Detailed information for compound 1722270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.434 | Formula: C21H25FN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H](C1CCCCC1)NC(=O)c1ccc(nc1)OCc1cccc(c1)F
  • InChi: 1S/C21H25FN2O2/c1-15(17-7-3-2-4-8-17)24-21(25)18-10-11-20(23-13-18)26-14-16-6-5-9-19(22)12-16/h5-6,9-13,15,17H,2-4,7-8,14H2,1H3,(H,24,25)/t15-/m1/s1
  • InChiKey: CTQRPHPMMNDRFL-OAHLLOKOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) DIX domain-containing protein 0.0006 0.0014 0.0045
Toxoplasma gondii proteasome regulatory subunit 0.0016 0.0106 0.3167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0059 0.0475 0.147
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0013 0.0073 0.0226
Brugia malayi hypothetical protein 0.001 0.0047 0.0145
Echinococcus multilocularis tyrosine kinase 0.0005 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0005 0.0004 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Echinococcus multilocularis bloom syndrome protein 0.0018 0.0121 0.0121
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0029 0.0837
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0008 0.0031 0.0612
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0091 1
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0004 0.0001 0.0004
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0016 0.0106 0.0106
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0248 0.4959
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0006 0.0014 0.0045
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.0047 0.0145
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0052 0.102
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0217 0.4329
Trichomonas vaginalis set domain proteins, putative 0.0265 0.2264 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.1809 0.56
Onchocerca volvulus Poor gastrulation protein homolog 0.0008 0.0033 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.05 0.2206
Leishmania major hypothetical protein, conserved 0.0016 0.0107 0.2121
Leishmania major hypothetical protein, conserved 0.0006 0.0015 0.0285
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0033 0.0248 0.4946
Leishmania major DNA polymerase eta, putative 0.001 0.0052 0.102
Schistosoma mansoni z-protein (S1r protein) 0.0006 0.0014 0.0045
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0012
Entamoeba histolytica protein tyrosine phosphatase, putative 0.001 0.0047 0.0939
Echinococcus multilocularis dna polymerase kappa 0.0033 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.023 0.1963 0.6074
Brugia malayi hypothetical protein 0.0006 0.0014 0.0045
Loa Loa (eye worm) hypothetical protein 0.0091 0.0755 0.2336
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0029 0.0837
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0004 0.0001 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.001 0.0047 0.0145
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0091 0.1808
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0059 0.0475 0.0475
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Onchocerca volvulus Serine\/threonine kinase homolog 0.0062 0.05 0.2206
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Giardia lamblia Kinase, PLK 0.0062 0.05 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0008 0.0031 0.0886
Brugia malayi Receptor family ligand binding region containing protein 0.0005 0.0004 0.0012
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0029 0.009
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0025 0.0178 0.3537
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.001 0.0047 0.0145
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0016 0.0106 0.0328
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0052 0.102
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0248 0.0504
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.032 0.099
Brugia malayi Flap endonuclease-1 0.0029 0.0217 0.0672
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Giardia lamblia Protein tyrosine phosphatase 0.001 0.0047 0.0649
Plasmodium vivax exonuclease I, putative 0.0006 0.0015 0.0429
Schistosoma mansoni receptor protein tyrosine phosphatase 0.001 0.0047 0.0145
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0012 0.0072 0.1419
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0248 0.4946
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.0802 0.2291
Echinococcus multilocularis regulator of G protein signaling 7 0.0006 0.0014 0.0014
Trypanosoma brucei unspecified product 0.0023 0.016 0.3179
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.0802 0.2291
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0048 0.0961
Brugia malayi hypothetical protein 0.001 0.0047 0.0145
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0012 0.0072 0.0318
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.001 0.0047 0.0145
Schistosoma mansoni tsg101-related 0.0038 0.0292 0.0905
Entamoeba histolytica Mov34/MPN/PAD-1 family protein 0.0004 0.0001 0.0026
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0217 0.4163
Loa Loa (eye worm) glutamate receptor 0.0049 0.0389 0.1203
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0376 0.3231 0.3231
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0161
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Entamoeba histolytica hypothetical protein 0.0008 0.003 0.0601
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Echinococcus granulosus regulator of G protein signaling 7 0.0006 0.0014 0.0045
Brugia malayi hypothetical protein 0.001 0.0047 0.0145
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.001 0.0047 0.0939
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.001 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.006 0.0487 0.1507
Trichomonas vaginalis pten, drome, putative 0.001 0.0047 0.0207
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0005 0.0004 0.0004
