Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | chemokine (C-C motif) receptor 1 | 355 aa | 289 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0253 | 0.1138 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1138 | 0.1138 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0253 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1138 | 0.1138 |
Trichomonas vaginalis | glutaminase, putative | 0.0308 | 0.1534 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1496 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0525 | 0.3076 | 0.2187 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0525 | 0.3076 | 0.2187 |
Onchocerca volvulus | 0.0253 | 0.1138 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1138 | 0.1138 |
Loa Loa (eye worm) | glutaminase 2 | 0.0308 | 0.1534 | 0.1534 |
Brugia malayi | glutaminase DH11.1 | 0.0308 | 0.1534 | 0.0448 |
Mycobacterium ulcerans | glutaminase | 0.0308 | 0.1534 | 1 |
Onchocerca volvulus | 0.0253 | 0.1138 | 0.5 | |
Schistosoma mansoni | glutaminase | 0.0308 | 0.1534 | 0.0448 |
Onchocerca volvulus | 0.0253 | 0.1138 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1138 | 0.1138 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0915 | 0.5858 | 0.5326 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1138 | 0.1138 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0253 | 0.1138 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1496 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1496 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1138 | 0.1138 |
Echinococcus granulosus | acetylcholinesterase | 0.1496 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1496 | 1 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0253 | 0.1138 | 0.1138 |
Loa Loa (eye worm) | glutaminase | 0.0308 | 0.1534 | 0.1534 |
Echinococcus granulosus | carboxylesterase 5A | 0.1496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.1138 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.1496 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1496 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0253 | 0.1138 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1496 | 1 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0525 | 0.3076 | 0.2187 |
Onchocerca volvulus | 0.0253 | 0.1138 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1496 | 1 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0525 | 0.3076 | 0.2187 |
Loa Loa (eye worm) | carboxylesterase | 0.0253 | 0.1138 | 0.1138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 121 nM | Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cells | ChEMBL. | 23075267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.