Detailed information for compound 1722914

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.513 | Formula: C23H23N3OS
  • H donors: 0 H acceptors: 2 LogP: 5.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(n1nc2c(c1C)CCCC2)CCN1c2ccccc2Sc2c1cccc2
  • InChi: 1S/C23H23N3OS/c1-16-17-8-2-3-9-18(17)24-26(16)23(27)14-15-25-19-10-4-6-12-21(19)28-22-13-7-5-11-20(22)25/h4-7,10-13H,2-3,8-9,14-15H2,1H3
  • InChiKey: MPUCYBTWPRSATC-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus tubulin alpha 3 chain 0.0657 0.5378 0.5371
Mycobacterium ulcerans thioesterase 0.0015 0.0047 0.0141
Brugia malayi tubulin alpha chain - mouse 0.0657 0.5378 0.5361
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0294 0.0259
Schistosoma mansoni hypothetical protein 0.0036 0.0217 0.0202
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.5378 0.5361
Echinococcus granulosus cathepsin l1 0.0045 0.0294 0.028
Brugia malayi Inositol-1 0.0027 0.0144 0.0108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0026 0.0138 0.0133
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0202 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0133
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0034 0.0202 0.0197
Trichomonas vaginalis inositol monophosphatase, putative 0.0027 0.0144 0.0108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0026 0.0138 0.0696
Loa Loa (eye worm) hypothetical protein 0.0657 0.5378 0.5375
Giardia lamblia Delta tubulin 0.0238 0.1899 0.187
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0101 0.0101
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Mycobacterium ulcerans Type I modular polyketide synthase 0.0018 0.0073 0.0277
Trypanosoma brucei alpha tubulin 0.0657 0.5378 0.5378
Plasmodium falciparum alpha tubulin 2 0.0657 0.5378 0.5338
Entamoeba histolytica tubulin alpha chain, putative 0.0657 0.5378 0.5361
Loa Loa (eye worm) beta-lactamase 0.0026 0.0138 0.0133
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0018 0.0073 0.0277
Loa Loa (eye worm) inositol-1 0.0027 0.0144 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.017 0.0134
Mycobacterium leprae Probable polyketide synthase Pks1 0.002 0.0082 0.0328
Brugia malayi Tubulin gamma chain 0.0549 0.448 0.446
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0045 0.0294 0.0211
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0101 0.0065
Loa Loa (eye worm) tubulin gamma chain 0.0549 0.448 0.4477
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0058 0.0402 0.0387
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0138 0.0102
Trichomonas vaginalis tubulin alpha chain, putative 0.031 0.25 0.2472
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0138 0.0626
Echinococcus multilocularis cysteine protease 0.0045 0.0294 0.028
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.002 0.0085 0.0042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0101 0.0065
Onchocerca volvulus 0.0045 0.0294 0.0951
Trypanosoma cruzi cruzipain precursor, putative 0.0015 0.0043 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0133 0.0097
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0101 0.0083
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0065 0.0458 0.0423
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0028 0.0149 0.0752
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0018 0.0068 0.0326
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0034 0.0202 0.0166
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0112 0.0097
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Echinococcus granulosus peptidase Clp S14 family 0.0038 0.0236 0.0221
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0101 0.0086
Onchocerca volvulus 0.0045 0.0294 0.0951
Echinococcus granulosus tubulin alpha chain 0.0657 0.5378 0.5371
Echinococcus multilocularis Tubulin alpha 1 chain 0.0657 0.5378 0.5371
Echinococcus granulosus tubulin alpha 1C chain 0.0657 0.5378 0.5371
Echinococcus multilocularis dna polymerase kappa 0.0014 0.0036 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0045 0.0294 0.0259
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0045 0.0294 0.028
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Loa Loa (eye worm) hypothetical protein 0.0074 0.0532 0.0527
Mycobacterium tuberculosis Probable hydrolase 0.0026 0.0138 0.0696
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0101 0.0101
Trypanosoma brucei alpha tubulin 0.0657 0.5378 0.5378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Brugia malayi Thioredoxin reductase 0.0063 0.0445 0.041
Mycobacterium ulcerans lipase LipD 0.0026 0.0138 0.0626
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0058 0.0402 0.1673
Echinococcus multilocularis peroxisome assembly protein 26 0.0657 0.5378 0.5371
Plasmodium vivax tubulin alpha chain, putative 0.0657 0.5378 0.5358
Treponema pallidum exodeoxyribonuclease (exoA) 0.0034 0.0202 0.0641
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0036 0.0159
Echinococcus granulosus survival motor neuron protein 1 0.0176 0.1379 0.1366
Echinococcus granulosus tubulin alpha chain 0.0657 0.5378 0.5371
Brugia malayi alpha-tubulin 0.0657 0.5378 0.5361
