TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.522 | Formula: C24H31N3O
H donors: 0 H acceptors: 1 LogP: 3.92 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)CN1CCN(CC1)CC(=O)N1[C@H](C)Cc2c1cccc2
InChi: 1S/C24H31N3O/c1-3-20-8-10-21(11-9-20)17-25-12-14-26(15-13-25)18-24(28)27-19(2)16-22-6-4-5-7-23(22)27/h4-11,19H,3,12-18H2,1-2H3/t19-/m1/s1
InChiKey: YIILQFFSXRRLJQ-LJQANCHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.005	0.0061
Schistosoma mansoni	neuropeptide f receptor 76f	0.0566	0.4396	0.4396
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0078	0.0408	0.0408
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0093	0.0534	0.0487
Echinococcus multilocularis	tubulin beta 1 chain	0.1027	0.816	0.8151
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0566	0.4396	0.4396
Leishmania major	beta tubulin	0.1027	0.816	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0408	0.0372
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0566	0.4396	0.4369
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0407	0.3094	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0231	0.025
Echinococcus multilocularis	beta tubulin	0.1027	0.816	0.8151
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0566	0.4396	0.4369
Schistosoma mansoni	opsin-like receptor	0.0566	0.4396	0.4396
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0566	0.4396	0.4369
Schistosoma mansoni	neuropeptide receptor	0.0566	0.4396	0.4396
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0408	0.0468
Echinococcus granulosus	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Onchocerca volvulus		0.0566	0.4396	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Brugia malayi	follicle stimulating hormone receptor	0.0566	0.4396	0.5372
Echinococcus granulosus	7TM GPCR rhodopsin	0.0566	0.4396	0.4369
Loa Loa (eye worm)	endoprotease bli-4	0.0142	0.0935	0.1116
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0408	0.0372
Echinococcus multilocularis	dro:myosuppressin receptor	0.0566	0.4396	0.4369
Trypanosoma brucei	beta tubulin	0.1027	0.816	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.005	0.0061
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0093	0.0534	0.0534
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0227	0.0178
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0123	0.0151
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0093	0.0534	0.0487
Loa Loa (eye worm)	tubulin beta chain	0.1027	0.816	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.012	0.0755	0.0803
Loa Loa (eye worm)	proprotein convertase 2	0.0034	0.005	0.0027
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0566	0.4396	0.4369
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0093	0.0534	0.0655
Schistosoma mansoni	hypothetical protein	0.0566	0.4396	0.4396
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0215	0.1527	0.1762
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0566	0.4396	0.4396
Echinococcus multilocularis	serotonin receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0566	0.4396	0.4369
Trypanosoma cruzi	beta tubulin, putative	0.1027	0.816	1
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0109	0.5
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0336	0.2515	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0078	0.0408	0.05
Echinococcus granulosus	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0055	0.0227	0.0178
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0093	0.0534	0.0655
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0566	0.4396	0.4396
Onchocerca volvulus		0.0566	0.4396	1
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0215	0.1527	0.1844
Schistosoma mansoni	tubulin subunit beta	0.1027	0.816	0.816
Echinococcus multilocularis	serotonin receptor	0.0566	0.4396	0.4369
Leishmania major	beta tubulin	0.1027	0.816	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0566	0.4396	0.5372
Loa Loa (eye worm)	neuropeptide F receptor	0.0566	0.4396	0.5372
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Brugia malayi	Serotonin receptor	0.0566	0.4396	0.5372
Toxoplasma gondii	beta tubulin	0.1027	0.816	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0055	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Schistosoma mansoni	growth hormone secretagogue receptor	0.0566	0.4396	0.4396
Echinococcus granulosus	Tubulin beta 2C chain	0.1027	0.816	0.8151
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0215	0.1527	0.1762
Echinococcus granulosus	7tm_1 domain containing protein	0.0566	0.4396	0.4369
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0055	0.0227	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Trypanosoma brucei	beta tubulin	0.1027	0.816	1
Echinococcus multilocularis	tubulin subunit beta	0.1027	0.816	0.8151
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0566	0.4396	0.4369
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0109	0.0099
Echinococcus granulosus	neuropeptide s receptor	0.0566	0.4396	0.4369
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	beta tubulin	0.1027	0.816	0.8151
Echinococcus granulosus	neuropeptides capa receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0078	0.0408	0.036
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0336	0.2515	0.2478
Schistosoma mansoni	biogenic amine receptor	0.0566	0.4396	0.4396
