TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.432 | Formula: C21H24FN3O3
H donors: 2 H acceptors: 5 LogP: 3.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C[C@@H]1CC[C@H](CC1)c1ccc(cc1F)c1nc(C(=O)N)c(nc1C)C
InChi: 1S/C21H24FN3O3/c1-11-19(25-20(21(23)28)12(2)24-11)15-7-8-16(17(22)10-15)14-5-3-13(4-6-14)9-18(26)27/h7-8,10,13-14H,3-6,9H2,1-2H3,(H2,23,28)(H,26,27)/t13-,14-
InChiKey: VWXCBIYKAIQGAT-HDJSIYSDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium parvum	diacylglycerol acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium falciparum	diacylglycerol O-acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Brugia malayi	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	sterol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus granulosus	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium hominis	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium yoelii	acyl transferase-related	Get druggable targets OG5_128200	All targets in OG5_128200
Babesia bovis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium berghei	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium knowlesi	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Theileria parva	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	glycerol uptake protein, putative	0.0026	0.0406	0.0934
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0161	0.3567	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0289	0.045
Echinococcus granulosus	sterol O acyltransferase 1	0.0026	0.0406	0.0685
Leishmania major	glycerol uptake protein, putative	0.0026	0.0406	0.0934
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0059	0.0047
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0153	0.3395	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0013	0.0015
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0059	0.0089
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0035	0.0067
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0667	0.113
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1296	0.357
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0153	0.3395	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0013	0.0013
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0289	0.045
Brugia malayi	nuclear receptor RXR	0.001	0.0032	0.0019
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0035	0.0055
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0032	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0289	0.0277
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0013	0.0016
Schistosoma mansoni	coup transcription factor	0.0021	0.0289	0.045
Schistosoma mansoni	topbp1	0.001	0.0035	0.0051
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0127	0.0211
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0364	1
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0127	0.0115
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0013	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0289	0.0277
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Echinococcus multilocularis	Protein lozenge	0.0055	0.1081	0.1694
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0013	0.0015
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.006	0.12	0.12
Brugia malayi	hypothetical protein	0.0036	0.0656	0.0644
Brugia malayi	conserved hypotetical protein	0.001	0.0032	0.0019
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0035	0.0051
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0161	0.3567	0.5601
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0035	0.0806
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0289	0.0488
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0013	0.0016
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0035	0.0806
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0035	0.0806
Trichomonas vaginalis	porcupine, putative	0.0026	0.0406	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0289	0.0277
Echinococcus multilocularis	thyroid hormone receptor alpha	0.028	0.6367	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.006	0.12	0.1189
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0289	0.0277
Entamoeba histolytica	hypothetical protein	0.0036	0.0656	0.4919
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0059	0.0089
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0026	0.0406	0.0685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0289	0.0289
Echinococcus granulosus	carbonic anhydrase	0.006	0.12	0.2037
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.006	0.12	0.1189
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0289	0.0277
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0406	0.0685
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0035	0.0023
Schistosoma mansoni	zinc finger protein	0.0026	0.0406	0.0633
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0032	0.0032
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0026	0.0406	0.0685
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0289	0.0277
Leishmania major	glycerol uptake protein, putative	0.0026	0.0406	0.0934
Brugia malayi	hypothetical protein	0.001	0.0032	0.0019
Brugia malayi	MBOAT family protein	0.0026	0.0406	0.0394
Brugia malayi	Cytochrome P450 family protein	0.0012	0.008	0.0068
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0222	0.0556
Entamoeba histolytica	vacuolar protein sorting 26	0.0026	0.0406	0.2937
Onchocerca volvulus		0.001	0.0035	0.0023
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0289	0.045
Schistosoma mansoni	nuclear receptor	0.001	0.0032	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0364	0.0364
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0364	0.261
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0032	0.0019
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0183	0.4087	0.4079
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0026	0.0406	1
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.008	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Onchocerca volvulus		0.0026	0.0406	0.0394
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0059	0.0096
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0032	0.0049
Brugia malayi	ecdysteroid receptor	0.0021	0.0289	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Loa Loa (eye worm)	runx1	0.0055	0.1081	0.1081
Plasmodium falciparum	carbonic anhydrase	0.006	0.12	0.3466
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0289	0.045
