Detailed information for compound 1722920

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.44 | Formula: C22H25NO
  • H donors: 0 H acceptors: 1 LogP: 4.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1[C@@H](CC(=O)C([C@@H]1c1ccccc1)(C)C)c1ccccc1
  • InChi: 1S/C22H25NO/c1-4-15-23-19(17-11-7-5-8-12-17)16-20(24)22(2,3)21(23)18-13-9-6-10-14-18/h4-14,19,21H,1,15-16H2,2-3H3/t19-,21-/m0/s1
  • InChiKey: NIGMYUZXIALJOI-FPOVZHCZSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0739 0.1167
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0248 0.0177
Trichomonas vaginalis tubulin alpha chain, putative 0.028 0.3145 0.3865
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1281 0.1573
Trypanosoma brucei alpha tubulin 0.0289 0.3245 0.391
Echinococcus granulosus tubulin epsilon chain 0.028 0.3145 0.3865
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0289 0.3245 0.3988
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.061 0.4292
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.061 0.0628
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0739 0.1167
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0288 0.0227
Schistosoma mansoni hypothetical protein 0.0047 0.0406 0.048
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0106 0.0129
Schistosoma mansoni tubulin subunit beta 0.0705 0.8135 1
Trypanosoma cruzi tubulin gamma chain 0.028 0.3145 0.3784
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0288 0.0227
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0288 0.0227
Brugia malayi follicle stimulating hormone receptor 0.0485 0.5549 0.6814
Mycobacterium ulcerans lipase LipD 0.0076 0.0739 0.539
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0739 0.0908
Entamoeba histolytica tubulin family protein 0.0705 0.8135 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0289 0.3245 0.3245
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0908
Trypanosoma brucei beta tubulin 0.0705 0.8135 1
Schistosoma mansoni tubulin subunit beta 0.0705 0.8135 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1562 0.192
Toxoplasma gondii alpha tubulin TUBA1 0.0289 0.3245 0.391
Leishmania major beta tubulin 0.0705 0.8135 1
Schistosoma mansoni tubulin subunit alpha 0.0289 0.3245 0.3977
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0288 0.0353
Echinococcus multilocularis GPCR, family 2 0.0146 0.1562 0.1562
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0167 0.1815 0.223
Echinococcus multilocularis Tubulin beta 2C chain 0.0705 0.8135 0.8135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.1002 0.1231
Trichomonas vaginalis tubulin epsilon chain, putative 0.0289 0.3245 0.3988
Plasmodium vivax tubulin beta chain, putative 0.0705 0.8135 1
Mycobacterium ulcerans cell division protein FtsZ 0.0122 0.1281 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0705 0.8135 1
Loa Loa (eye worm) hypothetical protein 0.046 0.5259 0.6465
Brugia malayi MH2 domain containing protein 0.012 0.1265 0.1538
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0146 0.1562 0.1903
Trypanosoma brucei alpha tubulin, putative 0.0159 0.1714 0.2003
Entamoeba histolytica hypothetical protein 0.0116 0.1213 0.1378
Echinococcus granulosus tubulin alpha chain 0.0289 0.3245 0.3989
Brugia malayi hypothetical protein 0.0163 0.1765 0.2154
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0485 0.5549 0.6821
Echinococcus granulosus tubulin delta chain 0.0122 0.1281 0.1574
Schistosoma mansoni cpg binding protein 0.006 0.0554 0.0663
Brugia malayi hypothetical protein 0.0028 0.0179 0.0201
Trypanosoma cruzi zeta tubulin, putative 0.0122 0.1281 0.1463
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.06 0.0737
Leishmania major zeta tubulin, putative 0.0122 0.1281 0.1463
Loa Loa (eye worm) hypothetical protein 0.0061 0.0562 0.0691
Schistosoma mansoni ap endonuclease 0.0022 0.0106 0.0111
Schistosoma mansoni tubulin subunit epsilon 0.028 0.3145 0.3854
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0739 0.089
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0179 0.0091
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0248 0.0177
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Schistosoma mansoni intermediate filament proteins 0.0026 0.0161 0.0179
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0333 0.0391
Entamoeba histolytica hypothetical protein 0.0116 0.1213 0.1378
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0161 0.0198
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0248 0.0305
