Onchocerca volvulus	Bile acid receptor homolog	0.2406	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0146	0.0542	0.07
Loa Loa (eye worm)	hypothetical protein	0.015	0.0558	0.0558
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0146	0.0542	0.07
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.006	0.0184	0.0184
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0134	0.0491	0.069
Brugia malayi	excitatory GABA receptor EXP-1A	0.006	0.0184	0.0184
Schistosoma mansoni	nAChR subunit	0.006	0.0184	0.0238
Loa Loa (eye worm)	nuclear hormone receptor	0.0134	0.0491	0.0491
Loa Loa (eye worm)	ACC-1 protein	0.006	0.0184	0.0184
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.006	0.0184	0.0184
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.006	0.0184	0.0259
Brugia malayi	ecdysone receptor	0.0134	0.0491	0.0491
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0283	0.1118	0.1571
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0283	0.1118	0.1118
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.006	0.0184	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0283	0.1118	0.1118
Brugia malayi	nuclear receptor RXR	0.015	0.0558	0.0558
Schistosoma mansoni	RAR-like nuclear receptor	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1118	0.1118
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0032	0.0068	0.0088
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0146	0.0542	0.0761
Onchocerca volvulus	Protein ultraspiracle homolog	0.0283	0.1118	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Onchocerca volvulus	Putative nachr subunit	0.0146	0.0542	0.0496
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1866	0.7743	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0134	0.0491	0.0635
Echinococcus multilocularis	nAChR subunit	0.006	0.0184	0.0259
Brugia malayi	hypothetical protein	0.015	0.0558	0.0558
Onchocerca volvulus		0.0134	0.0491	0.0445
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.006	0.0184	0.0238
Echinococcus granulosus	nAChR subunit	0.0032	0.0068	0.0088
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Brugia malayi	orphan nuclear receptor NR2E1	0.0134	0.0491	0.0491
Brugia malayi	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0147	0.0147
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0184	0.0184
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0028	0.0048	0.0048
Schistosoma mansoni	coup transcription factor	0.0283	0.1118	0.1443
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0146	0.0542	0.0542
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0134	0.0491	0.0491
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.006	0.0184	0.0259
Echinococcus granulosus	nuclear receptor nhr 48	0.0134	0.0491	0.0635
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1717	0.7116	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0032	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Brugia malayi	Nuclear hormone receptor-like 1	0.015	0.0558	0.0558
Brugia malayi	hypothetical protein	0.0028	0.0048	0.0048
Echinococcus granulosus	glycine receptor subunit alpha 1	0.006	0.0184	0.0238
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0134	0.0491	0.0635
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0146	0.0542	0.0542
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0283	0.1118	0.1118
Echinococcus multilocularis	glycine receptor subunit beta	0.006	0.0184	0.0259
Onchocerca volvulus		0.0283	0.1118	0.1075
Brugia malayi	Cation transporter family protein	0.006	0.0184	0.0184
Onchocerca volvulus		0.005	0.014	0.0092
Schistosoma mansoni	nAChR subunit	0.006	0.0184	0.0238
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.006	0.0184	0.0238
Schistosoma mansoni	neurotransmitter gated ion channel	0.0028	0.0048	0.0062
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0283	0.1118	0.1443
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.006	0.0184	0.0259
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0028	0.0048	0.0048
Brugia malayi	conserved hypotetical protein	0.0134	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0283	0.1118	0.1118
Brugia malayi	Nuclear hormone receptor E75	0.0134	0.0491	0.0491
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0134	0.0491	0.0635
Onchocerca volvulus		0.0146	0.0542	0.0496
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0283	0.1118	0.1571
Loa Loa (eye worm)	DR-78	0.0134	0.0491	0.0491
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0283	0.1118	0.1118
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0134	0.0491	0.069
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0425	0.0425
Schistosoma mansoni	thyroid hormone receptor	0.0283	0.1118	0.1443
Schistosoma mansoni	survival motor neuron protein	0.005	0.014	0.0181
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.014	0.014
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0283	0.1118	0.1443
Schistosoma mansoni	hypothetical protein	0.0175	0.0662	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Onchocerca volvulus		0.0146	0.0542	0.0496
Brugia malayi	steroid hormone receptor	0.0283	0.1118	0.1118
Schistosoma mansoni	zinc finger protein	0.0134	0.0491	0.0635
Schistosoma mansoni	nuclear receptor	0.0134	0.0491	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0134	0.0491	0.0445
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0184	0.0184
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0146	0.0542	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Brugia malayi	Cation transporter family protein	0.0146	0.0542	0.0542
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.006	0.0184	0.0238
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.015	0.0558	0.0558
Loa Loa (eye worm)	LGC-31 protein	0.006	0.0184	0.0184
Brugia malayi	nuclear receptor NHR-88	0.0134	0.0491	0.0491