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0018 0.0073 0.0277
Echinococcus multilocularis tubulin gamma 1 chain 0.0549 0.448 0.4472
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0133
Trichomonas vaginalis tubulin, putative 0.0238 0.1899 0.187
Entamoeba histolytica tubulin alpha-1 chain 0.0657 0.5378 0.5361
Trypanosoma brucei zeta tubulin, putative 0.0238 0.1899 0.1899
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.031 0.25 0.2472
Loa Loa (eye worm) tubulin alpha-3 chain 0.0346 0.2797 0.2793
Mycobacterium ulcerans thioesterase TesA 0.0015 0.0047 0.0141
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.017 0.0156
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0082 0.0064
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.002 0.0082 0.0328
Onchocerca volvulus 0.003 0.017 0.0442
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0138 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0112 0.0076
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0043 0.0007
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0018 0.0068 0.0326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Echinococcus multilocularis tubulin alpha chain 0.0657 0.5378 0.5371
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0294 0.0259
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0176 0.1379 0.1375
Echinococcus granulosus tubulin delta chain 0.0238 0.1899 0.1887
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Echinococcus granulosus cathepsin L cysteine proteinase 0.0045 0.0294 0.028
Echinococcus multilocularis peptidase Clp (S14 family) 0.0038 0.0236 0.0221
Toxoplasma gondii ABC1 family protein 0.0026 0.0138 0.012
Echinococcus granulosus tubulin alpha chain 0.0657 0.5378 0.5371
Mycobacterium ulcerans Type I modular polyketide synthase 0.0018 0.0073 0.0277
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0101 0.0101
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0101 0.0065
Loa Loa (eye worm) alpha-tubulin 0.0657 0.5378 0.5375
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0035 0.021 0.0175
Echinococcus multilocularis Tubulin alpha 1 chain 0.0657 0.5378 0.5371
Loa Loa (eye worm) tubulin beta chain 0.0238 0.1899 0.1895
Giardia lamblia Epsilon tubulin 0.0238 0.1899 0.187
Brugia malayi Cathepsin L-like cysteine proteinase 0.003 0.017 0.0134
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.002 0.0082 0.0328
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0133 0.0115
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0058 0.0402 0.203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0657 0.5378 0.5361
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0138 0.0095
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0203 0.0188
Brugia malayi beta-lactamase family protein 0.0026 0.0138 0.0102
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0015 0.0047 0.0141
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Brugia malayi beta-lactamase 0.0026 0.0138 0.0102
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0027 0.0144 0.0656
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0045 0.0294 0.029
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Echinococcus granulosus cathepsin l1 0.003 0.017 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.1899 0.187
Mycobacterium tuberculosis Conserved protein 0.0026 0.0138 0.0696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0112 0.0076
Trichomonas vaginalis tubulin epsilon chain, putative 0.0238 0.1899 0.187
Loa Loa (eye worm) hypothetical protein 0.003 0.017 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0027 0.0144 0.0108
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0058 0.0402 1
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0202 0.0166
Trypanosoma brucei tubulin gamma chain 0.0549 0.448 0.448
Trypanosoma cruzi tubulin delta chain 0.0238 0.1899 0.187
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0294 0.0951
Trypanosoma cruzi epsilon tubulin, putative 0.0549 0.448 0.446
Echinococcus granulosus Tubulin alpha 1 chain 0.0657 0.5378 0.5371
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0144 0.0144
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0202 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0034 0.0202 0.0166
Brugia malayi hypothetical protein 0.0176 0.1379 0.1348
Plasmodium falciparum tubulin epsilon chain, putative 0.0549 0.448 0.4432
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.016 0.1252 0.6579
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Mycobacterium ulcerans beta-lactamase 0.0026 0.0138 0.0626
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0101 0.0501
Schistosoma mansoni tubulin subunit alpha 0.0657 0.5378 0.5371
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0144 0.0108
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0101 0.0065
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0036 0.0084
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0112 0.0076
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0168 0.1319 0.6936
Plasmodium falciparum thioredoxin reductase 0.0022 0.0101 0.0016