Schistosoma mansoni	hypothetical protein	0.0036	0.0656	0.1026
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0406	1
Echinococcus granulosus	carbonic anhydrase	0.006	0.12	0.2037
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0161	0.3567	0.3567
Echinococcus multilocularis	Ankyrin	0.0014	0.013	0.02
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0127	0.0211
Schistosoma mansoni	dishevelled	0.0009	0.0013	0.0015
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0364	0.0352
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0.008	0.2137
Echinococcus multilocularis	carbonic anhydrase II	0.0161	0.3567	0.5601
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.008	0.008
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.1296	0.2032
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0013	0.0013
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0667	0.1043
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0222	1
Brugia malayi	hypothetical protein	0.0011	0.0059	0.0047
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0364	0.0815
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0032	0.0049
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.006	0.12	0.1189
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0406	0.0633
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0289	0.045
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0032	0.0049
Brugia malayi	topoisomerase	0.001	0.0035	0.0023
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0289	0.0277
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1296	0.357
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0364	0.0815
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0289	0.045
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0161	0.3567	0.3559
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0259	0.5879	1
Leishmania major	carbonic anhydrase-like protein	0.0161	0.3567	1
Brugia malayi	MBOAT family protein	0.0026	0.0406	0.0394
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0406	0.0633
Toxoplasma gondii	hypothetical protein	0.006	0.12	0.351
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0127	0.0115
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0127	0.0195
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0364	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0199	0.543
Brugia malayi	tailless protein	0.001	0.0032	0.0019
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0071	0.1469	0.2304
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0035	0.0023
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0032	0.0019
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0035	0.0067
Trypanosoma cruzi	GUP1, putative	0.0026	0.0406	0.1049
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0289	0.0488
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0153	0.3395	0.5331
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0289	0.0277
Echinococcus multilocularis	carbonic anhydrase	0.006	0.12	0.1881
Brugia malayi	steroid hormone receptor	0.0021	0.0289	0.0277
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0013	0.0015
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0026	0.0406	0.0633
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0032	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Brugia malayi	ecdysone receptor	0.001	0.0032	0.0019
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0364	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0032	0.0049
Trypanosoma cruzi	GUP1, putative	0.0026	0.0406	0.1049
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0013	0.0015
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0032	0.0045
Treponema pallidum	alginate O-acetylation protein (algI)	0.0026	0.0406	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0289	0.0488
Echinococcus multilocularis	carbonic anhydrase	0.006	0.12	0.1881
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.1296	0.2201
Echinococcus granulosus	nibrin	0.001	0.0035	0.0055
Brugia malayi	nuclear receptor NHR-67	0.001	0.0032	0.0019
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0289	0.0488
Loa Loa (eye worm)	DR-78	0.001	0.0032	0.0032
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0406	0.1049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0289	0.0289
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.1296	0.3488
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0364	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0032	0.0045
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0289	0.045
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0032	0.0045
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0127	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0364	0.0364
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0406	0.2937
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0289	0.045
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0289	0.0488
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Brugia malayi	DKFZp564C0469 protein	0.001	0.0035	0.0023
Echinococcus multilocularis	nibrin	0.001	0.0035	0.0051
Schistosoma mansoni	carbonic anhydrase-related	0.006	0.12	0.1881
Brugia malayi	nuclear hormone receptor	0.0021	0.0289	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0406	0.0406
Loa Loa (eye worm)	hhat protein	0.0026	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0059
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0289	0.0277
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0406	0.2937
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0406	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Entamoeba histolytica	hypothetical protein	0.0036	0.0656	0.4919
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0035	0.0051
Brugia malayi	nuclear hormone receptor	0.001	0.0032	0.0019
Schistosoma mansoni	zinc finger protein	0.001	0.0032	0.0045
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0032	0.0045
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0364	0.261
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0013	0.0016
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0222	0.6065
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0032	0.0045
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0406	0.0633
Brugia malayi	N-terminal motif family protein	0.0183	0.4087	0.4079
Entamoeba histolytica	hypothetical protein	0.0036	0.0656	0.4919