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.006	0.0184	0.0238
Echinococcus granulosus	glycine receptor subunit beta	0.006	0.0184	0.0238
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.015	0.0558	0.0721
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Schistosoma mansoni	neurotransmitter gated ion channel	0.0028	0.0048	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Schistosoma mansoni	nAChR subunit	0.006	0.0184	0.0238
Echinococcus multilocularis	nAChR subunit	0.0032	0.0068	0.0095
Onchocerca volvulus		0.0146	0.0542	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Loa Loa (eye worm)	steroid hormone receptor	0.0283	0.1118	0.1118
Echinococcus granulosus	ecdysone induced protein 78C	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Brugia malayi	hypothetical protein	0.015	0.0558	0.0558
Brugia malayi	photoreceptor-specific nuclear receptor	0.0283	0.1118	0.1118
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0283	0.1118	0.1118
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0028	0.0048	0.0062
Echinococcus multilocularis	ecdysone induced protein 78C	0.0283	0.1118	0.1571
Schistosoma mansoni	nuclear receptor	0.0134	0.0491	0.0635
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0283	0.1118	0.1443
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0283	0.1118	0.1118
Brugia malayi	tailless protein	0.0134	0.0491	0.0491
Onchocerca volvulus		0.006	0.0184	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Brugia malayi	Cation transporter family protein	0.006	0.0184	0.0184
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0283	0.1118	0.1571
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0032	0.0068	0.0068
Schistosoma mansoni	nuclear hormone receptor	0.0134	0.0491	0.0635
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0283	0.1118	0.1571
Schistosoma mansoni	nAChR subunit	0.006	0.0184	0.0238
Onchocerca volvulus		0.006	0.0184	0.0136
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0134	0.0491	0.0635
Schistosoma mansoni	nAChR subunit	0.006	0.0184	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0244	0.0951	0.0951
Brugia malayi	nuclear hormone receptor	0.0134	0.0491	0.0491
Schistosoma mansoni	retinoic acid receptor RXR	0.1866	0.7743	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0028	0.0048	0.0048
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0134	0.0491	0.069
Brugia malayi	hypothetical protein	0.0028	0.0048	0.0048
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0283	0.1118	0.1443
Brugia malayi	Nuclear hormone receptor E75	0.0134	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.015	0.0558	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0283	0.1118	0.1118
Onchocerca volvulus		0.006	0.0184	0.0136
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0147	0.0147
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0184	0.0184
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0134	0.0491	0.0635
Echinococcus granulosus	nAChR subunit	0.006	0.0184	0.0238
Brugia malayi	Nuclear hormone receptor-like 1	0.0283	0.1118	0.1118
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0028	0.0048	0.0068
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0146	0.0542	0.07
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0028	0.0048	0.0068
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.006	0.0184	0.0238
Echinococcus granulosus	glycine receptor subunit alpha 1	0.006	0.0184	0.0238
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0283	0.1118	0.1075
Schistosoma mansoni	thyroid hormone receptor	0.0283	0.1118	0.1443
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0028	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1118	0.1118
Brugia malayi	hypothetical protein	0.0134	0.0491	0.0491
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.006	0.0184	0.0184
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.006	0.0184	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0146	0.0542	0.0761
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0184	0.0184
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0134	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.015	0.0558	0.0558
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0283	0.1118	0.1443
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0028	0.0048	0.0068
Loa Loa (eye worm)	acetylcholine receptor protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0283	0.1118	0.1118
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0184	0.0184
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0134	0.0491	0.069
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0028	0.0048	0.0062
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.006	0.0184	0.0259
Echinococcus multilocularis	nuclear receptor nhr 48	0.0134	0.0491	0.069
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Brugia malayi	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	GABA receptor subunit	0.0032	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.2406	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0079	0.0079
Onchocerca volvulus		0.0134	0.0491	0.0445
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.006	0.0184	0.0238
Brugia malayi	nuclear receptor NHR-88	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Schistosoma mansoni	nAChR subunit	0.006	0.0184	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Schistosoma mansoni	acetylcholine receptor-related	0.0028	0.0048	0.0062
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0134	0.0491	0.0491
Schistosoma mansoni	nuclear receptor nhr-48	0.0134	0.0491	0.0635
Schistosoma mansoni	hypothetical protein	0.0175	0.0662	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Echinococcus granulosus	FTZ F1 alpha	0.0283	0.1118	0.1443
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0283	0.1118	0.1118