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0248 0.0177
Leishmania major beta tubulin 0.0705 0.8135 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0705 0.8135 0.8135
Trichomonas vaginalis tubulin beta chain, putative 0.0289 0.3245 0.3988
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0516 0.0634
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0908
Schistosoma mansoni inositol monophosphatase 0.0037 0.0288 0.0336
Entamoeba histolytica tubulin alpha chain, putative 0.0289 0.3245 0.391
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0946 0.1163
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.06 0.0737
Echinococcus multilocularis peroxisome assembly protein 26 0.0289 0.3245 0.3245
Trichomonas vaginalis tubulin gamma chain, putative 0.0122 0.1281 0.1573
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0739 0.1167
Brugia malayi Latrophilin receptor protein 2 0.0146 0.1562 0.1903
Trichomonas vaginalis esterase, putative 0.0076 0.0739 0.0907
Echinococcus multilocularis tubulin alpha chain 0.0289 0.3245 0.3245
Giardia lamblia Alpha-tubulin 0.0289 0.3245 0.391
Loa Loa (eye worm) tubulin alpha 2 0.0167 0.1815 0.2231
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0333 0.0283
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0739 0.0908
Schistosoma mansoni cpg binding protein 0.006 0.0554 0.0663
Echinococcus multilocularis Tubulin beta 2C chain 0.0705 0.8135 0.8135
Plasmodium vivax tubulin epsilon chain, putative 0.028 0.3145 0.3784
Brugia malayi beta-lactamase 0.0076 0.0739 0.089
Leishmania major beta tubulin 0.0705 0.8135 1
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Brugia malayi isocitrate dehydrogenase 0.0034 0.0248 0.0285
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0179 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1262 0.1535
Echinococcus multilocularis tubulin subunit TubB 0.0289 0.3245 0.3245
Echinococcus multilocularis Tubulin beta 2C chain 0.0705 0.8135 0.8135
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0248 0.0305
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0333 0.0283
Mycobacterium ulcerans hypothetical protein 0.0076 0.0739 0.539
Echinococcus multilocularis tubulin alpha chain 0.0289 0.3245 0.3245
Echinococcus granulosus GPCR family 2 0.0146 0.1562 0.192
Trypanosoma brucei epsilon tubulin 0.028 0.3145 0.3784
Loa Loa (eye worm) hypothetical protein 0.0289 0.3245 0.3989
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.1111 0.1252
Schistosoma mansoni ap endonuclease 0.0022 0.0106 0.0111
Loa Loa (eye worm) hypothetical protein 0.0315 0.3548 0.4361
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.0984 0.0984
Schistosoma mansoni tubulin subunit alpha 0.0122 0.1281 0.1558
Trypanosoma brucei beta tubulin 0.028 0.3145 0.3784
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0908
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0248 0.0285
Trichomonas vaginalis tubulin beta chain, putative 0.0705 0.8135 1
Echinococcus granulosus tubulin alpha 0.028 0.3145 0.3865
Mycobacterium tuberculosis Conserved protein 0.0076 0.0739 0.1167
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0333 0.041
Brugia malayi hypothetical protein 0.0232 0.2573 0.3149
Echinococcus granulosus tubulin beta 4A class IVa 0.0705 0.8135 1
Echinococcus granulosus tubulin alpha chain 0.0289 0.3245 0.3989
Brugia malayi latrophilin 2 splice variant baaae 0.0315 0.3548 0.435
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0333 0.0283
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0179 0.0091
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0248 0.0177
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0056 0.0069
Schistosoma mansoni inositol monophosphatase 0.0037 0.0288 0.0336
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0272 0.0334
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0146 0.1562 0.192
Brugia malayi CXXC zinc finger family protein 0.0057 0.0516 0.0615
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0739 0.0907
Loa Loa (eye worm) tubulin alpha-2 chain 0.0289 0.3245 0.3989
Brugia malayi Tubulin alpha chain 0.0122 0.1281 0.1557
Loa Loa (eye worm) hypothetical protein 0.0232 0.2573 0.3163
Loa Loa (eye worm) tubulin gamma chain 0.028 0.3145 0.3865
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.1002 0.1213
Echinococcus multilocularis lamin 0.0026 0.0161 0.0161
Echinococcus multilocularis tubulin alpha 1C chain 0.0289 0.3245 0.3245
