TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 433.543 | Formula: C26H31N3O3
H donors: 2 H acceptors: 4 LogP: 4.74 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cnn(c1C1CCCC1)c1ccc(cc1)C(=O)O)NC1C2CC3CC1CC(C2)C3
InChi: 1S/C26H31N3O3/c30-25(28-23-19-10-15-9-16(12-19)13-20(23)11-15)22-14-27-29(24(22)17-3-1-2-4-17)21-7-5-18(6-8-21)26(31)32/h5-8,14-17,19-20,23H,1-4,9-13H2,(H,28,30)(H,31,32)
InChiKey: YKRNKUQRDVITDV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxysteroid (11-beta) dehydrogenase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	short chain dehydrogenase	Get druggable targets OG5_132866	All targets in OG5_132866
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_132866	All targets in OG5_132866

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid (11-beta) dehydrogenase 1	292 aa	250 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	T-complex protein 1, beta subunit, putative	0.0026	0.0313	0.0198
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.2673	0.2673
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0184	0.0184
Echinococcus granulosus	heat shock protein	0.002	0.0118	0.0117
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0035	0.0569	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0529	0.0527
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0184	0.0183
Schistosoma mansoni	retinoic acid receptor RXR	0.0118	0.2995	0.2911
Loa Loa (eye worm)	hypothetical protein	0.003	0.0402	0.0402
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0079	0.0079
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0184	0.0183
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0184	0.0183
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0184	0.0184
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0184	0.0183
Echinococcus multilocularis	transfer RNA-Lys	0.0044	0.0819	0.0818
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0562	0.056
Loa Loa (eye worm)	heat shock protein 90	0.002	0.0118	0.0118
Mycobacterium ulcerans	putative regulatory protein	0.0044	0.0819	0.0751
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0079	0.0079
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0026	0.0313	0.0198
Brugia malayi	T-complex protein 1, beta subunit	0.0026	0.0313	0.0313
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0184	0.0184
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0184	0.0184
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.002	0.0118	0.5
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Loa Loa (eye worm)	TOPoisomerase family member	0.002	0.0118	0.0118
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0184	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2815	0.2815
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0184	0.0183
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0184	0.0183
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.1681	0.1681
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0079	0.0079
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0026	0.0313	1
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0026	0.0313	0.4401
Echinococcus granulosus	aryl hydrocarbon receptor	0.0128	0.328	0.3279
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.002	0.0118	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0079	0.0079
Mycobacterium ulcerans	short chain dehydrogenase	0.0338	0.9453	1
Toxoplasma gondii	t-complex protein beta subunit	0.0026	0.0313	0.0297
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.002	0.0118	0.0118
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0026	0.0313	1
Schistosoma mansoni	hypothetical protein	0.0073	0.1681	0.1581
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0079	0.0079
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0079	0.0079
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0128	0.328	0.3279
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0026	0.0313	0.0312
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0184	0.0183
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1005	0.1003
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0313	0.0198
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0184	0.0183
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Trichomonas vaginalis	chaperonin, putative	0.0026	0.0313	1
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0184	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0184	0.0184
Schistosoma mansoni	hypothetical protein	0.0178	0.4759	0.4697
Onchocerca volvulus		0.0022	0.0184	0.0331
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.002	0.0118	0.0117
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1005	0.1003
Brugia malayi	heat shock protein 90	0.002	0.0118	0.0118
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1005	0.1003
Echinococcus granulosus	tumor protein p63	0.0328	0.9169	0.9169
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.002	0.0118	0.5
Entamoeba histolytica	hypothetical protein	0.0035	0.0562	1
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0016	0.0002	0.0002
Echinococcus granulosus	GPCR family 2	0.0034	0.0529	0.0527
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0184	0.0067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0184	0.0184
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0125	0.3194	0.3113
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.002	0.0118	0.0123
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0125	0.3194	0.3113
Brugia malayi	nuclear hormone receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	heat shock protein 90	0.002	0.0118	0.0117
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0118	0.2995	0.2994
Echinococcus granulosus	survival motor neuron protein 1	0.0248	0.6825	0.6825
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0184	0.0067
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0386	0.0386
Echinococcus multilocularis	heat shock protein 90	0.002	0.0118	0.0117
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0529	0.0529
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0184	0.0183
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0184	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2673	0.2673
Echinococcus multilocularis	lamin dm0	0.003	0.0402	0.04
Echinococcus multilocularis	lamin	0.003	0.0402	0.04
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0026	0.0313	0.0312
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0184	0.0184
Echinococcus granulosus	single minded 2	0.0044	0.0819	0.0818
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0529	0.0527
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0529	0.0527
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0946	0.0838
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0184	0.0331
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0184	0.0183
Loa Loa (eye worm)	T-complex protein 1	0.0026	0.0313	0.0313
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0184	0.0184
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0184	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0112	0.283	0.283
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.002	0.0118	0.5
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0026	0.0313	0.0198
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.002	0.0118	0.0123
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0145	0.3776	0.4686
Echinococcus multilocularis	tumor protein p63	0.0328	0.9169	0.9169
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0106	0.2652	0.2651
Loa Loa (eye worm)	hypothetical protein	0.0248	0.6825	0.6825
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.2673	0.2673
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0184	0.0067
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0184	0.0183
Echinococcus multilocularis	heat shock protein	0.002	0.0118	0.0117
Brugia malayi	PAS domain containing protein	0.0059	0.127	0.127
Toxoplasma gondii	heat shock protein HSP90	0.002	0.0118	0.005