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0052 0.1043
Brugia malayi hypothetical protein 0.0212 0.1809 0.56
Echinococcus multilocularis glutamate receptor 2 0.0005 0.0004 0.0004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0029 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.05 0.2206
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0579 0.1793
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0012 0.0072 0.1167
Schistosoma mansoni dep domain containing protein 0.0006 0.0014 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0052 0.102
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0005 0.0004 0.0004
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0004 0.0001 0.0001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Trypanosoma brucei unspecified product 0.0023 0.016 0.3179
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0007 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Brugia malayi hypothetical protein 0.001 0.0047 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.003 0.0601
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0047
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0091 0.183
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.05 0.2206
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0217 0.0672
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Echinococcus granulosus nmda type glutamate receptor 0.0005 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0279 0.0863
Echinococcus granulosus atrial natriuretic peptide receptor 0.0005 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0128 0.1073 0.3321
Echinococcus granulosus tumor protein p63 0.0292 0.2498 0.773
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.001 0.0047 0.0939
Onchocerca volvulus 0.001 0.0047 0.0207
Trypanosoma cruzi DNA polymerase eta, putative 0.001 0.0052 0.1043
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.05 0.2206
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0007 0.0029 0.0837
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0091 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0229 0.1012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.1808
Onchocerca volvulus 0.001 0.0047 0.0207
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0005 0.0004 0.0004
Onchocerca volvulus 0.001 0.0047 0.0207
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0217 0.4329
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0059 0.0475 0.147
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0005 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.183
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.001 0.0047 0.0939
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0331 0.0774
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0025 0.0178 0.3554
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0006 0.0014 0.0014
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0007 0.0029 0.0029
Trypanosoma brucei trypanothione reductase 0.0042 0.0331 0.6626
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0025 0.0183 0.0565
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0015 0.031
Schistosoma mansoni hypothetical protein 0.0036 0.0279 0.0863
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0248 0.4959
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0579 0.1793
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0091 0.0283
Entamoeba histolytica protein tyrosine phosphatase, putative 0.001 0.0047 0.0939
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0487 0.1507
Echinococcus multilocularis GPCR, family 2 0.0036 0.0279 0.0279
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0579 0.1793
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0229 0.1012
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0372 0.3193 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0062 0.05 0.1546
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0243 0.0753
Brugia malayi Pre-SET motif family protein 0.0233 0.1985 0.6143
Onchocerca volvulus 0.0265 0.2264 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0005 0.0004 0.0012
Echinococcus multilocularis protein tyrosine phosphatase n9 0.001 0.0047 0.0047
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0062 0.05 0.1546
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.0047 0.0145
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Echinococcus granulosus geminin 0.0128 0.1073 0.3321
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0004 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0335 0.1037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0059 0.0475 0.147
Entamoeba histolytica serine/threonine protein kinase, putative 0.0062 0.05 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0091 0.0125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0059 0.0475 0.147
Echinococcus multilocularis COP9 signalosome complex subunit 6 0.0004 0.0001 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0279 0.0863
Echinococcus granulosus exonuclease 1 0.0006 0.0015 0.0048
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0052 0.0161
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0025 0.0183 0.0565
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0102
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0376 0.3231 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0248 0.0767
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.001 0.0047 0.0145
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0254 0.0254
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.0047 0.0145
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.001 0.0047 0.0145
Brugia malayi hypothetical protein 0.0045 0.0358 0.1109
Trypanosoma brucei protein tyrosine phosphatase 1 0.001 0.0047 0.0916
Plasmodium vivax DNA repair protein RAD2, putative 0.0006 0.0015 0.0429
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.0133
