TDR Targets

Basic information

Technical information

TDR Targets ID: 172232
Name: 2-[4-[(4-methoxyphenyl)methyl]piperazin-1-yl] -1-[(2R)-2-methyl-2,3-dihydroindol-1-yl]ethan one
MW: 379.495 | Formula: C23H29N3O2
H donors: 0 H acceptors: 1 LogP: 3.09 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CN1CCN(CC1)CC(=O)N1[C@H](C)Cc2c1cccc2
InChi: 1S/C23H29N3O2/c1-18-15-20-5-3-4-6-22(20)26(18)23(27)17-25-13-11-24(12-14-25)16-19-7-9-21(28-2)10-8-19/h3-10,18H,11-17H2,1-2H3/t18-/m1/s1
InChiKey: DSNCXRXGMZSRBV-GOSISDBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[(4-methoxyphenyl)methyl]piperazin-1-yl]-1-[(2R)-2-methylindolin-1-yl]ethanone
2-[4-[(4-methoxyphenyl)methyl]-1-piperazinyl]-1-[(2R)-2-methyl-1-indolinyl]ethanone
1-[(2R)-2-methylindolin-1-yl]-2-(4-p-anisylpiperazino)ethanone
2-[4-(4-methoxybenzyl)piperazin-1-yl]-1-[(2R)-2-methylindolin-1-yl]ethanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dopamine receptor D4	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0157	0.1289	0.1289
Onchocerca volvulus	Bile acid receptor homolog	0.0333	0.4238	1
Echinococcus granulosus	multidrug resistance protein 1	0.0081	0.0015	0.0015
Schistosoma mansoni	thyroid hormone receptor	0.0333	0.4238	0.4229
Trichomonas vaginalis	conserved hypothetical protein	0.0421	0.5723	0.5717
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0081	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0333	0.4238	0.4229
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Schistosoma mansoni	nuclear receptor nhr-48	0.0157	0.1289	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0176	0.1605	0.1605
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0333	0.4238	0.4238
Entamoeba histolytica	bromodomain-containing protein	0.0303	0.3745	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0333	0.4238	0.4229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0333	0.4238	0.4238
Entamoeba histolytica	bromodomain-containing protein	0.0303	0.3745	1
Echinococcus multilocularis	FTZ F1 alpha	0.0333	0.4238	0.4238
Toxoplasma gondii	bromodomain-containing protein	0.0303	0.3745	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0348	0.0348
Brugia malayi	Nuclear hormone receptor E75	0.0157	0.1289	0.1276
Echinococcus multilocularis	ecdysone induced protein 78C	0.0333	0.4238	0.4238
Brugia malayi	tailless protein	0.0157	0.1289	0.1276
Brugia malayi	steroid hormone receptor	0.0333	0.4238	0.4229
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0333	0.4238	0.4229
Brugia malayi	hypothetical protein	0.0176	0.1605	0.1592
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0157	0.1289	0.1289
Echinococcus multilocularis	multidrug resistance protein 1	0.0081	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	0.0303	0.3745	0.3736
Brugia malayi	nuclear hormone receptor	0.0157	0.1289	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Echinococcus granulosus	ecdysone induced protein 78C	0.0333	0.4238	0.4238
Schistosoma mansoni	zinc finger protein	0.0157	0.1289	0.1276
Onchocerca volvulus	Protein ultraspiracle homolog	0.0333	0.4238	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0176	0.1605	0.1592
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Schistosoma mansoni	nuclear receptor	0.0157	0.1289	0.1276
Schistosoma mansoni	CREB-binding protein 2	0.0259	0.301	0.3
Brugia malayi	hypothetical protein	0.0255	0.2932	0.2922
Echinococcus granulosus	FTZ F1 alpha	0.0333	0.4238	0.4238
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0333	0.4238	0.4229
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0333	0.4238	0.4238
Trichomonas vaginalis	conserved hypothetical protein	0.0373	0.4911	0.4903
Brugia malayi	orphan nuclear receptor NR2E1	0.0157	0.1289	0.1276
Entamoeba histolytica	bromodomain-containing protein	0.0303	0.3745	1
Echinococcus granulosus	multidrug resistance protein 1	0.0081	0.0015	0.0015
Brugia malayi	nuclear receptor NHR-67	0.0157	0.1289	0.1276
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0676	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0333	0.4238	0.4229
Echinococcus multilocularis	Bromodomain containing protein	0.0303	0.3745	0.3745
Onchocerca volvulus		0.0157	0.1289	0.3017
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0333	0.4238	0.4229
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0081	0.0015	0.0015
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0081	0.0015	0.5
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0176	0.1605	0.1592
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0333	0.4238	0.4238
Brugia malayi	hypothetical protein	0.0157	0.1289	0.1276
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0176	0.1605	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Schistosoma mansoni	RAR-like nuclear receptor	0.0333	0.4238	0.4229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0421	0.5723	0.5717
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0333	0.4238	0.4238
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0081	0.0015	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0333	0.4238	0.4229