Schistosoma mansoni	hypothetical protein	0.0034	0.0529	0.0416
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0402	0.0402
Echinococcus granulosus	lamin	0.003	0.0402	0.04
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.1005	0.1005
Entamoeba histolytica	hypothetical protein	0.0035	0.0562	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0337	0.9418	0.9411
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Brugia malayi	hypothetical protein	0.0035	0.0562	0.0562
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0184	0.0184
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0184	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0079	0.0079
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0184	0.0184
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.1635	0.1634
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0184	0.0067
Schistosoma mansoni	hypothetical protein	0.0178	0.4759	0.4697
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0184	0.0067
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0184	0.0184
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0184	0.0067
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0184	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0079	0.0079
Echinococcus granulosus	lamin dm0	0.003	0.0402	0.04
Brugia malayi	hypothetical protein	0.0248	0.6825	0.6825
Loa Loa (eye worm)	endoplasmin	0.002	0.0118	0.0118
Schistosoma mansoni	hypothetical protein	0.0051	0.1023	0.0916
Schistosoma mansoni	pyruvate dehydrogenase	0.0337	0.9418	0.9411
Schistosoma mansoni	hypothetical protein	0.0035	0.0562	0.0449
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.002	0.0118	0.005
Onchocerca volvulus		0.0051	0.1023	0.2962
Schistosoma mansoni	intermediate filament proteins	0.003	0.0402	0.0287
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0529	0.0527
Schistosoma mansoni	hypothetical protein	0.0034	0.0529	0.0416
Schistosoma mansoni	single-minded	0.0059	0.127	0.1165
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0562	0.056
Schistosoma mansoni	lamin	0.003	0.0402	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0079	0.0079
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0184	0.0183
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0184	0.0184
Schistosoma mansoni	coup transcription factor	0.0022	0.0184	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0184	0.0067
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0112	0.2815	0.2815
Onchocerca volvulus		0.003	0.0402	0.1014
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.797	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1005	0.0897
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.002	0.0118	0.5
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0026	0.0313	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0184	0.0067
Schistosoma mansoni	hypothetical protein	0.0034	0.0529	0.0416
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0184	0.0184
Onchocerca volvulus		0.0044	0.0834	0.237
Toxoplasma gondii	heat shock protein 90, putative	0.002	0.0118	0.005
Echinococcus granulosus	intermediate filament protein	0.003	0.0402	0.04
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0184	0.0184
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0313	0.0198
Schistosoma mansoni	hypothetical protein	0.0034	0.0529	0.0416
Echinococcus multilocularis	musashi	0.003	0.0402	0.04
Mycobacterium leprae	Probable two component sensor kinase MprB	0.002	0.0118	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0184	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Schistosoma mansoni	lamin	0.003	0.0402	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0529	0.0529
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0184	0.0183
Onchocerca volvulus		0.0048	0.0946	0.2721
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0184	0.0184
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.002	0.0118	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1005	0.0897
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0529	0.0529
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0184	0.0184
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0184	0.0183
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.1635	0.1634
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.2673	0.2673
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.002	0.0118	0.0117
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0402	0.0402
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.002	0.0118	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0946	0.0946
Mycobacterium leprae	Probable two-component sensor kinase	0.002	0.0118	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0338	0.9453	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0184	0.0067
Onchocerca volvulus		0.003	0.0402	0.1014
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1005	0.0897
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.002	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1005	0.1003
Onchocerca volvulus		0.0127	0.3265	1
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.797	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0184	0.0184
Schistosoma mansoni	aryl hydrocarbon receptor	0.0171	0.4563	0.4498
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.002	0.0118	0.005
Loa Loa (eye worm)	PAN domain-containing protein	0.0019	0.0079	0.0079
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0529	0.0529
Brugia malayi	intermediate filament protein	0.003	0.0402	0.0402
Brugia malayi	ecdysteroid receptor	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0079	0.0079
Brugia malayi	Endoplasmin precursor	0.002	0.0118	0.0118
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	survival motor neuron protein	0.0051	0.1023	0.0916
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0562	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0184	0.0184
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0402	0.0402
Echinococcus granulosus	geminin	0.0178	0.4759	0.4759
Brugia malayi	steroid hormone receptor	0.0022	0.0184	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0184	0.0184
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.1005	0.1005
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.002	0.0118	0.0118
Toxoplasma gondii	DNA topoisomerase 2, putative	0.002	0.0118	0.005
Loa Loa (eye worm)	hypothetical protein	0.002	0.0118	0.0118
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0313	0.0198
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.1023	0.1023
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0184	0.0184
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0125	0.3194	0.3113
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0125	0.3194	0.3948
Brugia malayi	PAN domain containing protein	0.0019	0.0079	0.0079
Entamoeba histolytica	hypothetical protein	0.0035	0.0562	1
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.002	0.0118	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1681	0.1681
Brugia malayi	bHLH-PAS transcription factor	0.0044	0.0819	0.0819
Entamoeba histolytica	hypothetical protein	0.0035	0.0562	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0248	0.6825	0.6825
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0079	0.0079
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0026	0.0313	1
Loa Loa (eye worm)	hypothetical protein	0.0127	0.3265	0.3265
Brugia malayi	T-complex protein 1, beta subunit	0.0026	0.0313	0.0313
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0529	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0184	0.0184
Brugia malayi	Probable DNA topoisomerase II	0.002	0.0118	0.0118
Echinococcus multilocularis	geminin	0.0178	0.4759	0.4759
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0184	0.0183

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.009 uM	Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assay	ChEMBL.	23088558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2177606

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1722426