Detailed information for compound 1723596

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 561.715 | Formula: C32H43N5O4
  • H donors: 3 H acceptors: 4 LogP: 3.12 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN[C@H](C(=O)N[C@H]1CN(CC[C@@H]2N(C1=O)[C@@H](CC2)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CC(C)C)C
  • InChi: 1S/C32H43N5O4/c1-21(2)19-28(38)36-18-17-25-15-16-27(37(25)32(41)26(20-36)34-30(39)22(3)33-4)31(40)35-29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-14,21-22,25-27,29,33H,15-20H2,1-4H3,(H,34,39)(H,35,40)/t22-,25+,26-,27-/m0/s1
  • InChiKey: LSXUTRRVVSPWDZ-MKKUMYSQSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens baculoviral IAP repeat containing 2 Starlite/ChEMBL References
Homo sapiens baculoviral IAP repeat containing 3 Starlite/ChEMBL References
Homo sapiens X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0087 0.0426 0.0717
Schistosoma mansoni cpg binding protein 0.0029 0.0102 0.0167
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Leishmania major oxidoreductase-like protein 0.0024 0.0072 0.0059
Trichomonas vaginalis pyruvate kinase, putative 0.0073 0.0345 0.0341
Echinococcus granulosus tubulin beta 4A class IVa 0.1057 0.5894 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0037 0.0061
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0024 0.0072 0.0123
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0109 0.0554 0.0937
Echinococcus granulosus WW domain containing oxidoreductase 0.0024 0.0072 0.0123
Echinococcus multilocularis Tubulin beta 2C chain 0.1057 0.5894 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0195 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0087 0.0426 0.0485
Loa Loa (eye worm) dehydrogenase 0.0024 0.0072 0.0082
Echinococcus multilocularis tubulin alpha 3 chain 0.0678 0.3757 0.6374
Schistosoma mansoni tubulin subunit beta 0.1057 0.5894 1
Schistosoma mansoni glutaminase 0.0886 0.4934 0.8371
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0317 0.1724 0.1964
Loa Loa (eye worm) hypothetical protein 0.0075 0.0357 0.0406
Echinococcus granulosus tubulin alpha 1C chain 0.0678 0.3757 0.6374
Brugia malayi Tubulin alpha-2 chain 0.0678 0.3757 0.4279
Entamoeba histolytica hypothetical protein 0.0035 0.0133 0.0219
Trypanosoma cruzi tubulin gamma chain 0.0522 0.2879 0.4852
Loa Loa (eye worm) fibroinase 0.0018 0.0037 0.0042
Brugia malayi Dehydrogenases, short chain protein 30 0.0024 0.0072 0.0082
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0048 0.0005
Echinococcus granulosus GPCR family 2 0.0017 0.0034 0.0058
Echinococcus granulosus pyruvate kinase 0.0073 0.0345 0.0586
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0072 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0094 0.0106
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Echinococcus granulosus pyruvate kinase 0.0073 0.0345 0.0586
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0321 0.0539
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0072 0.0116
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0072 0.01
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0274
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0767 0.1301
Brugia malayi jmjC domain containing protein 0.0098 0.0489 0.0557
Brugia malayi CXXC zinc finger family protein 0.0028 0.0094 0.0106
Giardia lamblia Alpha-tubulin 0.0678 0.3757 0.6344
Brugia malayi hypothetical protein 0.0035 0.0133 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0767 0.1301
Schistosoma mansoni alpha tubulin 0.0678 0.3757 0.6372
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Echinococcus multilocularis dna polymerase eta 0.0046 0.0196 0.0332
Plasmodium vivax tubulin alpha chain, putative 0.0678 0.3757 0.6373
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0321 0.0563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0225 0.1208 0.2044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0087 0.0426 0.0485
Loa Loa (eye worm) glutaminase 2 0.0886 0.4934 0.5621
Schistosoma mansoni nuclear receptor 0.0041 0.0168 0.0278
Leishmania major hypothetical protein, conserved 0.0024 0.0072 0.0059
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0083 0.0095
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0109 0.0554 0.0865
Echinococcus multilocularis oxidoreductase 0.0024 0.0072 0.0123
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Trypanosoma cruzi epsilon tubulin, putative 0.0522 0.2879 0.4852
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0018
Loa Loa (eye worm) carboxylesterase 0.0303 0.1643 0.1871
Echinococcus granulosus tubulin alpha 3 chain 0.0678 0.3757 0.6374
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0225 0.1208 0.2049
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Leishmania major beta tubulin 0.1057 0.5894 1
Trichomonas vaginalis tubulin beta chain, putative 0.0678 0.3757 0.3754
Echinococcus multilocularis tubulin delta chain 0.0227 0.1214 0.206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0767 0.1301
Trypanosoma brucei unspecified product 0.002 0.0048 0.0059
Trichomonas vaginalis tubulin beta chain, putative 0.0678 0.3757 0.3754
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0046 0.0076
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0168 0.0278
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0196 0.027
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0033 0.0124 0.0148
Onchocerca volvulus 0.0018 0.0037 0.0033
Schistosoma mansoni RAR-like nuclear receptor 0.0087 0.0426 0.0717
Trypanosoma brucei epsilon tubulin 0.0522 0.2879 0.4873
Brugia malayi Pre-SET motif family protein 0.1568 0.8779 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.1724 0.1964
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Onchocerca volvulus 0.0024 0.0072 0.0068
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Leishmania major beta tubulin 0.1057 0.5894 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0083 0.0094
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0072 0.0059
Echinococcus multilocularis Tubulin alpha 1 chain 0.0678 0.3757 0.6374
Echinococcus multilocularis tubulin epsilon chain 0.0522 0.2879 0.4885
Brugia malayi Tubulin beta-1 chain 0.1057 0.5894 0.6713
Schistosoma mansoni zinc finger protein 0.0041 0.0168 0.0278
Plasmodium vivax steroid dehydrogenase, putative 0.0024 0.0072 0.012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0052
Echinococcus granulosus tubulin alpha 0.0522 0.2879 0.4885
Brugia malayi nuclear receptor RXR 0.0046 0.0195 0.0222
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0024 0.0072 0.01
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0072 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Brugia malayi hypothetical protein 0.0046 0.0195 0.0222
Brugia malayi nuclear receptor RXR 0.0041 0.0168 0.019
Echinococcus granulosus peroxisome assembly protein 26 0.0678 0.3757 0.6374
Trichomonas vaginalis pyruvate kinase, putative 0.0073 0.0345 0.0341
Echinococcus multilocularis tubulin alpha chain 0.0678 0.3757 0.6374
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0087 0.0426 0.0717
Schistosoma mansoni tar DNA-binding protein 0.0126 0.065 0.1096
Trichomonas vaginalis tubulin, putative 0.0295 0.1601 0.1598
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Brugia malayi ecdysone receptor 0.0041 0.0168 0.019
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0168 0.0164
Loa Loa (eye worm) hypothetical protein 0.0073 0.0345 0.0393
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0037 0.0064
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0105 0.0119
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0195 0.0222
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0094 0.0106
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0133 0.0226
Leishmania major beta tubulin 0.1057 0.5894 1
Echinococcus granulosus Tubulin beta 2C chain 0.1057 0.5894 1
Loa Loa (eye worm) lipase 0.0026 0.0085 0.0096
Brugia malayi Lipase family protein 0.0026 0.0085 0.0096
Onchocerca volvulus Deterin homolog 0.0229 0.1226 0.1223
Trichomonas vaginalis tubulin gamma chain, putative 0.0522 0.2879 0.2876
Onchocerca volvulus 0.0026 0.0083 0.0079
Trypanosoma brucei alpha tubulin, putative 0.0295 0.1601 0.27
Trypanosoma cruzi alpha tubulin, putative 0.0678 0.3757 0.6351
Trichomonas vaginalis tubulin alpha chain, putative 0.0295 0.1601 0.1598
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0022 0.0038
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0321 0.0545
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0034 0.0058
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0072 0.0054
Leishmania major dehydrogenase-like protein 0.0024 0.0072 0.0059
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0024 0.0072 0.0082
Echinococcus granulosus peregrin 0.003 0.0105 0.0179
Loa Loa (eye worm) DR-78 0.0041 0.0168 0.019
Schistosoma mansoni hypothetical protein 0.003 0.0105 0.0172
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0048 0.0018
Mycobacterium tuberculosis Conserved protein 0.0108 0.0547 0.4316
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0059
Brugia malayi tubulin alpha chain - mouse 0.0678 0.3757 0.4279
Brugia malayi Steroid receptor seven-up type 2 0.0087 0.0426 0.0485
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0024 0.0072 0.0274
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.015 0.0254
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0217 0.1158 0.1964
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0168 0.019
