Detailed information for compound 1722373

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 481.516 | Formula: C26H28FN3O5
  • H donors: 1 H acceptors: 3 LogP: 1.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)CN1CCN(CC1)c1cc2c(cc1F)c(=O)c(cn2C1CC1)C(=O)O
  • InChi: 1S/C26H28FN3O5/c1-34-23-6-3-16(11-24(23)35-2)14-28-7-9-29(10-8-28)22-13-21-18(12-20(22)27)25(31)19(26(32)33)15-30(21)17-4-5-17/h3,6,11-13,15,17H,4-5,7-10,14H2,1-2H3,(H,32,33)
  • InChiKey: ULZBXZPUJITRPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin epsilon chain, putative 0.0776 0.6251 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0028
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0049 0.0268 0.0428
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0156 0.0249
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0162 0.018
Mycobacterium ulcerans beta-lactamase 0.0078 0.0506 0.3608
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0538 0.4294 0.6869
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0567 0.063
Plasmodium falciparum glutathione reductase 0.0101 0.0698 0.1117
Schistosoma mansoni alpha tubulin 0.0578 0.462 0.462
Echinococcus granulosus glycine receptor subunit beta 0.0195 0.1469 0.1469
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0506 0.1283
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0866 0.0962
Entamoeba histolytica hypothetical protein 0.0041 0.0205 0.029
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.1469 0.2351
Loa Loa (eye worm) hypothetical protein 0.0162 0.1204 0.1337
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0156 0.0249
Brugia malayi cytochrome P450 0.0049 0.0268 0.0428
Echinococcus multilocularis peroxisome assembly protein 26 0.0578 0.462 0.462
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0049 0.0268 0.0678
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0079 0.0127
Leishmania major gamma-tubulin 0.0417 0.3295 0.5271
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Brugia malayi Ets-domain containing protein 0.0074 0.0473 0.0757
Schistosoma mansoni alpha-glucosidase 0.0139 0.101 0.101
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0027 0.0068
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0049 0.0268 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0363 0.0363
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0049 0.0268 0.0678
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0195 0.1469 0.1469
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Leishmania major delta tubulin, putative 0.0181 0.1356 0.2169
Trypanosoma cruzi tubulin delta chain 0.0181 0.1356 0.2169
Entamoeba histolytica hypothetical protein 0.0041 0.0205 0.029
Loa Loa (eye worm) hypothetical protein 0.0063 0.0386 0.0428
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0156 0.021
Schistosoma mansoni tubulin subunit alpha 0.0181 0.1356 0.1356
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0162 0.026
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0363 0.0363
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0506 0.1283
Echinococcus granulosus nAChR subunit 0.0195 0.1469 0.1469
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2039 0.3235
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0027 0.0027
Brugia malayi hypoxia-induced factor 1 0.015 0.11 0.1761
Loa Loa (eye worm) tubulin alpha 2 0.0397 0.3132 0.348
Schistosoma mansoni DNA polymerase eta 0.0019 0.0027 0.0027
Schistosoma mansoni nAChR subunit 0.0195 0.1469 0.1469
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.0563 0.09
Trypanosoma brucei epsilon tubulin 0.0417 0.3295 0.5271
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0195 0.1469 0.2351
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1292 0.2036
Brugia malayi Fli-1 protein 0.0224 0.1706 0.273
Toxoplasma gondii alpha-tubulin I, putative 0.0578 0.462 0.7391
Leishmania major hypothetical protein, conserved 0.0078 0.0506 0.081
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.1469 0.2351
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0506 0.1399
Plasmodium falciparum tubulin epsilon chain, putative 0.0417 0.3295 0.5271
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0198 0.1286
Echinococcus granulosus tubulin subunit TubB 0.0578 0.462 0.462
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0246 0.0356
Echinococcus multilocularis 0.0049 0.0268 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0637 0.0984
Schistosoma mansoni alpha-glucosidase 0.0139 0.101 0.101
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0025
Leishmania major beta tubulin 0.0776 0.6251 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0094 0.0645 0.0645
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1292 0.2036
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0866 0.0962
Loa Loa (eye worm) hypothetical protein 0.0078 0.0506 0.0562
Echinococcus multilocularis thioredoxin glutathione reductase 0.0101 0.0698 0.0698
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0236 0.1807 0.2862
Echinococcus multilocularis nAChR subunit 0.0195 0.1469 0.1469
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Leishmania major epsilon tubulin, putative 0.0417 0.3295 0.5271
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0028
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0195 0.1469 0.1632
Trypanosoma brucei trypanothione reductase 0.0101 0.0698 0.1117
Trypanosoma brucei epsilon tubulin 0.0417 0.3295 0.5271
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0198 0.0198
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0256 0.1973 0.5
Schistosoma mansoni alpha tubulin 0.0578 0.462 0.462
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1195 0.1327
Echinococcus granulosus dna polymerase eta 0.0019 0.0027 0.0027
Mycobacterium tuberculosis Putative ferredoxin reductase 0.023 0.1762 0.4465
Echinococcus granulosus glycine receptor subunit alpha 1 0.0195 0.1469 0.1469
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0152
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0049 0.0268 0.1812
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0551 0.0882
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0025
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1356 0.2138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.007 0.0112
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0637 0.1306
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0198 0.0316
Loa Loa (eye worm) tubulin beta-4 chain 0.0776 0.6251 0.6944
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Schistosoma mansoni neurotransmitter gated ion channel 0.01 0.0693 0.0693
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.0563 0.0864
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.004
Trypanosoma brucei alpha tubulin, putative 0.0236 0.1807 0.2891
Loa Loa (eye worm) LGC-31 protein 0.0195 0.1469 0.1632
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0195 0.1469 0.1469
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0156 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2039 0.3235
