Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.1495 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1495 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1495 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1495 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1495 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1495 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1495 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1495 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1495 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1495 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1495 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1495 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 350 % | Inhibition of Class 1 histone deacetylase in human HeLa cells assessed as induction in p21 protein expression at 3 uM incubated for 16 hrs by luciferase reporter gene assay relative to HDAC inhibitor entinostat | ChEMBL. | 23061376 |
CL (ADMET) | = 74 ml/min.kg | Clearance in mouse liver microsomes at 1 uM incubated for 10 mins by LC-MS/MS method | ChEMBL. | 23061376 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.