Plasmodium vivax tubulin gamma chain, putative 0.028 0.3145 0.3784
Trypanosoma brucei beta tubulin 0.0705 0.8135 1
Giardia lamblia Alpha-tubulin 0.0289 0.3245 0.391
Trichomonas vaginalis tubulin alpha chain, putative 0.0159 0.1714 0.2106
Loa Loa (eye worm) tubulin beta-4 chain 0.0705 0.8135 1
Trypanosoma brucei alpha tubulin 0.0289 0.3245 0.391
Loa Loa (eye worm) hypothetical protein 0.0167 0.1815 0.2231
Echinococcus multilocularis Tubulin beta 2C chain 0.0705 0.8135 0.8135
Echinococcus multilocularis tubulin alpha chain 0.0289 0.3245 0.3245
Giardia lamblia Beta tubulin 0.0705 0.8135 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0333 0.0283
Trichomonas vaginalis tubulin epsilon chain, putative 0.0705 0.8135 1
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0739 0.1167
Echinococcus granulosus lamin 0.0026 0.0161 0.0198
Loa Loa (eye worm) latrophilin receptor protein 2 0.0146 0.1562 0.192
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0406 0.0479
Leishmania major epsilon tubulin, putative 0.028 0.3145 0.3784
Schistosoma mansoni tubulin subunit beta 0.0705 0.8135 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.1765 0.217
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0739 0.0739
Echinococcus multilocularis lamin dm0 0.0026 0.0161 0.0161
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.061 0.061
Leishmania major beta tubulin 0.0705 0.8135 1
Giardia lamblia Gamma tubulin 0.028 0.3145 0.3784
Trypanosoma cruzi zeta tubulin, putative 0.0122 0.1281 0.1463
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0146 0.1562 0.192
Giardia lamblia Beta tubulin 0.0705 0.8135 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0705 0.8135 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0288 0.0353
Loa Loa (eye worm) tubulin beta chain 0.0122 0.1281 0.1574
Schistosoma mansoni tubulin subunit beta 0.0705 0.8135 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0288 0.0227
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0106 0.013
Schistosoma mansoni tubulin subunit beta 0.0705 0.8135 1
Echinococcus multilocularis geminin 0.07 0.8081 0.8081
Trypanosoma brucei tubulin delta chain 0.0122 0.1281 0.1463
Plasmodium vivax tubulin alpha chain, putative 0.0289 0.3245 0.391
Echinococcus multilocularis beta tubulin 0.0705 0.8135 0.8135
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0122 0.1281 0.1463
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0272 0.0314
Mycobacterium leprae cell division protein FtsZ 0.0122 0.1281 1
Plasmodium falciparum tubulin epsilon chain, putative 0.028 0.3145 0.3784
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0248 0.0177
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0248 0.0287
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0483 0.5529 1
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0739 0.0907
Brugia malayi hypothetical protein 0.0116 0.1213 0.1473
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0019
Loa Loa (eye worm) tubulin alpha-3 chain 0.013 0.1381 0.1698
Brugia malayi beta-tubulin, identical 0.0705 0.8135 1
Echinococcus multilocularis musashi 0.0026 0.0161 0.0161
Giardia lamblia Delta tubulin 0.0122 0.1281 0.1463
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0161 0.0198
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Echinococcus granulosus tubulin alpha chain 0.0289 0.3245 0.3989
Leishmania major gamma-tubulin 0.028 0.3145 0.3784
Loa Loa (eye worm) tubulin beta chain 0.0705 0.8135 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.061 0.4292
Trichomonas vaginalis tubulin beta chain, putative 0.0289 0.3245 0.3988
Trichomonas vaginalis tubulin beta chain, putative 0.0289 0.3245 0.3988
Entamoeba histolytica hypothetical protein 0.0116 0.1213 0.1378
Brugia malayi hypothetical protein 0.0134 0.1423 0.1732
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.061 0.4292
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0739 0.0788
Loa Loa (eye worm) hypothetical protein 0.013 0.1381 0.1698
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0739 0.539
Trichomonas vaginalis tubulin, putative 0.0159 0.1714 0.2106
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0739 0.1167
Mycobacterium leprae Probable lipase LipE 0.0076 0.0739 0.4786
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0333 0.0333
Echinococcus multilocularis hypothetical protein 0.0289 0.3245 0.3245
Trypanosoma brucei zeta tubulin 0.0122 0.1281 0.1463
Leishmania major beta tubulin 0.0705 0.8135 1
