Detailed information for compound 1722855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.842 | Formula: C19H22ClFN2O2
  • H donors: 0 H acceptors: 0 LogP: 4.53 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)N1CCN(CC1)CCc1ccc2c(c1)OCO2.Cl
  • InChi: 1S/C19H21FN2O2.ClH/c20-16-2-4-17(5-3-16)22-11-9-21(10-12-22)8-7-15-1-6-18-19(13-15)24-14-23-18;/h1-6,13H,7-12,14H2;1H
  • InChiKey: ZRXZOEJJESLISP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0043 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0599 0.0598
Mycobacterium ulcerans DNA gyrase subunit B 0.0168 0.3858 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0856 0.1268
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0015 0.0187 0.048
Trichomonas vaginalis sensor histidine kinase, putative 0.0015 0.0187 0.0277
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0295 0.0294
Schistosoma mansoni zinc finger protein 0.002 0.0312 0.0311
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0016 0.0199 0.0261
Plasmodium vivax endoplasmin, putative 0.0015 0.0187 0.0007
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1094 0.1462
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0294 0.0395
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0187 0.0277
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0294 0.0436
Plasmodium vivax DNA gyrase subunit B, putative 0.0168 0.3858 0.5605
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0312 0.0236
Trichomonas vaginalis endoplasmin, putative 0.0015 0.0187 0.0277
Brugia malayi ecdysone receptor 0.002 0.0312 0.0461
Loa Loa (eye worm) hypothetical protein 0.007 0.1499 0.2004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.1831 0.2449
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0312 0.0311
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0187 0.0244
Toxoplasma gondii exonuclease III APE 0.0019 0.0294 0.0434
Onchocerca volvulus 0.0043 0.0856 0.1214
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0856 0.1268
Onchocerca volvulus 0.0059 0.1254 0.193
Echinococcus granulosus Ankyrin 0.0015 0.0183 0.0182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0856 0.1268
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.2335 0.2333
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0015 0.0187 0.1142
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0407 0.0604
Chlamydia trachomatis DNA topoisomerase I 0.0016 0.0199 0.0035
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0294 0.0292
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0288 0.674 0.6739
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0288 0.674 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0177 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0856 0.1268
Plasmodium falciparum endoplasmin, putative 0.0015 0.0187 0.0214
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0856 0.0854
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0856 0.0854
Loa Loa (eye worm) TOPoisomerase family member 0.0288 0.674 0.9019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.015 0.0222
Brugia malayi Cytochrome P450 family protein 0.0016 0.0219 0.0323
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0168 0.3858 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0407 0.0535
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0856 0.0854
Echinococcus multilocularis lamin 0.0084 0.1831 0.183
Schistosoma mansoni endoplasmin 0.0015 0.0187 0.0185
Giardia lamblia DNA topoisomerase III 0.0016 0.0199 0.0246
Plasmodium falciparum DNA gyrase subunit A 0.0062 0.1313 0.1897
Brugia malayi hypothetical protein 0.002 0.0312 0.0461
Loa Loa (eye worm) hypothetical protein 0.003 0.0543 0.0724
Treponema pallidum DNA topoisomerase I (topA) 0.0016 0.0199 0.0035
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0075 0.1623 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0494
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0294 0.0385
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0312 0.0416
Plasmodium vivax heat shock protein 86, putative 0.0015 0.0187 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.037 0.0547
Brugia malayi hypothetical protein 0.0023 0.037 0.0547
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0294 0.0434
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.015 0.0222
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.0187 0.012
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0043 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0599 0.0598
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1094 0.1621
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0062 0.1313 0.3402
Trichomonas vaginalis helicase, putative 0.0013 0.015 0.0222
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0794 0.0792
Mycobacterium ulcerans putative regultory protein 0.0015 0.0187 0.048
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0354 0.0523
Brugia malayi Melibiase family protein 0.007 0.1499 0.2222
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.1239 0.3209
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1094 0.1658
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0015 0.0187 0.0185
Plasmodium falciparum heat shock protein 90 0.0015 0.0187 0.0214
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0312 0.0311
Echinococcus granulosus lamin dm0 0.0084 0.1831 0.183
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0187 0.0277
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.2882 0.2881
Brugia malayi nuclear hormone receptor 0.0043 0.0856 0.1268
Entamoeba histolytica DNA topoisomerase III, putative 0.0016 0.0199 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.015 0.0222
Schistosoma mansoni ap endonuclease 0.0019 0.0294 0.0292
Brugia malayi intermediate filament protein 0.0084 0.1831 0.2715
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.018 0.0266
Entamoeba histolytica DNA topoisomerase II, putative 0.0288 0.674 1
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0219 0.0287