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0072 0.012
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0024 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0225 0.1208 0.1375
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Echinococcus granulosus acetylcholinesterase 0.0303 0.1643 0.2788
Schistosoma mansoni carbonyl reductase 0.0024 0.0072 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Mycobacterium ulcerans pyruvate kinase 0.0073 0.0345 0.0612
Brugia malayi Tubulin alpha-2 chain 0.0678 0.3757 0.4279
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0321 0.0484
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0037 0.0057
Schistosoma mansoni tubulin subunit alpha 0.0227 0.1214 0.2054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Giardia lamblia Gamma tubulin 0.0522 0.2879 0.4843
Echinococcus multilocularis thyroid hormone receptor alpha 0.0087 0.0426 0.0723
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0083 0.0095
Mycobacterium leprae cell division protein FtsZ 0.0227 0.1214 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0426 0.0485
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0024 0.0072 0.0059
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Brugia malayi steroid hormone receptor 0.0087 0.0426 0.0485
Plasmodium vivax hypothetical protein, conserved 0.003 0.0105 0.0177
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0024 0.0072 0.0123
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0048 0.0005
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0024 0.0072 0.0116
Echinococcus multilocularis neuropeptide s receptor 0.1014 0.5653 0.9591
Entamoeba histolytica short chain dehydrogenase family protein 0.0024 0.0072 0.0116
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0087 0.0426 0.0422
Echinococcus multilocularis pyruvate kinase 0.0057 0.0259 0.044
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0037 0.0042
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Brugia malayi hypothetical protein 0.0024 0.0072 0.0082
Echinococcus multilocularis microtubule associated protein 2 0.0756 0.4201 0.7127
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0087 0.0426 0.0723
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Toxoplasma gondii beta-tubulin, putative 0.1057 0.5894 1
Onchocerca volvulus 0.0018 0.0037 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.015 0.0247
Echinococcus granulosus neuroligin 0.0051 0.0225 0.0382
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Trypanosoma brucei alpha tubulin 0.0678 0.3757 0.6366
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0072 0.0123
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0024 0.0072 0.0068
Echinococcus multilocularis retinol dehydrogenase 11 0.0024 0.0072 0.0123
Leishmania major short chain dehydrogenase, putative 0.0024 0.0072 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Schistosoma mansoni tubulin subunit gamma 0.0522 0.2879 0.4881
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0083 0.0076
Echinococcus granulosus tubulin subunit TubB 0.0678 0.3757 0.6374
Mycobacterium ulcerans cell division protein FtsZ 0.0227 0.1214 0.239
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0225 0.1208 0.2049
Echinococcus granulosus Tubulin alpha 1 chain 0.0678 0.3757 0.6374
Leishmania major epsilon tubulin, putative 0.0522 0.2879 0.4852
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0035 0.0133 0.0793
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0037 0.0061
Mycobacterium tuberculosis Possible oxidoreductase 0.0024 0.0072 0.0274
Brugia malayi nuclear receptor NHR-88 0.0087 0.0426 0.0485
Schistosoma mansoni tar DNA-binding protein 0.0126 0.065 0.1096
Toxoplasma gondii alpha tubulin TUBA1 0.0678 0.3757 0.6351
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0101 0.0503 0.0854
Schistosoma mansoni gliotactin 0.0051 0.0225 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0087 0.0426 0.0485
Echinococcus multilocularis steroid dehydrogenase 0.0024 0.0072 0.0123
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.0023 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.0225 0.0375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Onchocerca volvulus 0.0087 0.0426 0.0422
Plasmodium falciparum tubulin beta chain 0.1057 0.5894 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0245 0.0278
Trichomonas vaginalis tubulin epsilon chain, putative 0.0227 0.1214 0.1211
Brugia malayi Flap endonuclease-1 0.0028 0.0094 0.0106
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0024 0.0072 0.0059
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Echinococcus granulosus tubulin epsilon chain 0.0522 0.2879 0.4885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0024 0.0072 0.0123
Trichomonas vaginalis tubulin beta chain, putative 0.0678 0.3757 0.3754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Onchocerca volvulus 0.0024 0.0072 0.0068
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0024 0.0072 0.0274
Echinococcus multilocularis pyruvate kinase 0.0037 0.0146 0.0248
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0037 0.0061
Echinococcus multilocularis cysteine protease 0.0018 0.0037 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0426 0.0485
Schistosoma mansoni thyroid hormone receptor 0.0087 0.0426 0.0717
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0037 0.0033
Echinococcus multilocularis citrate lyase subunit beta protein 0.0108 0.0547 0.0928
Trichomonas vaginalis tubulin alpha chain, putative 0.0522 0.2879 0.2876
Loa Loa (eye worm) BEN-1 protein 0.1057 0.5894 0.6713
Toxoplasma gondii oxidoreductase, putative 0.0024 0.0072 0.0059
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0168 0.019
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0274
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0024 0.0072 0.0059
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0094 0.0152
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0048 0.0059
Plasmodium vivax vivapain-2 0.0018 0.0037 0.0061
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0037 0.0064
Leishmania major cathepsin L-like protease 0.0068 0.0321 0.0484
Loa Loa (eye worm) hypothetical protein 0.0046 0.0196 0.0222
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0227 0.1214 1
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0072 0.0274
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0382 0.0588
Schistosoma mansoni tubulin subunit epsilon 0.0522 0.2879 0.4881
Echinococcus multilocularis tubulin beta 1 chain 0.1057 0.5894 1
Brugia malayi tailless protein 0.0041 0.0168 0.019
Plasmodium vivax tubulin epsilon chain, putative 0.0522 0.2879 0.4884
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0024 0.0072 0.01
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0321 0.2397
Echinococcus multilocularis pyruvate kinase 0.0073 0.0345 0.0586
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0024 0.0072 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0072 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0087 0.0426 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0087 0.0426 0.0485
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1568 0.8779 1
Schistosoma mansoni flap endonuclease-1 0.0025 0.0078 0.0126
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0072 0.012
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0059
Leishmania major hypothetical protein, conserved 0.0024 0.0072 0.0059
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.2172 0.3686
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0034 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0024 0.0072 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Brugia malayi nuclear receptor NHR-67 0.0041 0.0168 0.019
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0037 0.0057
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0094 0.0089
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0108 0.0547 0.0543
Echinococcus multilocularis peregrin 0.003 0.0105 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0126 0.065 0.1096
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0072 0.0059
Schistosoma mansoni DNA polymerase eta 0.0046 0.0196 0.0325
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0072 0.0274
Onchocerca volvulus 0.0024 0.0072 0.0068
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0108 0.0547 0.1024
Plasmodium falciparum tubulin gamma chain 0.0522 0.2879 0.4884
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0168 0.0278
Echinococcus multilocularis apoptotic protease activating factor 1 0.0075 0.0357 0.0606
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0024 0.0072 0.0082
Mycobacterium ulcerans carveol-like dehydrogenase 0.0024 0.0072 0.0054
Echinococcus multilocularis tubulin alpha 1C chain 0.0678 0.3757 0.6374
Leishmania major beta tubulin 0.1057 0.5894 1
Trypanosoma brucei hypothetical protein, conserved 0.094 0.5236 0.8881
Chlamydia trachomatis pyruvate kinase 0.0073 0.0345 0.6548
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0094 0.0159
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0024 0.0072 0.0054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.0255
Loa Loa (eye worm) hypothetical protein 0.0382 0.2092 0.2382
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Brugia malayi PHD-finger family protein 0.003 0.0105 0.0119
Entamoeba histolytica tubulin family protein 0.1057 0.5894 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0087 0.0426 0.0723
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.023 0.0328
