Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0098 | 0.0897 | 0.0897 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0369 | 0.9354 | 0.9354 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 1 | 1 |
Onchocerca volvulus | 0.0389 | 1 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0338 | 0.8386 | 0.8386 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.6994 | 0.6994 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0897 | 0.0897 |
Echinococcus granulosus | voltage gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Brugia malayi | hypothetical protein | 0.0185 | 0.3626 | 0.3626 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0369 | 0.9354 | 0.9354 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0315 | 0.7692 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0098 | 0.0897 | 0.0897 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0098 | 0.0897 | 0.0897 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0338 | 0.8386 | 0.8386 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0338 | 0.8386 | 0.8386 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0315 | 0.7692 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.0897 | 0.0897 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0338 | 0.8386 | 0.8386 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.03 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (functional) | = 0.8 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (functional) | = 0.8 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (binding) | = 0.94 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (binding) | = 0.94 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2231608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.