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0856 0.0854
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0015 0.0187 0.0244
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0354 0.0464
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0856 0.0854
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0187 0.0185
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0312 0.0311
Schistosoma mansoni ap endonuclease 0.0019 0.0294 0.0292
Echinococcus granulosus heat shock protein 0.0015 0.0187 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0219 0.0287
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.018 0.0239
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0043 0.0062
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0599 0.0887
Giardia lamblia DNA topoisomerase III 0.0016 0.0199 0.0246
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0199 0.0261
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0856 0.1268
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1094 0.1093
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0273 0.6367 0.8392
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.0187 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0312 0.0311
Leishmania major DNA topoisomerase 1A 0.0016 0.0199 0.0261
Onchocerca volvulus 0.0084 0.1831 0.2966
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0015 0.0187 0.048
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0015 0.0187 0.048
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.0187 0.0244
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0294 0.0758
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0219 0.0291
Loa Loa (eye worm) hypothetical protein 0.0015 0.0183 0.0244
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0015 0.0187 0.048
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.1499 0.1498
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0856 0.1268
Trypanosoma brucei DNA topoisomerase ii 0.0323 0.7586 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Brugia malayi RNA, U transporter 1 0.0085 0.1863 0.2763
Loa Loa (eye worm) DNA topoisomerase III 0.0016 0.0199 0.0265
Loa Loa (eye worm) hypothetical protein 0.0155 0.3537 0.4732
Schistosoma mansoni lamin 0.0084 0.1831 0.183
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0294 0.0292
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0294 0.0374
Plasmodium falciparum DNA topoisomerase 2 0.0288 0.674 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.1254 0.1677
Trypanosoma brucei protein kinase, putative 0.0053 0.1094 0.144
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0187 0.0244
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0195 0.4498 0.776
Brugia malayi conserved hypotetical protein 0.002 0.0312 0.0461
Echinococcus multilocularis importin subunit beta 1 0.003 0.0543 0.0541
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.09 0.1334
Entamoeba histolytica hypothetical protein 0.0024 0.0407 0.0452
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Brugia malayi ecdysteroid receptor 0.0043 0.0856 0.1268
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0312 0.0311
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0407 0.0604
Schistosoma mansoni nuclear receptor 0.002 0.0312 0.0311
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1239 0.3209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0856 0.1268
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0323 0.7586 1
Brugia malayi Death domain containing protein 0.0015 0.018 0.0266
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0312 0.0311
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0543 0.0714
Brugia malayi Cytochrome P450 family protein 0.0016 0.0219 0.0323
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0856 0.0854
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.037 0.0369
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0016 0.0199 0.1221
Onchocerca volvulus 0.0247 0.5745 1
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0187 0.0185
Entamoeba histolytica Ran family GTPase 0.0022 0.0354 0.0372
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0599 0.0598
Brugia malayi nuclear receptor NHR-88 0.0043 0.0856 0.1268
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0195 0.4498 0.776
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0187 0.0244
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.1239 0.1238
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0015 0.0187 0.048
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1239 0.3209
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0043 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0245 0.0327
Loa Loa (eye worm) hypothetical protein 0.0084 0.1831 0.2449
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0219 0.0291
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1094 0.1093
Mycobacterium leprae Probable two component sensor kinase MprB 0.0015 0.0187 0.1142
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0016 0.0199 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0599 0.0598
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1094 0.144
Loa Loa (eye worm) intermediate filament protein 0.0084 0.1831 0.2449
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0354 0.0464
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.2335 0.2333
Schistosoma mansoni intermediate filament proteins 0.0084 0.1831 0.183
Schistosoma mansoni pyruvate dehydrogenase 0.0015 0.0187 0.0185
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0016 0.0199 0.0198
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0187 0.0244
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0856 0.0854
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0015 0.0187 0.048
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0323 0.7586 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0856 0.1268
Schistosoma mansoni nuclear hormone receptor 0.002 0.0312 0.0311
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Brugia malayi DNA topoisomerase III 0.0016 0.0199 0.0294