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0522 0.2879 0.4852
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0083 0.0078
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0024 0.0072 0.0059
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0274
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0072 0.0054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.0225 0.0375
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0426 0.0485
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Trichomonas vaginalis tubulin epsilon chain, putative 0.0678 0.3757 0.3754
Echinococcus multilocularis Tubulin alpha 1 chain 0.0678 0.3757 0.6374
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0024 0.0072 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0024 0.0072 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0767 0.1295
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0072 0.0123
Brugia malayi Bromodomain containing protein 0.003 0.0105 0.0119
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0024 0.0072 0.0082
Giardia lamblia Reductase, putative 0.0024 0.0072 0.0041
Brugia malayi Cathepsin L-like precursor 0.0012 0.0004 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0072 0.0274
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Plasmodium falciparum flap endonuclease 1 0.0028 0.0094 0.0156
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0108
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0037 0.0057
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0196 0.0222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0426 0.0723
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0083 0.0076
Loa Loa (eye worm) pyruvate kinase 0.0073 0.0345 0.0393
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0195 0.0325
Onchocerca volvulus 0.0229 0.1226 0.1223
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0195 0.0222
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0048 0.0054
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Echinococcus granulosus cathepsin l1 0.0012 0.0004 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Mycobacterium ulcerans dehydrogenase/reductase 0.0024 0.0072 0.0054
Brugia malayi Cathepsin L-like precursor 0.0018 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0175 0.0923 0.1051
Brugia malayi hypothetical protein 0.0046 0.0195 0.0222
Leishmania major beta tubulin 0.1057 0.5894 1
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0041 0.0168 0.0284
Echinococcus granulosus neuropeptide receptor A26 0.1014 0.5653 0.9591
Echinococcus multilocularis tubulin alpha chain 0.0678 0.3757 0.6374
Echinococcus granulosus caspase 2 0.0075 0.0357 0.0606
Treponema pallidum cell division protein FtsZ 0.0227 0.1214 1
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0072 0.0059
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0024 0.0072 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0087 0.0426 0.0485
Schistosoma mansoni coup transcription factor 0.0087 0.0426 0.0717
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0229 0.1226 0.2081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Loa Loa (eye worm) hypothetical protein 0.0046 0.0195 0.0222
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0083 0.0076
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0382 0.0648
Brugia malayi Inositol-1 0.0079 0.0382 0.0434
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0087 0.0426 0.0717
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0321 0.0563
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0087 0.0426 0.0723
Trichomonas vaginalis tubulin alpha chain, putative 0.1057 0.5894 0.5892
Echinococcus granulosus pyruvate kinase 0.0037 0.0146 0.0248
Trichomonas vaginalis glutaminase, putative 0.0886 0.4934 0.4932
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0225 0.1208 0.2044
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0083 0.0078
Leishmania major cathepsin L-like protease 0.0068 0.0321 0.0484
Echinococcus granulosus dnaJ subfamily B 0.0397 0.2172 0.3686
Trichomonas vaginalis tubulin alpha chain, putative 0.0295 0.1601 0.1598
Brugia malayi glutaminase DH11.1 0.0886 0.4934 0.5621
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0072 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0426 0.0723
Giardia lamblia Hypothetical protein 0.0024 0.0072 0.0041
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0087 0.0426 0.0485
Echinococcus granulosus tubulin beta 1 chain 0.1057 0.5894 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0037 0.0033
Brugia malayi Cell division protein ftsZ 0.0227 0.1214 0.1382
Echinococcus granulosus dna polymerase eta 0.0046 0.0196 0.0332
Schistosoma mansoni thyroid hormone receptor 0.0087 0.0426 0.0717
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.0255
Giardia lamblia PHD finger protein 15 0.003 0.0105 0.0098
Echinococcus granulosus tubulin alpha chain 0.0678 0.3757 0.6374
Echinococcus multilocularis neuroligin 0.0051 0.0225 0.0382
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0321 0.0485
Schistosoma mansoni retinoic acid receptor RXR 0.0087 0.0426 0.0717
Brugia malayi Pyruvate kinase, muscle isozyme 0.0073 0.0345 0.0393
Schistosoma mansoni cpg binding protein 0.0028 0.0094 0.0152
Schistosoma mansoni tubulin subunit beta 0.1057 0.5894 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0767 0.1295
Trypanosoma cruzi zeta tubulin, putative 0.0227 0.1214 0.2009
Entamoeba histolytica tubulin alpha chain, putative 0.0678 0.3757 0.6372
Schistosoma mansoni caspase-7 (C14 family) 0.0075 0.0357 0.06
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0168 0.019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0087 0.0426 0.0485
Leishmania major beta tubulin 0.1057 0.5894 1
Trypanosoma brucei tubulin delta chain 0.0227 0.1214 0.2042
Echinococcus multilocularis cpg binding protein 0.0029 0.0102 0.0174
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0083 0.0134
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0034 0.0038
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0072 0.0116
Giardia lamblia Alpha-tubulin 0.0678 0.3757 0.6344
Echinococcus multilocularis tubulin subunit TubB 0.0678 0.3757 0.6374
Echinococcus multilocularis Tubulin beta 2C chain 0.1057 0.5894 1
Echinococcus granulosus tubulin subunit beta 0.1057 0.5894 1
Mycobacterium ulcerans hypothetical protein 0.0108 0.0547 0.1024
Loa Loa (eye worm) tubulin alpha-2 chain 0.0678 0.3757 0.4279
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0101 0.0503 0.0833
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0051 0.0225 0.1575
Trichomonas vaginalis tubulin epsilon chain, putative 0.1057 0.5894 0.5892
Leishmania major beta tubulin 0.1057 0.5894 1
Echinococcus granulosus neuropeptide s receptor 0.1014 0.5653 0.9591
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Onchocerca volvulus 0.0018 0.0037 0.0033
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0024 0.0072 0.0116
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Giardia lamblia Epsilon tubulin 0.0227 0.1214 0.1994
Loa Loa (eye worm) tubulin beta-1 chain 0.1057 0.5894 0.6713
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0108 0.0547 0.4316
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0083 0.0076
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0024 0.0072 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Leishmania major hypothetical protein, conserved 0.0024 0.0072 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0225 0.1208 0.2044
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0024 0.0072 0.0082
Brugia malayi Pyruvate kinase, M2 isozyme 0.0073 0.0345 0.0393
Schistosoma mansoni alpha tubulin 0.0678 0.3757 0.6372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0048 0.007
Trypanosoma brucei epsilon tubulin 0.0522 0.2879 0.4873
Onchocerca volvulus Sepiapterin reductase homolog 0.0024 0.0072 0.0068
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0168 0.019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0087 0.0426 0.0723
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0094 0.0156
Leishmania major short chain dehydrogenase/reductase, putative 0.0024 0.0072 0.0059
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0072 0.01
Echinococcus multilocularis BC026374 protein (S09 family) 0.0051 0.0225 0.0382
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Trypanosoma brucei pyruvate kinase 1 0.0073 0.0345 0.0564
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0038
Brugia malayi hypothetical protein 0.0034 0.0126 0.0142
Mycobacterium ulcerans hypothetical protein 0.0026 0.0083 0.0076
Giardia lamblia Delta tubulin 0.0227 0.1214 0.1994
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Entamoeba histolytica tubulin alpha-1 chain 0.0678 0.3757 0.6372
Trichomonas vaginalis conserved hypothetical protein 0.0227 0.1214 0.1211
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0037 0.0064
Brugia malayi dehydrogenases, short chain protein 9 0.0024 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Schistosoma mansoni tubulin subunit beta 0.1057 0.5894 1
Brugia malayi Pre-SET motif family protein 0.0225 0.1208 0.1375
Mycobacterium ulcerans oxidoreductase 0.0024 0.0072 0.0054
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0024 0.0072 0.0123
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0382 0.0687
Trypanosoma brucei oxidoreductase-like protein 0.0024 0.0072 0.01
Echinococcus multilocularis neuropeptide receptor A26 0.1014 0.5653 0.9591