Echinococcus granulosus	CREB binding protein	0.0259	0.301	0.301
Brugia malayi	Bromodomain containing protein	0.0676	1	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0176	0.1605	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1605	0.1605
Brugia malayi	nuclear hormone receptor family member odr-7	0.0157	0.1289	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0676	1	1
Brugia malayi	TAZ zinc finger family protein	0.0259	0.301	0.3
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0303	0.3745	0.3736
Schistosoma mansoni	nuclear hormone receptor	0.0157	0.1289	0.1276
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0157	0.1289	0.1276
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0157	0.1289	0.1289
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0081	0.0015	0.0015
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0333	0.4238	0.4229
Brugia malayi	Nuclear hormone receptor-like 1	0.0176	0.1605	0.1592
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0081	0.0015	0.0015
Brugia malayi	nuclear receptor NHR-88	0.0157	0.1289	0.1276
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0333	0.4238	0.4238
Loa Loa (eye worm)	nuclear hormone receptor	0.0157	0.1289	0.1289
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Trichomonas vaginalis	bromodomain containing protein, putative	0.0303	0.3745	0.3736
Echinococcus granulosus	nuclear receptor nhr 48	0.0157	0.1289	0.1289
Echinococcus granulosus	bromodomain containing 2	0.0676	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0333	0.4238	0.4229
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0333	0.4238	0.4238
Brugia malayi	Steroid receptor seven-up type 2	0.0333	0.4238	0.4229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0421	0.5723	0.5717
Loa Loa (eye worm)	multidrug resistance protein 3	0.0081	0.0015	0.0015
Giardia lamblia	Kinase, putative	0.0303	0.3745	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.0081	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0333	0.4238	0.4238
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0081	0.0015	0.0015
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0081	0.0015	0.0015
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0081	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0333	0.4238	0.4229
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0157	0.1289	0.1276
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0157	0.1289	0.1289
Schistosoma mansoni	nuclear receptor	0.0157	0.1289	0.1276
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0333	0.4238	0.4238
Leishmania major	p-glycoprotein	0.0081	0.0015	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0333	0.4238	0.4238
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0333	0.4238	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Onchocerca volvulus		0.0333	0.4238	1
Brugia malayi	nuclear receptor NHR-88	0.0333	0.4238	0.4229
Schistosoma mansoni	nuclear hormone receptor	0.0157	0.1289	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1605	0.1605
Loa Loa (eye worm)	bromodomain containing protein	0.0303	0.3745	0.3745
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0421	0.5723	0.5717
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0157	0.1289	0.3017
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0333	0.4238	0.4238
Brugia malayi	Nuclear hormone receptor E75	0.0157	0.1289	0.1276
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0333	0.4238	0.4238
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0333	0.4238	0.4229
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1605	0.1605
Schistosoma mansoni	nuclear hormone receptor	0.0333	0.4238	0.4229
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0333	0.4238	0.4238
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Brugia malayi	Nuclear hormone receptor-like 1	0.0333	0.4238	0.4229
Trichomonas vaginalis	bromodomain containing protein, putative	0.0421	0.5723	0.5717
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0157	0.1289	0.1289
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0157	0.1289	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0157	0.1289	0.1289
Schistosoma mansoni	bromodomain-containing protein 3 brd3	0.0676	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0157	0.1289	0.3017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0333	0.4238	0.4238
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0333	0.4238	0.4238
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0333	0.4238	0.4229
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0081	0.0015	0.5
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0081	0.0015	0.0015
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0157	0.1289	0.1289
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0333	0.4238	0.4229
Onchocerca volvulus		0.0303	0.3745	0.8833
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Trichomonas vaginalis	conserved hypothetical protein	0.0303	0.3745	0.3736