Mycobacterium ulcerans DNA polymerase IV 0.0033 0.0248 0.0623
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0091 0.2729
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0248 0.4959
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0107 0.0896 0.2593
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0012
Plasmodium falciparum thioredoxin reductase 0.0042 0.0331 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0008 0.0031 0.0612
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0016 0.0106 0.0328
Loa Loa (eye worm) hypothetical protein 0.0118 0.0987 0.3056
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0145
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.0047 0.0047
Trichomonas vaginalis DNA polymerase eta, putative 0.0033 0.0248 0.1094
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0091 0.2729
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0171 0.0529
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.05 0.1546
Onchocerca volvulus 0.001 0.0047 0.0207
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0005 0.0004 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0254 0.0786
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Echinococcus multilocularis regulator of G protein signaling 7 0.0006 0.0014 0.0014
Leishmania major trypanothione reductase 0.0042 0.0331 0.6626
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0052 0.1043
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0016 0.0106 0.212
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0015 0.0068
Trichomonas vaginalis exonuclease%2C+putative 0.0006 0.0015 0.0068
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0015 0.009 0.1783
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.001 0.0047 0.0145
Onchocerca volvulus 0.001 0.0047 0.0207
Mycobacterium tuberculosis Probable oxidoreductase 0.0107 0.0896 0.2593
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0006 0.0014 0.0045
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0331 0.6635
Schistosoma mansoni tsg101-related 0.0038 0.0292 0.0905
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0058 0.0178
Trypanosoma brucei PAB1-binding protein , putative 0.0016 0.0107 0.2121
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.009
Onchocerca volvulus 0.001 0.0047 0.0207
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.032 0.099
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0217 0.0958
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0376 0.3231 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Plasmodium vivax ataxin-2 like protein, putative 0.0016 0.0107 0.3201
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0016 0.0106 0.3167
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0091 0.1568
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0254 0.0786
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0015 0.009 0.1805
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Loa Loa (eye worm) proteasome 26S subunit 0.0012 0.0072 0.0223
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0091 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Echinococcus granulosus dna polymerase eta 0.0033 0.0248 0.0767
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0579 0.0579
Entamoeba histolytica exonuclease, putative 0.0006 0.0015 0.031
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0217 0.0217
Onchocerca volvulus 0.001 0.0047 0.0207
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0372 0.3193 1
Toxoplasma gondii hypothetical protein 0.0006 0.0014 0.0398
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0015 0.0429
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0091 0.2729
Plasmodium vivax DNA repair protein REV1, putative 0.001 0.0052 0.1539
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0091 0.0283
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0389 0.1203
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0025 0.0178 0.3537
Schistosoma mansoni DNA polymerase eta 0.0033 0.0248 0.0767
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0045
Brugia malayi XPG I-region family protein 0.0006 0.0015 0.0048
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.023 0.1963 0.6074
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.001 0.0052 0.1539
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0336 0.0336
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.001 0.0047 0.0047
Brugia malayi Protein-tyrosine phosphatase 1 0.001 0.0047 0.0145
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.001 0.0047 0.0047
Schistosoma mansoni flap endonuclease-1 0.0026 0.0193 0.0596
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0579 0.1793
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.032 0.032
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0091 0.0404
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0025 0.0178 0.3554
Schistosoma mansoni hypothetical protein 0.0007 0.0028 0.0087
Schistosoma mansoni protein kinase 0.0005 0.0004 0.0012
Onchocerca volvulus 0.0005 0.0004 0.0018
Brugia malayi N-terminal motif family protein 0.0118 0.0987 0.3056
Echinococcus multilocularis nmda type glutamate receptor 0.0005 0.0004 0.0004
Onchocerca volvulus 0.001 0.0047 0.0207
Trypanosoma brucei polo-like protein kinase 0.0062 0.05 1
Echinococcus multilocularis GPCR, family 3, C terminal 0.0008 0.0033 0.0033
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0033 0.0248 0.0504
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Echinococcus multilocularis expressed protein 0.0025 0.0183 0.0183
Schistosoma mansoni dishevelled 0.0006 0.0014 0.0045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Leishmania major DNA polymerase eta, putative 0.0033 0.0248 0.4946
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0007 0.0028 0.0087
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.001 0.0047 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0059 0.0475 0.147