Echinococcus multilocularis inhibitor of apoptosis protein 0.0229 0.1226 0.2081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Plasmodium vivax pyruvate kinase, putative 0.0073 0.0345 0.0584
Toxoplasma gondii pyruvate kinase PyK1 0.0073 0.0345 0.0526
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Loa Loa (eye worm) TAR-binding protein 0.0126 0.065 0.0739
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0024 0.0072 0.0116
Schistosoma mansoni hypothetical protein 0.0554 0.3058 0.5184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0426 0.0723
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0094
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0024 0.0072 0.0059
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Brugia malayi RNA binding protein 0.0126 0.065 0.0739
Leishmania major gamma-tubulin 0.0522 0.2879 0.4852
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.0503 0.0795
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0101 0.0503 1
Plasmodium vivax vivapain-2 0.0018 0.0037 0.0061
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0105 0.0172
Mycobacterium ulcerans ketoacyl reductase 0.0024 0.0072 0.0054
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0024 0.0072 0.0059
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0451 0.2479 0.2476
Echinococcus multilocularis pyruvate kinase 0.0037 0.0146 0.0248
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.015 0.017
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0024 0.0072 0.0054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0048 0.0044
Brugia malayi Carboxylesterase family protein 0.0303 0.1643 0.1871
Echinococcus granulosus Tubulin alpha 1 chain 0.0678 0.3757 0.6374
Brugia malayi Dehydrogenases, short chain protein 2 0.0024 0.0072 0.0082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0037 0.0064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.0767 0.0873
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0048 0.0075
Plasmodium falciparum steroid dehydrogenase, putative 0.0024 0.0072 0.012
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0018
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0382 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0072 0.0059
Trypanosoma brucei beta tubulin 0.1057 0.5894 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0087 0.0426 0.0723
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0048 0.0044
Trypanosoma brucei tubulin gamma chain 0.0522 0.2879 0.4873
Echinococcus multilocularis retinol dehydrogenase 11 0.0024 0.0072 0.0123
Echinococcus granulosus pyruvate kinase 0.0037 0.0146 0.0248
Onchocerca volvulus 0.0026 0.0085 0.0081
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0066 0.0307 0.0533
Brugia malayi N-terminal motif family protein 0.0175 0.0923 0.1051
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0024 0.0072 0.0059
Echinococcus multilocularis pyruvate kinase 0.0073 0.0345 0.0586
Entamoeba histolytica hypothetical protein 0.0035 0.0133 0.0219
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Schistosoma mansoni hypothetical protein 0.0075 0.0357 0.06
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0048 0.007
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Schistosoma mansoni BC026374 protein (S09 family) 0.0051 0.0225 0.0375
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0105 0.0116
Onchocerca volvulus Cell death protein 3 homolog 0.0075 0.0357 0.0353
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0133 0.0226
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0109 0.0554 0.055
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.065 0.0739
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0072 0.0116
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0083 0.0076
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0108 0.0547 0.1024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.0255
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0024 0.0072 0.0123
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0229 0.1226 0.2075
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0034 0.0038
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0321 0.0484
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0024 0.0072 0.0116
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0147 0.0167
Toxoplasma gondii beta-1 tubulin, putative 0.1057 0.5894 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.023 0.0387
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0077 0.0124
Leishmania major pteridine reductase 1 0.0024 0.0072 0.0059
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0024 0.0072 0.0274
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Brugia malayi beta-tubulin, identical 0.1057 0.5894 0.6713
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0037 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Trichomonas vaginalis tubulin gamma chain, putative 0.0522 0.2879 0.2876
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0037 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Loa Loa (eye worm) inositol-1 0.0079 0.0382 0.0434
Schistosoma mansoni pyruvate kinase 0.0073 0.0345 0.0579
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0087 0.0426 0.0723
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0072 0.0274
Echinococcus granulosus acetylcholinesterase 0.0303 0.1643 0.2788
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0087 0.0426 0.0717
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Echinococcus multilocularis Tubulin beta 2C chain 0.1057 0.5894 1
Loa Loa (eye worm) BEN-1 protein 0.1057 0.5894 0.6713
Mycobacterium tuberculosis Probable dehydrogenase 0.0024 0.0072 0.0274
Trichomonas vaginalis spcc417.12 protein, putative 0.0051 0.0225 0.0221
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0083 0.0094
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0335 0.2514
Brugia malayi Tubulin alpha chain 0.0678 0.3757 0.4279
Onchocerca volvulus 0.0051 0.0225 0.0221
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0094 0.0096
Trichomonas vaginalis steroid dehydrogenase, putative 0.0024 0.0072 0.0068
Giardia lamblia Beta tubulin 0.1057 0.5894 1
Echinococcus multilocularis pyruvate kinase 0.0037 0.0146 0.0248
Entamoeba histolytica hypothetical protein 0.0035 0.0133 0.0219
Leishmania major short chain dehydrogenase-like protein 0.0024 0.0072 0.0059
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1057 0.5894 1
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Brugia malayi hypothetical protein 0.0024 0.0072 0.0082
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0426 0.0485
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Echinococcus multilocularis acetylcholinesterase 0.0303 0.1643 0.2788
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0245 0.0278
Mycobacterium leprae Probable pyruvate kinase PykA 0.0073 0.0345 0.2392
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0489 0.083
Entamoeba histolytica pyruvate kinase, putative 0.0051 0.0222 0.0369
Leishmania major DNA polymerase kappa, putative 0.002 0.0048 0.0018
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0072 0.0123
Echinococcus granulosus hypothetical protein 0.0024 0.0072 0.0123
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0051
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0382 0.2092 0.2089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.0767 0.0873
Loa Loa (eye worm) alpha-tubulin 0.0678 0.3757 0.4279
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0321 0.0563
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0168 0.0278
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0285 0.0324
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Trichomonas vaginalis tubulin gamma chain, putative 0.0227 0.1214 0.1211
Echinococcus multilocularis steroid dehydrogenase 0.0024 0.0072 0.0123
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Loa Loa (eye worm) hypothetical protein 0.0052 0.023 0.0261
Echinococcus multilocularis carbonyl reductase 1 0.0024 0.0072 0.0123
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0022 0.0038
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0168 0.019
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.0503 0.0795
Brugia malayi glucose-6-phosphate dehydrogenase 0.0101 0.0503 0.0573
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0024 0.0072 0.0068
Schistosoma mansoni nuclear receptor 0.0041 0.0168 0.0278
Onchocerca volvulus Pyruvate kinase homolog 0.0073 0.0345 0.0341
Giardia lamblia Beta tubulin 0.1057 0.5894 1
Echinococcus granulosus BC026374 protein S09 family 0.0051 0.0225 0.0382
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0105 0.0179
Schistosoma mansoni cpg binding protein 0.0029 0.0102 0.0167
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0024 0.0072 0.0274
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0678 0.3757 0.3754
Schistosoma mansoni acetylcholinesterase 0.0051 0.0225 0.0375
Trypanosoma cruzi pyruvate kinase 2, putative 0.0073 0.0345 0.0526
Schistosoma mansoni hypothetical protein 0.0554 0.3058 0.5184
Leishmania major lipase precursor-like protein 0.0026 0.0085 0.0081
Echinococcus granulosus para nitrobenzyl esterase 0.0051 0.0225 0.0382
Loa Loa (eye worm) pyruvate kinase 0.0073 0.0345 0.0393
Brugia malayi Cell death protein 3 precursor 0.0075 0.0357 0.0406
Leishmania major short chain dehydrogenase, putative 0.0024 0.0072 0.0059
Echinococcus granulosus Tubulin beta 2C chain 0.1057 0.5894 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0141 0.0239