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0025
Echinococcus granulosus tubulin alpha 3 chain 0.0578 0.462 0.462
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0195 0.1469 0.1469
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0637 0.0984
Brugia malayi Cell division protein ftsZ 0.0181 0.1356 0.2169
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1292 0.2036
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0049 0.0268 0.1812
Loa Loa (eye worm) acetyltransferase 0.0313 0.2445 0.2716
Schistosoma mansoni alpha tubulin 0.0578 0.462 0.462
Echinococcus multilocularis Tubulin alpha 1 chain 0.0578 0.462 0.462
Echinococcus multilocularis Tubulin beta 2C chain 0.0776 0.6251 0.6251
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0551 0.0882
Echinococcus multilocularis tubulin alpha chain 0.0578 0.462 0.462
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0162 0.0221
Trypanosoma brucei alpha tubulin 0.0578 0.462 0.7391
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0181 0.1356 0.2169
Leishmania major beta tubulin 0.0776 0.6251 1
Giardia lamblia Beta tubulin 0.0776 0.6251 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Plasmodium vivax SET domain protein, putative 0.006 0.0363 0.0581
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0198 0.0316
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0049 0.0268 0.0678
Toxoplasma gondii beta-1 tubulin, putative 0.0776 0.6251 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0049 0.0268 0.0678
Plasmodium vivax glutathione reductase, putative 0.0101 0.0698 0.1117
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0156 0.0249
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0156 0.0249
Loa Loa (eye worm) beta-lactamase 0.0078 0.0506 0.0562
Echinococcus multilocularis tubulin alpha 1C chain 0.0578 0.462 0.462
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0049 0.0268 0.0678
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.023 0.1762 0.8761
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0195 0.1469 0.1469
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0027 0.0004
Onchocerca volvulus 0.006 0.0363 0.0552
Loa Loa (eye worm) beta-tubulin 0.0776 0.6251 0.6944
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0318 0.0508
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1369 0.2159
Loa Loa (eye worm) hypothetical protein 0.0351 0.2752 0.3057
Schistosoma mansoni DNA helicase recq5 0.0019 0.0024 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1292 0.2036
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.01 0.0693 0.1108
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0276 0.0403
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.0025
Echinococcus granulosus dna polymerase kappa 0.0019 0.0027 0.0027
Giardia lamblia Beta tubulin 0.0776 0.6251 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0027 0.0027
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0167 0.0167
Trichomonas vaginalis tubulin epsilon chain, putative 0.0578 0.462 0.7381
Schistosoma mansoni nAChR subunit 0.0195 0.1469 0.1469
Echinococcus multilocularis tubulin alpha chain 0.0578 0.462 0.462
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.0626 0.1001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0025 0.0028
Schistosoma mansoni nAChR subunit 0.0195 0.1469 0.1469
Trichomonas vaginalis tubulin beta chain, putative 0.0776 0.6251 1
Loa Loa (eye worm) GABA receptor subunit 0.01 0.0693 0.0769
Toxoplasma gondii LsmAD domain-containing protein 0.0083 0.0551 0.0882
Onchocerca volvulus 0.01 0.0693 0.1458
Loa Loa (eye worm) tubulin alpha chain 0.0578 0.462 0.5132
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0027 0.0003
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.004
Leishmania major beta tubulin 0.0776 0.6251 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0198 0.0198
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0198 0.0278
Leishmania major beta tubulin 0.0776 0.6251 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0025 0.0025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0156 0.0249
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0256 0.1973 1
Loa Loa (eye worm) cytochrome P450 0.0049 0.0268 0.0297
Brugia malayi hypothetical protein 0.0094 0.0645 0.1031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0192 0.0214
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Trichomonas vaginalis tubulin, putative 0.0236 0.1807 0.2862
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0043
Toxoplasma gondii beta tubulin 0.0776 0.6251 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0049 0.0268 0.0678
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0085 0.0567 0.063
Loa Loa (eye worm) ACC-1 protein 0.0195 0.1469 0.1632
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0049 0.0268 0.1812
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0506 0.1283
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0162 0.026
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0195 0.1469 0.2351
Echinococcus multilocularis tubulin subunit beta 0.0776 0.6251 0.6251
Trypanosoma brucei glucosidase, putative 0.0036 0.0162 0.026
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0181 0.1356 0.2138
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0195 0.1469 0.1469
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0363 0.0581
Onchocerca volvulus 0.0195 0.1469 0.3594
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.023 0.1762 0.4465
Plasmodium vivax tubulin gamma chain, putative 0.0417 0.3295 0.5271
Trichomonas vaginalis tubulin beta chain, putative 0.0578 0.462 0.7381
Brugia malayi hypothetical protein 0.0041 0.0205 0.0328
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0124 0.0198
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0506 0.3608
Loa Loa (eye worm) hypothetical protein 0.0578 0.462 0.5132
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0156 0.0249
Loa Loa (eye worm) hypothetical protein 0.0397 0.3132 0.348
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0397 0.3132 0.4991
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0506 0.081
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0025
Plasmodium vivax ataxin-2 like protein, putative 0.0083 0.0551 0.0882
Entamoeba histolytica recQ family helicase, putative 0.0025 0.007 0.0073
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0506 0.0506
Leishmania major beta tubulin 0.0776 0.6251 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0049 0.0268 0.1812
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0027 0.0003
Trichomonas vaginalis tubulin, putative 0.0236 0.1807 0.2862
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0242 0.0269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0028
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0162 0.0221
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0363 0.0363
Leishmania major DNA polymerase eta, putative 0.0019 0.0027 0.0043
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.01 0.0693 0.1108
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0027 0.0027
