Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0109 | 0.1205 | 0.1241 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0088 | 0.0633 |
Brugia malayi | hypothetical protein | 0.0109 | 0.1205 | 0.1383 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0242 | 0.003 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0088 | 0.0633 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0954 | 0.0729 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1641 |
Echinococcus granulosus | acetylcholinesterase | 0.0648 | 0.8168 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0109 | 0.1205 | 0.1215 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0321 | 0.0379 |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.1205 | 0.1383 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0321 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1205 | 0.1462 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0012 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0587 | 0.0704 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0417 | 0.0407 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0012 | 0.0101 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0109 | 0.1205 | 0.1241 |
Loa Loa (eye worm) | carboxylesterase | 0.0109 | 0.1205 | 0.1462 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0321 | 0.01 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0648 | 0.8168 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1641 |
Onchocerca volvulus | 0.0109 | 0.1205 | 1 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.1561 | 0.1351 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0109 | 0.1205 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.1029 | 0.0806 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0417 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0093 |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.1205 | 0.1383 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0587 | 0.0618 |
Echinococcus multilocularis | neuroligin | 0.0109 | 0.1205 | 0.0987 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0417 | 0.0407 |
Onchocerca volvulus | 0.0109 | 0.1205 | 1 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0088 | 0.0633 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0441 | 0.0526 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0109 | 0.1205 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0587 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0093 |
Loa Loa (eye worm) | carboxylesterase | 0.0648 | 0.8168 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0587 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1029 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.8168 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0109 | 0.1205 | 0.1462 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0587 | 0.0464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0587 | 0.0464 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0587 | 0.0353 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0587 | 0.0704 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0109 | 0.1205 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0109 | 0.1205 | 0.1241 |
Echinococcus granulosus | carboxylesterase 5A | 0.0648 | 0.8168 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0109 | 0.1205 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0587 | 0.0464 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0109 | 0.1205 | 0.1241 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.1029 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0587 | 0.0704 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0109 | 0.1205 | 0.0987 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1641 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0109 | 0.1205 | 0.0987 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0242 | 0.0191 |
Echinococcus multilocularis | acetylcholinesterase | 0.0648 | 0.8168 | 0.8123 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0587 | 0.0618 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0109 | 0.1205 | 0.1241 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.0633 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0109 | 0.1205 | 0.0987 |
Onchocerca volvulus | 0.0109 | 0.1205 | 1 | |
Echinococcus granulosus | neuroligin | 0.0109 | 0.1205 | 0.1215 |
Echinococcus multilocularis | acetylcholinesterase | 0.0648 | 0.8168 | 0.8123 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0088 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1205 | 0.1462 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0396 | 0.0158 |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.1205 | 0.1383 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0417 | 0.0496 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0109 | 0.1205 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0218 | 0.0253 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.1048 | 0.1044 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0587 | 0.0618 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0242 | 0.003 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.0633 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0109 | 0.1205 | 0.1215 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0218 | 0.0162 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0109 | 0.1205 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0109 | 0.1205 | 0.1215 |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.1205 | 0.1383 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1205 | 0.1462 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0648 | 0.8168 | 1 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0321 | 0.0129 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0321 | 0.0081 |
Onchocerca volvulus | 0.0109 | 0.1205 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0587 | 0.0464 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0012 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.1029 | 0.0993 |
Echinococcus granulosus | acetylcholinesterase | 0.0648 | 0.8168 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1205 | 0.1462 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0105 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0105 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0648 | 0.8168 | 0.8123 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0321 | 0.01 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.0633 |
Schistosoma mansoni | gliotactin | 0.0109 | 0.1205 | 0.1241 |
Brugia malayi | Carboxylesterase family protein | 0.0648 | 0.8168 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.0633 |
Brugia malayi | Carboxylesterase family protein | 0.0648 | 0.8168 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1641 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0105 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0109 | 0.1205 | 0.1241 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0088 | 0.0727 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.1029 | 0.1165 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1205 | 0.1462 |
Onchocerca volvulus | 0.0109 | 0.1205 | 1 | |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0954 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0321 | 0.0379 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.1561 | 0.1664 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.8168 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0105 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0321 | 0.0081 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1205 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1205 | 0.1462 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 40.57 % | Antiproliferative activity against human Jurkat cells assessed as 5th generation cell population at 10 uM after 24 hrs using CFSE staining by flow cytometry (Rvb = 18.43 %) | ChEMBL. | 23063518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.