Leishmania major beta tubulin 0.0705 0.8135 1
Echinococcus granulosus geminin 0.07 0.8081 0.9934
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0333 0.041
Echinococcus granulosus tubulin subunit TubB 0.0289 0.3245 0.3989
Leishmania major beta tubulin 0.0705 0.8135 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0333 0.039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1002 0.1231
Echinococcus granulosus Tubulin alpha 1 chain 0.0289 0.3245 0.3989
Echinococcus granulosus Tubulin beta 2C chain 0.0705 0.8135 1
Trypanosoma cruzi alpha tubulin, putative 0.0289 0.3245 0.391
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0159 0.1714 0.2106
Onchocerca volvulus 0.0076 0.0739 0.3605
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0739 0.0907
Trypanosoma brucei epsilon tubulin 0.028 0.3145 0.3784
Plasmodium vivax delta tubulin, putative 0.0122 0.1281 0.1463
Schistosoma mansoni hypothetical protein 0.0146 0.1562 0.1904
Schistosoma mansoni alpha tubulin 0.0289 0.3245 0.3977
Schistosoma mansoni hypothetical protein 0.0146 0.1562 0.1904
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.06 0.06
Giardia lamblia Beta tubulin 0.0705 0.8135 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0106 0.0129
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.061 0.0628
Loa Loa (eye worm) tubulin alpha 2 0.0167 0.1815 0.2231
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0248 0.0177
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0288 0.0354
Brugia malayi tubulin alpha-2 chain 0.0289 0.3245 0.3977
Trichomonas vaginalis tubulin alpha chain, putative 0.0159 0.1714 0.2106
Brugia malayi Tubulin beta-1 chain 0.0705 0.8135 1
Schistosoma mansoni hypothetical protein 0.0401 0.456 0.5596
Echinococcus granulosus tubulin alpha 1C chain 0.0289 0.3245 0.3989
Trichomonas vaginalis tubulin beta chain, putative 0.0289 0.3245 0.3988
Trypanosoma brucei epsilon tubulin 0.028 0.3145 0.3784
Trichomonas vaginalis tubulin beta chain, putative 0.0159 0.1714 0.2106
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0161 0.0178
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0053 0.0045
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0122 0.1281 0.1463
Trichomonas vaginalis tubulin beta chain, putative 0.0289 0.3245 0.3988
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0146 0.1562 0.1562
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.061 0.0732
Loa Loa (eye worm) tubulin beta-1 chain 0.0705 0.8135 1
Brugia malayi Tubulin gamma chain 0.028 0.3145 0.3853
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0056 0.0056
Echinococcus granulosus Tubulin beta 2C chain 0.0705 0.8135 1
Schistosoma mansoni cpg binding protein 0.0057 0.0516 0.0616
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0015 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0106 0.0106
Trypanosoma cruzi epsilon tubulin, putative 0.028 0.3145 0.3784
Echinococcus multilocularis tubulin beta 1 chain 0.0705 0.8135 0.8135
Echinococcus multilocularis Tubulin beta 2C chain 0.0705 0.8135 0.8135
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0333 0.0333
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0248 0.0177
Schistosoma mansoni alpha tubulin 0.0289 0.3245 0.3977
Loa Loa (eye worm) alpha-tubulin 0.0289 0.3245 0.3989
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.028 0.3145 0.3784
Plasmodium vivax tubulin alpha chain, putative 0.0289 0.3245 0.391
Trichomonas vaginalis tubulin, putative 0.0122 0.1281 0.1573
Echinococcus multilocularis beta tubulin 0.0705 0.8135 0.8135
Trypanosoma cruzi epsilon tubulin, putative 0.028 0.3145 0.3784
Echinococcus granulosus tubulin alpha 1C chain 0.0289 0.3245 0.3989
Mycobacterium ulcerans beta-lactamase 0.0076 0.0739 0.539
Brugia malayi Inositol-1 0.0037 0.0288 0.0334
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0015 0.0019
Brugia malayi Tubulin beta chain 0.0122 0.1281 0.1557
Echinococcus granulosus tubulin alpha chain 0.0289 0.3245 0.3989
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0739 0.0907
Onchocerca volvulus 0.0047 0.0406 0.1526
Plasmodium falciparum tubulin beta chain 0.0705 0.8135 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0272 0.0272
Echinococcus granulosus Tubulin beta 2C chain 0.0705 0.8135 1
Onchocerca volvulus 0.0076 0.0739 0.3605
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Brugia malayi intermediate filament protein 0.0026 0.0161 0.0178