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0025 0.0025
Brugia malayi intermediate filament protein 0.0085 0.0567 0.0907
Loa Loa (eye worm) thioredoxin reductase 0.0101 0.0698 0.0776
Schistosoma mansoni nAChR subunit 0.0094 0.0645 0.0645
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0025 0.0025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.1469 0.2351
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1356 0.2138
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0049 0.0268 0.0428
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0195 0.1469 0.1469
Brugia malayi acetyltransferase, GNAT family protein 0.0313 0.2445 0.3911
Leishmania major hypothetical protein, conserved 0.0083 0.0551 0.0882
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0162 0.0221
Onchocerca volvulus 0.0195 0.1469 0.3594
Onchocerca volvulus Putative nachr subunit 0.0195 0.1469 0.3594
Plasmodium falciparum alpha tubulin 1 0.0578 0.462 0.7391
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0049 0.0268 0.1812
Mycobacterium tuberculosis Conserved protein 0.0078 0.0506 0.1283
Trichomonas vaginalis tubulin, putative 0.0776 0.6251 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Brugia malayi Thioredoxin reductase 0.0101 0.0698 0.1117
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1292 0.2036
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0086 0.0577 0.4139
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0038
Brugia malayi hypothetical protein 0.0172 0.1284 0.2055
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.01 0.0693 0.0693
Brugia malayi Cation transporter family protein 0.0195 0.1469 0.2351
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0162 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Mycobacterium leprae cell division protein FtsZ 0.0181 0.1356 0.638
Onchocerca volvulus 0.0094 0.0645 0.1326
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0049 0.0268 0.1812
Echinococcus granulosus peroxisome assembly protein 26 0.0578 0.462 0.462
Trypanosoma brucei tubulin gamma chain 0.0417 0.3295 0.5271
Echinococcus multilocularis Tubulin beta 2C chain 0.0776 0.6251 0.6251
Loa Loa (eye worm) hypothetical protein 0.0133 0.096 0.1067
Echinococcus multilocularis glycine receptor subunit beta 0.0195 0.1469 0.1469
Trypanosoma brucei beta tubulin 0.0776 0.6251 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0162 0.0162
Entamoeba histolytica hypothetical protein 0.0041 0.0205 0.029
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Trichomonas vaginalis tubulin beta chain, putative 0.0578 0.462 0.7381
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0198 0.0278
Brugia malayi beta-lactamase family protein 0.0078 0.0506 0.081
Schistosoma mansoni acetylcholine receptor-related 0.0094 0.0645 0.0645
Entamoeba histolytica tubulin gamma chain 0.0417 0.3295 0.5252
Schistosoma mansoni microtubule-associated protein tau 0.0782 0.6303 0.6303
Leishmania major beta tubulin 0.0776 0.6251 1
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0506 0.3608
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0198 0.0316
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0195 0.1469 0.1469
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0156 0.021
Echinococcus multilocularis Tubulin beta 2C chain 0.0776 0.6251 0.6251
Echinococcus granulosus Tubulin beta 2C chain 0.0776 0.6251 0.6251
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0024 0.0024
Leishmania major beta tubulin 0.0776 0.6251 1
Schistosoma mansoni nAChR subunit 0.0195 0.1469 0.1469
Echinococcus granulosus glycine receptor subunit alpha 1 0.0195 0.1469 0.1469
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0313 0.2445 0.2445
Loa Loa (eye worm) ACC-1 protein 0.0195 0.1469 0.1632
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0174 0.0174
Loa Loa (eye worm) tubulin alpha-3 chain 0.0342 0.2681 0.2979
Onchocerca volvulus 0.0195 0.1469 0.3594
Trichomonas vaginalis tubulin beta chain, putative 0.0578 0.462 0.7381
Trichomonas vaginalis esterase, putative 0.0078 0.0506 0.0773
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0024 0.0024
Onchocerca volvulus 0.0172 0.1284 0.3085
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.0626 0.0626
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0025 0.0025
Brugia malayi hypothetical protein 0.0121 0.0864 0.1383
Echinococcus multilocularis tubulin alpha 3 chain 0.0578 0.462 0.462
Schistosoma mansoni lamin 0.0085 0.0567 0.0567
Giardia lamblia Kinase, PLK 0.0094 0.0637 0.0985
Onchocerca volvulus 0.0085 0.0567 0.1112
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0637 0.102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0094 0.0645 0.0645
Loa Loa (eye worm) tubulin beta-1 chain 0.0776 0.6251 0.6944
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0049 0.0268 0.0428
Echinococcus granulosus tubulin alpha chain 0.0578 0.462 0.462
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0551 0.0882
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0049 0.0268 0.1812
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0049 0.0268 0.0678
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0049 0.0268 0.0678
Plasmodium falciparum alpha tubulin 2 0.0578 0.462 0.7391
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0094 0.0645 0.0716
Echinococcus granulosus thioredoxin glutathione reductase 0.0101 0.0698 0.0698
Plasmodium vivax tubulin alpha chain, putative 0.0578 0.462 0.7391
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0506 0.0773
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0195 0.1469 0.1469
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0156 0.0969
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0637 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0266 0.0266
Brugia malayi tubulin alpha chain - mouse 0.0578 0.462 0.7391
Leishmania major cytochrome p450-like protein 0.0049 0.0268 0.0428
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0506 0.1283
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0024 0.0024
Echinococcus granulosus Tubulin alpha 1 chain 0.0578 0.462 0.462
Echinococcus granulosus Tubulin beta 2C chain 0.0776 0.6251 0.6251
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0049 0.0268 0.0678
Schistosoma mansoni tubulin subunit beta 0.0776 0.6251 0.6251
Trypanosoma cruzi tubulin gamma chain 0.0417 0.3295 0.5271
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0198 0.0351
Plasmodium vivax delta tubulin, putative 0.0181 0.1356 0.2169
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.0626 0.0965
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0506 0.0506
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0506 0.0773
Echinococcus granulosus cytochrome P450 2K1 0.0049 0.0268 0.0268
Brugia malayi follicle stimulating hormone receptor 0.0472 0.3753 0.6003
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0195 0.1469 0.1469
Onchocerca volvulus 0.0085 0.0567 0.1112
Schistosoma mansoni nAChR subunit 0.0195 0.1469 0.1469
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0195 0.1469 0.2351