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0101 0.0065
Brugia malayi hypothetical protein 0.0024 0.0119 0.0083
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.002 0.0085 0.0345
Schistosoma mansoni hypothetical protein 0.0034 0.0203 0.0188
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0036 0.0021
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0024 0.012 0.0602
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0053 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0402 0.1745
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0043 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0031
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0101 0.0101
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0036 0.0036
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0017 0.0063 0.0297
Loa Loa (eye worm) hypothetical protein 0.0034 0.0203 0.0198
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0133
Schistosoma mansoni tubulin subunit gamma 0.0549 0.448 0.4472
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0112 0.0097
Echinococcus granulosus thioredoxin glutathione reductase 0.0064 0.0448 0.0433
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0065 0.0458 0.0444
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0034 0.0202 0.0187
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0101 0.0058
Entamoeba histolytica hypothetical protein 0.0024 0.0119 0.0083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0172
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.5378 0.5361
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0101 0.0065
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0045 0.0294 0.0211
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0532 0.0497
Onchocerca volvulus 0.0045 0.0294 0.0951
Trypanosoma brucei epsilon tubulin 0.0549 0.448 0.448
Echinococcus multilocularis tubulin alpha chain 0.0657 0.5378 0.5371
Loa Loa (eye worm) tubulin alpha chain 0.0657 0.5378 0.5375
Loa Loa (eye worm) tubulin alpha chain 0.0657 0.5378 0.5375
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0238 0.1899 0.1884
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0197 0.0183
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0101 0.0058
Plasmodium falciparum cysteine proteinase falcipain 3 0.0045 0.0294 0.0211
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0034 0.0202 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0034 0.0202 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Plasmodium falciparum cysteine proteinase falcipain 1 0.0023 0.0112 0.0027
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0445 0.0403
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0034 0.0202 0.0559
Brugia malayi hypothetical protein 0.0017 0.0057 0.0021
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Mycobacterium leprae cell division protein FtsZ 0.0238 0.1899 1
Brugia malayi Tubulin alpha chain 0.0238 0.1899 0.187
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0036 0.0036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0101 0.0428
Onchocerca volvulus 0.0045 0.0294 0.0951
Echinococcus granulosus tubulin alpha 3 chain 0.0657 0.5378 0.5371
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0402 0.0319
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0144 0.0108
Brugia malayi hypothetical protein 0.0026 0.0133 0.0097
Brugia malayi Cathepsin L-like precursor 0.003 0.017 0.0134
Onchocerca volvulus 0.0026 0.0138 0.031
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0445 0.044
Toxoplasma gondii hypothetical protein 0.002 0.0085 0.0067
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0458 0.0423
Giardia lamblia Alpha-tubulin 0.0657 0.5378 0.5361
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0144 0.0108
Plasmodium vivax vivapain-3 0.0023 0.0112 0.007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0038
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0065 0.0458 0.0444
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Leishmania major cathepsin L-like protease 0.0172 0.135 0.1318
Schistosoma mansoni hypothetical protein 0.0034 0.0203 0.0188
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0101 0.0083
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0101 0.0086
Echinococcus multilocularis tubulin alpha 1C chain 0.0657 0.5378 0.5371
Loa Loa (eye worm) MH2 domain-containing protein 0.0081 0.0595 0.0591
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0294 0.0259
Echinococcus granulosus tubulin alpha chain 0.0657 0.5378 0.5371
Loa Loa (eye worm) hypothetical protein 0.0101 0.0759 0.0754
Echinococcus granulosus tubulin alpha chain 0.0657 0.5378 0.5371
Loa Loa (eye worm) hypothetical protein 0.003 0.017 0.0165
Plasmodium vivax vivapain-2 0.0045 0.0294 0.0252
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0101 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0133 0.0048
Loa Loa (eye worm) fatty acid synthase 0.0018 0.0071 0.0066
Loa Loa (eye worm) hypothetical protein 0.0418 0.3397 0.3394
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0023 0.0112 0.0076
Echinococcus granulosus Tubulin alpha 1 chain 0.0657 0.5378 0.5371