Echinococcus granulosus cpg binding protein 0.006 0.0554 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0333 0.0409
Loa Loa (eye worm) hypothetical protein 0.0036 0.0272 0.0334
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0739 0.4786
Schistosoma mansoni hypothetical protein 0.0146 0.1562 0.1904
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.061 0.0732
Echinococcus multilocularis tubulin epsilon chain 0.028 0.3145 0.3145
Trypanosoma cruzi tubulin delta chain 0.0122 0.1281 0.1463
Echinococcus multilocularis tubulin alpha 0.028 0.3145 0.3145
Echinococcus granulosus tubulin alpha 3 chain 0.0289 0.3245 0.3989
Echinococcus granulosus tubulin beta 1 chain 0.0705 0.8135 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1265 0.1555
Schistosoma mansoni tubulin subunit gamma 0.028 0.3145 0.3854
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.456 0.456
Schistosoma mansoni lamin 0.0026 0.0161 0.0179
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Brugia malayi Tubulin alpha chain 0.0289 0.3245 0.3977
Plasmodium falciparum alpha tubulin 1 0.0289 0.3245 0.391
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0146 0.1562 0.1562
Brugia malayi alpha-tubulin 0.0289 0.3245 0.3977
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0242 0.0251
Leishmania major hypothetical protein, conserved 0.0076 0.0739 0.0788
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1002 0.1002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1002 0.1214
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.0984 0.1192
Leishmania major beta tubulin 0.0705 0.8135 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0167 0.1815 0.2231
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0248 0.0177
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0333 0.0409
Leishmania major beta tubulin 0.0705 0.8135 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0289 0.3245 0.3989
Schistosoma mansoni hypothetical protein 0.0146 0.1562 0.1904
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0179 0.0091
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.06 0.06
Leishmania major beta tubulin 0.0705 0.8135 1
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.0984 0.1209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1002 0.1231
Schistosoma mansoni alpha tubulin 0.0289 0.3245 0.3977
Echinococcus multilocularis tubulin alpha chain 0.0289 0.3245 0.3245
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0288 0.0227
Mycobacterium tuberculosis Conserved protein 0.0076 0.0739 0.1167
Schistosoma mansoni transient receptor potential channel 0.0064 0.06 0.072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0155 0.0191
Loa Loa (eye worm) hypothetical protein 0.0033 0.0234 0.0288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0161 0.0198
Trypanosoma brucei tubulin gamma chain 0.028 0.3145 0.3784
Trypanosoma brucei zeta tubulin, putative 0.0122 0.1281 0.1463
Echinococcus granulosus Tubulin beta 2C chain 0.0705 0.8135 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0289 0.3245 0.3989
Brugia malayi Tubulin alpha-2 chain 0.0289 0.3245 0.3977
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1265 0.1555
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0016 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0739 0.0788
Trichomonas vaginalis tubulin epsilon chain, putative 0.0289 0.3245 0.3988
Trypanosoma cruzi beta tubulin, putative 0.0705 0.8135 1
Schistosoma mansoni hypothetical protein 0.07 0.8081 0.9934
Echinococcus granulosus alpha tubulin 0.0289 0.3245 0.3989
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0739 0.0891
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0288 0.1549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1002 0.1002
Brugia malayi beta-lactamase family protein 0.0076 0.0739 0.089
Loa Loa (eye worm) tubulin alpha chain 0.0289 0.3245 0.3989
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Echinococcus granulosus lamin dm0 0.0026 0.0161 0.0198
Schistosoma mansoni tubulin subunit beta 0.0122 0.1281 0.1558
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0946 0.0946
Giardia lamblia Epsilon tubulin 0.0122 0.1281 0.1463
Mycobacterium tuberculosis Cell division protein FtsZ 0.0122 0.1281 0.2166
Onchocerca volvulus 0.0076 0.0739 0.3605
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.046 0.5259 0.6458
Leishmania major beta tubulin 0.0705 0.8135 1
Echinococcus granulosus tubulin subunit beta 0.0705 0.8135 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0908