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0049 0.0268 0.0678
Trypanosoma brucei beta tubulin 0.0776 0.6251 1
Loa Loa (eye worm) tubulin alpha 2 0.0161 0.1193 0.1326
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0178 0.0178
Echinococcus multilocularis tubulin alpha chain 0.0578 0.462 0.462
Schistosoma mansoni calcium-activated potassium channel 0.0281 0.2178 0.2178
Echinococcus granulosus intermediate filament protein 0.0085 0.0567 0.0567
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0025 0.004
Brugia malayi Cytochrome P450 family protein 0.0086 0.0577 0.0923
Trichomonas vaginalis tubulin alpha chain, putative 0.0417 0.3295 0.5252
Plasmodium falciparum tubulin gamma chain 0.0417 0.3295 0.5271
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0049 0.0268 0.0678
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0025
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0049 0.0268 0.0678
Mycobacterium tuberculosis Conserved protein 0.0078 0.0506 0.1283
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0195 0.1469 0.1469
Loa Loa (eye worm) acetylcholine receptor protein 0.0094 0.0645 0.0716
Plasmodium falciparum thioredoxin reductase 0.0035 0.0156 0.0249
Loa Loa (eye worm) BEN-1 protein 0.0776 0.6251 0.6944
Brugia malayi hypothetical protein 0.0162 0.1204 0.1926
Trichomonas vaginalis tubulin gamma chain, putative 0.0181 0.1356 0.2138
Trypanosoma cruzi tubulin delta chain 0.0181 0.1356 0.2169
Echinococcus granulosus nAChR subunit 0.01 0.0693 0.0693
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0156 0.0249
Echinococcus granulosus beta tubulin 0.0776 0.6251 0.6251
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Schistosoma mansoni cytochrome P450 0.0049 0.0268 0.0268
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0195 0.1469 0.1632
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0506 0.081
Giardia lamblia Gamma tubulin 0.0417 0.3295 0.5253
Echinococcus granulosus tubulin epsilon chain 0.0417 0.3295 0.3295
Schistosoma mansoni hypothetical protein 0.0055 0.0318 0.0318
Echinococcus granulosus tubulin delta chain 0.0181 0.1356 0.1356
Schistosoma mansoni DNA helicase recq1 0.0019 0.0024 0.0024
Schistosoma mansoni tubulin subunit delta 0.0181 0.1356 0.1356
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0049 0.0268 0.1812
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0319 0.0319
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0162 0.0221
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0178 0.0178
Loa Loa (eye worm) CYP4Cod1 0.0086 0.0577 0.0641
Echinococcus multilocularis tubulin subunit TubB 0.0578 0.462 0.462
Echinococcus multilocularis tubulin gamma 1 chain 0.0417 0.3295 0.3295
Trichomonas vaginalis tubulin gamma chain, putative 0.0417 0.3295 0.5252
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0637 0.0637
Toxoplasma gondii thioredoxin reductase 0.0101 0.0698 0.1117
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0698 0.1117
Plasmodium vivax tubulin epsilon chain, putative 0.0417 0.3295 0.5271
Echinococcus multilocularis tubulin delta chain 0.0181 0.1356 0.1356
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0156 0.0249
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0472 0.3753 0.4169
Trichomonas vaginalis tubulin gamma chain, putative 0.0776 0.6251 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0205 0.0205
Echinococcus granulosus Tubulin alpha 1 chain 0.0578 0.462 0.462
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0506 0.0773
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0195 0.1469 0.2351
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0049 0.0268 0.1812
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0256 0.1973 0.5
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.2039 0.3261
Echinococcus granulosus tumor protein p63 0.0375 0.2953 0.2953
Mycobacterium tuberculosis Probable oxidoreductase 0.0256 0.1973 0.5
Toxoplasma gondii alpha tubulin TUBA1 0.0578 0.462 0.7391
Entamoeba histolytica tubulin family protein 0.0776 0.6251 1
Brugia malayi hypothetical protein 0.0094 0.0645 0.1031
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0024 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2039 0.3235
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0506 0.081
Loa Loa (eye worm) hypothetical protein 0.0172 0.1284 0.1427
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0198 0.0316
Toxoplasma gondii exonuclease III APE 0.004 0.0198 0.0316
Loa Loa (eye worm) RecQ helicase 0.0046 0.0246 0.0274
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0025
Brugia malayi Tubulin gamma chain 0.0417 0.3295 0.5271
Leishmania major DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0156 0.0156
Brugia malayi Cytochrome P450 family protein 0.0086 0.0577 0.0923
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0094 0.0645 0.1031
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0024 0.0038
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0025
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0195 0.1469 0.1469
Schistosoma mansoni tubulin subunit alpha 0.0578 0.462 0.462
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0156 0.0249
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0049 0.0268 0.1812
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.01 0.0693 0.1108
Loa Loa (eye worm) cytochrome P450 family protein 0.0086 0.0577 0.0641
Onchocerca volvulus 0.0055 0.0318 0.0426
Echinococcus granulosus tubulin alpha chain 0.0578 0.462 0.462
Onchocerca volvulus 0.0195 0.1469 0.3594
Schistosoma mansoni hypothetical protein 0.0041 0.0205 0.0205
Leishmania major beta tubulin 0.0776 0.6251 1
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0156 0.0249
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Trichomonas vaginalis tubulin epsilon chain, putative 0.0578 0.462 0.7381
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0027 0.0043
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0162 0.0221
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0156 0.0249
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0195 0.1469 0.1469
Brugia malayi Pre-SET motif family protein 0.006 0.0363 0.0581
Trichomonas vaginalis tubulin gamma chain, putative 0.0417 0.3295 0.5252
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0363 0.0363
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0637 0.0984
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0195 0.1469 0.1469
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0637 0.0637
Mycobacterium tuberculosis Conserved protein 0.0078 0.0506 0.1283
Trypanosoma brucei epsilon tubulin 0.0417 0.3295 0.5271
Onchocerca volvulus 0.0078 0.0506 0.0945
Trichomonas vaginalis tubulin alpha chain, putative 0.0236 0.1807 0.2862
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0637 0.0984
Echinococcus multilocularis tubulin alpha chain 0.0578 0.462 0.462
Schistosoma mansoni kinase 0.0048 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0055 0.0324 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2039 0.3235
Echinococcus multilocularis Tubulin alpha 1 chain 0.0578 0.462 0.462