Brugia malayi cathepsin L-like precursor 0.0012 0.0004 0.0004
Plasmodium falciparum tubulin delta chain, putative 0.0227 0.1214 0.2058
Entamoeba histolytica hypothetical protein 0.0024 0.0072 0.0116
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0037 0.0033
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Echinococcus granulosus Tubulin alpha 1 chain 0.0678 0.3757 0.6374
Onchocerca volvulus Pyruvate kinase homolog 0.0073 0.0345 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0072 0.0059
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Echinococcus multilocularis muscleblind protein 0.0317 0.1724 0.2926
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0024 0.0072 0.0274
Trypanosoma brucei lipase, putative 0.0026 0.0085 0.0121
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0072 0.0274
Echinococcus multilocularis tubulin alpha 0.0522 0.2879 0.4885
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0087 0.0426 0.0485
Trypanosoma cruzi epsilon tubulin, putative 0.0522 0.2879 0.4852
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0046 0.0051
Loa Loa (eye worm) tubulin beta-4 chain 0.1057 0.5894 0.6713
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.0225 0.0375
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0094 0.0096
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0072 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Entamoeba histolytica short chain dehydrogenase family protein 0.0024 0.0072 0.0116
Echinococcus granulosus cpg binding protein 0.0029 0.0102 0.0174
Schistosoma mansoni alpha tubulin 0.0678 0.3757 0.6372
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0101 0.0503 0.0935
Echinococcus multilocularis carboxylesterase 5A 0.0303 0.1643 0.2788
Trypanosoma brucei pyruvate kinase 1, putative 0.0073 0.0345 0.0564
Echinococcus granulosus tubulin delta chain 0.0227 0.1214 0.206
Echinococcus granulosus carbonyl reductase 1 0.0024 0.0072 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0052
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0168 0.0284
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0108 0.0547 0.087
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0083 0.0076
Mycobacterium ulcerans oxidoreductase 0.0024 0.0072 0.0054
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0382 0.2712
Schistosoma mansoni inhibitor of apoptosis protein 0.0229 0.1226 0.2075
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0024 0.0072 0.012
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0229 0.1226 0.1396
Echinococcus multilocularis tubulin alpha chain 0.0678 0.3757 0.6374
Onchocerca volvulus 0.0024 0.0072 0.0068
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0051
Leishmania major beta tubulin 0.1057 0.5894 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0051 0.0225 0.0375
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0059
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Plasmodium falciparum alpha tubulin 2 0.0678 0.3757 0.6373
Leishmania major cathepsin L-like protease 0.0068 0.0321 0.0484
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Echinococcus granulosus Tubulin beta 2C chain 0.1057 0.5894 1
Onchocerca volvulus 0.0024 0.0072 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0083 0.0076
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0024 0.0072 0.0116
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0072 0.0059
Echinococcus granulosus retinol dehydrogenase 11 0.0024 0.0072 0.0123
Echinococcus multilocularis retinol dehydrogenase 13 0.0024 0.0072 0.0123
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.006 0.0068
Echinococcus multilocularis acetylcholinesterase 0.0303 0.1643 0.2788
Echinococcus granulosus tubulin gamma 1 chain 0.0522 0.2879 0.4885
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0037 0.0033
Plasmodium vivax SET domain protein, putative 0.0225 0.1208 0.2047
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0168 0.0284
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0274
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0024 0.0072 0.0059
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0225 0.1208 0.1998
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0094 0.0096
Schistosoma mansoni hypothetical protein 0.0037 0.0147 0.0243
Loa Loa (eye worm) hypothetical protein 0.0303 0.1643 0.1871
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0168 0.019
Echinococcus granulosus Tubulin beta 2C chain 0.1057 0.5894 1
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0048 0.0082
Loa Loa (eye worm) tubulin alpha 2 0.0451 0.2479 0.2824
Echinococcus multilocularis beta tubulin 0.1057 0.5894 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0024 0.0072 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0087 0.0426 0.0485
Echinococcus multilocularis tubulin alpha chain 0.0678 0.3757 0.6374
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0048 0.0075
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0119
Toxoplasma gondii oxidoreductase, putative 0.0024 0.0072 0.0059
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0024 0.0072 0.0123
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0072 0.0059
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0101 0.0503 0.0854
Trichomonas vaginalis conserved hypothetical protein 0.0227 0.1214 0.1211
Echinococcus multilocularis Tubulin alpha 1 chain 0.0678 0.3757 0.6374
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0335 0.2303
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.0072 0.0123
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0087 0.0426 0.0723
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.0255
Brugia malayi nuclear receptor NHR-88 0.0041 0.0168 0.019
Mycobacterium ulcerans ketoacyl reductase 0.0024 0.0072 0.0054
Loa Loa (eye worm) tubulin alpha-3 chain 0.0382 0.2092 0.2382
Onchocerca volvulus 0.0051 0.0225 0.0221
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0281 0.0415
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Echinococcus granulosus tar DNA binding protein 0.0126 0.065 0.1102
Echinococcus granulosus geminin 0.0554 0.3058 0.5188
Loa Loa (eye worm) tubulin alpha chain 0.0678 0.3757 0.4279
Trichomonas vaginalis tubulin epsilon chain, putative 0.0678 0.3757 0.3754
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0066 0.0307 0.046
Brugia malayi Tubulin beta chain 0.0295 0.1601 0.1824
Onchocerca volvulus 0.0024 0.0072 0.0068
Onchocerca volvulus 0.0295 0.1601 0.1598
Loa Loa (eye worm) tubulin gamma chain 0.0522 0.2879 0.3279
Loa Loa (eye worm) tubulin alpha 2 0.0451 0.2479 0.2824
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0229 0.1226 0.1396
Onchocerca volvulus 0.0051 0.0225 0.0221
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0168 0.019
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0024 0.0072 0.0059
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0382 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0426 0.0485
Loa Loa (eye worm) hypothetical protein 0.0046 0.0195 0.0222
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0083 0.0366
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0024 0.0072 0.0059
Loa Loa (eye worm) alpha-tubulin 0.0678 0.3757 0.4279
Onchocerca volvulus 0.0041 0.0168 0.0164
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0767 0.1301
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0195 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Onchocerca volvulus 0.0018 0.0037 0.0033
Echinococcus granulosus beta tubulin 0.1057 0.5894 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0087 0.0426 0.0485
Echinococcus granulosus hypothetical protein 0.0024 0.0072 0.0123
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0195 0.0331
Schistosoma mansoni steroid hormone receptor ad4bp 0.0087 0.0426 0.0717
Giardia lamblia Beta tubulin 0.1057 0.5894 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0037 0.0057
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0108 0.0547 0.1024
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0083 0.0078
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0382 0.0588
Trypanosoma cruzi tubulin delta chain 0.0227 0.1214 0.2009
Onchocerca volvulus Huntingtin homolog 0.0126 0.0646 0.0642
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0048 0.0059
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0382 0.0378
Brugia malayi hypothetical protein 0.0052 0.023 0.0261
Trypanosoma brucei zeta tubulin, putative 0.0227 0.1214 0.2042
Loa Loa (eye worm) tubulin beta chain 0.0227 0.1214 0.1382
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0227 0.1214 0.1211
Leishmania major beta tubulin 0.1057 0.5894 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.065 0.1096
Schistosoma mansoni tubulin subunit beta 0.1057 0.5894 1
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0024 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.0255
Trypanosoma brucei alpha tubulin 0.0678 0.3757 0.6366
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Echinococcus multilocularis dna polymerase kappa 0.002 0.0048 0.0082
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0105 0.0116
Plasmodium vivax tubulin alpha chain, putative 0.0678 0.3757 0.6373
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0032 0.0054
Trichomonas vaginalis tubulin, putative 0.0295 0.1601 0.1598
Brugia malayi conserved hypotetical protein 0.0041 0.0168 0.019
Giardia lamblia Short-chain dehydrogenase, putative 0.0024 0.0072 0.0041
Loa Loa (eye worm) cysteine protease 0.0018 0.0037 0.0042
