Detailed information for compound 1722654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 496.562 | Formula: C31H24N6O
  • H donors: 2 H acceptors: 4 LogP: 5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)NCc1ccc(cc1)n1c(nc2c1ncc(c2)c1ccccc1)c1cccnc1N
  • InChi: 1S/C31H24N6O/c32-28-26(12-7-17-33-28)29-36-27-18-24(22-8-3-1-4-9-22)20-34-30(27)37(29)25-15-13-21(14-16-25)19-35-31(38)23-10-5-2-6-11-23/h1-18,20H,19H2,(H2,32,33)(H,35,38)
  • InChiKey: GBDIQLKYOXQPND-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major alpha tubulin 0.0036 0.8574 1
Loa Loa (eye worm) tubulin alpha 2 0.0028 0.5498 0.5452
Brugia malayi Tubulin alpha-2 chain 0.0036 0.8574 0.856
Brugia malayi tubulin alpha chain - mouse 0.0036 0.8574 0.856
Echinococcus multilocularis tubulin alpha 3 chain 0.0036 0.8574 1
Leishmania major alpha tubulin 0.0036 0.8574 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0025 0.4509 0.3313
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0028 0.5498 0.5498
Entamoeba histolytica tubulin gamma chain 0.0019 0.2495 0.2419
Echinococcus granulosus tubulin alpha chain 0.0036 0.8574 1
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0101 0.0101
Schistosoma mansoni tubulin subunit beta 0.0019 0.2495 0.2825
Trichomonas vaginalis tubulin epsilon chain, putative 0.0019 0.2495 0.2495
Echinococcus granulosus tubulin alpha 1C chain 0.0036 0.8574 1
Trichomonas vaginalis tubulin beta chain, putative 0.0019 0.2495 0.2495
Echinococcus granulosus tubulin subunit TubB 0.0036 0.8574 1
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.4408 0.5083
Schistosoma mansoni alpha tubulin 0.0036 0.8574 1
Trypanosoma brucei alpha tubulin 0.0036 0.8574 0.81
Echinococcus multilocularis Tubulin alpha 1 chain 0.0036 0.8574 1
Trichomonas vaginalis tubulin, putative 0.0019 0.2495 0.2495
Entamoeba histolytica tubulin alpha-1 chain 0.0036 0.8574 0.856
Echinococcus granulosus tubulin alpha chain 0.0036 0.8574 1
Echinococcus multilocularis tubulin alpha chain 0.0036 0.8574 1
Echinococcus granulosus alpha tubulin 0.0036 0.8574 1
Echinococcus multilocularis tubulin alpha chain 0.0036 0.8574 1
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.8574 0.8574
Echinococcus multilocularis Tubulin alpha 1 chain 0.0036 0.8574 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0036 0.8574 0.8574
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.8574 0.8574
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0028 0.5498 0.5452
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.541 0.6266
Echinococcus granulosus beta tubulin 0.0019 0.2495 0.2825
Brugia malayi Tubulin gamma chain 0.0019 0.2495 0.2419
Giardia lamblia Kinase, AGC PKA 0.0025 0.4509 0.3313
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.4408 0.5083
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.541 0.6266
Trichomonas vaginalis tubulin alpha chain, putative 0.0019 0.2495 0.2495
Schistosoma mansoni tubulin subunit alpha 0.0036 0.8574 1
Echinococcus granulosus tubulin gamma 1 chain 0.0019 0.2495 0.2825
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.2495 0.2825
Brugia malayi Tubulin beta-1 chain 0.0019 0.2495 0.2419
Leishmania major alpha tubulin 0.0036 0.8574 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0025 0.4509 0.5203
Toxoplasma gondii alpha-tubulin I, putative 0.0036 0.8574 0.9205
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.4408 0.5083
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.2495 0.2825
Entamoeba histolytica protein kinase, putative 0.0038 0.9099 0.909
Trichomonas vaginalis tubulin epsilon chain, putative 0.0036 0.8574 0.8574
Schistosoma mansoni tubulin subunit alpha 0.0036 0.8574 1
Echinococcus multilocularis tubulin alpha chain 0.0036 0.8574 1
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.8574 0.8574
Leishmania major alpha tubulin 0.0036 0.8574 1
Loa Loa (eye worm) alpha-tubulin 0.0036 0.8574 0.856
Loa Loa (eye worm) tubulin alpha 2 0.0028 0.5498 0.5452
Plasmodium falciparum alpha tubulin 2 0.0036 0.8574 1
Echinococcus multilocularis hypothetical protein 0.0036 0.8574 1
Echinococcus granulosus tubulin alpha 3 chain 0.0036 0.8574 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0036 0.8574 1
Leishmania major alpha tubulin 0.0036 0.8574 1
Loa Loa (eye worm) BEN-1 protein 0.0019 0.2495 0.2419
Brugia malayi p70 ribosomal S6 kinase beta 0.0038 0.9099 0.909
Loa Loa (eye worm) hypothetical protein 0.0025 0.4565 0.451
Plasmodium vivax tubulin alpha chain, putative 0.0036 0.8574 1
Entamoeba histolytica tubulin alpha chain, putative 0.0036 0.8574 0.856