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0289	0.0289
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0289	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0035	0.0806
Schistosoma mansoni	carbonic anhydrase	0.006	0.12	0.1881
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0032	0.0019
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0127	0.0195
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0153	0.3395	0.5774
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0364	1
Brugia malayi	hypothetical protein	0.001	0.0035	0.0023
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0289	0.045
Schistosoma mansoni	hypothetical protein	0.0026	0.0406	0.0633
Loa Loa (eye worm)	hypothetical protein	0.006	0.12	0.12
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0032	0.0019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0127	0.0115
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0032	0.0019
Loa Loa (eye worm)	hypothetical protein	0.006	0.12	0.12
Onchocerca volvulus		0.0021	0.0289	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0406	0.0406
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0406	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0161	0.3567	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0289	0.0488
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0289	0.0277
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Toxoplasma gondii	hypothetical protein	0.0026	0.0406	0.1162
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.008	0.008
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0406	0.0633
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0013	0.0016
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0289	0.0277
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.0183	0.4087	0.4087
Trypanosoma brucei	carbonic anhydrase-like protein	0.0161	0.3567	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.006	0.12	0.1189
Schistosoma mansoni	hypothetical protein	0.0014	0.0127	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0059
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0364	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0364	0.0815
Loa Loa (eye worm)	hypothetical protein	0.006	0.12	0.12
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0289	0.0277
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0032	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0289	0.0277
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0013	0.0016
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.1296	0.1285
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0059
Leishmania major	glycerol uptake protein, putative	0.0026	0.0406	0.0934
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0035	0.0806
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0406	0.0406
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0222	0.6065
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.1296	0.1296
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0199	0.543
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0289	0.045
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0026	0.0406	0.0633
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0026	0.0406	0.0633
Schistosoma mansoni	nuclear receptor	0.001	0.0032	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0364	0.0364
Entamoeba histolytica	hypothetical protein	0.0036	0.0656	0.4919
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0406	0.0406
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0289	0.0289
Onchocerca volvulus		0.0024	0.0364	0.0352
Schistosoma mansoni	carbonic anhydrase-related	0.006	0.12	0.1881
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0035	0.0898
Echinococcus granulosus	Ankyrin	0.0014	0.013	0.0216
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0035	0.0806
Brugia malayi	Cytochrome P450 family protein	0.0012	0.008	0.0068
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0364	1
Onchocerca volvulus		0.001	0.0032	0.0019
Echinococcus multilocularis	carbonic anhydrase	0.006	0.12	0.1881
Schistosoma mansoni	dishevelled	0.0009	0.0013	0.0015
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0059	0.0047
Brugia malayi	diacylglycerol acyltransferase	0.0153	0.3395	0.3387
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0035	0.0806
Brugia malayi	MBOAT family protein	0.0026	0.0406	0.0394
Schistosoma mansoni	topbp1	0.001	0.0035	0.0051
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0032	0.0032
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0127	0.0195
Schistosoma mansoni	hypothetical protein	0.006	0.12	0.1881
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1296	0.357
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0014	0.013	0.013
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0026	0.0406	0.0633
Schistosoma mansoni	sterol O-acyltransferase 1	0.0026	0.0406	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0127	0.0127
Onchocerca volvulus		0.001	0.0032	0.0019
Echinococcus multilocularis	sterol O acyltransferase 1	0.0026	0.0406	0.0633
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0289	0.0488
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0259	0.5879	0.9233
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0289	0.0277
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0013	0.0013
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0289	0.045
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0059
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Brugia malayi	Hhat protein	0.0026	0.0406	0.0394
Schistosoma mansoni	thyroid hormone receptor	0.028	0.6367	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0289	0.0289
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0032	0.0045
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0364	0.0352
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0035	0.0806
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0289	0.0488
Schistosoma mansoni	lozenge	0.0055	0.1081	0.1694
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0406	0.1049
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0013	0.0013
Brugia malayi	nuclear receptor NHR-88	0.001	0.0032	0.0019
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.008	0.008
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0.0406	0.2937
Schistosoma mansoni	DNA ligase IV	0.001	0.0035	0.0051
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0289	0.045