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0006 0.0014 0.0045
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0012 0.0072 0.0318
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0447 0.1383
Loa Loa (eye worm) RecQ helicase 0.0018 0.0121 0.0375
Trypanosoma brucei exonuclease, putative 0.0006 0.0015 0.0285
Toxoplasma gondii peptidylprolyl isomerase 0.0025 0.0178 0.5338
Onchocerca volvulus 0.001 0.0047 0.0207
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Brugia malayi serine/threonine-protein kinase plk-2 0.0062 0.05 0.1546
Schistosoma mansoni hypothetical protein 0.0078 0.0644 0.1994
Onchocerca volvulus 0.001 0.0047 0.0207
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0091 0.1808
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0349 0.108
Echinococcus multilocularis receptor type guanylyl cyclase 0.0005 0.0004 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0059 0.0475 0.147
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0091 1
Plasmodium falciparum thioredoxin reductase 0.0015 0.0091 0.2729
Echinococcus multilocularis exonuclease 1 0.0006 0.0015 0.0015
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0145
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Brugia malayi hypothetical protein 0.0011 0.0056 0.0174
Leishmania major DNA damage repair protein, putative 0.001 0.0052 0.102
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0006 0.0015 0.0048
Brugia malayi hypothetical protein 0.0006 0.0014 0.0045
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0279 0.0863
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Onchocerca volvulus 0.001 0.0047 0.0207
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.001 0.0047 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.05 0.2206
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0052 0.1043
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0091 0.2729
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0487 0.0487
Leishmania major extracellular receptor, putative 0.0005 0.0004 0.0054
Entamoeba histolytica hypothetical protein 0.0008 0.003 0.0601
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Plasmodium falciparum flap endonuclease 1 0.0029 0.0217 0.6533
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0059 0.0475 0.147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0254 0.0786
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0183 0.0807
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0045 0.0358 0.0358
Plasmodium falciparum glutathione reductase 0.0015 0.0091 0.2729
Onchocerca volvulus 0.001 0.0047 0.0207
Plasmodium falciparum DNA repair protein RAD2, putative 0.0006 0.0015 0.0429
Brugia malayi TAR-binding protein 0.0071 0.0579 0.1793
Echinococcus granulosus receptor type guanylyl cyclase 0.0005 0.0004 0.0012
Echinococcus granulosus expressed protein 0.0025 0.0183 0.0565
Entamoeba histolytica hypothetical protein 0.0008 0.003 0.0601
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Onchocerca volvulus 0.001 0.0047 0.0207
Onchocerca volvulus 0.0005 0.0004 0.0018
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0254 0.7654
Echinococcus granulosus GPCR family 3 C terminal 0.0008 0.0033 0.0102
Brugia malayi Dual specificity protein phosphatase CDC14B 0.001 0.0047 0.0145
Brugia malayi glutathione reductase 0.0042 0.0331 0.1026
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.001 0.0047 0.0047
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0217 0.4344
Echinococcus multilocularis geminin 0.0128 0.1073 0.1073
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0107 0.0896 0.2593
Echinococcus granulosus segment polarity protein dishevelled 0.0006 0.0014 0.0045
Schistosoma mansoni tsg101-related 0.0031 0.0232 0.0719
Plasmodium falciparum exonuclease I, putative 0.0006 0.0015 0.0429
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0031 0.0232 0.4649
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0091 0.1808
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.001 0.0047 0.0145
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0248 0.4959
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Schistosoma mansoni hypothetical protein 0.0036 0.0279 0.0863
Entamoeba histolytica DNA-repair protein, putative 0.0006 0.0015 0.031
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0145
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0004 0.0001 0.0026
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0091 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.05 0.2206
Trichomonas vaginalis rotamase, putative 0.0025 0.0178 0.0784
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.003 0.0601
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0226
Entamoeba histolytica recQ family helicase, putative 0.001 0.0048 0.0961
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0217 0.6533
Brugia malayi DIX domain containing protein 0.0006 0.0014 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Loa Loa (eye worm) hypothetical protein 0.0078 0.0644 0.1994
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0376 0.3231 1
Loa Loa (eye worm) XPG I-region family protein 0.0006 0.0015 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.183
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Brugia malayi RNA binding protein 0.0071 0.0579 0.1793
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0004 0.0001 0.0004
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0015 0.0068
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0091 0.2729
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.003 0.0133
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0091 0.183
Echinococcus multilocularis flap endonuclease GEN 1 0.0006 0.0015 0.0015
Echinococcus granulosus tyrosine kinase 0.0005 0.0004 0.0012
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0007 0.0029 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0015 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0091 0.183