Echinococcus multilocularis cpg binding protein 0.0063 0.1336 0.1334
Echinococcus multilocularis musashi 0.0084 0.1831 0.183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Toxoplasma gondii DNA topoisomerase 2, putative 0.0288 0.674 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0015 0.0187 0.048
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0273 0.6367 0.8392
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0187 0.0277
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0856 0.0854
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0856 0.1268
Onchocerca volvulus 0.0084 0.1831 0.2966
Echinococcus granulosus snurportin 1 0.0319 0.7473 0.7472
Schistosoma mansoni retinoic acid receptor RXR 0.0145 0.3305 0.3304
Trichomonas vaginalis DNA topoisomerase II, putative 0.0288 0.674 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0856 0.1143
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0015 0.0187 0.048
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0062 0.1313 0.3069
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0856 0.0854
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0187 0.0244
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0015 0.0187 0.1142
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0208 0.0207
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.1831 0.2715
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.2335 0.2333
Brugia malayi hypothetical protein 0.002 0.0312 0.0461
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0015 0.0187 0.0277
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0352 0.052
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0312 0.0311
Echinococcus granulosus cpg binding protein 0.0063 0.1336 0.1334
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0183 0.0182
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0016 0.0199 0.0296
Onchocerca volvulus 0.0032 0.0599 0.0753
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0856 0.0854
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.164 0.1638
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0354 0.0352
Plasmodium vivax DNA gyrase subunit A, putative 0.0062 0.1313 0.1726
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.2335 0.2333
Plasmodium falciparum DNA gyrase subunit B 0.0168 0.3858 0.5696
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0199 0.0261
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.164 0.1638
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.037 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.0777 0.1037
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.1499 0.1498
Loa Loa (eye worm) histone methyltransferase 0.002 0.0295 0.0393
Schistosoma mansoni importin beta-1 0.003 0.0543 0.0541
Leishmania major DNA topoisomerase III, putative 0.0016 0.0199 0.0261
Leishmania major cytochrome p450-like protein 0.0016 0.0219 0.0287
Entamoeba histolytica DNA topoisomerase III, putative 0.0016 0.0199 0.0139
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0312 0.0461
Schistosoma mansoni nuclear hormone receptor 0.002 0.0312 0.0311
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0294 0.0292
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1094 0.144
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.037 0.0369
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0107 0.0159
Trypanosoma brucei developmentally regulated phosphoprotein 0.0015 0.0187 0.0244
Trypanosoma cruzi DNA topoisomerase II, putative 0.0273 0.6367 0.8392
Brugia malayi nuclear receptor RXR 0.002 0.0312 0.0461
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.1144 0.1529
Echinococcus granulosus muscleblind protein 0.0155 0.3537 0.3536
Brugia malayi hypothetical protein 0.0023 0.037 0.0547
Echinococcus multilocularis heat shock protein 0.0015 0.0187 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0856 0.1143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.015 0.0222
Loa Loa (eye worm) hypothetical protein 0.0039 0.0757 0.1011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.015 0.0222
Loa Loa (eye worm) hypothetical protein 0.0082 0.1794 0.24
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0312 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0856 0.1268
Mycobacterium leprae Probable two-component sensor kinase 0.0015 0.0187 0.1142
Echinococcus granulosus intermediate filament protein 0.0084 0.1831 0.183
Giardia lamblia Pms1-like protein 0.0015 0.0187 0.0226
Brugia malayi DNA topoisomerase III beta-1 0.0016 0.0199 0.0294
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0043 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0777 0.1037
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0015 0.0187 0.048
Schistosoma mansoni hypothetical protein 0.0319 0.7473 0.7472
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0354 0.0464
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0856 0.1143
Loa Loa (eye worm) hypothetical protein 0.0155 0.3537 0.4732
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0312 0.0311
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0856 0.1143
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0856 0.1214
Trypanosoma cruzi Heat shock protein 83, putative 0.0015 0.0187 0.0244
Chlamydia trachomatis DNA gyrase subunit A 0.0062 0.1313 0.3069
Brugia malayi Probable DNA topoisomerase II 0.0288 0.674 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1094 0.144
Mycobacterium ulcerans two component sensor kinase MprB 0.0015 0.0187 0.048
Toxoplasma gondii DNA topoisomerase family protein 0.0016 0.0199 0.0294
Trypanosoma brucei Heat shock protein 83, putative 0.0015 0.0187 0.0244
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0354 0.0262
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0016 0.0199 0.0296
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.1499 0.2224
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0856 0.0854
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0058 0.0057