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0013	0.0015
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0026	0.0406	0.0685
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0289	0.045
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0406	0.1049
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0071	0.1469	0.2495
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.1296	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0406	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0406	0.0406
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0032	0.0019
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0153	0.3395	1
Brugia malayi	hypothetical protein	0.001	0.0035	0.0023
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0406	0.2937
Schistosoma mansoni	carbonic anhydrase-related	0.006	0.12	0.1881
Entamoeba histolytica	hypothetical protein	0.0026	0.0406	0.2937
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.013	0.02
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0406	0.0406
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.008	0.0127
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0059	0.0089
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0035	1
Leishmania major	glycerol uptake protein, putative	0.0026	0.0406	0.0934
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0026	0.0406	0.0633
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0026	0.0406	0.0633
Brugia malayi	Death domain containing protein	0.0014	0.0127	0.0115
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0364	0.0352
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0364	1
Echinococcus granulosus	carbonic anhydrase II	0.0161	0.3567	0.6066
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0153	0.3395	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0656	0.1026
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0289	0.045
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0364	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0013	0.0015
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0364	1
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0153	0.3395	0.3395
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0289	0.0277
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0289	0.045
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.006	0.12	0.1189
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0289	0.0488
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0026	0.0406	0.0406
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0656	0.1111
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0289	0.0277
Schistosoma mansoni	hypothetical protein	0.0259	0.5879	0.9233
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0032	0.0045
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0032	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0032	0.0032
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0161	0.3567	0.5601
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0059	0.0059
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0406	0.1049
Brugia malayi	hypothetical protein	0.0011	0.0059	0.0047
Loa Loa (eye worm)	hhat protein	0.0026	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0289	0.0289
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0406	0.1049
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0032	0.0045
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0035	0.0898
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0222	0.0556
Loa Loa (eye worm)	carbonic anhydrase 3	0.0161	0.3567	0.3567
Schistosoma mansoni	dep domain containing protein	0.0009	0.0013	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0032	0.0032
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0406	0.0633
Schistosoma mansoni	thyroid hormone receptor	0.028	0.6367	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0289	0.045
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0199	0.543
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0032	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0222	0.0222
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0161	0.3567	0.3559
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0289	0.0277
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0059	0.0059
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0013	0.0015
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0032	0.0049
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0406	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2791	0.2791
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0406	0.0685
Brugia malayi	MBOAT family protein	0.0026	0.0406	0.0394
Brugia malayi	hypothetical protein	0.001	0.0032	0.0019
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.008	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0289	0.0277
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0289	0.045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0364	0.261
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0199	0.543
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0026	0.0406	0.0685
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0656	0.1026
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0035	0.0806
Echinococcus granulosus	carbonic anhydrase	0.006	0.12	0.2037
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0035	0.0806
Brugia malayi	nuclear receptor RXR	0.0011	0.0059	0.0047
Brugia malayi	MBOAT family protein	0.0026	0.0406	0.0394
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0153	0.3395	0.5331
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0289	0.0289
Treponema pallidum	DNA ligase (lig)	0.001	0.0035	0.0806
Brugia malayi	Uncoordinated protein 44	0.0014	0.0127	0.0115
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0289	0.0289
Echinococcus granulosus	death domain containing protein	0.0014	0.0127	0.0211
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0289	0.0277
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0032	0.0045
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0289	0.045
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.1296	0.2032
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0406	0.0685

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.06 uM	Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography	ChEMBL.	23116186

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2178942

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1722731