Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.1346 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1346 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1346 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1346 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1346 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1346 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1346 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1346 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1346 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1346 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1346 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1346 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Induction of atoC transcription in Escherichia coli K-12 BW25113 by beta-galactosidase reporter assay | ChEMBL. | 21757361 | |
Activity (functional) | Induction of atoC transcription in Escherichia coli K-12 BW25113 at 1 mM by beta-galactosidase reporter assay | ChEMBL. | 21757361 | |
Activity (functional) | Reduction in AtoS protein level in Escherichia coli K-12 BW25113 grown to OD600 0.5 to 0.6 at 2.5 mM by immunoblot method | ChEMBL. | 21757361 | |
Activity (functional) | Effect on HSP60 protein level in Escherichia coli K-12 BW25113 harboring plasmid containing atoC-lacZ at 0.25 to 5 mM by Western blot method | ChEMBL. | 21757361 | |
Activity (functional) | Increase in AtoC protein level in Escherichia coli K-12 BW25113 grown to OD600 0.5 to 0.6 at 1 to 2.5 mM by immunoblot method | ChEMBL. | 21757361 | |
Activity (functional) | Increase in DnaK protein level in Escherichia coli K-12 BW25113 by Western blot method | ChEMBL. | 21757361 | |
Activity (functional) | Reduction in AtoC protein level in Escherichia coli K-12 BW25113 harboring plasmid containing atoC-lacZ at 5 mM by immunoblot method | ChEMBL. | 21757361 | |
Activity (functional) | Effect on AtoS protein level in Escherichia coli K-12 BW25113 grown to OD600 0.5 to 0.6 at 1 mM by immunoblot method | ChEMBL. | 21757361 | |
Activity (functional) | Repression of atoDAEB transcription in Escherichia coli K-12 BW25113 at 1 mM by beta-galactosidase reporter assay | ChEMBL. | 21757361 | |
Activity (functional) | Reduction in AtoS protein level in Escherichia coli K-12 BW25113 at 1 to 5 mM by immunoblot method | ChEMBL. | 21757361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.