Trichomonas vaginalis tubulin beta chain, putative 0.031 0.25 0.2472
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0038 0.0236 0.1211
Trypanosoma cruzi major cysteine proteinase, putative 0.0135 0.1043 0.1011
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0101 0.0016
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0028 0.0149 0.0752
Onchocerca volvulus 0.0026 0.0138 0.031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0138 0.0123
Loa Loa (eye worm) hypothetical protein 0.0065 0.0458 0.0453
Trichomonas vaginalis tubulin gamma chain, putative 0.0549 0.448 0.446
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0138 0.0102
Giardia lamblia Alpha-tubulin 0.0657 0.5378 0.5361
Echinococcus granulosus beta LACTamase domain containing family member 0.0026 0.0138 0.0123
Brugia malayi Cathepsin L-like precursor 0.0045 0.0294 0.0259
Leishmania major epsilon tubulin, putative 0.0549 0.448 0.446
Trichomonas vaginalis tubulin epsilon chain, putative 0.0657 0.5378 0.5361
Leishmania major cathepsin L-like protease 0.0172 0.135 0.1318
Entamoeba histolytica cysteine proteinase 1, putative 0.0023 0.0112 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0112
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.5378 0.5361
Trypanosoma brucei zeta tubulin 0.0238 0.1899 0.1899
Brugia malayi Cathepsin L-like precursor 0.003 0.017 0.0134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0128
Echinococcus multilocularis cysteine protease 0.0045 0.0294 0.028
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Mycobacterium tuberculosis Probable thioesterase TesA 0.0015 0.0047 0.0215
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0036 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0138 0.0102
Mycobacterium tuberculosis Probable lipase LipE 0.0026 0.0138 0.0696
Onchocerca volvulus 0.0045 0.0294 0.0951
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0018 0.0073 0.035
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0038 0.0236 0.1144
Leishmania major cathepsin L-like protease 0.0045 0.0294 0.0259
Toxoplasma gondii exonuclease III APE 0.0034 0.0202 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0816 0.0782
Trichomonas vaginalis tubulin, putative 0.031 0.25 0.2472
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.5378 0.5361
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0133 0.0097
Echinococcus multilocularis cathepsin L cysteine protease 0.0045 0.0294 0.028
Mycobacterium tuberculosis Cell division protein FtsZ 0.0238 0.1899 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0144 0.0108
Mycobacterium tuberculosis Probable esterase LipL 0.0026 0.0138 0.0696
Schistosoma mansoni transcription factor LCR-F1 0.0024 0.0119 0.0104
Echinococcus multilocularis beta LACTamase domain containing family member 0.0026 0.0138 0.0123
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0101 0.0428
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0144 0.0108
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Brugia malayi MH2 domain containing protein 0.0081 0.0595 0.0561
Schistosoma mansoni peptidase Clp (S14 family) 0.0058 0.0402 0.0387
Echinococcus granulosus cathepsin L 0.0023 0.0112 0.0097
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0026 0.0138 0.0696
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0202 0.0166
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0026 0.0138 0.0102
Loa Loa (eye worm) hypothetical protein 0.0058 0.0402 0.0397
Onchocerca volvulus 0.0045 0.0294 0.0951
Schistosoma mansoni tubulin subunit beta 0.0238 0.1899 0.1887
Entamoeba histolytica cysteine protease, putative 0.0045 0.0294 0.0259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0065 0.0458 0.0423
Loa Loa (eye worm) fibroinase 0.0045 0.0294 0.029
Toxoplasma gondii alpha tubulin TUBA1 0.0657 0.5378 0.5369
Toxoplasma gondii type I fatty acid synthase, putative 0.0013 0.0028 0.001
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.5378 0.5361
Echinococcus multilocularis tubulin alpha 3 chain 0.0657 0.5378 0.5371
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0065 0.0458 0.0423
Brugia malayi Tubulin alpha chain 0.0657 0.5378 0.5361
Brugia malayi hypothetical protein 0.0101 0.0759 0.0725
Plasmodium vivax delta tubulin, putative 0.0238 0.1899 0.1864
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0065 0.0458 0.0423
Mycobacterium ulcerans esterase/lipase LipP 0.0026 0.0138 0.0626
Schistosoma mansoni inositol monophosphatase 0.0027 0.0144 0.0129
Brugia malayi cathepsin L-like precursor 0.003 0.017 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Entamoeba histolytica cysteine proteinase, putative 0.003 0.017 0.0134
Schistosoma mansoni hypothetical protein 0.0024 0.0119 0.0104
Leishmania major cathepsin L-like protease 0.0045 0.0294 0.0259
Plasmodium vivax vivapain-2 0.0045 0.0294 0.0252
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0058 0.0402 0.0387
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0157 0.1225 0.1193
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0203 0.0167