Trichomonas vaginalis tubulin gamma chain, putative 0.028 0.3145 0.3865
Schistosoma mansoni tubulin subunit delta 0.0122 0.1281 0.1558
Brugia malayi Tubulin alpha-2 chain 0.0289 0.3245 0.3977
Brugia malayi tubulin alpha chain - mouse 0.0289 0.3245 0.3977
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Echinococcus granulosus intermediate filament protein 0.0026 0.0161 0.0198
Loa Loa (eye worm) hypothetical protein 0.0134 0.1423 0.1749
Entamoeba histolytica tubulin alpha-1 chain 0.0289 0.3245 0.391
Echinococcus multilocularis tubulin alpha chain 0.0289 0.3245 0.3245
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0739 0.0788
Echinococcus multilocularis Tubulin alpha 1 chain 0.0289 0.3245 0.3245
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0333 0.0409
Loa Loa (eye worm) hypothetical protein 0.0041 0.0333 0.041
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0106 0.013
Toxoplasma gondii alpha-tubulin I, putative 0.0289 0.3245 0.391
Schistosoma mansoni tubulin subunit beta 0.0705 0.8135 1
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2573 0.3163
Echinococcus multilocularis tubulin gamma 1 chain 0.028 0.3145 0.3145
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0333 0.0283
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0248 0.0248
Loa Loa (eye worm) beta-lactamase 0.0076 0.0739 0.0908
Onchocerca volvulus 0.0057 0.0516 0.2212
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Echinococcus multilocularis tubulin alpha 1C chain 0.0289 0.3245 0.3245
Loa Loa (eye worm) hypothetical protein 0.0134 0.1423 0.1749
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0179 0.0091
Echinococcus granulosus beta tubulin 0.0705 0.8135 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0289 0.3245 0.3245
Leishmania major beta tubulin 0.0705 0.8135 1
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1281 0.1573
Trichomonas vaginalis tubulin, putative 0.0705 0.8135 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0705 0.8135 1
Echinococcus granulosus peroxisome assembly protein 26 0.0289 0.3245 0.3989
Brugia malayi hypothetical protein 0.0018 0.0063 0.0057
Echinococcus multilocularis tubulin delta chain 0.0122 0.1281 0.1281
Trypanosoma brucei alpha tubulin 0.0289 0.3245 0.391
Echinococcus multilocularis cpg binding protein 0.006 0.0554 0.0554
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2573 0.2573
Onchocerca volvulus 0.0163 0.1765 1
Leishmania major beta tubulin 0.0705 0.8135 1
Leishmania major beta tubulin 0.0705 0.8135 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0015 0.0015
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0122 0.1281 0.1573
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0179 0.0091
Brugia malayi Tubulin beta chain 0.0159 0.1714 0.2091
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0122 0.1281 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.046 0.5259 0.6465
Schistosoma mansoni tubulin subunit alpha 0.0289 0.3245 0.3977
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.013 0.1381 0.1697
Trichomonas vaginalis tubulin alpha chain, putative 0.0159 0.1714 0.2106
Schistosoma mansoni survival motor neuron protein 0.0047 0.0406 0.048
Echinococcus granulosus dnaJ subfamily B 0.0401 0.456 0.5605
Trypanosoma brucei beta tubulin 0.0705 0.8135 1
Plasmodium falciparum tubulin gamma chain 0.028 0.3145 0.3784
Mycobacterium tuberculosis Conserved protein 0.0076 0.0739 0.1167
Leishmania major beta tubulin 0.0705 0.8135 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1002 0.1214
Entamoeba histolytica tubulin gamma chain 0.028 0.3145 0.3784
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0333 0.0333
Loa Loa (eye worm) BEN-1 protein 0.0705 0.8135 1
Leishmania major beta tubulin 0.0705 0.8135 1
Onchocerca volvulus 0.0159 0.1714 0.9681
Schistosoma mansoni transient receptor potential channel 0.0064 0.06 0.072
Loa Loa (eye worm) inositol-1 0.0037 0.0288 0.0354
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0739 0.0891
Toxoplasma gondii beta tubulin 0.0705 0.8135 1
Leishmania major delta tubulin, putative 0.0122 0.1281 0.1463
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.1213 0.1491
Echinococcus multilocularis Tubulin alpha 1 chain 0.0289 0.3245 0.3245
Loa Loa (eye worm) hypothetical protein 0.0028 0.0179 0.0221
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.061 0.075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0248 0.0248
Leishmania major alpha tubulin 0.0289 0.3245 0.391