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0048	0.0048
Schistosoma mansoni	nAChR subunit	0.006	0.0184	0.0238
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0028	0.0048	0.0048
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.006	0.0184	0.0238
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0028	0.0048	0.0062
Schistosoma mansoni	hypothetical protein	0.0035	0.0079	0.0102
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.006	0.0184	0.0184
Schistosoma mansoni	nAChR subunit	0.0028	0.0048	0.0062
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.006	0.0184	0.0184
Echinococcus granulosus	glycine receptor subunit beta	0.006	0.0184	0.0238
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0134	0.0491	0.0445
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0134	0.0491	0.0635
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0283	0.1118	0.1443
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0283	0.1118	0.1118
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0283	0.1118	0.1571
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0542	0.0542
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0283	0.1118	0.1118
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Echinococcus granulosus	geminin	0.0175	0.0662	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.015	0.0558	0.0721
Echinococcus multilocularis	geminin	0.0175	0.0662	0.0931
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0032	0.0068	0.0088
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.006	0.0184	0.0184
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.015	0.0558	0.0785
Schistosoma mansoni	nuclear hormone receptor	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0283	0.1118	0.1443
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0283	0.1118	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0542	0.0542
Brugia malayi	nuclear hormone receptor	0.0283	0.1118	0.1118
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.015	0.0558	0.0558
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.006	0.0184	0.0238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1118	0.1118
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0134	0.0491	0.0491
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.015	0.0558	0.0721
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.006	0.0184	0.0184
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0079	0.0079
Echinococcus multilocularis	glycine receptor subunit beta	0.006	0.0184	0.0259
Onchocerca volvulus		0.0032	0.0068	0.002
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0283	0.1118	0.1443
Schistosoma mansoni	nuclear hormone receptor	0.0134	0.0491	0.0635
Echinococcus granulosus	glycine receptor subunit alpha 1	0.006	0.0184	0.0238
Schistosoma mansoni	hypothetical protein	0.005	0.014	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Onchocerca volvulus		0.0032	0.0068	0.002
Schistosoma mansoni	neurotransmitter gated ion channel	0.0032	0.0068	0.0088
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0048	0.0048
Brugia malayi	nuclear receptor NHR-67	0.0134	0.0491	0.0491
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0134	0.0491	0.0635
Entamoeba histolytica	hypothetical protein	0.0032	0.0068	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0283	0.1118	0.1118
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0283	0.1118	0.1571
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0283	0.1118	0.1118
Brugia malayi	Steroid receptor seven-up type 2	0.0283	0.1118	0.1118
Brugia malayi	nuclear receptor RXR	0.0134	0.0491	0.0491
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.015	0.0558	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor-like 1	0.015	0.0558	0.0558
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0491	0.0491
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.006	0.0184	0.0238
Echinococcus multilocularis	FTZ F1 alpha	0.0283	0.1118	0.1571
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0068	0.0068
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0146	0.0542	0.07
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0032	0.0068	0.0068
Loa Loa (eye worm)	ACC-1 protein	0.006	0.0184	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0146	0.0542	0.07
Brugia malayi	hypothetical protein	0.0134	0.0491	0.0491
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0283	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.006	0.0184	0.0184
Schistosoma mansoni	nAChR subunit	0.0028	0.0048	0.0062
Brugia malayi	nuclear hormone receptor family member odr-7	0.0134	0.0491	0.0491
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.006	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1118	0.1118
Brugia malayi	hypothetical protein	0.0244	0.0951	0.0951
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0283	0.1118	0.1118
Echinococcus multilocularis	survival motor neuron protein 1	0.0244	0.0951	0.1337
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0283	0.1118	0.1443
Loa Loa (eye worm)	hypothetical protein	0.006	0.0184	0.0184
Echinococcus granulosus	survival motor neuron protein 1	0.0244	0.0951	0.1229
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.006	0.0184	0.0259
Brugia malayi	hypothetical protein	0.0028	0.0048	0.0048

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 340 nM	Agonist activity at human alpha7 nAChR	ChEMBL.	21919481
Emax (functional)	= 58 %	Agonist activity at human alpha7 nAChR relative to control	ChEMBL.	21919481
Ki (binding)	= 3 nM	Binding affinity to human alpha7 nAchR	ChEMBL.	21919481
Ki (binding)	= 12 nM	Binding affinity to human 5HT3A receptor	ChEMBL.	21919481
Ki (binding)	= 140 nM	Binding affinity to human alpha4beta2 nAChR	ChEMBL.	21919481

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2151437

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1721595