Mycobacterium tuberculosis Probable reductase 0.023 0.1762 0.4465
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Echinococcus granulosus tubulin alpha 1C chain 0.0578 0.462 0.462
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0198 0.0278
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0567 0.0907
Brugia malayi beta-lactamase family protein 0.0078 0.0506 0.081
Echinococcus multilocularis expressed protein 0.0371 0.2924 0.2924
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1292 0.2036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0506 0.081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0205 0.0205
Echinococcus multilocularis tubulin alpha chain 0.0578 0.462 0.462
Leishmania major cytochrome p450-like protein 0.0086 0.0577 0.0923
Loa Loa (eye worm) tubulin gamma chain 0.0417 0.3295 0.366
Trypanosoma brucei alpha tubulin 0.0578 0.462 0.7391
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Treponema pallidum cell division protein FtsZ 0.0181 0.1356 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0506 0.0506
Echinococcus multilocularis tubulin alpha 3 chain 0.0578 0.462 0.462
Echinococcus granulosus small conductance calcium activated potassium 0.0351 0.2752 0.2752
Leishmania major beta tubulin 0.0776 0.6251 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0024 0.0027
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0049 0.0268 0.1812
Loa Loa (eye worm) cytochrome P450 family protein 0.0169 0.1259 0.1398
Giardia lamblia Delta tubulin 0.0181 0.1356 0.2139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0496 0.3947 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0637 0.102
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0181 0.1356 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0027 0.003
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0094 0.0645 0.1031
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0156 0.0394
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0195 0.1469 0.1469
Plasmodium falciparum tubulin beta chain 0.0776 0.6251 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0776 0.6251 0.6251
Loa Loa (eye worm) tubulin alpha-2 chain 0.0578 0.462 0.5132
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0079 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.0083 0.0551 0.0882
Brugia malayi alpha-tubulin 0.0578 0.462 0.7391
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.0626 0.1001
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Schistosoma mansoni alpha glucosidase 0.0036 0.0162 0.0162
Brugia malayi hypothetical protein 0.0094 0.0645 0.1031
Trypanosoma brucei beta tubulin 0.0776 0.6251 1
Loa Loa (eye worm) alpha-tubulin 0.0578 0.462 0.5132
Onchocerca volvulus 0.0055 0.0319 0.0431
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0027 0.0043
Schistosoma mansoni acetylcholine receptor subunit beta 0.0094 0.0645 0.0645
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0025 0.004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Schistosoma mansoni ap endonuclease 0.004 0.0198 0.0198
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0049 0.0268 0.1812
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0025
Echinococcus granulosus bloom syndrome protein 0.0046 0.0246 0.0246
Loa Loa (eye worm) cytochrome P450 family protein 0.0086 0.0577 0.0641
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0027 0.0043
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.023 0.1762 0.4465
Echinococcus multilocularis microtubule associated protein 2 0.0782 0.6303 0.6303
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0101 0.0698 0.1769
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0679 0.5457 0.873
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0049 0.0268 0.1812
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0637 0.102
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0156 0.0969
Entamoeba histolytica hypothetical protein 0.0041 0.0205 0.029
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.2073 0.2073
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.1292 0.3107
Loa Loa (eye worm) hypothetical protein 0.0055 0.0319 0.0355
Plasmodium vivax thioredoxin reductase, putative 0.0101 0.0698 0.1117
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0506 0.0506
Mycobacterium tuberculosis Cell division protein FtsZ 0.0181 0.1356 0.3435
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0679 0.5457 0.6062
Trichomonas vaginalis set domain proteins, putative 0.0478 0.3798 0.6061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0198 0.0316
Mycobacterium tuberculosis Probable dehydrogenase 0.023 0.1762 0.4465
Onchocerca volvulus 0.0078 0.0506 0.0945
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Onchocerca volvulus 0.0078 0.0506 0.0945
Trypanosoma cruzi cytochrome P450, putative 0.0086 0.0577 0.0923
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0473 0.0526
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0195 0.1469 0.1469
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0198 0.0279
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0049 0.0268 0.1812
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0163 0.0163
Brugia malayi Tubulin alpha-2 chain 0.0578 0.462 0.7391
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0049 0.0268 0.0678
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0195 0.1469 0.2351
Giardia lamblia Alpha-tubulin 0.0578 0.462 0.7381
Trypanosoma brucei unspecified product 0.0019 0.0027 0.0043
Loa Loa (eye worm) hypothetical protein 0.0268 0.2073 0.2303
Loa Loa (eye worm) hypothetical protein 0.006 0.0363 0.0403
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.2073 0.2073
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0417 0.3295 0.5271
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0195 0.1469 0.1469
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Schistosoma mansoni lamin 0.0085 0.0567 0.0567
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0205 0.0205
Echinococcus multilocularis tubulin alpha 0.0417 0.3295 0.3295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0028
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0195 0.1469 0.1469
Loa Loa (eye worm) hypothetical protein 0.0037 0.017 0.0188
Trichomonas vaginalis tubulin alpha chain, putative 0.0236 0.1807 0.2862
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0028
Trypanosoma brucei alpha tubulin 0.0578 0.462 0.7391
Plasmodium falciparum thioredoxin reductase 0.0101 0.0698 0.1117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.3321 0.3689
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0578 0.462 0.7381
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0049 0.0268 0.1812
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0205 0.0205
Echinococcus granulosus tubulin subunit beta 0.0776 0.6251 0.6251
Trichomonas vaginalis tubulin beta chain, putative 0.0578 0.462 0.7381
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0206 0.0206
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0195 0.1469 0.1469
