Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3744 | 0.3201 |
Schistosoma mansoni | histone deacetylase hda2 | 0.015 | 0.1821 | 0.1111 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.2356 | 0.217 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0287 | 0.582 | 0.582 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0237 | 0.0237 |
Echinococcus granulosus | protein kinase C gamma type | 0.0168 | 0.2364 | 0.2179 |
Echinococcus granulosus | histone deacetylase 7 | 0.0237 | 0.4353 | 0.4215 |
Echinococcus multilocularis | histone deacetylase | 0.0237 | 0.4353 | 0.4215 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0237 | 0.4353 | 0.3095 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0234 | 0.4265 | 0.4125 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0168 | 0.2364 | 0.2179 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0287 | 0.582 | 0.5719 |
Echinococcus granulosus | histone deacetylase 6 | 0.0237 | 0.4353 | 0.4215 |
Trypanosoma brucei | histone deacetylase 4 | 0.0237 | 0.4353 | 0.3095 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0287 | 0.582 | 0.5719 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0103 | 0.0456 | 0.0456 |
Echinococcus multilocularis | histone deacetylase 8 | 0.015 | 0.1821 | 0.1622 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0237 | 0.4353 | 0.3095 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7159 | 0.7159 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0237 | 0.4353 | 0.4215 |
Echinococcus granulosus | protein kinase c iota type | 0.0115 | 0.0799 | 0.0575 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0237 | 0.4353 | 0.3095 |
Onchocerca volvulus | 0.0333 | 0.7159 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7159 | 0.7159 |
Echinococcus granulosus | histone deacetylase | 0.0237 | 0.4353 | 0.4215 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.911 | 0.911 |
Brugia malayi | protein kinase C II. | 0.0287 | 0.582 | 0.489 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0237 | 0.4353 | 0.4353 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0237 | 0.4353 | 0.3862 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0256 | 0.4907 | 0.4465 |
Echinococcus granulosus | histone deacetylase 6 | 0.0237 | 0.4353 | 0.4215 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.8539 | 0.8539 |
Plasmodium vivax | histone deacetylase, putative | 0.0237 | 0.4353 | 0.3095 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0237 | 0.4353 | 0.3862 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1821 | 0.1821 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0237 | 0.4353 | 0.4215 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.015 | 0.1821 | 0.1821 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0237 | 0.4353 | 0.3095 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.582 | 0.5458 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0216 | 0.3744 | 0.3592 |
Brugia malayi | Histone deacetylase family protein | 0.0237 | 0.4353 | 0.3095 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0256 | 0.4907 | 0.4783 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0216 | 0.3744 | 0.3592 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.015 | 0.1821 | 0.1111 |
Echinococcus granulosus | histone deacetylase 6 | 0.0256 | 0.4907 | 0.4783 |
Brugia malayi | Histone deacetylase family protein | 0.0237 | 0.4353 | 0.3095 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0237 | 0.4353 | 0.3095 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0237 | 0.4353 | 0.4215 |
Brugia malayi | Protein kinase c protein 2 | 0.015 | 0.1835 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1617 | 0.1617 |
Trypanosoma brucei | histone deacetylase, putative | 0.0237 | 0.4353 | 0.3095 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7159 | 0.7159 |
Echinococcus granulosus | histone deacetylase 8 | 0.015 | 0.1821 | 0.1622 |
Loa Loa (eye worm) | histone deacetylase | 0.0237 | 0.4353 | 0.4353 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0555 | 0.0555 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3744 | 0.3201 |
Trypanosoma brucei | histone deacetylase 3 | 0.0237 | 0.4353 | 0.3095 |
Echinococcus multilocularis | protein kinase c iota type | 0.0115 | 0.0799 | 0.0575 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12 nM | Inhibition of PKCdelta by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 71 nM | Inhibition of PKCtheta by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 283 nM | Inhibition of PKCeta by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | > 316 nM | Inhibition of PKCalpha by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | > 316 nM | Inhibition of PKCbeta-1 by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | > 316 nM | Inhibition of PKCepsilon by scintillation proximity assay | ChEMBL. | 21797275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.