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0288 0.1549
Trichomonas vaginalis tubulin, putative 0.0159 0.1714 0.2106
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0333 0.041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.1213 0.1213
Trichomonas vaginalis tubulin beta chain, putative 0.0289 0.3245 0.3988
Brugia malayi beta-lactamase family protein 0.0076 0.0739 0.089
Trypanosoma cruzi tubulin delta chain 0.0122 0.1281 0.1463
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.1213 0.1474
Echinococcus granulosus tubulin gamma 1 chain 0.028 0.3145 0.3865
Entamoeba histolytica hypothetical protein 0.0116 0.1213 0.1378
Schistosoma mansoni tubulin subunit alpha 0.0289 0.3245 0.3977
Loa Loa (eye worm) tubulin alpha chain 0.0289 0.3245 0.3989
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1002 0.1214
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0179 0.0091
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0106 0.011
Loa Loa (eye worm) alpha-tubulin 0.0289 0.3245 0.3989
Schistosoma mansoni hypothetical protein 0.0315 0.3548 0.435
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0908
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0248 0.0177
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0288 0.0288
Onchocerca volvulus Huntingtin homolog 0.0134 0.1423 0.7865
Treponema pallidum cell division protein FtsZ 0.0122 0.1281 1
Schistosoma mansoni transient receptor potential channel 0.0096 0.0984 0.1192
Echinococcus granulosus tubulin alpha 3 chain 0.0289 0.3245 0.3989
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0056 0.0069
Loa Loa (eye worm) hypothetical protein 0.0076 0.0739 0.0908
Loa Loa (eye worm) hypothetical protein 0.0096 0.0984 0.1209
Toxoplasma gondii beta-1 tubulin, putative 0.0705 0.8135 1
Entamoeba histolytica tubulin family protein 0.0705 0.8135 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0248 0.0262
Echinococcus granulosus tubulin alpha chain 0.0289 0.3245 0.3989
Echinococcus granulosus Tubulin beta 2C chain 0.0705 0.8135 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0739 0.539
Toxoplasma gondii beta-tubulin, putative 0.0705 0.8135 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0705 0.8135 1
Schistosoma mansoni hypothetical protein 0.07 0.8081 0.9934
Leishmania major beta tubulin 0.0705 0.8135 1
Leishmania major beta tubulin 0.0705 0.8135 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0333 0.0283
Trypanosoma brucei beta tubulin 0.0705 0.8135 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0248 0.0248
Plasmodium falciparum alpha tubulin 2 0.0289 0.3245 0.391
Toxoplasma gondii ABC1 family protein 0.0076 0.0739 0.0788
Schistosoma mansoni lamin 0.0026 0.0161 0.0179
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.061 0.093
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0288 0.0353
Trypanosoma brucei alpha tubulin 0.0289 0.3245 0.391
Echinococcus granulosus beta tubulin 0.0705 0.8135 1
Onchocerca volvulus Huntingtin homolog 0.0134 0.1423 0.7865
Brugia malayi Cell division protein ftsZ 0.0122 0.1281 0.1557
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0739 0.0907
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0248 0.0248
Plasmodium falciparum tubulin delta chain, putative 0.0122 0.1281 0.1463
Echinococcus multilocularis Tubulin alpha 1 chain 0.0289 0.3245 0.3245
Leishmania major hypothetical protein, conserved 0.0028 0.0179 0.0091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0739 0.1167
Trichomonas vaginalis tubulin epsilon chain, putative 0.0122 0.1281 0.1573
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0333 0.0391
Trichomonas vaginalis tubulin gamma chain, putative 0.028 0.3145 0.3865
Loa Loa (eye worm) BEN-1 protein 0.0705 0.8135 1
Loa Loa (eye worm) beta-tubulin 0.0705 0.8135 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0739 0.0788
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0739 0.1167
Echinococcus multilocularis tubulin subunit beta 0.0705 0.8135 0.8135
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0288 0.0227
Brugia malayi Calcitonin receptor-like protein seb-1 0.046 0.5259 0.6458
Schistosoma mansoni hypothetical protein 0.0116 0.1213 0.1474

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 25 ug ml-1 Antibacterial activity against Escherichia coli ATCC 26032 after 24 hrs by two fold serial dilution method ChEMBL. 23031593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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