Mycobacterium ulcerans cell division protein FtsZ 0.0238 0.1899 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0203 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Trypanosoma brucei beta tubulin 0.0549 0.448 0.448
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0197 0.0183
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0144 0.1118 0.5872
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0058 0.0402 0.036
Brugia malayi Cathepsin L-like precursor 0.0015 0.0043 0.0007
Echinococcus multilocularis tubulin subunit TubB 0.0657 0.5378 0.5371
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0294 0.0951
Plasmodium falciparum thioredoxin reductase 0.0063 0.0445 0.0362
Giardia lamblia Gamma tubulin 0.0549 0.448 0.446
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0203 0.0188
Leishmania major trypanothione reductase 0.0063 0.0445 0.041
Trichomonas vaginalis esterase, putative 0.0026 0.0138 0.0102
Brugia malayi Cathepsin L-like precursor 0.0045 0.0294 0.0259
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0063 0.0058
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0238 0.1899 0.1884
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0024 0.012 0.053
Schistosoma mansoni tubulin subunit alpha 0.0657 0.5378 0.5371
Entamoeba histolytica cysteine proteinase 2 0.0023 0.0112 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0038
Brugia malayi Cathepsin L-like precursor 0.0045 0.0294 0.0259
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Echinococcus granulosus tubulin alpha 1C chain 0.0657 0.5378 0.5371
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0197 0.0183
Echinococcus granulosus cathepsin l cysteine peptidase 0.0045 0.0294 0.028
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Leishmania major cathepsin L-like protease 0.0045 0.0294 0.0259
Trypanosoma brucei alpha tubulin 0.0657 0.5378 0.5378
Plasmodium vivax tubulin epsilon chain, putative 0.0549 0.448 0.4456
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.002 0.0082 0.0328
Loa Loa (eye worm) tubulin alpha 2 0.0418 0.3397 0.3394
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0014 0.0036 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Echinococcus granulosus dna polymerase kappa 0.0014 0.0036 0.0021
Plasmodium vivax glutathione reductase, putative 0.0063 0.0445 0.0403
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Trypanosoma brucei epsilon tubulin 0.0549 0.448 0.448
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0133 0.0048
Plasmodium vivax tubulin gamma chain, putative 0.0549 0.448 0.4456
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0294 0.0259
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0101 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0197 0.0183
Schistosoma mansoni survival motor neuron protein 0.0036 0.0217 0.0202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Onchocerca volvulus 0.0045 0.0294 0.0951
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0034 0.0202 0.0166
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0549 0.448 0.4469
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0133
Mycobacterium ulcerans polyketide synthase 0.002 0.0082 0.0328
Trypanosoma cruzi cysteine protease, putative 0.0023 0.0112 0.0076
Trypanosoma cruzi zeta tubulin, putative 0.0238 0.1899 0.187
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0065 0.0458 0.0423
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0018 0.0073 0.035
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0015 0.0043 0.0117
Schistosoma mansoni inositol monophosphatase 0.0027 0.0144 0.0129
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0034 0.0202 0.0187
Mycobacterium ulcerans polyketide synthase 0.0018 0.0073 0.0277
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0036 0.0031
Echinococcus multilocularis microtubule associated protein 2 0.0916 0.7534 0.753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Onchocerca volvulus 0.0032 0.0187 0.0509
Trypanosoma cruzi cruzipain precursor, putative 0.0172 0.135 0.1318
Plasmodium falciparum tubulin gamma chain 0.0549 0.448 0.4432
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0065 0.0458 0.0444
Schistosoma mansoni tubulin subunit delta 0.0238 0.1899 0.1887
Echinococcus granulosus dna polymerase eta 0.0014 0.0036 0.0021
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0018 0.0073 0.0036
Loa Loa (eye worm) tubulin alpha 2 0.0108 0.0817 0.0812
Loa Loa (eye worm) transcription factor SMAD2 0.0081 0.0595 0.0591
Loa Loa (eye worm) glutathione reductase 0.0063 0.0445 0.044
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0018 0.0073 0.0277
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0445 0.041
Mycobacterium ulcerans hypothetical protein 0.0026 0.0138 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Schistosoma mansoni ap endonuclease 0.0034 0.0202 0.0187
Onchocerca volvulus Fatty acid synthase homolog 0.0033 0.0196 0.0548
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0133
Echinococcus multilocularis survival motor neuron protein 1 0.0176 0.1379 0.1366
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0015 0.0043 0.0117