Trichomonas vaginalis tubulin epsilon chain, putative 0.0181 0.1356 0.2138
Trypanosoma cruzi epsilon tubulin, putative 0.0417 0.3295 0.5271
Trypanosoma brucei alpha tubulin 0.0578 0.462 0.7391
Echinococcus granulosus glycine receptor subunit beta 0.0195 0.1469 0.1469
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Schistosoma mansoni tubulin subunit beta 0.0776 0.6251 0.6251
Echinococcus granulosus Tubulin beta 2C chain 0.0776 0.6251 0.6251
Loa Loa (eye worm) hypothetical protein 0.0585 0.468 0.5199
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0156 0.0249
Schistosoma mansoni nAChR subunit 0.0195 0.1469 0.1469
Leishmania major beta tubulin 0.0776 0.6251 1
Onchocerca volvulus 0.0195 0.1469 0.3594
Echinococcus multilocularis beta tubulin 0.0776 0.6251 0.6251
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0178 0.0198
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0195 0.1469 0.2351
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0121 0.0193
Leishmania major protein kinase, putative 0.0018 0.0015 0.0024
Schistosoma mansoni tubulin subunit alpha 0.0578 0.462 0.462
Trypanosoma cruzi zeta tubulin, putative 0.0181 0.1356 0.2169
Loa Loa (eye worm) tubulin alpha 2 0.0397 0.3132 0.348
Echinococcus granulosus tubulin alpha chain 0.0578 0.462 0.462
Echinococcus multilocularis nAChR subunit 0.01 0.0693 0.0693
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1195 0.1195
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0156 0.0969
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0156 0.0249
Mycobacterium ulcerans hypothetical protein 0.0078 0.0506 0.3608
Echinococcus granulosus tubulin alpha chain 0.0578 0.462 0.462
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0313 0.2445 0.2445
Leishmania major cytochrome p450-like protein 0.0049 0.0268 0.0428
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0195 0.1469 0.2351
Trypanosoma brucei beta tubulin 0.0417 0.3295 0.5271
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0637 0.0708
Leishmania major trypanothione reductase 0.0101 0.0698 0.1117
Brugia malayi hypothetical protein 0.0083 0.0551 0.0882
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0637 0.0984
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0049 0.0268 0.1812
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0198 0.0501
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0473 0.0473
Trypanosoma brucei zeta tubulin 0.0181 0.1356 0.2169
Echinococcus granulosus single minded 2 0.0039 0.0191 0.0191
Toxoplasma gondii beta-tubulin, putative 0.0776 0.6251 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0192 0.0214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0198 0.0316
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0551 0.0882
Leishmania major beta tubulin 0.0776 0.6251 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0025
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.023 0.1762 0.4465
Schistosoma mansoni nAChR subunit 0.0094 0.0645 0.0645
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1292 0.2036
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.007 0.0112
Onchocerca volvulus 0.0093 0.0635 0.1301
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0506 0.0562
Brugia malayi Ets-domain containing protein 0.0074 0.0473 0.0757
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0195 0.1469 0.1469
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0506 0.0773
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0025
Leishmania major beta tubulin 0.0776 0.6251 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0049 0.0268 0.1812
Giardia lamblia Beta tubulin 0.0776 0.6251 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0156 0.5
Echinococcus multilocularis beta tubulin 0.0776 0.6251 0.6251
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0049 0.0268 0.1812
Trypanosoma cruzi cytochrome P450, putative 0.0086 0.0577 0.0923
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0025
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0397 0.3132 0.348
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0637 0.0984
Onchocerca volvulus 0.0094 0.0645 0.1326
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0198 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0162 0.026
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0242 0.0388
Brugia malayi hypothetical protein 0.0054 0.0309 0.0494
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0037 0.0174 0.0174
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0506 0.1283
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0043
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0195 0.1469 0.1632
Loa Loa (eye worm) glutathione reductase 0.0101 0.0698 0.0776
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0094 0.0645 0.1031
Brugia malayi Cation transporter family protein 0.0195 0.1469 0.2351
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0195 0.1469 0.2351
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0506 0.1283
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0027 0.003
Leishmania major beta tubulin 0.0776 0.6251 1
Brugia malayi Pre-SET motif family protein 0.042 0.3321 0.5313
Loa Loa (eye worm) hypothetical protein 0.0078 0.0506 0.0562
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0049 0.0268 0.0678
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0195 0.1469 0.1632
Echinococcus granulosus tubulin beta 1 chain 0.0776 0.6251 0.6251
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0027 0.0027
Trypanosoma cruzi alpha tubulin, putative 0.0578 0.462 0.7391
Entamoeba histolytica tubulin family protein 0.0776 0.6251 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.01 0.0693 0.1108
Trichomonas vaginalis tubulin beta chain, putative 0.0578 0.462 0.7381
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Brugia malayi excitatory GABA receptor EXP-1A 0.0195 0.1469 0.2351
Leishmania major beta tubulin 0.0776 0.6251 1
Brugia malayi hypothetical protein 0.0094 0.0645 0.1031
Loa Loa (eye worm) tubulin beta chain 0.0181 0.1356 0.1506
Schistosoma mansoni gabp alpha 0.0074 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0078 0.0506 0.0562
Brugia malayi MH2 domain containing protein 0.0121 0.0866 0.1386
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0198 0.022
Onchocerca volvulus 0.0195 0.1469 0.3594
Schistosoma mansoni nAChR subunit 0.0195 0.1469 0.1469
Echinococcus granulosus tubulin alpha 3 chain 0.0578 0.462 0.462
Echinococcus multilocularis Tubulin beta 2C chain 0.0776 0.6251 0.6251
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1195 0.1195
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0049 0.0268 0.0678
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.007 0.0073
Schistosoma mansoni neurotransmitter gated ion channel 0.0094 0.0645 0.0645
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0246 0.0394
Brugia malayi glutathione reductase 0.0101 0.0698 0.1117
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0776 0.6251 0.6251
Schistosoma mansoni hypothetical protein 0.0049 0.0268 0.0268
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0094 0.0645 0.0645