Toxoplasma gondii AGC kinase 0.0038 0.9099 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.541 0.4795
Echinococcus granulosus tubulin alpha 1C chain 0.0036 0.8574 1
Echinococcus granulosus beta tubulin 0.0019 0.2495 0.2825
Schistosoma mansoni tubulin subunit beta 0.0019 0.2495 0.2825
Leishmania major alpha tubulin 0.0036 0.8574 1
Echinococcus granulosus tubulin alpha 3 chain 0.0036 0.8574 1
Echinococcus granulosus tubulin alpha chain 0.0036 0.8574 1
Loa Loa (eye worm) beta-tubulin 0.0019 0.2495 0.2419
Echinococcus multilocularis tubulin alpha 1C chain 0.0036 0.8574 1
Brugia malayi Tubulin alpha-2 chain 0.0036 0.8574 0.856
Brugia malayi alpha-tubulin 0.0036 0.8574 0.856
Echinococcus multilocularis nervana 2 0.0025 0.4408 0.5083
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.4509 0.3313
Echinococcus granulosus tubulin alpha 0.0019 0.2495 0.2825
Schistosoma mansoni tubulin subunit alpha 0.0036 0.8574 1
Loa Loa (eye worm) tubulin beta chain 0.0019 0.2495 0.2419
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.2495 0.2825
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.2495 0.2825
Echinococcus multilocularis tubulin alpha 1C chain 0.0036 0.8574 1
Echinococcus granulosus tubulin alpha chain 0.0036 0.8574 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0019 0.2495 0.2825
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.2495 0.2825
Schistosoma mansoni tubulin subunit beta 0.0019 0.2495 0.2825
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0101 0.0101
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.8574 0.8574
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.2495 0.2825
Trichomonas vaginalis tubulin alpha chain, putative 0.0019 0.2495 0.2495
Echinococcus multilocularis tubulin subunit beta 0.0019 0.2495 0.2825
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.8574 0.8574
Echinococcus multilocularis beta tubulin 0.0019 0.2495 0.2825
Loa Loa (eye worm) tubulin beta-4 chain 0.0019 0.2495 0.2419
Toxoplasma gondii alpha tubulin TUBA1 0.0036 0.8574 0.9205
Echinococcus multilocularis tubulin subunit TubB 0.0036 0.8574 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.541 0.5363
Loa Loa (eye worm) BEN-1 protein 0.0019 0.2495 0.2419
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.2495 0.2825
Echinococcus granulosus tubulin subunit beta 0.0019 0.2495 0.2825
Schistosoma mansoni alpha tubulin 0.0036 0.8574 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.541 0.5363
Brugia malayi beta-tubulin, identical 0.0019 0.2495 0.2419
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.8574 0.8574
Schistosoma mansoni tubulin subunit beta 0.0019 0.2495 0.2825
Loa Loa (eye worm) hypothetical protein 0.0036 0.8574 0.856
Echinococcus multilocularis tubulin alpha chain 0.0036 0.8574 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.5498 0.5452
Entamoeba histolytica tubulin family protein 0.0019 0.2495 0.2419
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.2495 0.2825
Leishmania major alpha tubulin 0.0036 0.8574 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.2495 0.2825
Trypanosoma cruzi Protein kinase B 0.0028 0.541 0.4795
Schistosoma mansoni tubulin subunit beta 0.0019 0.2495 0.2825
Echinococcus granulosus tubulin alpha chain 0.0036 0.8574 1
Echinococcus multilocularis tubulin beta 1 chain 0.0019 0.2495 0.2825
Echinococcus multilocularis tubulin alpha 3 chain 0.0036 0.8574 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0025 0.4509 0.5203
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.2495 0.2495
Echinococcus granulosus Tubulin alpha 1 chain 0.0036 0.8574 1
Trypanosoma cruzi alpha tubulin, putative 0.0036 0.8574 1
Loa Loa (eye worm) tubulin gamma chain 0.0019 0.2495 0.2419
Trichomonas vaginalis tubulin epsilon chain, putative 0.0019 0.2495 0.2495
Leishmania major alpha tubulin 0.0036 0.8574 1
Schistosoma mansoni alpha tubulin 0.0036 0.8574 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.4408 0.5083
Echinococcus multilocularis beta tubulin 0.0019 0.2495 0.2825
Echinococcus granulosus tubulin beta 1 chain 0.0019 0.2495 0.2825
Brugia malayi Tubulin alpha chain 0.0036 0.8574 0.856
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0101 0.0101
Trypanosoma brucei alpha tubulin 0.0036 0.8574 0.81
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0025 0.4565 0.4565
Echinococcus granulosus peroxisome assembly protein 26 0.0036 0.8574 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0019 0.2495 0.2825
Loa Loa (eye worm) tubulin beta-1 chain 0.0019 0.2495 0.2419
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0019 0.2495 0.2825