Plasmodium falciparum glutathione reductase 0.0063 0.0445 0.0362
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0043 0.0038
Toxoplasma gondii cathepsin CPL 0.0045 0.0294 0.0276
Loa Loa (eye worm) hypothetical protein 0.0108 0.0816 0.0811
Echinococcus multilocularis Tubulin alpha 1 chain 0.0657 0.5378 0.5371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0112 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0063 0.0026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0144 0.1118 0.5872
Leishmania major zeta tubulin, putative 0.0238 0.1899 0.187
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0238 0.1899 0.187
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Trypanosoma brucei trypanothione reductase 0.0063 0.0445 0.0445
Onchocerca volvulus 0.031 0.25 1
Trypanosoma cruzi zeta tubulin, putative 0.0238 0.1899 0.187
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0294 0.028
Brugia malayi glutathione reductase 0.0063 0.0445 0.041
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0058 0.0402 0.203
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0101 0.0065
Schistosoma mansoni tubulin subunit alpha 0.0657 0.5378 0.5371
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0015 0.0045 0.0202
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0418 0.3397 0.3373
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0036 0.0036
Echinococcus granulosus cathepsin L cysteine protease 0.0023 0.0112 0.0097
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0027 0.0144 0.0125
Leishmania major gamma-tubulin 0.0549 0.448 0.446
Echinococcus multilocularis cathepsin L cysteine protease 0.0045 0.0294 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0024 0.0119 0.0104
Onchocerca volvulus 0.0036 0.0217 0.0633
Echinococcus multilocularis dna polymerase eta 0.0014 0.0036 0.0021
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0238 0.1899 1
Brugia malayi exodeoxyribonuclease III family protein 0.0034 0.0202 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Onchocerca volvulus 0.0026 0.0138 0.031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0065 0.0458 0.0423
Trichomonas vaginalis tubulin, putative 0.031 0.25 0.2472
Echinococcus multilocularis tubulin alpha chain 0.0657 0.5378 0.5371
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0112 0.0076
Trypanosoma cruzi tubulin gamma chain 0.0549 0.448 0.446
Schistosoma mansoni DNA polymerase eta 0.0014 0.0036 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0065 0.0458 0.0458
Trichomonas vaginalis tubulin gamma chain, putative 0.0238 0.1899 0.187
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0045 0.0294 0.028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0294 0.0259
Loa Loa (eye worm) ctsf protein 0.0045 0.0294 0.029
Trypanosoma brucei tubulin delta chain 0.0238 0.1899 0.1899
Onchocerca volvulus 0.0101 0.0759 0.2858
Brugia malayi tubulin alpha-2 chain 0.0657 0.5378 0.5361
Plasmodium falciparum alpha tubulin 1 0.0657 0.5378 0.5338
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0013 0.0029 0.0122
Trichomonas vaginalis tubulin epsilon chain, putative 0.0657 0.5378 0.5361
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0036 0.0084
Trypanosoma cruzi epsilon tubulin, putative 0.0549 0.448 0.446
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0038 0.0236 0.1211
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0144 0.1118 0.5841
Leishmania major cathepsin L-like protease 0.0172 0.135 0.1318
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0065 0.0458 0.0444
Entamoeba histolytica hypothetical protein 0.0024 0.0119 0.0083
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Brugia malayi Cathepsin L-like precursor 0.0045 0.0294 0.0259
Echinococcus multilocularis tubulin alpha 3 chain 0.0657 0.5378 0.5371
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0038
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0058 0.0402 0.0384
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0112 0.0076
Trichomonas vaginalis tubulin alpha chain, putative 0.031 0.25 0.2472
Echinococcus granulosus inositol monophosphatase 1 0.0027 0.0144 0.0129
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.0197 0.0162
Trichomonas vaginalis tubulin beta chain, putative 0.0657 0.5378 0.5361
Plasmodium falciparum tubulin delta chain, putative 0.0238 0.1899 0.183
Schistosoma mansoni tubulin subunit epsilon 0.0549 0.448 0.4472
Plasmodium vivax tubulin alpha chain, putative 0.0657 0.5378 0.5358
Brugia malayi beta-lactamase family protein 0.0026 0.0138 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.135 0.1318
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0138 0.0123
Echinococcus granulosus tubulin subunit TubB 0.0657 0.5378 0.5371
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.135 0.1318
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0138 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Mycobacterium leprae Probable lipase LipE 0.0026 0.0138 0.0626
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Echinococcus multilocularis thioredoxin glutathione reductase 0.0064 0.0448 0.0433
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0203 0.0167