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0004 0.0001 0.0026
Echinococcus granulosus bloom syndrome protein 0.0018 0.0121 0.0375
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0336 0.1041
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0012 0.0072 0.1419
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0015 0.031
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0248 0.0767
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0012
Brugia malayi Bloom's syndrome protein homolog 0.0018 0.0121 0.0375
Onchocerca volvulus 0.001 0.0047 0.0207
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0012 0.0072 0.1441
Echinococcus multilocularis segment polarity protein dishevelled 0.0006 0.0014 0.0014
Leishmania major hypothetical protein, conserved 0.0015 0.009 0.1783
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0006 0.0015 0.0015
Echinococcus multilocularis segment polarity protein dishevelled 0.0006 0.0014 0.0014
Echinococcus multilocularis eukaryotic translation initiation factor 3 0.0004 0.0001 0.0001
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0004 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0033 0.0254 0.0786
Echinococcus granulosus regulator of G protein signaling 7 0.0006 0.0014 0.0045
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0012 0.0072 0.1419
Loa Loa (eye worm) glutamate receptor 0.0019 0.0131 0.0406
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0279 0.0863
Plasmodium falciparum glutathione reductase 0.0042 0.0331 1
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.001 0.0047 0.0145
Echinococcus granulosus Pleckstrin G protein interacting region 0.0006 0.0014 0.0045
Trichomonas vaginalis hypothetical protein 0.0022 0.0156 0.0689
Echinococcus granulosus tar DNA binding protein 0.0071 0.0579 0.1793
Giardia lamblia Sgs1 DNA helicase, putative 0.0007 0.0029 0.0278
Trypanosoma cruzi polo-like protein kinase, putative 0.0062 0.05 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0025 0.0178 0.3554
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.0047 0.0047
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0073 0.0226
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0107 0.3201
Giardia lamblia DINP protein human, muc B family 0.0033 0.0248 0.4798
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0217 0.6533
Schistosoma mansoni protein tyrosine phosphatase 0.001 0.0047 0.0145
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0005 0.0004 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Schistosoma mansoni rotamase 0.0025 0.0183 0.0565
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.0047 0.0047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0033 0.0248 0.1094
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0016 0.0106 0.3167
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0091 0.0283
Onchocerca volvulus 4.1 G protein, putative homolog 0.001 0.0047 0.0207
Schistosoma mansoni hypothetical protein 0.0128 0.1073 0.3321
Trichomonas vaginalis DNA helicase recq1, putative 0.0018 0.0121 0.0535
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0052 0.102
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0052 0.1043
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.1808
Onchocerca volvulus 0.0006 0.0014 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0012
Echinococcus granulosus protein tyrosine phosphatase n9 0.001 0.0047 0.0145
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.0802 0.2291
Entamoeba histolytica hypothetical protein 0.0005 0.0004 0.0081
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Plasmodium vivax SET domain protein, putative 0.0033 0.0254 0.7654
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.1985 0.6143
Brugia malayi Thioredoxin reductase 0.0042 0.0331 0.1026
Echinococcus granulosus flap endonuclease GEN 1 0.0006 0.0015 0.0048
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0091 0.1808
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0007 0.0028 0.0028
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0052 0.1539
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0579 0.1793
Schistosoma mansoni tyrosine kinase 0.0005 0.0004 0.0012
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0091 0.1808
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0091 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.3179
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0331
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0644 0.1994
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.3179
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0062 0.05 1
Schistosoma mansoni cellular tumor antigen P53 0.0043 0.0335 0.1037
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0248 0.0767
Onchocerca volvulus 0.001 0.0047 0.0207
Loa Loa (eye worm) hypothetical protein 0.0033 0.0248 0.0767
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0012 0.0072 0.0223
Schistosoma mansoni pcd6 interacting protein-related 0.001 0.0047 0.0145
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0069 0.2052
Brugia malayi Protein-tyrosine phosphatase 0.001 0.0047 0.0145
Brugia malayi polk-prov protein 0.001 0.0052 0.0161
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0248 0.0767
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0248 0.4959
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0372 0.3193 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0008 0.0031 0.0587
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0045 0.0358 0.1109
Loa Loa (eye worm) RGC/RGC protein kinase 0.0005 0.0004 0.0012
Schistosoma mansoni dishevelled 0.0006 0.0014 0.0045
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0107 0.3201
Onchocerca volvulus 0.0043 0.0335 0.1479
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Brugia malayi Pre-SET motif family protein 0.0033 0.0254 0.0786