Entamoeba histolytica hypothetical protein 0.01 0.0693 0.1073
Brugia malayi hypothetical protein 0.0019 0.0025 0.004
Echinococcus granulosus microtubule associated protein 2 0.0782 0.6303 0.6303
Loa Loa (eye worm) hypothetical protein 0.0316 0.2465 0.2738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Brugia malayi beta-tubulin, identical 0.0776 0.6251 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0554 0.0615
Trichomonas vaginalis tubulin beta chain, putative 0.0578 0.462 0.7381
Brugia malayi Cytochrome P450 family protein 0.0049 0.0268 0.0428
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0027 0.0004
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0156 0.0249
Loa Loa (eye worm) hypothetical protein 0.0078 0.0506 0.0562
Brugia malayi beta-lactamase 0.0078 0.0506 0.081
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0162 0.0221
Trypanosoma brucei zeta tubulin, putative 0.0181 0.1356 0.2169
Loa Loa (eye worm) BEN-1 protein 0.0776 0.6251 0.6944
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0473 0.0473
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0027 0.0068
Plasmodium falciparum tubulin delta chain, putative 0.0181 0.1356 0.2169
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0027 0.0027
Brugia malayi Tubulin beta chain 0.0181 0.1356 0.2169
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0049 0.0268 0.0678
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0094 0.0645 0.0716
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0506 0.1283
Schistosoma mansoni calcium-activated potassium channel 0.0351 0.2752 0.2752
Echinococcus granulosus lamin dm0 0.0085 0.0567 0.0567
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0027 0.0003
Leishmania major beta tubulin 0.0776 0.6251 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0195 0.1469 0.1632
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.11 0.1222
Leishmania major beta tubulin 0.0776 0.6251 1
Echinococcus multilocularis hypothetical protein 0.0578 0.462 0.462
Echinococcus granulosus tubulin alpha chain 0.0578 0.462 0.462
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0162 0.0221
Entamoeba histolytica tubulin alpha-1 chain 0.0578 0.462 0.7381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Echinococcus multilocularis Tubulin alpha 1 chain 0.0578 0.462 0.462
Brugia malayi Cation transporter family protein 0.0195 0.1469 0.2351
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0049 0.0268 0.0678
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0195 0.1469 0.2351
Schistosoma mansoni ap endonuclease 0.004 0.0198 0.0198
Schistosoma mansoni single-minded 0.0048 0.0266 0.0266
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0181 0.1356 0.2169
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Giardia lamblia Epsilon tubulin 0.0181 0.1356 0.2139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0156 0.0156
Mycobacterium ulcerans cell division protein FtsZ 0.0181 0.1356 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0043
Mycobacterium ulcerans lipase LipD 0.0078 0.0506 0.3608
Loa Loa (eye worm) hypothetical protein 0.0078 0.0506 0.0562
Trypanosoma cruzi epsilon tubulin, putative 0.0417 0.3295 0.5271
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0027
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0027 0.0044
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0195 0.1469 0.1632
Plasmodium falciparum glutathione reductase 0.0035 0.0156 0.0249
Trypanosoma brucei polo-like protein kinase 0.0094 0.0637 0.102
Loa Loa (eye worm) hypothetical protein 0.0342 0.2681 0.2979
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.0626 0.0965
Echinococcus multilocularis lamin 0.0085 0.0567 0.0567
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0206 0.0206
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0094 0.0645 0.0645
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0205 0.0205
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0567 0.063
Echinococcus multilocularis lamin dm0 0.0085 0.0567 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0027 0.003
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0049 0.0268 0.0678
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.0626 0.1001
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0249 0.036
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0506 0.081
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Trichomonas vaginalis tubulin, putative 0.0181 0.1356 0.2138
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.1469 0.2351
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.003
Brugia malayi Tubulin alpha chain 0.0578 0.462 0.7391
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0025
Leishmania major alpha tubulin 0.0578 0.462 0.7391
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0156 0.0249
Schistosoma mansoni intermediate filament proteins 0.0085 0.0567 0.0567
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0249 0.036
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.02 0.032
Schistosoma mansoni tubulin subunit beta 0.0776 0.6251 0.6251
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0094 0.0645 0.1031
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Brugia malayi Tubulin beta chain 0.0236 0.1807 0.2891
Leishmania major beta tubulin 0.0776 0.6251 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0776 0.6251 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0024 0.0024
Echinococcus granulosus Tubulin alpha 1 chain 0.0578 0.462 0.462
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0156 0.0249
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0094 0.0645 0.0645
Loa Loa (eye worm) fli-1 protein 0.0224 0.1706 0.1896
Toxoplasma gondii cytochrome p450 superfamily protein 0.0049 0.0268 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0637 0.0984
Echinococcus granulosus glycine receptor subunit alpha 1 0.0195 0.1469 0.1469
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1195 0.1195
Brugia malayi hypothetical protein 0.0268 0.2073 0.3317
Trypanosoma brucei beta tubulin 0.0776 0.6251 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0342 0.2681 0.4267
Schistosoma mansoni tubulin subunit gamma 0.0417 0.3295 0.3295
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.1469 0.2351
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0174 0.0174
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0156 0.0211
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0049 0.0268 0.1812
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0276 0.0403
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1195 0.1912
Loa Loa (eye worm) hypothetical protein 0.0148 0.1085 0.1205
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0094 0.0645 0.1031
Schistosoma mansoni tubulin subunit beta 0.0776 0.6251 0.6251
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0506 0.0773
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0829 0.6684 0.6684
Leishmania major zeta tubulin, putative 0.0181 0.1356 0.2169
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0345 0.0345