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0346 0.2797 0.2771
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0112 0.0076
Echinococcus granulosus Tubulin alpha 1 chain 0.0657 0.5378 0.5371
Toxoplasma gondii alpha-tubulin I, putative 0.0657 0.5378 0.5369
Brugia malayi Tubulin beta chain 0.0238 0.1899 0.187
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0065 0.0458 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Echinococcus granulosus tubulin gamma 1 chain 0.0549 0.448 0.4472
Trypanosoma cruzi tubulin delta chain 0.0238 0.1899 0.187
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0026 0.0138 0.0696
Echinococcus multilocularis ubiquitin specific protease 41 0.0065 0.0458 0.0444
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0816 0.0811
Mycobacterium ulcerans polyketide synthase Pks13 0.0028 0.0149 0.0682
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0053 0.0016
Echinococcus multilocularis hypothetical protein 0.0657 0.5378 0.5371
Leishmania major hypothetical protein, conserved 0.0026 0.0138 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Trichomonas vaginalis tubulin alpha chain, putative 0.0549 0.448 0.446
Brugia malayi Cell division protein ftsZ 0.0238 0.1899 0.187
Mycobacterium ulcerans Type I modular polyketide synthase 0.0018 0.0073 0.0277
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0058 0.0402 0.203
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0034 0.0202 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Schistosoma mansoni tubulin subunit alpha 0.0238 0.1899 0.1887
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0197 0.0183
Echinococcus multilocularis tubulin alpha chain 0.0657 0.5378 0.5371
Schistosoma mansoni cathepsin s 0.0015 0.0043 0.0028
Brugia malayi Cathepsin L-like precursor 0.0045 0.0294 0.0259
Schistosoma mansoni ap endonuclease 0.0034 0.0202 0.0187
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.002 0.0082 0.0328
Mycobacterium tuberculosis Polyketide synthase Pks12 0.002 0.0082 0.0401
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0065 0.0458 0.0444
Toxoplasma gondii thioredoxin reductase 0.0063 0.0445 0.0427
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0346 0.2797 0.2793
Loa Loa (eye worm) tubulin alpha 2 0.0418 0.3397 0.3394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Mycobacterium tuberculosis Conserved protein 0.0026 0.0138 0.0696
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.002 0.0082 0.0401
Trypanosoma brucei alpha tubulin 0.0657 0.5378 0.5378
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.135 0.1318
Echinococcus granulosus peroxisome assembly protein 26 0.0657 0.5378 0.5371
Entamoeba histolytica hypothetical protein 0.0024 0.0119 0.0083
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0034 0.0202 0.1031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0445 0.2315
Mycobacterium tuberculosis Probable lipase LipD 0.0026 0.0138 0.0696
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0112 0.0076
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0015 0.0043 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0045 0.0294 0.0259
Entamoeba histolytica cysteine protease, putative 0.0023 0.0112 0.0076
Leishmania major hypothetical protein, conserved 0.0026 0.0133 0.0097
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.1252 0.6579
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0058 0.0402 0.0384
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0058 0.0402 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0657 0.5378 0.5371
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0112 0.0097
Trypanosoma brucei unspecified product 0.0014 0.0036 0.0036
Echinococcus granulosus tubulin epsilon chain 0.0549 0.448 0.4472
Echinococcus granulosus alpha tubulin 0.0657 0.5378 0.5371
Mycobacterium tuberculosis Probable dehydrogenase 0.0144 0.1118 0.5872
Brugia malayi Tubulin alpha-2 chain 0.0657 0.5378 0.5361
Echinococcus multilocularis GPCR, family 2 0.0034 0.0203 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0036 0.0021
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0018 0.0073 0.035
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0133 0.009
Leishmania major delta tubulin, putative 0.0238 0.1899 0.187
Echinococcus granulosus microtubule associated protein 2 0.0916 0.7534 0.753
Trypanosoma brucei epsilon tubulin 0.0549 0.448 0.448
Echinococcus multilocularis tubulin alpha chain 0.0657 0.5378 0.5371
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0015 0.0043 0.0007
Mycobacterium tuberculosis Conserved protein 0.0026 0.0138 0.0696
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0144 0.1118 0.5872
Schistosoma mansoni hypothetical protein 0.0074 0.0532 0.0518
Trypanosoma brucei alpha tubulin, putative 0.031 0.25 0.25
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Treponema pallidum NADH oxidase 0.0022 0.0101 0.0087
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.016 0.1252 0.6553
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0024 0.0119 0.0104