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0408	0.0372
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trichomonas vaginalis	tubulin alpha chain, putative	0.1027	0.816	1
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0086	0.0481	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	Tubulin beta 2C chain	0.1027	0.816	0.8151
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0109	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.023	0.165	0.1608
Echinococcus granulosus	tm gpcr rhodopsin	0.0566	0.4396	0.4369
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Echinococcus granulosus	Tubulin beta 2C chain	0.1027	0.816	0.8151
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0566	0.4396	0.4369
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0071	0.0022
Echinococcus granulosus	tyrosine protein kinase ABL1	0.023	0.165	0.1608
Echinococcus multilocularis	fmrfamide receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	tubulin beta-4 chain	0.1027	0.816	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0566	0.4396	0.5372
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0107	0.0651	0.0604
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0566	0.4396	0.4369
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Brugia malayi	G-protein coupled receptor	0.0566	0.4396	0.5372
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.0109	0.0133
Schistosoma mansoni	neuropeptide receptor	0.0566	0.4396	0.4396
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.012	0.0755	0.0803
Echinococcus multilocularis	allatostatin A receptor	0.0566	0.4396	0.4369
Schistosoma mansoni	tyrosine kinase	0.0219	0.156	0.156
Echinococcus granulosus	neuropeptides capa receptor	0.0566	0.4396	0.4369
Echinococcus granulosus	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0078	0.0408	0.0408
Echinococcus granulosus	neuropeptide FF receptor 2	0.0566	0.4396	0.4369
Schistosoma mansoni	biogenic amine receptor	0.0566	0.4396	0.4396
Schistosoma mansoni	neuropeptide receptor	0.0566	0.4396	0.4396
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0566	0.4396	0.4369
Echinococcus granulosus	fmrfamide receptor	0.0566	0.4396	0.4369
Schistosoma mansoni	hypothetical protein	0.0566	0.4396	0.4396
Brugia malayi	neuropeptide F receptor	0.0566	0.4396	0.5372
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0755	0.0926
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0105	0.0629	0.0771
Leishmania major	beta tubulin	0.1027	0.816	1
Loa Loa (eye worm)	BEN-1 protein	0.1027	0.816	1
Echinococcus multilocularis	orexin receptor type 2	0.0566	0.4396	0.4369
Giardia lamblia	High cysteine membrane protein Group 2	0.0053	0.0207	0.0253
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0045	0.0139	0.009
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0258	0.1882	0.2281
Schistosoma mansoni	biogenic amine receptor	0.0566	0.4396	0.4396
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0215	0.1527	0.1485
Echinococcus granulosus	Tubulin beta 2C chain	0.1027	0.816	0.8151
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0336	0.2515	0.3082
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.012	0.0755	0.0709
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0566	0.4396	0.5372
Echinococcus multilocularis	neuropeptides capa receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis	neuropeptide receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis	neuropeptide Y receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.005	0.0061
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0227	0.0178
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0227	0.0178
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0078	0.0408	0.0408
Loa Loa (eye worm)	BEN-1 protein	0.1027	0.816	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0071	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0123	0.0151
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Brugia malayi	beta-tubulin, identical	0.1027	0.816	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0566	0.4396	0.5372
Echinococcus granulosus	furin	0.0142	0.0935	0.089
Leishmania major	beta tubulin	0.1027	0.816	1
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Trichomonas vaginalis	tubulin, putative	0.1027	0.816	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0227	0.0178
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0566	0.4396	0.4369
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0566	0.4396	0.4396
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0105	0.0629	0.0771
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0078	0.0408	0.036
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0566	0.4396	0.5372
Echinococcus granulosus	neuroendocrine convertase 2	0.0089	0.0504	0.0457
Onchocerca volvulus		0.0566	0.4396	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0055	0.0227	0.0178
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0566	0.4396	0.4369
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Onchocerca volvulus		0.0566	0.4396	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0078	0.0408	0.05
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0408	0.0372
Brugia malayi	Tubulin beta-1 chain	0.1027	0.816	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Loa Loa (eye worm)	tubulin beta-2A chain	0.1027	0.816	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Schistosoma mansoni	neuropeptide F-like receptor	0.0566	0.4396	0.4396
