Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aminopeptidase N | 0.0044 | 0.0136 | 0.0136 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | carboxylesterase | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1629 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0275 | 0.1575 | 0.1575 |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Brugia malayi | hypothetical protein | 0.0275 | 0.1575 | 0.1512 |
Echinococcus multilocularis | acetylcholinesterase | 0.1629 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0275 | 0.1575 | 0.1524 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0275 | 0.1575 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Schistosoma mansoni | gliotactin | 0.0275 | 0.1575 | 0.1575 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0044 | 0.0136 | 0.0075 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1629 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1629 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0044 | 0.0136 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1629 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0275 | 0.1575 | 0.1512 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0044 | 0.0136 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1629 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0275 | 0.1575 | 0.1512 |
Echinococcus multilocularis | aminopeptidase N | 0.0034 | 0.0075 | 0.0014 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0044 | 0.0136 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0275 | 0.1575 | 0.1524 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0275 | 0.1575 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0275 | 0.1575 | 0.1524 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1629 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0275 | 0.1575 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1629 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | carboxylesterase | 0.0275 | 0.1575 | 0.1575 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0275 | 0.1575 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0044 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0275 | 0.1575 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1629 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0075 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Onchocerca volvulus | 0.0275 | 0.1575 | 1 | |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0044 | 0.0136 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0275 | 0.1575 | 0.1512 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0275 | 0.1575 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0275 | 0.1575 | 0.1512 |
Brugia malayi | Carboxylesterase family protein | 0.1629 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.1629 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0034 | 0.0075 | 0.5508 |
Brugia malayi | Peptidase family M1 containing protein | 0.0044 | 0.0136 | 0.0061 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1575 | 0.1512 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0275 | 0.1575 | 0.1524 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0044 | 0.0136 | 0.0061 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0034 | 0.0075 | 0.0075 |
Entamoeba histolytica | aminopeptidase, putative | 0.0044 | 0.0136 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Echinococcus granulosus | acetylcholinesterase | 0.1629 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1575 | 0.1575 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 18.91 % | Antiproliferative activity against human Jurkat cells assessed as 5th generation cell population at 10 uM after 24 hrs using CFSE staining by flow cytometry (Rvb = 18.43 %) | ChEMBL. | 23063518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.