Echinococcus multilocularis cathepsin L 0.0023 0.0112 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.017 0.0165
Echinococcus multilocularis inositol monophosphatase 1 0.0027 0.0144 0.0129
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0027 0.0144 0.0238
Schistosoma mansoni hypothetical protein 0.0034 0.0203 0.0188
Loa Loa (eye worm) hypothetical protein 0.0045 0.0294 0.029
Brugia malayi Probable ClpP-like protease 0.0058 0.0402 0.0367
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0101 0.0086
Trichomonas vaginalis tubulin alpha chain, putative 0.031 0.25 0.2472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.016 0.1252 0.6579
Leishmania major cathepsin L-like protease 0.0045 0.0294 0.0259
Plasmodium vivax vivapain-1 0.0023 0.0112 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0197 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.135 0.135
Echinococcus multilocularis tubulin delta chain 0.0238 0.1899 0.1887
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0816 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0076
Entamoeba histolytica tubulin gamma chain 0.0549 0.448 0.446
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0065 0.0458 0.0423
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0112 0.0076
Schistosoma mansoni alpha tubulin 0.0657 0.5378 0.5371
Treponema pallidum cell division protein FtsZ 0.0238 0.1899 1
Schistosoma mansoni alpha tubulin 0.0657 0.5378 0.5371
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0144 0.1118 0.5872
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0076
Loa Loa (eye worm) cysteine protease 0.0045 0.0294 0.029
Plasmodium vivax unspecified product 0.0023 0.0112 0.007
Echinococcus granulosus ubiquitin specific protease 41 0.0065 0.0458 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.017 0.0134
Echinococcus multilocularis tubulin alpha 0.0549 0.448 0.4472
Schistosoma mansoni hypothetical protein 0.0034 0.0203 0.0188
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0418 0.3397 0.3394
Leishmania major cysteine peptidase A (CPA) 0.0045 0.0294 0.0259
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0203 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Brugia malayi Tubulin beta chain 0.031 0.25 0.2472
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0034 0.0202 0.0963
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0101 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.1899 0.187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0197 0.0183
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.002 0.0082 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0294 0.0259
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0101 0.0428
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0133
Schistosoma mansoni microtubule-associated protein tau 0.0916 0.7534 0.753
Mycobacterium tuberculosis Probable reductase 0.0144 0.1118 0.5872
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0036 0.0217 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0138 0.0102
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0026 0.0138 0.0626
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0294 0.029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0203 0.0188
Echinococcus granulosus GPCR family 2 0.0034 0.0203 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0065 0.0458 0.0444
Loa Loa (eye worm) alpha-tubulin 0.0657 0.5378 0.5375
Plasmodium falciparum glutathione reductase 0.0022 0.0101 0.0016
Echinococcus granulosus tubulin alpha 0.0549 0.448 0.4472
Entamoeba histolytica hypothetical protein 0.0024 0.0119 0.0083
Onchocerca volvulus Cathepsin F homolog 0.0045 0.0294 0.0951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0112
Mycobacterium leprae Polyketide synthase Pks13 0.0028 0.0149 0.0682
Echinococcus multilocularis tubulin epsilon chain 0.0549 0.448 0.4472
Trypanosoma cruzi alpha tubulin, putative 0.0657 0.5378 0.5361
Brugia malayi Tubulin alpha-2 chain 0.0657 0.5378 0.5361
Loa Loa (eye worm) tubulin alpha-2 chain 0.0657 0.5378 0.5375
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0294 0.028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0101 0.0065
Trichomonas vaginalis tubulin gamma chain, putative 0.0549 0.448 0.446
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0036
Brugia malayi Cathepsin L-like precursor 0.0045 0.0294 0.0259
Leishmania major alpha tubulin 0.0657 0.5378 0.5361
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.0197 0.0192
Schistosoma mansoni alpha tubulin 0.0657 0.5378 0.5371
Leishmania major cathepsin L-like protease 0.0045 0.0294 0.0259
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0138 0.0102
Echinococcus granulosus cysteine protease 0.0023 0.0112 0.0097

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 11.2 % Growth inhibition of human MDA-MB-468 cells at 10 uM after 48 hrs by single dose SRB assay ChEMBL. 23036952
Inhibition (binding) = 0 % Inhibition of recombinant human FTase using dansyl-GCVLS as substrate at 100 uM after 15 mins by fluorimetric analysis ChEMBL. 23036952

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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