Brugia malayi	SH2 domain containing protein	0.0047	0.0161	0.0164
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0227	0.0178
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0045	0.0139	0.009
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1027	0.816	1
Onchocerca volvulus		0.0566	0.4396	1
Onchocerca volvulus		0.0566	0.4396	1
Echinococcus multilocularis	g protein coupled receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0078	0.0408	0.05
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0078	0.0408	0.0468
Echinococcus granulosus	biogenic amine 5HT receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0935	0.1116
Onchocerca volvulus		0.0566	0.4396	1
Leishmania major	beta tubulin	0.1027	0.816	1
Brugia malayi	RE15519p	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	tubulin gamma chain, putative	0.1027	0.816	1
Trichomonas vaginalis	tubulin beta chain, putative	0.1027	0.816	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0336	0.2515	0.2478
Brugia malayi	Melatonin receptor type 1A	0.0566	0.4396	0.5372
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0566	0.4396	0.4396
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0663	0.519	0.5166
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0566	0.4396	0.4396
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.005	0.0061
Echinococcus granulosus	neuropeptide receptor A26	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Giardia lamblia	Beta tubulin	0.1027	0.816	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0566	0.4396	0.4396
Loa Loa (eye worm)	hypothetical protein	0.0336	0.2515	0.3059
Schistosoma mansoni	amine GPCR	0.0566	0.4396	0.4396
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	dro:myosuppressin receptor	0.0566	0.4396	0.4369
Brugia malayi	Dopamine receptor protein 1	0.0566	0.4396	0.5372
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.0481	0.0589
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0078	0.0408	0.0468
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0566	0.4396	0.4396
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0093	0.0534	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Giardia lamblia	Beta tubulin	0.1027	0.816	1
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0566	0.4396	0.4369
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Echinococcus granulosus	neuropeptide receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0078	0.0408	0.05
Echinococcus granulosus	serotonin receptor	0.0566	0.4396	0.4369
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0078	0.0408	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0408	0.05
Brugia malayi	endoprotease bli-4 precursor	0.0142	0.0935	0.1116
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0071	0.0022
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1027	0.816	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0036	0.0071	0.0053
Echinococcus granulosus	allatostatin A receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0078	0.0408	0.05
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0041	0.0114	0.0065
Echinococcus multilocularis	Tubulin beta 2C chain	0.1027	0.816	0.8151
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0078	0.0408	0.05
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Brugia malayi	GnHR receptor homolog	0.0566	0.4396	0.5372
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0408	0.0372
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0566	0.4396	0.4396
Echinococcus granulosus	g-protein coupled receptor	0.0566	0.4396	0.4369
Onchocerca volvulus		0.0566	0.4396	1
Schistosoma mansoni	tyrosine kinase	0.0055	0.0227	0.0227
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.0408	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0123	0.0151
Loa Loa (eye worm)	SRC-1	0.0055	0.0227	0.0245
Leishmania major	beta tubulin	0.1027	0.816	1
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0055	0.0227	0.0178
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0566	0.4396	0.4396
Onchocerca volvulus		0.0566	0.4396	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0078	0.0408	0.0408
Loa Loa (eye worm)	TK protein kinase	0.0045	0.0139	0.0138
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0566	0.4396	0.4369
Schistosoma mansoni	tubulin subunit beta	0.1027	0.816	0.816
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	tubulin beta 4A class IVa	0.1027	0.816	0.8151
Echinococcus granulosus	sex peptide receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis		0.0115	0.0711	0.0665
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0109	0.0059
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0055	0.0227	0.0178
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0071	0.0022
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0258	0.1882	0.1842
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Echinococcus granulosus	tyrosine kinase	0.0045	0.0139	0.009
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Schistosoma mansoni	neuropeptide F-like receptor	0.0566	0.4396	0.4396
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.012	0.0755	0.0895
Leishmania major	beta tubulin	0.1027	0.816	1
Trypanosoma brucei	beta tubulin	0.1027	0.816	1
Loa Loa (eye worm)	TK protein kinase	0.0034	0.005	0.0027