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0107 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0856 0.0854
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0187 0.0275
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0354 0.0463
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0016 0.0199 0.0035
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.1239 0.1836
Loa Loa (eye worm) hypothetical protein 0.0032 0.0599 0.08
Brugia malayi Muscleblind-like protein 0.0155 0.3537 0.5247
Plasmodium vivax importin-beta 2, putative 0.003 0.0543 0.055
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1094 0.144
Brugia malayi Importin beta-1 subunit 0.003 0.0543 0.0803
Chlamydia trachomatis DNA gyrase subunit A 0.0062 0.1313 0.3069
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0312 0.0416
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Brugia malayi Nuclear hormone receptor E75 0.002 0.0312 0.0461
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0107 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Echinococcus granulosus importin subunit beta 1 0.003 0.0543 0.0541
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0016 0.0199 0.0198
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0294 0.0758
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1094 0.1093
Brugia malayi kinase, mitochondrial precursor 0.0015 0.0187 0.0275
Brugia malayi MAP kinase sur-1 0.0053 0.1094 0.1621
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0181 0.018
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0312 0.0416
Loa Loa (eye worm) hypothetical protein 0.0039 0.0757 0.1011
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0219 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0856 0.1268
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0168 0.3858 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0856 0.0854
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.7473 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0015 0.0187 0.0277
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0043 0.0042
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.018 0.0179
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1094 0.1623
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.2335 0.2333
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0354 0.0523
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0187 0.0275
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0352 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Schistosoma mansoni ran 0.0022 0.0354 0.0352
Schistosoma mansoni heat shock protein 0.0015 0.0187 0.0185
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.015 0.0222
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Loa Loa (eye worm) hypothetical protein 0.0117 0.2638 0.3529
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0294 0.0292
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1239 0.1238
Toxoplasma gondii heat shock protein HSP90 0.0015 0.0187 0.0275
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0294 0.0391
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0015 0.0187 0.048
Giardia lamblia DNA topoisomerase II 0.0273 0.638 1
Brugia malayi steroid hormone receptor 0.0043 0.0856 0.1268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0294 0.0385
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0122 0.2761 0.276
Loa Loa (eye worm) hypothetical protein 0.004 0.0794 0.1061
Loa Loa (eye worm) endoplasmin 0.0015 0.0187 0.0248
Brugia malayi Endoplasmin precursor 0.0015 0.0187 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0856 0.1143
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.0187 0.0244
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Echinococcus granulosus bloom syndrome protein 0.0022 0.0352 0.035
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0312 0.0461
Loa Loa (eye worm) hypothetical protein 0.0195 0.4505 0.6028
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0856 0.1214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0856 0.1268
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1094 0.1093
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0062 0.1313 0.3069
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0312 0.0461
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0016 0.0199 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Schistosoma mansoni DNA helicase recq5 0.0009 0.0043 0.0042
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0294 0.0385
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0015 0.0187 0.048
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0494
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0208 0.0207
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0015 0.0187 0.048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.2559 0.3795
Loa Loa (eye worm) heat shock protein 90 0.0015 0.0187 0.0248
Echinococcus granulosus netrin receptor unc 5 0.0015 0.018 0.0179
Mycobacterium ulcerans two component regulator - sensor kinase 0.0015 0.0187 0.048
Leishmania major importin beta-1 subunit, putative 0.0024 0.0407 0.0535
Plasmodium vivax SET domain protein, putative 0.0032 0.0599 0.0637
Schistosoma mansoni lamin 0.0084 0.1831 0.183
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0062 0.1313 0.1947
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0294 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0599 0.0598
Echinococcus multilocularis muscleblind protein 0.0155 0.3537 0.3536
Echinococcus multilocularis muscleblind protein 1 0.0155 0.3537 0.3536
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0354 0.0471
Loa Loa (eye worm) RecQ helicase 0.0022 0.0352 0.0469
Echinococcus granulosus heat shock protein 90 0.0015 0.0187 0.0185
Echinococcus multilocularis heat shock protein 90 0.0015 0.0187 0.0185
Loa Loa (eye worm) DR-78 0.002 0.0312 0.0416
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0294 0.0385
Echinococcus multilocularis snurportin 1 0.0319 0.7473 0.7472
