Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bombesin-like receptor 3 | Starlite/ChEMBL | References |
Mus musculus | bombesin-like receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bombesin-like receptor 3 | 399 aa | 380 aa | 20.8 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bombesin-like receptor 3 | 399 aa | 375 aa | 21.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.1612 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1612 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1612 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1612 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1612 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1612 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1612 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1612 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1612 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1612 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1612 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1612 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 88 nM | Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay | ChEMBL. | 24900283 |
EC50 (functional) | = 209 nM | Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay | ChEMBL. | 24900283 |
IC50 (binding) | = 2.2 nM | Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting | ChEMBL. | 24900283 |
max activation (functional) | = 103 % | Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay relative to [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) | ChEMBL. | 24900283 |
max activation (functional) | = 115 % | Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay relative to [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) | ChEMBL. | 24900283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.