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0215	0.1527	0.1748
Loa Loa (eye worm)	beta-tubulin	0.1027	0.816	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0663	0.519	0.6348
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0258	0.1882	0.2281
Loa Loa (eye worm)	SH2 domain-containing protein	0.0044	0.0136	0.0133
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.012	0.0755	0.0926
Brugia malayi	protein-tyrosine kinase	0.0045	0.0139	0.0138
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0078	0.0408	0.05
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0215	0.1527	0.1748
Echinococcus multilocularis	neuroendocrine convertase 2	0.0089	0.0504	0.0457
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0093	0.0534	0.0623
Echinococcus multilocularis	dnaJ subfamily B	0.1253	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Loa Loa (eye worm)	neuropeptide F receptor	0.0566	0.4396	0.5372
Echinococcus granulosus	tm gpcr rhodopsin	0.0566	0.4396	0.4369
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0078	0.0408	0.0372
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0055	0.0227	0.0178
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0663	0.519	0.519
Echinococcus granulosus	G protein coupled receptor 139	0.0566	0.4396	0.4369
Schistosoma mansoni	tyrosine kinase	0.0055	0.0227	0.0227
Onchocerca volvulus		0.0566	0.4396	1
Plasmodium vivax	tubulin beta chain, putative	0.1027	0.816	1
Echinococcus multilocularis	Furin 1	0.0034	0.005	0.0000020529
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	neuropeptide Y receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis	somatostatin receptor	0.0566	0.4396	0.4369
Echinococcus granulosus	neuropeptide Y receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0566	0.4396	0.4396
Brugia malayi	neuroendocrine convertase 1 precursor	0.0089	0.0504	0.0586
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0078	0.0408	0.036
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	g protein coupled receptor	0.0566	0.4396	0.4369
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0078	0.0408	0.0408
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0566	0.4396	0.4369
Brugia malayi	Dopamine receptor	0.0566	0.4396	0.5372
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0215	0.1527	0.1485
Leishmania major	beta tubulin	0.1027	0.816	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.005	0.0061
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1027	0.816	0.8151
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0041	0.0114	0.0065
Loa Loa (eye worm)	tubulin beta-1 chain	0.1027	0.816	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.005	0.0061
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0566	0.4396	1
Toxoplasma gondii	beta-1 tubulin, putative	0.1027	0.816	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0093	0.0534	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0055	0.0227	0.0178
Leishmania major	beta tubulin	0.1027	0.816	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0566	0.4396	0.5372
Echinococcus multilocularis	g protein coupled receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	tubulin subunit beta	0.1027	0.816	0.816
Leishmania major	beta tubulin	0.1027	0.816	1
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0109	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0473	0.0548
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0336	0.2515	0.2478
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0078	0.0408	0.05
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0071	0.0022
Brugia malayi	Dopamine receptor protein 2	0.0566	0.4396	0.5372
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0139	0.009
Loa Loa (eye worm)	TK/ABL protein kinase	0.023	0.165	0.1995
Trypanosoma brucei	unspecified product	0.0034	0.0055	0.0034
Schistosoma mansoni	adenoreceptor	0.0566	0.4396	0.4396
Brugia malayi	G protein-coupled receptor F59B2.13	0.0566	0.4396	0.5372
Schistosoma mansoni	myosin xvIII	0.0566	0.4396	0.4396
Loa Loa (eye worm)	hypothetical protein	0.0329	0.2462	0.2993
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Echinococcus granulosus	neuropeptide receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0071	0.0022
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.012	0.0755	0.0926
Schistosoma mansoni	hypothetical protein	0.0566	0.4396	0.4396
Schistosoma mansoni	hypothetical protein	0.0566	0.4396	0.4396
Echinococcus multilocularis	Tubulin beta 2C chain	0.1027	0.816	0.8151
Echinococcus granulosus	c src tyrosine kinase	0.0058	0.0249	0.02
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0336	0.2515	0.2515
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0215	0.1527	0.1444
Echinococcus multilocularis	neuropeptide receptor A26	0.0566	0.4396	0.4369
Echinococcus granulosus	beta tubulin	0.1027	0.816	0.8151
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0566	0.4396	0.5372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Schistosoma mansoni	tyrosine kinase	0.0058	0.0249	0.0249
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0055	0.0227	0.0178
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0566	0.4396	0.4369
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Giardia lamblia	Hypothetical protein	0.0078	0.0408	0.05
Brugia malayi	sulfakinin receptor protein	0.0566	0.4396	0.5372
