Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.5873 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.5873 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0037 | 0.5873 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0037 | 0.5873 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0037 | 0.5873 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0526 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4619 | 0.6977 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.6391 | 0.6391 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0037 | 0.5873 | 0.9095 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.6391 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.5873 | 0.5873 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.2661 | 0.3636 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.6391 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0819 | 0.0269 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.2661 | 0.3636 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.6391 | 0.6391 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.2661 | 0.3636 |
Leishmania major | pyruvate kinase | 0.0037 | 0.5873 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0037 | 0.5873 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0037 | 0.5873 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.5873 | 0.5873 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4619 | 0.6977 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3876 | 0.6166 |
Mycobacterium ulcerans | pyruvate kinase | 0.0037 | 0.5873 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4331 | 0.4331 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.5873 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4331 | 0.6403 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0026 | 0.3876 | 0.6166 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.5873 | 0.9116 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.2661 | 0.3636 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0037 | 0.5873 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0037 | 0.5873 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.2661 | 0.3636 |
Plasmodium falciparum | pyruvate kinase | 0.0037 | 0.5873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.5873 | 1 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0011 | 0.1271 | 0.1059 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0531 | 0.0531 |
Giardia lamblia | Pyruvate kinase | 0.0037 | 0.5873 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0037 | 0.5873 | 0.9095 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.2661 | 0.3636 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0526 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0037 | 0.5873 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4331 | 0.704 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0037 | 0.5873 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0037 | 0.5873 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0019 | 0.2661 | 0.2661 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.6391 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.6391 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.6391 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.6391 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.6391 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.5873 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0037 | 0.5873 | 0.5186 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0839 | 0.0335 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.5873 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.5873 | 0.9116 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.5873 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.5873 | 0.9116 |
Leishmania major | pyruvate kinase | 0.0037 | 0.5873 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.5873 | 0.9116 |
Echinococcus multilocularis | pyruvate kinase | 0.0029 | 0.4483 | 0.6744 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8854 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.