Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Brugia malayi | Histone deacetylase family protein | 0.0684322 | 0.741536 | 0.770405 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0471856 | 0.255234 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0797245 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0471856 | 0.255234 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0684322 | 0.741536 | 0.65296 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0684322 | 0.741536 | 0.65296 |
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0747641 | 0.886463 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0471856 | 0.255234 | 0.287924 |
Schistosoma mansoni | histone deacetylase | 0.0747641 | 0.886463 | 0.847554 |
Echinococcus granulosus | histone deacetylase 6 | 0.0684322 | 0.741536 | 0.65296 |
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Echinococcus granulosus | histone deacetylase 6 | 0.0684322 | 0.741536 | 0.65296 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0797245 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0747641 | 0.886463 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0747641 | 0.886463 | 0.847554 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0747641 | 0.886463 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0747641 | 0.886463 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0747641 | 0.886463 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0747641 | 0.886463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Loa Loa (eye worm) | histone deacetylase | 0.0684322 | 0.741536 | 0.836511 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0747641 | 0.886463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0471856 | 0.255234 | 0.287924 |
Loa Loa (eye worm) | hypothetical protein | 0.0747641 | 0.886463 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0471856 | 0.255234 | 0.287924 |
Schistosoma mansoni | histone deacetylase | 0.0747641 | 0.886463 | 0.847554 |
Echinococcus granulosus | histone deacetylase 7 | 0.0684322 | 0.741536 | 0.65296 |
Plasmodium falciparum | histone deacetylase 1 | 0.0747641 | 0.886463 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0471856 | 0.255234 | 0.287924 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0747641 | 0.886463 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0471856 | 0.255234 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0747641 | 0.886463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Leishmania major | histone deacetylase, putative | 0.0747641 | 0.886463 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0684322 | 0.741536 | 0.770405 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0747641 | 0.886463 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0747641 | 0.886463 | 0.847554 |
Leishmania major | histone deacetylase, putative | 0.0747641 | 0.886463 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0684322 | 0.741536 | 0.65296 |
Loa Loa (eye worm) | hypothetical protein | 0.0473267 | 0.258464 | 0.291568 |
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Entamoeba histolytica | histone deacetylase, putative | 0.0747641 | 0.886463 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0747641 | 0.886463 | 0.847554 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0747641 | 0.886463 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.0747641 | 0.886463 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0747641 | 0.886463 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0684322 | 0.741536 | 0.65296 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0747641 | 0.886463 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0471856 | 0.255234 | 0.287924 |
Onchocerca volvulus | 0.0471856 | 0.255234 | 0.5 | |
Trichomonas vaginalis | histone deacetylase, putative | 0.0747641 | 0.886463 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0684322 | 0.741536 | 0.836511 |
Trypanosoma brucei | histone deacetylase 1 | 0.0747641 | 0.886463 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0684322 | 0.741536 | 0.65296 |
Echinococcus multilocularis | histone deacetylase | 0.0684322 | 0.741536 | 0.65296 |
Echinococcus granulosus | histone deacetylase 1 | 0.0747641 | 0.886463 | 0.847554 |
Echinococcus granulosus | histone deacetylase | 0.0684322 | 0.741536 | 0.65296 |
Echinococcus granulosus | histone deacetylase 6 | 0.0797245 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0471856 | 0.255234 | 0.287924 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0747641 | 0.886463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0471856 | 0.255234 | 0.287924 |
Brugia malayi | Histone deacetylase 1 | 0.0747641 | 0.886463 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0747641 | 0.886463 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0471856 | 0.255234 | 0.287924 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0747641 | 0.886463 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0747641 | 0.886463 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0471856 | 0.255234 | 0.287924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 50 uM | Cytotoxicity against human MRC5 cells | ChEMBL. | 23240776 |
EC50 (functional) | = 2.5 uM | Antimalarial activity against erythrocytic stages of Plasmodium falciparum 3D7 infected in human O positive RBC after 48 hrs by SYBR-green assay | ChEMBL. | 23240776 |
Ki (binding) | = 132 uM | Inhibition of recombinant Plasmodium falciparum TMPK using TMP as substrate by pyruvate kinase and lactate dehydrogenase enzyme coupled assay | ChEMBL. | 23240776 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 23240776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.