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.023 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.094 0.5236 0.8876
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0168 0.0284
Onchocerca volvulus 0.0018 0.0037 0.0033
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0168 0.0164
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0108 0.0547 0.087
Onchocerca volvulus 0.0024 0.0072 0.0068
Schistosoma mansoni inositol monophosphatase 0.0079 0.0382 0.0641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Brugia malayi nuclear hormone receptor 0.0087 0.0426 0.0485
Plasmodium vivax tubulin beta chain, putative 0.1057 0.5894 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0168 0.0284
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0109 0.0554 0.0937
Brugia malayi hypothetical protein 0.0126 0.0646 0.0735
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.015 0.0247
Echinococcus granulosus retinol dehydrogenase 11 0.0024 0.0072 0.0123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0052
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0024 0.0072 0.0116
Loa Loa (eye worm) RNA binding protein 0.0126 0.065 0.0739
Trichomonas vaginalis tubulin, putative 0.1057 0.5894 0.5892
Schistosoma mansoni tubulin subunit beta 0.1057 0.5894 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.0024 0.0072 0.0059
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0024 0.0072 0.0059
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0024 0.0072 0.0068
Echinococcus granulosus carboxylesterase 5A 0.0303 0.1643 0.2788
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0072 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0083 0.0094
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0048 0.0082
Loa Loa (eye worm) hypothetical protein 0.0126 0.0646 0.0735
Brugia malayi Carboxylesterase family protein 0.0051 0.0225 0.0255
Schistosoma mansoni hypothetical protein 0.0229 0.1226 0.2075
Trypanosoma brucei beta tubulin 0.0522 0.2879 0.4873
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0119 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0087 0.0426 0.0485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0022 0.0038
Echinococcus granulosus steroid dehydrogenase 0.0024 0.0072 0.0123
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0168 0.0284
Echinococcus granulosus tubulin alpha 3 chain 0.0678 0.3757 0.6374
Loa Loa (eye worm) hypothetical protein 0.0051 0.0222 0.0252
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0024 0.0072 0.0274
Echinococcus multilocularis tubulin alpha 1C chain 0.0678 0.3757 0.6374
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0048 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0034 0.0058
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0032 0.0054
Leishmania major beta tubulin 0.1057 0.5894 1
Trichomonas vaginalis tubulin beta chain, putative 0.1057 0.5894 0.5892
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Brugia malayi Carboxylesterase family protein 0.0303 0.1643 0.1871
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0923 0.092
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Trypanosoma cruzi zeta tubulin, putative 0.0227 0.1214 0.2009
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Onchocerca volvulus 0.0032 0.0115 0.0111
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Brugia malayi Cathepsin L-like precursor 0.0018 0.0037 0.0042
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0168 0.0278
Echinococcus multilocularis caspase 2 0.0075 0.0357 0.0606
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0083 0.0134
Onchocerca volvulus 0.0051 0.0225 0.0221
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0024 0.0072 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Brugia malayi pyruvate kinase 0.0015 0.0023 0.0025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0022 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Trypanosoma brucei zeta tubulin 0.0227 0.1214 0.2042
Entamoeba histolytica hypothetical protein 0.0035 0.0133 0.0219
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0086 0.0098
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0321 0.0484
Toxoplasma gondii beta tubulin 0.1057 0.5894 1
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Leishmania major zeta tubulin, putative 0.0227 0.1214 0.2009
Loa Loa (eye worm) tubulin beta chain 0.1057 0.5894 0.6713
Echinococcus granulosus flap endonuclease 1 0.0028 0.0094 0.0159
Leishmania major DNA polymerase eta, putative 0.0032 0.0119 0.0139
Plasmodium falciparum alpha tubulin 1 0.0678 0.3757 0.6373
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Brugia malayi Carboxylesterase family protein 0.0051 0.0225 0.0255
Schistosoma mansoni tubulin subunit delta 0.0227 0.1214 0.2054
Schistosoma mansoni tubulin subunit alpha 0.0678 0.3757 0.6372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0225 0.1208 0.2044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0087 0.0426 0.0485
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0072 0.0059
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0087 0.0426 0.0717
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0083 0.0134
Leishmania major beta tubulin 0.1057 0.5894 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Trypanosoma brucei alpha tubulin 0.0678 0.3757 0.6366
Echinococcus multilocularis hypothetical protein 0.0678 0.3757 0.6374
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0171 0.0291
Loa Loa (eye worm) pyruvate kinase 0.0015 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0167
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0046 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0075 0.0357 0.0406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0037 0.0033
Onchocerca volvulus 0.0024 0.0072 0.0068
Entamoeba histolytica tubulin gamma chain 0.0522 0.2879 0.4881
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0024 0.0072 0.0123
Echinococcus granulosus tubulin alpha chain 0.0678 0.3757 0.6374
Echinococcus multilocularis Tubulin beta 2C chain 0.1057 0.5894 1
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0426 0.0717
Brugia malayi dehydrogenases, short chain protein 2 0.0024 0.0072 0.0082
Echinococcus multilocularis cysteine protease 0.0018 0.0037 0.0064
Leishmania major pyruvate kinase 0.0073 0.0345 0.0526
Leishmania major beta tubulin 0.1057 0.5894 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0024 0.0072 0.0059
Echinococcus granulosus microtubule associated protein 2 0.0756 0.4201 0.7127
Trichomonas vaginalis tubulin beta chain, putative 0.0678 0.3757 0.3754
Echinococcus granulosus histone lysine methyltransferase setb 0.0225 0.1208 0.2049
Mycobacterium tuberculosis Cell division protein FtsZ 0.0227 0.1214 1
Leishmania major DNA polymerase eta, putative 0.0046 0.0196 0.027
Loa Loa (eye worm) carboxylesterase 0.0051 0.0225 0.0255
Trichomonas vaginalis tubulin alpha chain, putative 0.0295 0.1601 0.1598
Echinococcus granulosus citrate lyase subunit beta protein 0.0108 0.0547 0.0928
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0321 0.0539
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Onchocerca volvulus 0.0075 0.0357 0.0353
Onchocerca volvulus 0.0028 0.0094 0.0089
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0094 0.0136
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0295 0.1601 0.1598
Mycobacterium ulcerans dehydrogenase 0.0024 0.0072 0.0054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0226 0.0257
Toxoplasma gondii alpha-tubulin I, putative 0.0678 0.3757 0.6351
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0274
Schistosoma mansoni tubulin subunit alpha 0.0678 0.3757 0.6372
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0168 0.019
Trichomonas vaginalis tubulin, putative 0.0227 0.1214 0.1211
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0032 0.0119 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0168 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0426 0.0485
Mycobacterium ulcerans carboxylesterase, LipT 0.0051 0.0225 0.0366
Brugia malayi Cathepsin L-like precursor 0.0018 0.0037 0.0042
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0073 0.0345 0.2601
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.023 0.0387
Brugia malayi hypothetical protein 0.0041 0.0168 0.019
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Loa Loa (eye worm) beta-tubulin 0.1057 0.5894 0.6713
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0037 0.0042
Plasmodium vivax delta tubulin, putative 0.0227 0.1214 0.2058
Brugia malayi photoreceptor-specific nuclear receptor 0.0087 0.0426 0.0485
Loa Loa (eye worm) tubulin alpha 2 0.0156 0.0814 0.0927
Echinococcus multilocularis conserved hypothetical protein 0.0024 0.0072 0.0123
Leishmania major alpha tubulin 0.0678 0.3757 0.6351
Onchocerca volvulus Alhambra homolog 0.003 0.0105 0.0101
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0072 0.0059
Giardia lamblia Pyruvate kinase 0.0073 0.0345 0.0508
Plasmodium vivax tubulin gamma chain, putative 0.0522 0.2879 0.4884
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0051
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0245 0.0278
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0101 0.0503 0.0573
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0072 0.01
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0168 0.0284
Trypanosoma cruzi short chain dehydrogenase, putative 0.0024 0.0072 0.0059
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0146 0.0246
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0168 0.0284