Loa Loa (eye worm) tubulin beta-2A chain 0.0019 0.2495 0.2419
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0038 0.9099 0.909
Echinococcus multilocularis nervana 2 0.0025 0.4408 0.5083
Leishmania major alpha tubulin 0.0036 0.8574 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.2495 0.2495
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0025 0.4509 0.5203
Echinococcus granulosus tubulin epsilon chain 0.0019 0.2495 0.2825
Loa Loa (eye worm) tubulin alpha-2 chain 0.0036 0.8574 0.856
Plasmodium falciparum alpha tubulin 1 0.0036 0.8574 1
Echinococcus granulosus nervana 2 0.0025 0.4408 0.5083
Echinococcus multilocularis peroxisome assembly protein 26 0.0036 0.8574 1
Schistosoma mansoni tubulin subunit gamma 0.0019 0.2495 0.2825
Leishmania major alpha tubulin 0.0036 0.8574 1
Trypanosoma brucei alpha tubulin 0.0036 0.8574 0.81
Echinococcus multilocularis tubulin alpha chain 0.0036 0.8574 1
Schistosoma mansoni tubulin subunit beta 0.0019 0.2495 0.2825
Echinococcus multilocularis tubulin epsilon chain 0.0019 0.2495 0.2825
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.541 0.6266
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0036 0.8574 0.8574
Entamoeba histolytica protein kinase 2, putative 0.0025 0.4509 0.4453
Echinococcus granulosus Tubulin alpha 1 chain 0.0036 0.8574 1
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.1489 0.1402
Echinococcus granulosus Tubulin alpha 1 chain 0.0036 0.8574 1
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.541 0.6266
Loa Loa (eye worm) tubulin alpha chain 0.0036 0.8574 0.856
Leishmania major alpha tubulin 0.0036 0.8574 1
Leishmania major alpha tubulin 0.0036 0.8574 1
Giardia lamblia Alpha-tubulin 0.0036 0.8574 1
Brugia malayi tubulin alpha-2 chain 0.0036 0.8574 0.856
Schistosoma mansoni tubulin subunit epsilon 0.0019 0.2495 0.2825
Loa Loa (eye worm) alpha-tubulin 0.0036 0.8574 0.856
Loa Loa (eye worm) tubulin alpha-3 chain 0.0025 0.4565 0.451
Entamoeba histolytica tubulin family protein 0.0019 0.2495 0.2419
Trypanosoma brucei alpha tubulin 0.0036 0.8574 0.81
Giardia lamblia Alpha-tubulin 0.0036 0.8574 1
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.2495 0.2825
Loa Loa (eye worm) tubulin alpha chain 0.0036 0.8574 0.856
Plasmodium vivax tubulin alpha chain, putative 0.0036 0.8574 1
Echinococcus multilocularis tubulin alpha 0.0019 0.2495 0.2825
Trichomonas vaginalis AGC family protein kinase 0.0015 0.1002 0.1002
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0025 0.4509 0.3313
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.2495 0.2495
Echinococcus granulosus nervana 2 0.0025 0.4408 0.5083

Activities

Activity type Activity value Assay description Source Reference
Delta Tm (binding) = 1.2 degrees C Binding affinity to Akt2 (1 to 481) expressed in Sf9 cells assessed as change in melting temperature at 15 uM ChEMBL. 22533986
Delta Tm (binding) = 5.61 degrees C Binding affinity to Akt1 (1 to 480) expressed in Sf9 cells assessed as change in melting temperature at 30 uM ChEMBL. 22533986
IC50 (binding) = 0.033 uM Inhibition of Akt1 (1 to 480) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay ChEMBL. 22533986
IC50 (binding) = 0.16 uM Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysis ChEMBL. 22533986
IC50 (binding) = 0.33 uM Inhibition of Akt1 in human A2780 cells assessed as phosphorylation of Akt at S473 after 2 hrs by Western Blot analysis ChEMBL. 22533986
IC50 (binding) = 0.68 uM Inhibition of Akt 1 in human A2780 cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysis ChEMBL. 22533986
IC50 (binding) = 0.98 uM Inhibition of Akt1 in human AN3CA cells assessed as phosphorylation PRAS40 at T246 after 2 hrs by Western Blot analysis ChEMBL. 22533986
IC50 (binding) = 1.1 uM Inhibition of Akt 1 in human AN3CA cells assessed as phosphorylation of Akt at T308 after 2 hrs by Western Blot analysis ChEMBL. 22533986
IC50 (binding) = 1.8 uM Inhibition of Akt1 in human A2780 cells assessed as phosphorylation PRAS40 at T246 after 2 hrs by Western Blot analysis ChEMBL. 22533986
IC50 (binding) = 51 uM Inhibition of Akt2 (1 to 481) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay ChEMBL. 22533986
IC50 (binding) > 100 uM Inhibition of Akt3 (1 to 479) expressed in Sf9 cells using biotin-GRPRTSSFAEG as substrate after 20 mins by Alpha-screen assay ChEMBL. 22533986
IC50 (functional) > 100 uM Antiproliferative activity against human AN3CA cells after 72 hrs by MTS assay ChEMBL. 22533986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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