Brugia malayi Uncoordinated protein 44 0.0015 0.018 0.0266
Schistosoma mansoni cpg binding protein 0.0063 0.1336 0.1334
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0312 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0856 0.1143
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0856 0.0854
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0856 0.0854
Trypanosoma brucei DNA topoisomerase III, putative 0.0016 0.0199 0.0261
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0312 0.0311
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0856 0.0854
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0541 0.0539
Schistosoma mansoni endoplasmin 0.0015 0.0187 0.0185
Leishmania major DNA topoisomerase ii 0.0273 0.6367 0.8392
Onchocerca volvulus 0.0016 0.0199 0.0034
Onchocerca volvulus 0.002 0.0312 0.0236
Loa Loa (eye worm) hypothetical protein 0.004 0.0777 0.1037
Brugia malayi Nuclear hormone receptor E75 0.002 0.0312 0.0461
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.037 0.0494
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0354 0.0352
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0856 0.0854
Echinococcus multilocularis rho GTPase activating protein 20 0.0016 0.0199 0.0198
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1094 0.1623
Plasmodium vivax DNA topoisomerase II, putative 0.0288 0.674 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Leishmania major hypothetical protein, conserved 0.0015 0.0187 0.0244
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0015 0.0187 0.048
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1239 0.1238
Onchocerca volvulus 0.002 0.0312 0.0236
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0043 0.0056
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0168 0.3858 1
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Brugia malayi tailless protein 0.002 0.0312 0.0461
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0288 0.0365
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.015 0.0222
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0599 0.0598
Toxoplasma gondii melibiase subfamily protein 0.0105 0.2335 0.3462
Leishmania major DNA topoisomerase III, putative 0.0016 0.0199 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0856 0.1143
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0856 0.1214
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0015 0.0187 0.0214
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0856 0.0854
Brugia malayi Protein kinase domain containing protein 0.0015 0.0192 0.0283
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0312 0.0236
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0543 0.0803
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0015 0.0187 0.048
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0015 0.0187 0.048
Plasmodium vivax DNA topoisomerase 3, putative 0.0016 0.0199 0.0027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.0057
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0208 0.0207
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0288 0.674 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0856 0.1268
Schistosoma mansoni netrin receptor unc5 0.0015 0.018 0.0179
Loa Loa (eye worm) hypothetical protein 0.0015 0.0187 0.0248
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0187 0.0007
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1094 0.144
Trichomonas vaginalis ran, putative 0.0022 0.0354 0.0525
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0794 0.0792
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.018 0.0179
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.018 0.0179
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.1239 0.1631
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0187 0.0244
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1094 0.1623
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0288 0.674 0.6739
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.015 0.0222
Brugia malayi nuclear receptor RXR 0.0023 0.037 0.0547
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0016 0.0199 0.0294
Mycobacterium tuberculosis Probable two component sensor kinase 0.0015 0.0187 0.048
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0187 0.0277
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0312 0.0311
Mycobacterium tuberculosis Conserved protein 0.0015 0.0187 0.048
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0856 0.0854
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0494
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.2335 0.2333
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0295 0.0294
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0181 0.0267
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0015 0.0187 0.0277
Brugia malayi nuclear receptor NHR-67 0.002 0.0312 0.0461
Echinococcus multilocularis lamin dm0 0.0084 0.1831 0.183
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0294 0.0436
Schistosoma mansoni ran 0.0022 0.0354 0.0352
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1094 0.1093
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0195 0.4498 0.776
Chlamydia trachomatis DNA gyrase subunit B 0.0168 0.3858 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0543 0.0714
Schistosoma mansoni cpg binding protein 0.0059 0.1254 0.1253
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.5027 0.6727
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Brugia malayi nuclear hormone receptor 0.002 0.0312 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1094 0.144
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1094 0.1623
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0352 0.0522
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0856 0.0854
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0856 0.1268
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0856 0.1268
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0241 0.024
Echinococcus granulosus lamin 0.0084 0.1831 0.183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0856 0.1268