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0168 0.0278
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0024 0.0072 0.01
Echinococcus granulosus tubulin alpha chain 0.0678 0.3757 0.6374
Trichomonas vaginalis tubulin beta chain, putative 0.0678 0.3757 0.3754
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0168 0.0284
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0094
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.0255
Echinococcus granulosus ecdysone induced protein 78C 0.0087 0.0426 0.0723
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Echinococcus granulosus apoptotic protease activating factor 1 0.0075 0.0357 0.0606
Leishmania major delta tubulin, putative 0.0227 0.1214 0.2009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Plasmodium falciparum tubulin epsilon chain, putative 0.0522 0.2879 0.4884
Echinococcus granulosus Tubulin beta 2C chain 0.1057 0.5894 1
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Plasmodium falciparum pyruvate kinase 0.0073 0.0345 0.0584
Onchocerca volvulus 0.0024 0.0072 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.094 0.5236 0.8876
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0109 0.0554 0.055
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0382 0.0648
Brugia malayi Tubulin alpha chain 0.0227 0.1214 0.1382
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0034 0.0058
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0051 0.0225 0.1575
Leishmania major hypothetical protein, conserved 0.0052 0.023 0.0328
Echinococcus granulosus dna polymerase kappa 0.002 0.0048 0.0082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Trypanosoma cruzi short chain dehydrogenase, putative 0.0024 0.0072 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0037 0.0033
Leishmania major hypothetical protein, conserved 0.0024 0.0072 0.0059
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0108 0.0547 0.087
Onchocerca volvulus Pyruvate kinase homolog 0.0073 0.0345 0.0341
Echinococcus multilocularis geminin 0.0554 0.3058 0.5188
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0024 0.0072 0.0041
Echinococcus multilocularis tubulin alpha 3 chain 0.0678 0.3757 0.6374
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0004 0.0004
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0101 0.0503 0.0847
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0072 0.0059
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0024 0.0072 0.0068
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0024 0.0072 0.0059
Brugia malayi ecdysteroid receptor 0.0087 0.0426 0.0485
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0146 0.0186
Onchocerca volvulus 0.0225 0.1208 0.1204
Echinococcus granulosus cathepsin l1 0.0018 0.0037 0.0064
Schistosoma mansoni retinal dehydrogenase 0.0024 0.0072 0.0116
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Leishmania major lipase, putative 0.0026 0.0085 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0316 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0767 0.1295
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Brugia malayi hypothetical protein 0.0041 0.0168 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Brugia malayi hypothetical protein 0.0051 0.0225 0.0255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0382 0.0378
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0048 0.0018
Plasmodium falciparum phd finger protein, putative 0.003 0.0105 0.0177
Onchocerca volvulus 0.0024 0.0072 0.0068
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0227 0.1214 0.2009
Schistosoma mansoni inositol monophosphatase 0.0079 0.0382 0.0641
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0083 0.0366
Echinococcus granulosus pyruvate kinase 0.0037 0.0146 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Brugia malayi Muscleblind-like protein 0.0317 0.1724 0.1964
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0239 0.0344
Trypanosoma brucei beta tubulin 0.1057 0.5894 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0321 0.0484
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0051 0.0225 0.0382
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0072 0.0054
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0245 0.0278
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0109 0.0554 0.055
Schistosoma mansoni tubulin subunit alpha 0.0678 0.3757 0.6372
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0171 0.0291
Loa Loa (eye worm) pyruvate kinase-PB 0.0051 0.0222 0.0252
Trypanosoma brucei short-chain dehydrogenase, putative 0.0024 0.0072 0.01
Echinococcus multilocularis tubulin alpha chain 0.0678 0.3757 0.6374
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0133 0.0219
Echinococcus multilocularis peroxisome assembly protein 26 0.0678 0.3757 0.6374
Trypanosoma brucei beta tubulin 0.1057 0.5894 1
Schistosoma mansoni pyruvate kinase 0.0073 0.0345 0.0579
Echinococcus multilocularis Tubulin beta 2C chain 0.1057 0.5894 1
Echinococcus multilocularis beta tubulin 0.1057 0.5894 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Mycobacterium tuberculosis Carboxylesterase LipT 0.0051 0.0225 0.1575
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0382 0.0588
Mycobacterium ulcerans ketoacyl reductase 0.0024 0.0072 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0426 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Mycobacterium tuberculosis Possible oxidoreductase 0.0024 0.0072 0.0274
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0024 0.0072 0.0054
Trypanosoma cruzi beta tubulin, putative 0.1057 0.5894 1
Brugia malayi hypothetical protein 0.0075 0.0357 0.0406
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0168 0.0284
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Leishmania major beta tubulin 0.1057 0.5894 1
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0196 0.031
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Entamoeba histolytica tubulin family protein 0.1057 0.5894 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0195 0.0222
Leishmania major hypothetical protein, conserved 0.094 0.5236 0.8876
Brugia malayi TAR-binding protein 0.0126 0.065 0.0739
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0048 0.0054
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0382 0.0641
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0024 0.0072 0.01
Loa Loa (eye worm) ctsf protein 0.0018 0.0037 0.0042
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0051 0.0225 0.0221
Echinococcus multilocularis para nitrobenzyl esterase 0.0051 0.0225 0.0382
Trypanosoma cruzi tubulin delta chain 0.0227 0.1214 0.2009
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0195 0.0222
Brugia malayi Cathepsin L-like precursor 0.0018 0.0037 0.0042
Schistosoma mansoni microtubule-associated protein tau 0.0756 0.4201 0.7125
Onchocerca volvulus Huntingtin homolog 0.0126 0.0646 0.0642
Echinococcus granulosus FTZ F1 alpha 0.0087 0.0426 0.0723
Echinococcus granulosus inhibitor of apoptosis protein 0.0229 0.1226 0.2081
Leishmania major short chain dehydrogenase/reductase, putative 0.0024 0.0072 0.0059
Brugia malayi tubulin alpha-2 chain 0.0678 0.3757 0.4279
Schistosoma mansoni carbonyl reductase 0.0024 0.0072 0.0116
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0037 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.023 0.0328
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0024 0.0072 0.01
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0051 0.0225 0.0382
Echinococcus granulosus muscleblind protein 0.0317 0.1724 0.2926
Brugia malayi oxidoreductase 0.0024 0.0072 0.0082
Brugia malayi Cathepsin L-like precursor 0.0012 0.0004 0.0004
Trypanosoma brucei beta tubulin 0.1057 0.5894 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0068 0.0115
Loa Loa (eye worm) hypothetical protein 0.0229 0.1226 0.1396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0321 0.0485
Schistosoma mansoni hypothetical protein 0.0397 0.2172 0.3681
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Brugia malayi Retinol dehydrogenase 12 0.0024 0.0072 0.0082
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0489 0.083
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0024 0.0072 0.0116
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0087 0.0426 0.0485
Loa Loa (eye worm) pyruvate kinase 0.0073 0.0345 0.0393
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0087 0.0426 0.0723
Toxoplasma gondii carbonyl reductase 1, putative 0.0024 0.0072 0.0059
Brugia malayi alpha-tubulin 0.0678 0.3757 0.4279
Loa Loa (eye worm) hypothetical protein 0.0678 0.3757 0.4279
Trypanosoma brucei epsilon tubulin 0.0522 0.2879 0.4873
Loa Loa (eye worm) hypothetical protein 0.0229 0.1226 0.1396
Leishmania major beta tubulin 0.1057 0.5894 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Loa Loa (eye worm) dehydrogenase 0.0024 0.0072 0.0082
Trichomonas vaginalis tubulin epsilon chain, putative 0.1057 0.5894 0.5892
Onchocerca volvulus 0.0024 0.0072 0.0068
Loa Loa (eye worm) acetylcholinesterase 1 0.0303 0.1643 0.1871
Onchocerca volvulus 0.0018 0.0037 0.0033
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0068 0.0115
Echinococcus granulosus tubulin alpha 1C chain 0.0678 0.3757 0.6374
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0274
Loa Loa (eye worm) oxidoreductase 0.0024 0.0072 0.0082
Onchocerca volvulus Bile acid receptor homolog 0.0087 0.0426 0.0422
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0105 0.0179