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0015 0.0068
Echinococcus multilocularis hypothetical protein 0.001 0.0047 0.0047
Schistosoma mansoni DNA helicase recq5 0.0007 0.0029 0.009
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.001 0.0047 0.0047
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0579 0.1793
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.001 0.0047 0.0145
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0008 0.0033 0.0102
Echinococcus granulosus glutamate receptor 2 0.0005 0.0004 0.0012
Leishmania major tyrosine specific protein phosphatase, putative 0.001 0.0047 0.0916
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0217 0.4344
Onchocerca volvulus 0.0033 0.0254 0.1122
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0171 0.0529
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.007 0.209
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0012 0.0072 0.0072
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0015 0.0429
Trypanosoma brucei DNA repair protein RAD2, putative 0.0006 0.0015 0.0285
Schistosoma mansoni regulator of G protein signaling 0.0006 0.0014 0.0045
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0118 0.0987 0.436
Echinococcus granulosus flap endonuclease 1 0.0029 0.0217 0.0672
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Leishmania major protein-tyrosine phosphatase 1-like protein 0.001 0.0047 0.0916
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.016 0.3179
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0091 0.2729
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0254 0.0786
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Treponema pallidum NADH oxidase 0.0015 0.0091 0.5
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.0047 0.0047
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0006 0.0014 0.0045
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0058 0.0178
Loa Loa (eye worm) hypothetical protein 0.0045 0.0358 0.1109
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0331 0.1026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0279 0.0279
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0005 0.0004 0.0012
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0007 0.0029 0.009
Schistosoma mansoni hypothetical protein 0.0036 0.0279 0.0863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.0959 0.2968
Schistosoma mansoni blooms syndrome DNA helicase 0.0014 0.0088 0.0273
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.183
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0052 0.102
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0091 0.1808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0059 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.0121 0.0535
Plasmodium vivax glutathione reductase, putative 0.0042 0.0331 1
Echinococcus granulosus GPCR family 2 0.0036 0.0279 0.0863
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0107 0.0896 0.0391
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.0802 0.2291
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0279 0.0863
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Trypanosoma cruzi polo-like protein kinase, putative 0.0062 0.05 1
Onchocerca volvulus 0.001 0.0047 0.0207
Onchocerca volvulus 0.001 0.0047 0.0207
Echinococcus multilocularis glutamate receptor 2 0.0005 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0248 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0248 0.4946
Mycobacterium ulcerans DNA polymerase IV 0.0033 0.0248 0.0623
Onchocerca volvulus 0.001 0.0047 0.0207
Onchocerca volvulus 0.001 0.0047 0.0207
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0012 0.0072 0.0318
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0005 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.05 0.2206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.183
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0004 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0008 0.0033 0.0102
Onchocerca volvulus 0.001 0.0047 0.0207
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0013 0.0073 0.0226
Trypanosoma brucei unspecified product 0.0033 0.0248 0.4946
Onchocerca volvulus 0.001 0.0047 0.0207
Schistosoma mansoni protein-tyrosine phosphatase n9 0.001 0.0047 0.0145
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0016 0.0102 0.3053
Schistosoma mansoni protein tyrosine phosphatase 0.001 0.0047 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.183
Trichomonas vaginalis rotamase, putative 0.0025 0.0183 0.0807
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0152 0.1282 0.1282
Schistosoma mansoni kinase 0.0031 0.0236 0.0731
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0005 0.0004 0.0012
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0015 0.0429
Trypanosoma brucei chrX additional, unordered contigs 0.001 0.0052 0.102
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Plasmodium falciparum DNA repair protein REV1, putative 0.001 0.0052 0.1539
Schistosoma mansoni exonuclease 0.0006 0.0015 0.0048
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.0047 0.0145
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0008 0.0033 0.0146
Schistosoma mansoni hypothetical protein 0.0036 0.0279 0.0863
Echinococcus granulosus eukaryotic translation initiation factor 3 0.0004 0.0001 0.0004
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0145
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0015 0.0429
Onchocerca volvulus 0.0212 0.1809 0.7991
Echinococcus granulosus glutamate receptor 2 0.0005 0.0004 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Schistosoma mansoni DNA helicase recq1 0.0007 0.0029 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0107 0.2142
Onchocerca volvulus 0.001 0.0047 0.0207
Echinococcus multilocularis 0.001 0.0047 0.0047
Echinococcus granulosus dna polymerase kappa 0.0033 0.0248 0.0767