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.012	0.0755	0.0755
Leishmania major	beta tubulin	0.1027	0.816	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	Furin 1	0.0034	0.005	0.0000020529
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0055	0.0227	0.0178
Leishmania major	beta tubulin	0.1027	0.816	1
Schistosoma mansoni	histamine h1 receptor	0.0566	0.4396	0.4396
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0055	0.0227	0.0178
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0258	0.1882	0.1842
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Brugia malayi	ORL1-like opioid receptor	0.0566	0.4396	0.5372
Schistosoma mansoni	amine GPCR	0.0566	0.4396	0.4396
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0566	0.4396	0.4369
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0071	0.0022
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0566	0.4396	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Echinococcus granulosus	tyrosine protein kinase Blk	0.0045	0.0139	0.009
Leishmania major	beta tubulin	0.1027	0.816	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Onchocerca volvulus		0.0566	0.4396	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0336	0.2515	0.2976
Entamoeba histolytica	tubulin family protein	0.1027	0.816	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0566	0.4396	0.4369
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0034	0.005	0.005
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0078	0.0408	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Trypanosoma brucei	beta tubulin	0.1027	0.816	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Schistosoma mansoni	amine GPCR	0.0566	0.4396	0.4396
Brugia malayi	Tyrosine-protein kinase abl-1	0.0133	0.0862	0.1026
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0078	0.0408	0.0468
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0566	0.4396	0.5372
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0408	0.05
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	tubulin subunit beta	0.1027	0.816	0.816
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0078	0.0408	0.0468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Echinococcus granulosus	orexin receptor type 2	0.0566	0.4396	0.4369
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Brugia malayi	Serotonin receptor	0.0566	0.4396	0.5372
Echinococcus granulosus	Tubulin beta 2C chain	0.1027	0.816	0.8151
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0086	0.0481	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Brugia malayi	G protein-coupled receptor	0.0566	0.4396	0.5372
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0566	0.4396	0.4369
Echinococcus multilocularis	g-protein coupled receptor	0.0566	0.4396	0.4369
Echinococcus granulosus	tubulin beta 1 chain	0.1027	0.816	0.8151
Brugia malayi	celfurPC protein	0.0115	0.0711	0.084
Echinococcus multilocularis	neuropeptide receptor	0.0566	0.4396	0.4369
Brugia malayi	SRC-1	0.0055	0.0227	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	c src tyrosine kinase	0.0058	0.0249	0.02
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus multilocularis	sex peptide receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	G-protein coupled receptor	0.0566	0.4396	0.5372
Loa Loa (eye worm)	PDE1B protein	0.0663	0.519	0.6348
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.012	0.0755	0.0803
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0566	0.4396	0.5372
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0227	0.0178
Leishmania major	beta tubulin	0.1027	0.816	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0566	0.4396	0.4396
Echinococcus granulosus	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0215	0.1527	0.1444
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0566	0.4396	0.4396
Schistosoma mansoni	opsin-like receptor	0.0566	0.4396	0.4396
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.012	0.0755	0.0926
Brugia malayi	putative neuropeptide receptor	0.0566	0.4396	0.5372
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0408	0.0372
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0055	0.0227	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Leishmania major	beta tubulin	0.1027	0.816	1
Echinococcus granulosus	tubulin subunit beta	0.1027	0.816	0.8151
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.012	0.0755	0.0895
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0566	0.4396	0.4369
Brugia malayi	Tyrosine-protein kinase abl-1	0.0107	0.0651	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0534	0.0623
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0566	0.4396	0.4396
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0566	0.4396	0.4369
Echinococcus multilocularis	g protein coupled receptor	0.0566	0.4396	0.4369
Echinococcus multilocularis	fmrfamide receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0045	0.0139	0.009
Onchocerca volvulus		0.0566	0.4396	1
Brugia malayi	AKH receptor	0.0566	0.4396	0.5372
Echinococcus granulosus	biogenic amine 5HT receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Onchocerca volvulus		0.0566	0.4396	1
Echinococcus multilocularis	beta tubulin	0.1027	0.816	0.8151
Schistosoma mansoni	amine GPCR	0.0566	0.4396	0.4396