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0333	0.4238	0.4229
Brugia malayi	conserved hypotetical protein	0.0157	0.1289	0.1276
Brugia malayi	nuclear hormone receptor	0.0333	0.4238	0.4229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus granulosus	thyroid hormone receptor alpha	0.0157	0.1289	0.1289
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0333	0.4238	0.4238
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0333	0.4238	0.4238
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Onchocerca volvulus		0.0157	0.1289	0.3017
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Brugia malayi	hypothetical protein	0.0176	0.1605	0.1592
Schistosoma mansoni	thyroid hormone receptor	0.0333	0.4238	0.4229
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0333	0.4238	0.4238
Echinococcus granulosus	CREB binding protein	0.0177	0.1629	0.1629
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1605	0.1605
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0081	0.0015	0.0015
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Plasmodium vivax	multidrug resistance protein 1, putative	0.0081	0.0015	0.5
Plasmodium falciparum	multidrug resistance protein 1	0.0081	0.0015	0.5
Brugia malayi	nuclear receptor RXR	0.0157	0.1289	0.1276
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0333	0.4238	0.4238
Loa Loa (eye worm)	CBP-B	0.0194	0.1909	0.1909
Schistosoma mansoni	coup transcription factor	0.0333	0.4238	0.4229
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0157	0.1289	0.1276
Brugia malayi	Nuclear hormone receptor-like 1	0.0176	0.1605	0.1592
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0157	0.1289	0.1289
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0333	0.4238	0.4238
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1289	0.1289
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0081	0.0015	0.0015
Echinococcus multilocularis	nuclear receptor nhr 48	0.0157	0.1289	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0015	0.0015
Echinococcus multilocularis	bromodomain containing 2	0.0676	1	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Brugia malayi	ecdysteroid receptor	0.0333	0.4238	0.4229
Schistosoma mansoni	retinoic acid receptor RXR	0.0333	0.4238	0.4229
Brugia malayi	nuclear receptor RXR	0.0176	0.1605	0.1592
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0333	0.4238	0.4229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0676	1	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0333	0.4238	0.4238
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0333	0.4238	0.4229
Echinococcus multilocularis	multidrug resistance protein 1	0.0081	0.0015	0.0015
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0157	0.1289	0.1289
Echinococcus multilocularis	CREB binding protein	0.0192	0.1877	0.1877
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0333	0.4238	0.4229
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0259	0.301	0.3
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0333	0.4238	0.4229
Loa Loa (eye worm)	DR-78	0.0157	0.1289	0.1289
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0157	0.1289	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4238	0.4238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0157	0.1289	0.1289
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0157	0.1289	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1605	0.1605
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0333	0.4238	0.4229
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0333	0.4238	0.4238
Brugia malayi	ecdysone receptor	0.0157	0.1289	0.1276
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0333	0.4238	0.4229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0303	0.3745	0.3736
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0333	0.4238	0.4229

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 9.9 nM	Binding affinity towards Dopamine type 4 receptor was determined by competitive displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 673 nM	Binding affinity towards Dopamine type 2 receptor was determined by displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 9.9 uM	Binding affinity towards Dopamine type 4 receptor was determined by competitive displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 673 uM	Binding affinity towards Dopamine type 2 receptor was determined by displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 724 uM	Binding affinity towards Alpha-1 adrenergic receptor was determined by competitive displacement assays using rat brain homogenate with [3H]-prazosin as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 724 uM	Binding affinity towards Alpha-1 adrenergic receptor was determined by competitive displacement assays using rat brain homogenate with [3H]-prazosin as the competitive ligand	ChEMBL.	12372513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL105317
PubChem: 9129986

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 172232