Echinococcus granulosus Tubulin beta 2C chain 0.0776 0.6251 0.6251
Trichomonas vaginalis tubulin beta chain, putative 0.0236 0.1807 0.2862
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.1469 0.2351
Trypanosoma brucei tubulin delta chain 0.0181 0.1356 0.2169
Plasmodium vivax tubulin alpha chain, putative 0.0578 0.462 0.7391
Brugia malayi Tubulin beta-1 chain 0.0776 0.6251 1
Giardia lamblia Alpha-tubulin 0.0578 0.462 0.7381
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0162 0.0162
Onchocerca volvulus 0.0094 0.0645 0.1326
Schistosoma mansoni tubulin subunit epsilon 0.0417 0.3295 0.3295
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0195 0.1469 0.1469
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2039 0.3235
Echinococcus granulosus expressed protein 0.0371 0.2924 0.2924
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0195 0.1469 0.1469
Trichomonas vaginalis tubulin epsilon chain, putative 0.0776 0.6251 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0551 0.0612
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0049 0.0268 0.0678
Brugia malayi Tubulin alpha-2 chain 0.0578 0.462 0.7391
Onchocerca volvulus 0.0478 0.3798 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0506 0.0562
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.004
Schistosoma mansoni tubulin subunit beta 0.0776 0.6251 0.6251
Echinococcus granulosus tubulin alpha 1C chain 0.0578 0.462 0.462
Trypanosoma cruzi beta tubulin, putative 0.0776 0.6251 1
Brugia malayi hypothetical protein 0.0019 0.0025 0.004
Echinococcus granulosus tubulin beta 4A class IVa 0.0776 0.6251 0.6251
Echinococcus multilocularis tubulin alpha 1C chain 0.0578 0.462 0.462
Schistosoma mansoni survival motor neuron protein 0.0055 0.0318 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0027 0.0043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.01 0.0693 0.0693
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0049 0.0268 0.0428
Echinococcus multilocularis tumor protein p63 0.0375 0.2953 0.2953
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0163 0.026
Onchocerca volvulus 0.0236 0.1807 0.4523
Loa Loa (eye worm) hypothetical protein 0.0038 0.0177 0.0197
Plasmodium vivax tubulin beta chain, putative 0.0776 0.6251 1
Echinococcus granulosus alpha tubulin 0.0578 0.462 0.462
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0195 0.1469 0.1469
Schistosoma mansoni tubulin subunit beta 0.0776 0.6251 0.6251
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0162 0.0221
Leishmania major beta tubulin 0.0776 0.6251 1
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.0716
Echinococcus granulosus tubulin alpha 0.0417 0.3295 0.3295
Entamoeba histolytica tubulin alpha chain, putative 0.0578 0.462 0.7381
Onchocerca volvulus 0.01 0.0693 0.1458
Echinococcus multilocularis glycine receptor subunit beta 0.0195 0.1469 0.1469
Giardia lamblia DINP protein human, muc B family 0.0019 0.0027 0.0004
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0025 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2039 0.3235
Loa Loa (eye worm) alpha-tubulin 0.0578 0.462 0.5132
Brugia malayi hypothetical protein 0.0094 0.0645 0.1031
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0162 0.026
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0363 0.0363
Echinococcus multilocularis tubulin beta 1 chain 0.0776 0.6251 0.6251
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0363 0.0363
Trypanosoma brucei cytochrome P450, putative 0.0086 0.0577 0.0923
Brugia malayi PAS domain containing protein 0.0048 0.0266 0.0426
Schistosoma mansoni ets-related 0.0224 0.1706 0.1706
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0178 0.0285
Echinococcus multilocularis small conductance calcium activated potassium 0.0351 0.2752 0.2752
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0162 0.026
Echinococcus granulosus beta tubulin 0.0776 0.6251 0.6251
Echinococcus multilocularis tubulin epsilon chain 0.0417 0.3295 0.3295
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0027 0.0043
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0094 0.0645 0.1031
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0025
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.2039 0.2265
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0246 0.0356
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0195 0.1469 0.1469
Schistosoma mansoni hypothetical protein 0.0351 0.2752 0.2752
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.0563 0.0865
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0049 0.0268 0.0678
Schistosoma mansoni tubulin subunit alpha 0.0578 0.462 0.462
Loa Loa (eye worm) hypothetical protein 0.01 0.0693 0.0769
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0025 0.004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0195 0.1469 0.1632
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0025 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0162 0.0221
Echinococcus granulosus histone acetyltransferase KAT2B 0.0304 0.2372 0.2372
Loa Loa (eye worm) hypothetical protein 0.0041 0.0205 0.0228
Trypanosoma cruzi zeta tubulin, putative 0.0181 0.1356 0.2169
Loa Loa (eye worm) tubulin alpha chain 0.0578 0.462 0.5132
Brugia malayi Tubulin alpha chain 0.0181 0.1356 0.2169
Loa Loa (eye worm) tubulin beta-2A chain 0.0776 0.6251 0.6944
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0094 0.0645 0.0645
Mycobacterium leprae Probable lipase LipE 0.0078 0.0506 0.1399
Trichomonas vaginalis tubulin alpha chain, putative 0.0236 0.1807 0.2862
Brugia malayi tubulin alpha-2 chain 0.0578 0.462 0.7391
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0162 0.0221
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0027 0.0027
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0195 0.1469 0.1469
Toxoplasma gondii ABC1 family protein 0.0078 0.0506 0.081
Echinococcus granulosus lamin 0.0085 0.0567 0.0567
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.007 0.0112
Echinococcus multilocularis dna polymerase eta 0.0019 0.0027 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1369 0.2159
Echinococcus granulosus Tubulin beta 2C chain 0.0776 0.6251 0.6251
Brugia malayi Cytochrome P450 family protein 0.0169 0.1259 0.2013
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0049 0.0268 0.1812
Echinococcus granulosus tubulin gamma 1 chain 0.0417 0.3295 0.3295
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0637 0.102
Loa Loa (eye worm) tubulin beta chain 0.0776 0.6251 0.6944
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0163 0.1022
Loa Loa (eye worm) hypothetical protein 0.111 0.9002 1
Echinococcus multilocularis musashi 0.0085 0.0567 0.0567
Schistosoma mansoni tubulin subunit beta 0.0181 0.1356 0.1356
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0198 0.0316

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.5 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by NCCLS method ChEMBL. 22884110
MIC (functional) = 16 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay ChEMBL. 22884110

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.