Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.1554 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1554 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1554 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1554 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1554 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1554 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1554 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1554 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1554 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1554 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1554 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1554 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Stability (ADMET) | = 99 % | Metabolic stability of the compound in human serum at 3.7 to 5.6 MBq after 120 mins | ChEMBL. | 23210516 |
Stability (ADMET) | = 99.6 % | Metabolic stability of the compound in mouse serum at 3.7 to 5.6 MBq after 120 mins | ChEMBL. | 23210516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.