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Onchocerca volvulus		0.0566	0.4396	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0078	0.0408	0.0408
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0078	0.0408	0.05
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0105	0.0629	0.0647
Echinococcus multilocularis	neuropeptide Y receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.0109	0.0133
Loa Loa (eye worm)	G-protein coupled receptor	0.0566	0.4396	0.5372
Schistosoma mansoni	opsin-like receptor	0.0566	0.4396	0.4396
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0663	0.519	0.5166
Leishmania major	beta tubulin	0.1027	0.816	1
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Brugia malayi	proprotein convertase 2	0.0089	0.0504	0.0586
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0566	0.4396	0.4369
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0078	0.0408	0.036
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0078	0.0408	0.05
Echinococcus multilocularis	G protein coupled receptor 139	0.0566	0.4396	0.4369
Schistosoma mansoni	furin-1 (S08 family)	0.0062	0.028	0.028
Entamoeba histolytica	tubulin family protein	0.1027	0.816	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1027	0.816	0.8151
Giardia lamblia	hypothetical protein	0.0078	0.0408	0.05
Leishmania major	beta tubulin	0.1027	0.816	1
Echinococcus multilocularis	neuropeptide s receptor	0.0566	0.4396	0.4369
Onchocerca volvulus		0.0566	0.4396	1
Schistosoma mansoni	tubulin subunit beta	0.1027	0.816	0.816
Toxoplasma gondii	beta-tubulin, putative	0.1027	0.816	1
Loa Loa (eye worm)	TYRA-2 protein	0.0566	0.4396	0.5372
Plasmodium falciparum	tubulin beta chain	0.1027	0.816	1
Schistosoma mansoni	tubulin subunit beta	0.1027	0.816	0.816
Schistosoma mansoni	amine GPCR	0.0566	0.4396	0.4396
Onchocerca volvulus		0.0566	0.4396	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Brugia malayi	larval opioid receptor	0.0566	0.4396	0.5372
Echinococcus granulosus	g protein coupled receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0566	0.4396	0.5372
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.012	0.0755	0.0709
Echinococcus granulosus	g protein coupled receptor	0.0566	0.4396	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	hypothetical protein	0.1253	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0566	0.4396	0.4396
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0109	0.0099
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0566	0.4396	0.4396
Brugia malayi	hypothetical protein	0.0566	0.4396	0.5372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0566	0.4396	0.4396
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.0481	0.0589
Echinococcus multilocularis	Tubulin beta 2C chain	0.1027	0.816	0.8151
Loa Loa (eye worm)	hypothetical protein	0.0566	0.4396	0.5372
Echinococcus granulosus	hypothetical protein	0.0566	0.4396	0.4369
Brugia malayi	G-protein coupled receptor	0.0566	0.4396	0.5372
Schistosoma mansoni	neuropeptide receptor	0.0566	0.4396	0.4396
Loa Loa (eye worm)	hypothetical protein	0.0407	0.3094	0.3771
Echinococcus granulosus	rhodopsin orphan GPCR	0.0566	0.4396	0.4369
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0078	0.0408	0.0408
Echinococcus granulosus	somatostatin receptor	0.0566	0.4396	0.4369
Leishmania major	beta tubulin	0.1027	0.816	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0142	0.0935	0.0935
Brugia malayi	putative neuropeptide receptor NPR1	0.0566	0.4396	0.5372
Echinococcus multilocularis	neuropeptides capa receptor	0.0566	0.4396	0.4369
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.012	0.0755	0.0926
Giardia lamblia	Beta tubulin	0.1027	0.816	1
Brugia malayi	neuropeptide F receptor	0.0566	0.4396	0.5372
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0078	0.0408	0.0372
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0566	0.4396	0.4369
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0109	0.0099
Echinococcus granulosus	tm gpcr rhodopsin	0.0566	0.4396	0.4369
Onchocerca volvulus		0.0566	0.4396	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0078	0.0408	0.0355
Echinococcus multilocularis	Tubulin beta 2C chain	0.1027	0.816	0.8151

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 3 nM	Binding affinity towards Dopamine type 4 receptor was determined by competitive displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 758 nM	Binding affinity towards Dopamine type 2 receptor was determined by displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 3 uM	Binding affinity towards Dopamine type 4 receptor was determined by competitive displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 758 uM	Binding affinity towards Dopamine type 2 receptor was determined by displacement assays using [3H]-YM 09151 as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 1357 uM	Binding affinity towards Alpha-1 adrenergic receptor was determined by competitive displacement assays using rat brain homogenate with [3H]-prazosin as the competitive ligand	ChEMBL.	12372513
Ki (binding)	= 1357 uM	Binding affinity towards Alpha-1 adrenergic receptor was determined by competitive displacement assays using rat brain homogenate with [3H]-prazosin as the competitive ligand	ChEMBL.	12372513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL106169

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 172338