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0087 0.0426 0.0723
Loa Loa (eye worm) tubulin beta-2A chain 0.1057 0.5894 0.6713
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0321 0.0545
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Brugia malayi Cathepsin L-like precursor 0.0018 0.0037 0.0042
Echinococcus multilocularis GPCR, family 2 0.0017 0.0034 0.0058
Onchocerca volvulus Protein ultraspiracle homolog 0.0087 0.0426 0.0422
Brugia malayi nuclear hormone receptor 0.0041 0.0168 0.019
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0168 0.019
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0274
Schistosoma mansoni tubulin subunit beta 0.0227 0.1214 0.2054
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0072 0.0059
Trypanosoma cruzi pyruvate kinase 2, putative 0.0073 0.0345 0.0526
Mycobacterium ulcerans glutaminase 0.0886 0.4934 1
Schistosoma mansoni tubulin subunit beta 0.1057 0.5894 1
Loa Loa (eye worm) glutaminase 0.0886 0.4934 0.5621
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.065 0.0739
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Schistosoma mansoni steroid dehydrogenase 0.0024 0.0072 0.0116
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0288 0.0427
Echinococcus multilocularis FTZ F1 alpha 0.0087 0.0426 0.0723
Trichomonas vaginalis tubulin gamma chain, putative 0.1057 0.5894 0.5892
Trichomonas vaginalis tubulin beta chain, putative 0.0678 0.3757 0.3754
Loa Loa (eye worm) steroid hormone receptor 0.0087 0.0426 0.0485
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0024 0.0072 0.0054
Leishmania major hypothetical protein, conserved 0.0024 0.0072 0.0059
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Mycobacterium ulcerans short-chain type oxidoreductase 0.0024 0.0072 0.0054
Brugia malayi jmjC domain containing protein 0.0038 0.015 0.017
Onchocerca volvulus 0.0051 0.0225 0.0221
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0024 0.0072 0.0068
Onchocerca volvulus 0.0041 0.0168 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0168 0.0284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0052
Echinococcus multilocularis tubulin gamma 1 chain 0.0522 0.2879 0.4885
Echinococcus granulosus alpha tubulin 0.0678 0.3757 0.6374
Onchocerca volvulus 0.0018 0.0037 0.0033
Leishmania major beta tubulin 0.1057 0.5894 1
Echinococcus multilocularis muscleblind protein 1 0.0317 0.1724 0.2926
Leishmania major beta tubulin 0.1057 0.5894 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Loa Loa (eye worm) carboxylesterase 0.0051 0.0225 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0321 0.0523
Loa Loa (eye worm) hypothetical protein 0.0087 0.0426 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0087 0.0426 0.0485
Brugia malayi Tubulin gamma chain 0.0522 0.2879 0.3279
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0195 0.0222
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0303 0.1643 0.2783
Loa Loa (eye worm) hypothetical protein 0.0126 0.0646 0.0735
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0072 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.023 0.0328
Loa Loa (eye worm) hypothetical protein 0.0451 0.2479 0.2824
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0382 0.0626
Echinococcus granulosus oxidoreductase 0.0024 0.0072 0.0123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0087 0.0426 0.0723
Leishmania major pyruvate kinase 0.0073 0.0345 0.0526
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0024 0.0072 0.0123
Brugia malayi Tubulin beta chain 0.0227 0.1214 0.1382
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0037 0.0042
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0072 0.0274
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0109 0.0554 0.0881
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Schistosoma mansoni carbonyl reductase 0.0024 0.0072 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0072 0.0059
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.023 0.0367
Trypanosoma cruzi lipase, putative 0.0026 0.0085 0.0081
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0451 0.2479 0.2824
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0048 0.0075
Schistosoma mansoni pyruvate kinase 0.0037 0.0146 0.0242
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0376 0.0631
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0024 0.0072 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0126 0.065 0.1096
Schistosoma mansoni short chain dehydrogenase 0.0024 0.0072 0.0116
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0024 0.0072 0.0274
Onchocerca volvulus 0.0024 0.0072 0.0068
Echinococcus granulosus tubulin alpha chain 0.0678 0.3757 0.6374
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0051
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0227 0.1214 0.2009
Leishmania major beta tubulin 0.1057 0.5894 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0034 0.0038
Leishmania major beta tubulin 0.1057 0.5894 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0048 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0052
Loa Loa (eye worm) tubulin alpha chain 0.0678 0.3757 0.4279
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0094 0.0077
Loa Loa (eye worm) hypothetical protein 0.0303 0.1643 0.1871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0037 0.0033
Trypanosoma brucei alpha tubulin 0.0678 0.3757 0.6366
Brugia malayi Carboxylesterase family protein 0.0051 0.0225 0.0255
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0024 0.0072 0.0054
Giardia lamblia Pyruvate kinase 0.0037 0.0146 0.0168
Echinococcus granulosus beta tubulin 0.1057 0.5894 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0087 0.0426 0.0717
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0195 0.0325
Leishmania major quinonoid dihydropteridine reductase 0.0024 0.0072 0.0059
Echinococcus granulosus tubulin alpha chain 0.0678 0.3757 0.6374
Echinococcus multilocularis tubulin subunit beta 0.1057 0.5894 1
Brugia malayi Carboxylesterase family protein 0.0051 0.0225 0.0255
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0229 0.1226 0.2081
Brugia malayi Cathepsin L-like precursor 0.0018 0.0037 0.0042
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0024 0.0072 0.0059
Schistosoma mansoni hypothetical protein 0.0035 0.0133 0.0219
Mycobacterium ulcerans short chain dehydrogenase 0.0024 0.0072 0.0054
Mycobacterium ulcerans hypothetical protein 0.0108 0.0547 0.1024
Echinococcus multilocularis tar DNA binding protein 0.0126 0.065 0.1102
Mycobacterium ulcerans short-chain dehydrogenase 0.0024 0.0072 0.0054
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0024 0.0072 0.0274
Trichomonas vaginalis tubulin beta chain, putative 0.0295 0.1601 0.1598
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0146 0.0246
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0119 0.0139

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Induction of degradation of cIAP1 in human MDA-MB-231 cells at 100 nM after 15 mins by Western blot analysis ChEMBL. 21443232
Activity (binding) Induction of degradation of cIAP1 in human MDA-MB-231 cells at 10 nM by Western blot analysis ChEMBL. 21443232
Activity (functional) = 50 % Induction of cell death in human MDA-MB-231 cells at 1 uM incubated for 24 hrs by trypan blue exclusion assay ChEMBL. 21443232
AUC (ADMET) = 3.8 hr.microg/ml AUC (0 to t) in human MDA-MB-231 cells xenografted SCID mouse plasma at 10 mg/kg, iv administered as single dose ChEMBL. 21443232
EC50 (functional) = 0.0021 uM Cytotoxicity against human sensitive EVSA-T cells assessed as inhibition of cell growth after 72 hrs by Alamar Blue assay ChEMBL. 26218264
EC50 (binding) = 0.034 uM Antagonist activity at full-length FLAG-tagged XIAP (unknown origin) transfected in HEK293 cells assessed as inhibition of interaction with caspase 9 after 2 hrs by immunoprecipitation assay ChEMBL. 26218264
IC50 (binding) = 12.3 nM Competitive inhibition of human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay ChEMBL. 21443232
IC50 (binding) = 22.1 nM Competitive inhibition of human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay ChEMBL. 21443232
IC50 (functional) = 144 nM Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay ChEMBL. 21443232
IC50 (binding) = 225 nM Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay ChEMBL. 21443232
Inhibition (functional) Antagonist activity at human XIAP BIR3 domain assessed as restoration of caspase 9 activity using human MDA-MB-231 cells lysates using Z-LEHD-AFC by fluorescence assay based cell-free assay ChEMBL. 21443232
Inhibition (binding) = 70 % Antagonist activity at XIAP-BIR3 domain (unknown origin) assessed as inhibition of interaction with SMAC at 0.05 uM by fluorescence polarization assay relative to control ChEMBL. 26218264
Inhibition (binding) = 98 % Antagonist activity at cIAP1-BIR3 domain (unknown origin) assessed as inhibition of interaction with SMAC at 0.01 uM by fluorescence polarization assay relative to control ChEMBL. 26218264
Ki (binding) = 1.9 nM Competitive inhibition of human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay ChEMBL. 21443232
Ki (binding) = 5.1 nM Competitive inhibition of human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay ChEMBL. 21443232
Ki (binding) = 66.4 nM Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay ChEMBL. 21443232

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21443232

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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