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1094 0.144
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0043 0.0062
Trichomonas vaginalis set domain proteins, putative 0.0246 0.5742 0.8519
Trypanosoma brucei DNA topoisomerase III, putative 0.0016 0.0199 0.0261
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0599 0.0598
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0219 0.0287
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.09 0.1203
Brugia malayi Pre-SET motif family protein 0.0032 0.0599 0.0887
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0856 0.0854
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0043 0.0042
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0312 0.0311
Trypanosoma cruzi DNA topoisomerase III, putative 0.0016 0.0199 0.0261
Loa Loa (eye worm) hypothetical protein 0.002 0.0312 0.0416
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Leishmania major developmentally regulated phosphoprotein-like protein 0.0015 0.0187 0.0244
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0352 0.035
Brugia malayi CXXC zinc finger family protein 0.0059 0.1254 0.1859
Schistosoma mansoni cpg binding protein 0.0063 0.1336 0.1334
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0312 0.0311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.037 0.0369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0856 0.1143
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0856 0.0854
Schistosoma mansoni hypothetical protein 0.0015 0.018 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0856 0.0854
Schistosoma mansoni coup transcription factor 0.0043 0.0856 0.0854
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0015 0.0187 0.048
Echinococcus multilocularis Ankyrin 0.0015 0.0183 0.0182
Loa Loa (eye worm) hypothetical protein 0.0043 0.0856 0.1143
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0015 0.0187 0.048
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0208 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0494
Loa Loa (eye worm) hypothetical protein 0.0195 0.4505 0.6028
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0168 0.3858 0.5723
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.037 0.0547
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0856 0.0854
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0016 0.0199 0.0261
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0494
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0015 0.0187 0.048
Mycobacterium ulcerans DNA topoisomerase I 0.0016 0.0199 0.0513
Mycobacterium ulcerans DNA gyrase subunit A 0.0062 0.1313 0.3402
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0187 0.0277
Schistosoma mansoni nuclear receptor 0.002 0.0312 0.0311
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.018 0.0179
Schistosoma mansoni DNA helicase recq1 0.0009 0.0043 0.0042
Leishmania major mitochondrial DNA topoisomerase II 0.0323 0.7586 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0016 0.0199 0.0198
Giardia lamblia Heat shock protein HSP 90-alpha 0.0015 0.0187 0.0226
Leishmania major GTP-binding protein, putative 0.0022 0.0354 0.0464
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0145 0.3305 0.3304
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Brugia malayi Pre-SET motif family protein 0.0217 0.5027 0.7459
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0016 0.0199 0.0198
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0294 0.0171
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0354 0.049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0856 0.0854
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Trypanosoma brucei heat shock protein, putative 0.0015 0.0187 0.0244
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0312 0.0461
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0107 0.0139
Chlamydia trachomatis DNA gyrase subunit B 0.0133 0.3011 0.7695
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.029 0.0428
Brugia malayi GRF zinc finger family protein 0.0016 0.0199 0.0294
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0187 0.0277
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0407 0.0604
Schistosoma mansoni DNA topoisomerase II 0.0288 0.674 0.6739
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.2335 0.2333
Trypanosoma brucei DNA topoisomerase IA, putative 0.0016 0.0199 0.0261
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0187 0.0244
Trypanosoma cruzi DNA topoisomerase II, putative 0.0273 0.6367 0.8392
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0208 0.0207
Loa Loa (eye worm) hypothetical protein 0.0015 0.018 0.0239
Schistosoma mansoni heat shock protein 0.0015 0.0187 0.0185
Leishmania major heat shock protein 83-1 0.0015 0.0187 0.0244
Loa Loa (eye worm) hypothetical protein 0.0117 0.2638 0.3529
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0015 0.0187 0.048
Brugia malayi heat shock protein 90 0.0015 0.0187 0.0275
Brugia malayi nuclear receptor NHR-88 0.002 0.0312 0.0461
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0856 0.0854
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0856 0.0854
Plasmodium falciparum importin beta, putative 0.003 0.0543 0.0746
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0219 0.0564
Echinococcus granulosus death domain containing protein 0.0015 0.018 0.0179
Toxoplasma gondii heat shock protein 90, putative 0.0015 0.0187 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.015 0.0222
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0856 0.0854
Plasmodium falciparum DNA topoisomerase 3, putative 0.0016 0.0199 0.0233

Activities

Activity type Activity value Assay description Source Reference
Kb (binding) = 0.41 uM Binding affinity to rabbit aorta adrenergic alpha1A receptor assessed as inhibition of phenylephrine-induced constriction after 30 mins ChEMBL. 21549456

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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