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Loa Loa (eye worm) glutathione reductase 0.0042 0.0331 0.1026
Loa Loa (eye worm) protein tyrosine phosphatase 0.001 0.0047 0.0145
Leishmania major DNA polymerase kappa, putative 0.001 0.0052 0.102
Entamoeba histolytica hypothetical protein 0.0008 0.003 0.0601
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.0047 0.0145
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0152 0.1282 0.3969
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.001 0.0047 0.0145
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.001 0.0047 0.0939
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.0047 0.0047
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0601
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0579 0.1793
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.0047 0.0145
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0008 0.0031 0.0587
Echinococcus multilocularis dna polymerase eta 0.0033 0.0248 0.0248
Onchocerca volvulus 0.001 0.0047 0.0207
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0007 0.0029 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0015 0.031
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0012
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0005 0.0004 0.0012
Echinococcus granulosus segment polarity protein dishevelled 0.0006 0.0014 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0248 0.4946
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0048 0.0937
Brugia malayi hypothetical protein 0.0016 0.0107 0.0331
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0248 0.0767
Brugia malayi Mov34/MPN/PAD-1 family protein 0.0004 0.0001 0.0004
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0006 0.0014 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.0047 0.0047
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0006 0.0015 0.0048
Brugia malayi hypothetical protein 0.001 0.0047 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0579 0.1793
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0005 0.0004 0.0012
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.0047 0.0047
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0091 0.0404
Leishmania major DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Giardia lamblia DNA damage repair protein 0.001 0.0052 0.0757
Echinococcus multilocularis tumor protein p63 0.0292 0.2498 0.2498
Schistosoma mansoni glutamate receptor NMDA 0.0005 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0062 0.05 0.05
Schistosoma mansoni protein tyrosine phosphatase 0.001 0.0047 0.0145
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0052 0.102
Toxoplasma gondii LsmAD domain-containing protein 0.0016 0.0107 0.3201
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0004 0.0001 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.001 0.0047 0.0047
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0008 0.003 0.0576
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0376 0.3231 1
Echinococcus granulosus COP9 signalosome complex subunit 6 0.0004 0.0001 0.0004
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0015 0.031
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0006 0.0015 0.0048
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.0047 0.0047
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.0047 0.0145
Brugia malayi regulator of G-protein signaling egl-10 0.0006 0.0014 0.0045
Loa Loa (eye worm) RGC/RGC protein kinase 0.0005 0.0004 0.0012
Loa Loa (eye worm) RNA binding protein 0.0071 0.0579 0.1793
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.0047 0.0047
Loa Loa (eye worm) RGC/RGC protein kinase 0.0005 0.0004 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0091 0.183
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.0959 0.2968
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0048 0.0937
Trypanosoma cruzi DNA polymerase kappa, putative 0.0033 0.0248 0.4959
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0052 0.1539
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.001 0.0047 0.0145
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0016 0.0106 0.0328
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Brugia malayi hypothetical protein 0.0005 0.0004 0.0012
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0248 0.4946
Trypanosoma cruzi extracellular receptor, putative 0.0005 0.0004 0.0081
Schistosoma mansoni rgs-gaip interacting protein gipc 0.001 0.0047 0.0145
Brugia malayi Protein-tyrosine phosphatase 0.001 0.0047 0.0145
Entamoeba histolytica exonuclease, putative 0.0006 0.0015 0.031
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0254 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0248 0.4946
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.001 0.0047 0.0145
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0016 0.0106 0.0328
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.001 0.0047 0.0145
Brugia malayi Guanylyl cyclase protein 23 0.0005 0.0004 0.0012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.0047 0.0047
Toxoplasma gondii thioredoxin reductase 0.0042 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0145
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.0047 0.0145
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.0802 0.2291
Trichomonas vaginalis DNA helicase recq, putative 0.001 0.0048 0.0212
Mycobacterium tuberculosis Probable reductase 0.0096 0.0802 0.2291
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0107 0.2142
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0248 0.0767

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 7.82 Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization ChEMBL. 22981332
EC50 (binding) = 15 nM Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization ChEMBL. 22981332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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